Crohn's Disease and Colitis

You have been diagnosed with Crohn's disease (including a form that causes tunnels or passages called fistulas) for at least 3 months, affecting your colon, small intestine, or both, confirmed at some point by imaging, tissue samples, or a camera procedure Your Crohn's disease is considered moderate to severe, based…

You have been diagnosed with Crohn's disease for at least 3 months. Your Crohn's disease is considered moderate to severe, based on symptoms such as stool frequency, abdominal pain, and results from a bowel camera examination (endoscopy). Previous treatments for Crohn's disease — either standard medications or…

You have had moderate to severe ulcerative colitis (UC) symptoms for at least 3 months before the screening visit. Your UC affects a large enough portion of your colon (reaching at least 15 cm from the opening of the rectum). You have tried at least one UC treatment in the past — such as aminosalicylates (e.g.…

You must have already taken part in one of two specific earlier studies (called CDP870-031 or CDP870-032) and completed it at the 26-week point, whether you received the active treatment, a dummy treatment (placebo), or both. You must be able to understand the information given to you about the trial and sign a…

You must have already successfully completed one of two specific earlier clinical trials (called M02-404 or M04-691) to be eligible for this study You have been diagnosed with Crohn's disease You are willing and able to agree to take part and sign a consent form

You can be either male or female You must be between 18 and 75 years old (inclusive) You have been officially diagnosed with Crohn's disease Your Crohn's disease is currently considered moderate to severe, based on a specific scoring system called the CDAI (with a score between 225 and 450) You have never previously…

You have been diagnosed with Crohn's disease (including a type involving abnormal tunnels called fistulas) for at least 3 months. You have previously been treated with at least one of these medications at the standard approved dose: Remicade (infliximab), Humira (adalimumab), or Cimzia (certolizumab pegol). Your…

Children and teenagers between the ages of 5 and 17 years old, with permission given by both the parent/guardian and the child themselves. You have been diagnosed with ulcerative colitis for at least 3 months. If you are currently taking a medication called 5-ASA (or a medication that works like it), you must have…

You have tried anti-TNF medications (a type of treatment for inflammatory conditions) but they did not work for you, or you were unable to tolerate them Your blood test shows a certain level of inflammation in your body (a marker called hsCRP of 5.0 mg/L or higher) A camera examination of your bowel (colonoscopy) done…

You must have already taken part in a previous related study (called B0151003) and completed the first 12 weeks (84 days) of that study. You must be willing and able to attend scheduled appointments, follow the treatment plan, and complete all required tests and procedures. If you are a woman who could become pregnant…

You have been diagnosed with Crohn's disease for at least 3 months, affecting your colon, small intestine, or both, confirmed at some point by imaging, tissue testing, or a camera examination of the gut. Your Crohn's disease is currently active, based on a specific scoring system that measures disease activity…

You are between 18 and 75 years old (note: the upper age limit is 64 in India and 65 in the Netherlands) You have been diagnosed with Crohn's disease for at least 6 months before the screening visit Your Crohn's disease is currently moderately to severely active, affecting the small intestine, large intestine, or…

You must have already taken part in a related study called A3921083 and completed your visit at Week 8 of that study. Your Crohn's disease symptoms must have improved significantly or gone into remission (very low disease activity) during the A3921083 study, based on a standard scoring system called the CDAI. If you…

You must be at least 18 years old You must have been officially diagnosed with ulcerative colitis (UC) at least 4 months before joining the study Your ulcerative colitis must currently be considered moderate to severe based on a standard scoring system used by doctors You must have already tried at least one of the…

You previously took part in a related study (called A3921094 or A3921095) and your condition did not improve enough to meet the required response levels by the end of that study. You previously took part in another related study (called A3921096) and either completed it fully, or had to stop early because the…

You have been diagnosed with ulcerative colitis (UC) for at least 3 months, confirmed by a camera examination of the bowel and a tissue sample. Your UC is considered moderate to severe, based on specific scoring measurements taken before the study begins. You have not responded well to, stopped responding to, or could…

You are between 18 and 66 years old You were previously part of a specific related study (called A7281009 / NCT01620255) and have completed the full 12-week starting phase of that study

You are willing and able to sign a consent form to take part in the study. You have been diagnosed with Crohn's Disease, confirmed by a scope, scan, or tissue sample, at least 6 months before joining the study. Your Crohn's Disease affects the small intestine (ileum) and/or the large intestine (colon). Your Crohn's…

You have been diagnosed with moderately to severely active Crohn's Disease, confirmed through symptom scoring, patient-reported symptoms, and a camera examination (endoscopy) of the small intestine and/or colon You have tried steroids, immune-suppressing medications, or anti-TNF medications (a type of biologic drug)…

You are between 18 and 75 years old You have been diagnosed with ulcerative colitis (UC), confirmed by a camera examination of the bowel (endoscopy) Your ulcerative colitis is classed as moderately to severely active, based on a standard scoring system used by doctors You are currently being treated with one of these…

You were diagnosed with Crohn's disease (CD) at least 3 months before the study screening, confirmed by a camera examination of the gut and a tissue sample analysis. Your Crohn's disease is moderately to severely active, based on a specific scoring system (called CDAI, scored between 220 and 450), plus at least one of…

You have been diagnosed with ulcerative colitis for at least 90 days, confirmed by a colonoscopy during the screening period, with no signs of current infection or cancer in the colon. Your ulcerative colitis is currently active, with disease activity scores in a moderate range as measured by a colonoscopy and a…

You (or your parent or legal representative) are willing and able to fully follow all study rules and procedures. You (or your parent or legal representative) are able to give written, signed, and dated consent to take part in the study. You previously took part in specific earlier studies (SHP647-301 or SHP647-302)…

You (or your parent or legal representative) must be willing and able to follow all study rules and attend all required visits. You must be able to give your written, signed, and dated agreement to take part in the study (either yourself or through a legal representative). You must have already completed the full…

You have been diagnosed with Crohn's disease (CD) for at least 3 months before the study starts. Your Crohn's disease has been confirmed as moderate to severe, based on how often you have bowel movements and your level of abdominal pain. A camera test (endoscopy) has shown active inflammation in your gut, confirmed by…

You have been diagnosed with Crohn's disease for at least 3 months, confirmed by a camera examination of the gut (endoscopy) and tissue sample (biopsy) Previous treatments have not worked well enough for you, or have stopped working — including steroids, immune-suppressing medicines, and/or biologic medicines Your…

You have been diagnosed with Crohn's disease for at least 3 months before the start of the trial. Your Crohn's disease has been confirmed as moderate to severe, based on specific medical assessments (confirm with trial site). Previous treatments for your Crohn's disease — either standard medications or biologic…

You have been diagnosed with ulcerative colitis (UC) — a condition causing inflammation in the large intestine — that spreads at least 15 cm inside the bowel, confirmed by a camera test (colonoscopy or sigmoidoscopy) before joining the trial You have had a confirmed diagnosis of ulcerative colitis for at least 3…

You have moderately to severely active ulcerative colitis (UC) that is not responding well to your current treatment, or you cannot tolerate your current treatment. You weigh at least 10 kg (about 22 pounds) at the time of screening. You have been diagnosed with UC for at least 1 month before screening, and tests…

You must have already taken part in and completed a previous related study (called a "parent study") for Crohn's disease or ulcerative colitis, where the treatment was given in an open, non-blinded way.

You have a confirmed diagnosis of Crohn's disease (CD) Your Crohn's disease is considered moderately to severely active, based on a specific activity score and a camera examination of your bowel reviewed by a central medical team You either depend on steroids to manage your condition, or you have not responded well…

You have been diagnosed with, or are suspected to have, Crohn's disease that affects the small bowel A scan has shown that the wall of the last part of your small intestine (called the terminal ileum) is thicker than normal (more than 3mm) A scan has shown that the last part of your small intestine did not fill out…

People who are generally healthy men or women between 18 and 60 years old (inclusive) Men who weigh at least 50 kg and women who weigh at least 45 kg, with a body mass index (BMI) between 18 and 32 People who are able to fully understand what the study involves and are willing to sign a consent form agreeing to take…

People whose Crohn's Disease symptoms score at a certain level of severity (a score of 220 or higher on a standard measurement tool called the CDAI) People who have had a confirmed diagnosis of Crohn's Disease for at least 90 days before the study start date People whose bowel inflammation has been confirmed by a…

People who were diagnosed with Crohn's disease (CD) at least 12 weeks before the screening visit, confirmed by both a camera examination of the gut (endoscopy) and a tissue sample report (biopsy/histopathology). People whose Crohn's disease is moderately to severely active, based on a specific scoring system (CDAI)…

People who have already completed the full dosing period in the original children's guselkumab study. People who, in the treating doctor's view, have continued to benefit from guselkumab treatment. People who are either not able to become pregnant, or if they could become pregnant, are either not sexually active or…

You have been diagnosed with a rare disease, a disease where the number of people affected is unknown, or you have not yet received a diagnosis for your condition You have been identified as a carrier of a rare or uncommon disease, meaning you carry the gene for a condition but may not have symptoms yourself

People with moderately to severely active Crohn's disease that has not responded to, or has been unable to be tolerated by, their current standard treatment. People who weigh at least 10 kg at the time of screening and enrolling in the study. People who have been diagnosed with Crohn's disease for at least 1 month…

You have been diagnosed with active Crohn's disease that has been confirmed by a camera test (endoscopy) showing active inflammation within the last 6 months — or, if your disease is in a part of the small bowel that can't be reached by endoscopy, an ultrasound scan showing inflammation is acceptable instead. Your…

People who have been diagnosed with moderately to severely active Ulcerative Colitis (UC) before the screening visit People whose UC affects areas beyond just the rectum, as confirmed by a camera examination of the bowel done at the start of the trial People whose UC has not responded well to at least one previous…

You completed one of two specific earlier studies (MLN0002-3024 or MLN0002-3025) and your condition improved enough — without needing steroids — by Week 54 of that study (meeting specific score improvements for either ulcerative colitis or Crohn's disease) If you are male and sexually active with a female partner who…

You are 18 years old or older and have been diagnosed with Crohn's disease You have had surgery to remove a section of your bowel, and the two ends were joined together (called an anastomosis), with no visible signs of disease remaining after the operation You previously had a temporary bag (ileostomy) after Crohn's…

You (or your child) must have been diagnosed with Crohn's Disease (including a type that causes tunnels or tracts, called fistulizing Crohn's Disease), affecting the large intestine, small intestine, or both, confirmed at some point in the past through clinical assessment, a camera examination of the gut, and tissue…

People who were assigned male at birth, or people who were assigned female at birth and are not currently pregnant or breastfeeding, and who are between 18 and 75 years old at the time of the screening visit. People who have had a confirmed diagnosis of ulcerative colitis (a type of inflammatory bowel disease…

You have had signs or symptoms of Crohn's disease (CD) for at least 90 days before the screening visit. Your Crohn's disease is considered moderately to severely active, based on a specific scoring system called the CDAI (with a score between 220 and 450), and you have frequent loose stools and/or significant…

People aged 18 to 75 years old (or 19 and older in South Korea) who have been diagnosed with Crohn's disease for at least 30 days People whose Crohn's disease is considered moderately to severely active, based on specific medical scoring tests People whose previous treatments for Crohn's disease did not work well…

You are between 18 and 80 years old You have moderately to severely active Crohn's disease, based on specific scoring measurements your doctor uses to assess disease activity (confirm with trial site) An ultrasound of your bowel shows thickening of the bowel wall in certain areas of your intestine (confirm with trial…

You weigh at least 10 kg (about 22 pounds) at the time of screening and at the start of the trial. You have been diagnosed with moderate to severe Crohn's Disease in children or teens, confirmed by specific activity scores and a camera examination of the gut (colonoscopy) showing inflammation. Your Crohn's Disease…

You have been diagnosed with Crohn's disease (CD) for at least 3 months before joining the study. Your Crohn's disease is considered moderately to severely active. Previous treatments have not worked well enough for you, stopped working, or caused side effects you could not tolerate — this includes steroids…

You have a confirmed diagnosis of ulcerative colitis (UC) Your UC is considered moderately to severely active, based on a specific scoring system used by doctors You weigh at least 40 kilograms (about 88 pounds) You are up to date with bowel cancer screening, as recommended in your local area Previous treatments for…

You are between 18 and 55 years old You are in good general health with no significant medical history Your routine blood and lab test results are within the normal range Your Body Mass Index (BMI) is between 18 and 35 You are willing to use contraception as required by local guidelines (applies to both men and women)…

People who are male or female, aged 18 to 55 years old, with a body mass index (a measure of body weight relative to height) between 18.5 and 32.0, who have not used any tobacco or nicotine products in the 3 months before screening People who are generally in good health, with no significant illnesses or surgery in…

You are between 18 and 75 years old You have been diagnosed with Crohn's disease (CD) for at least 3 months before the study begins Your Crohn's disease has been confirmed as moderate to severe, based on specific scoring systems measuring disease activity, bowel habits, and abdominal pain, checked through a camera…

You have a confirmed diagnosis of Crohn's disease (CD) Your Crohn's disease is considered moderately to severely active You weigh at least 40 kilograms (about 88 pounds) You have tried at least one standard or advanced Crohn's disease treatment but it did not work well enough, stopped working, or you could not…

You have been officially diagnosed with Crohn's disease (CD) Your Crohn's disease is considered moderately to severely active You weigh at least 40 kilograms (about 88 pounds) Previous treatments for Crohn's disease (either standard or newer therapies) have not worked well enough, stopped working, or caused you…

People who have a confirmed diagnosis of ulcerative colitis (UC) People whose UC is considered moderate to severely active, based on a specific scoring system called the Modified Mayo clinic score People whose UC did not respond well to, stopped responding to, or who could not tolerate at least one of the following…

You are between 18 and 75 years old (inclusive) You have been diagnosed with ulcerative colitis (UC) with confirmed symptoms for at least 3 months before the screening visit Your UC is considered moderately to severely active, based on specific scores measured during a scope procedure (confirm with trial site) You…

People who have been diagnosed with Crohn's Disease (a type of inflammatory bowel condition) for at least 3 months before the screening visit People whose Crohn's Disease has been confirmed as moderate-to-severe People who have previously tried at least one standard treatment (such as certain anti-inflammatory…

People aged 18 to 75 years old at the time of signing the consent form, of any gender People who have had confirmed signs of active ulcerative colitis (UC) for at least 3 months before screening, confirmed by a camera examination of the bowel during the screening period People whose UC is considered moderately to…

People who have been diagnosed with ulcerative colitis (a type of inflammatory bowel disease affecting the large intestine) for at least 3 months People whose ulcerative colitis is considered moderately to severely active, based on a specific medical assessment scale People whose ulcerative colitis has not responded…

People who have been diagnosed with ulcerative colitis (a type of inflammatory bowel disease affecting the large intestine) for at least 3 months before the study start date, confirmed by a camera examination of the bowel and tissue samples taken either before or during the screening period People whose ulcerative…

You weigh at least 10 kilograms (about 22 pounds) You have been confirmed to have ulcerative colitis (UC) You have tried one or more of the following types of treatment — steroid medicines, immune-suppressing medicines, and/or biologic therapies — and either they did not work well enough for you or you could not…

Adults aged 18 to 80 years old at the time of screening, or in some locations, people aged 16 to 17 who have reached full physical maturity (confirm with trial site) People who have had a confirmed diagnosis of moderately to severely active Crohn's Disease for at least 3 months before the study start date People whose…

You have been diagnosed with Crohn's disease (CD) for at least 12 weeks before screening, confirmed by both a camera examination of the gut (endoscopy) and a tissue sample test (biopsy). Your Crohn's disease is considered moderately to severely active, based on a specific scoring system (CDAI score between 220 and…

You have been diagnosed with ulcerative colitis (UC) for at least 12 weeks before the screening visit, confirmed by both a camera examination of the bowel and a tissue sample test Your UC is considered moderately to severely active, based on a specific scoring system measured during a bowel camera examination reviewed…

People who weigh at least 10 kilograms People who have active Crohn's disease that has been confirmed by a camera examination of the bowel (a procedure called ileocolonoscopy) People whose Crohn's disease is considered moderately to severely active, based on specific scoring systems used by doctors to measure disease…

You have been diagnosed with Crohn's disease (CD) or Crohn's disease with fistulas (tunnels forming between body parts), and this diagnosis was confirmed at least 12 weeks before the study screening, with both a camera examination of the gut and a tissue sample supporting that diagnosis. Your Crohn's disease is…

You have been diagnosed with Crohn's disease affecting the small intestine, large intestine, or both, for at least 6 months before starting the study medication Your Crohn's disease is considered moderately to severely active, based on a specific disease activity score (called a CDAI score) measured at the start of…

You have been officially diagnosed with Crohn's disease, confirmed through camera examinations of the gut, tissue samples, and/or imaging scans before or during surgery You have had surgery to remove part of your small intestine and colon (ileocolonic resection) You are considered to be at a higher-than-average risk…

People who were enrolled in the related earlier study (NCT01150890) and completed their Week 12 check-up in that study. People whose Week 12 check-up in the earlier study took place no more than 1 year before the planned start date in this trial. The person joining, or their legal representative, must have given…

You must have already taken part in a related induction study (Study CCX114151 or another GSK-sponsored study) and shown improvement in your Crohn's disease symptoms or reached remission during that study You must be willing and able to sign a consent form before any procedures in this study begin If you are a woman…

Adults aged 18 or older, of any gender People who are willing and able to provide written consent before any screening steps begin, including stopping any medications that are not allowed in the trial People who have been diagnosed with Crohn's disease for more than 4 months, with the disease affecting the small bowel…

You previously took part in a related etrolizumab study (called GA29144 / NCT02394028) and meet the requirements to continue receiving the open-label treatment in Part 1 of this trial You took part in the related etrolizumab study (GA29144 / NCT02394028) but are either not eligible for, or have chosen not to enter…

You are 18 years of age or older (male or female) You have been diagnosed with active Crohn's disease, confirmed by specific scoring tests used by doctors to measure disease activity and gut inflammation You have a minimum number of daily bowel movements or a certain level of abdominal pain on most days over a 7-day…

You are 18 years of age or older (for adult participants) You previously took part in a specific related clinical study called GED-0301-CD-002 or GED-0301-CD-003 You are willing and able to use an approved method of contraception as required by the study You are between 12 and 17 years old (for adolescent…

You previously received vedolizumab (not a placebo or comparison drug) as part of an earlier qualifying clinical study. Your doctor believes you are still benefiting from vedolizumab and that continuing it is important, either because there is no similar alternative available to you, or because stopping treatment…

You met the requirements to join the earlier part of this study (called the "induction study") and completed all required assessments at the 12-week mark. At week 12 of the induction study, you were showing improvement or were in remission, meaning your symptoms — such as number of bowel movements per day and…

You did not fully respond to (or achieve remission from) a related induction study after 12 weeks of treatment You experienced a return of symptoms (relapse) during or after completing a related maintenance study You have already completed a study of ozanimod for Crohn's Disease and meet the specific requirements to…

People aged 16 to 80 years old (those under 18 must weigh at least 40 kg and have a body mass index of at least 16.5) People who have active moderate to severe Crohn's disease (CD) affecting the lower small intestine, the junction between the small and large intestine, or the colon, confirmed by specific symptom…

You have been diagnosed with Crohn's Disease for at least 3 months before the screening visit, affecting the small intestine, large intestine, or both You have tried one or more standard treatments for Crohn's Disease but they did not work well enough, stopped working, or you could not tolerate them Your Crohn's…

You are at least 18 years old at the time of screening You are male or female and have been diagnosed with Crohn's disease for at least 3 months before screening Your Crohn's disease is considered moderately to severely active, based on a specific scoring system used by doctors (called the CDAI, with a score between…

You are a man, or a woman who is not pregnant or breastfeeding, and are at least 18 years old. You have been diagnosed with ulcerative colitis (UC) for at least 3 months, confirmed by a camera examination of the bowel (endoscopy) and tissue sample (biopsy) at some point in the past, and the disease affects at least 15…

You are a man or woman between 18 and 80 years old You are able to give written consent and are able to follow the schedule of visits and assessments required by the trial You have been diagnosed with Crohn's disease for at least 3 months Your Crohn's disease is considered moderately to severely active at the time of…

You have been diagnosed with moderately to severely active ulcerative colitis (UC), confirmed by a specific scoring system and a scope procedure (colonoscopy/endoscopy) done within 14 days before the study starts. Your UC affects more than just the rectum — it extends further into the colon (at least 15 cm of the…

You have been diagnosed with Crohn's Disease for at least 3 months before the study starts. Your Crohn's Disease activity falls within a certain range of severity, based on a standard scoring system called the CDAI (with a score between 220 and 450), meaning your disease is moderately to severely active. A camera…

Your child's Crohn's disease must be rated as moderately to severely active based on a specific symptom score (called PCDAI), AND a camera examination of the gut (called an endoscopy) must show a certain level of inflammation based on a scoring system called SES-CD (confirm with trial site for exact score details)…

You are currently taking, have tried without success, or cannot take (for medical reasons) at least one of these medications: corticosteroids (taken by mouth or through a vein), 6-mercaptopurine, methotrexate, or azathioprine — OR you have been unable to stop taking corticosteroids without your ulcerative colitis (UC)…

You took part in a previous related clinical trial (called study C87037 or NCT00291668) and your Crohn's disease symptoms improved during that study.

You must have already completed a specific previous clinical trial called study C87042 (NCT00308581), which involved treatment with a medicine called infliximab.

You have been diagnosed with Crohn's disease Your Crohn's disease symptoms have come back within the last 8 weeks, even though you have been taking a regular maintenance dose of REMICADE (infliximab), and your doctor feels the current treatment is not working well enough for you

Adults between 18 and 65 years old (male or female) who are not able to become pregnant. People diagnosed with mild-to-moderately active ulcerative colitis that extends beyond the rectum, confirmed by symptoms and a camera examination of the bowel (endoscopy). People whose disease activity falls within a specific…

You must be between 18 and 76 years old. You must have already taken part in one of two specific related studies (called A7281006 or A7281008) and completed the first 12 weeks of treatment, and shown signs that the treatment is working (as defined by those studies).

You have been diagnosed with Crohn's disease for at least 4 months. Your Crohn's disease is currently active and considered moderate to severe (based on a symptom scoring system called the Harvey-Bradshaw Index). You have already tried steroid medications and/or immune-suppressing medications, but they did not work…

You are between 17 and 22 years old (young adult group) OR between 12 and 16 years old (pediatric group) You have been diagnosed with moderately to severely active Crohn's disease or ulcerative colitis, confirmed by a scope procedure or special MRI scan within the last 2 months Your disease has not responded well to…

You were at least 12 years old when you were first diagnosed with Crohn's disease (CD) or ulcerative colitis (UC), and you are at least 18 years old at the time of joining the study. Your doctor has prescribed you either CT-P13 (a biosimilar infliximab) or Remicade (infliximab) to treat your Crohn's disease or…

You have been diagnosed with Crohn's Disease confirmed by a biopsy. You either do or do not have back pain that is related to inflammation (the trial is looking for a mix of both groups). You are 18 years old or older. You speak English.

You have active, moderate to severe Crohn's disease affecting the small intestine and/or colon, confirmed by a symptom score and a camera examination (endoscopy) showing signs of active disease Previous treatments for Crohn's disease either did not work well enough, stopped working, caused side effects you could not…

You have been diagnosed with Crohn's disease (affecting the small intestine, large intestine, or both) for at least 12 weeks before agreeing to take part. Your Crohn's disease is currently moderate to severe, based on two specific scoring systems used by doctors (confirm with trial site for exact score details). A…

People older than 7 years of age who are having an upper or lower endoscopy (a camera procedure to look inside the digestive tract) or bowel surgery, whether or not they have been diagnosed with inflammatory bowel disease (IBD).

A person must have been diagnosed with Inflammatory Bowel Disease (a condition causing long-term inflammation in the digestive tract) through a camera examination of the bowel, imaging scans, and clinical assessment. The person must be 3 years of age or older. The person must have a recurring Clostridioides difficile…

People who are 18 years of age or older. People who have been diagnosed with Crohn's disease, ulcerative colitis, or inflammatory bowel disease (IBD) that has not been classified into a specific type. People who agree to the terms and conditions of the study's consent and authorisation documents. People who are…

People diagnosed with inflammatory bowel disease (IBD) who are between 18 and 85 years old at the time of joining the study. The IBD diagnosis must be confirmed using standard methods, including blood tests and colonoscopy. Women with IBD who could become pregnant, or who are currently pregnant, are eligible to be…

People aged between 12 and 25 years old. People who have been diagnosed with Crohn's disease (the type affecting the digestive tract) or ulcerative colitis. People who are currently receiving infliximab infusions every 8 weeks, or adalimumab injections every 2 weeks. People for whom this is their first anti-TNF…

You have been diagnosed with Crohn's disease (CD) A narrowing (blockage) in your colon was found during a colonoscopy, and surgery is not currently being considered for you The narrowed section of your colon is less than 5 cm long You agree to have a balloon procedure performed through a scope to widen the narrowing…

People aged 13 or older who have been diagnosed with inflammatory bowel disease (IBD), including Crohn's disease, ulcerative colitis, or indeterminate colitis. People who are being cared for at a participating trial site and have had an appointment there (either in person or online) within the past 12 months. People…

People who have been diagnosed with left-sided ulcerative colitis (disease covering more than 15 cm but not past a certain point in the colon called the splenic flexure), extensive ulcerative colitis (disease extending past the splenic flexure), IBD-unclassified, or Crohn's disease affecting at least two segments of…

You must be 21 years of age or older You must be able to speak English You must be a registered attendee of the advanced 7-day meditation retreat You must be willing to wear a Garmin wearable device for the entire duration of the retreat You must agree to and sign the research consent form to take part in the study…

People who have been diagnosed with Crohn's disease (CD) based on widely accepted diagnostic standards that consider clinical symptoms, camera examination of the gut, and tissue samples. People who have signs of inflammation in the oesophagus (food pipe), stomach, or duodenum (first part of the small intestine)…

People who have been diagnosed with one of the two main types of inflammatory bowel disease: Crohn's disease or ulcerative colitis. People who have been invited to take part by their gastroenterologist (gut specialist) as part of a routine check-up. People who are already scheduled to have a calprotectin test (a stool…

The person has signed a consent form agreeing to take part in the trial. A doctor has confirmed a diagnosis of Crohn's disease at least 6 months before the screening visit, based on a recognised Chinese medical guideline for inflammatory bowel disease. The person's Crohn's disease activity score (CDAI) is 220 or…

People aged between 10 and 80 years old. People who have had a diagnosis of ulcerative colitis for at least 3 months. People with mild to moderate ulcerative colitis, measured by a specific scoring system (called the Mayo score) falling within a defined range (confirm with trial site if unsure about your score).…

People aged 10 years or older who have recently been diagnosed with inflammatory bowel disease (a condition causing long-term inflammation in the digestive tract) or who are already being monitored for this condition.

People with Crohn's Disease (CD) who completed the full course of double-blinded treatment at Week 52 of a related study called SPECIFI-CD (DRI18212). People with Crohn's Disease who completed open-label treatment and reached the required health outcomes at Week 52 of the SPECIFI-CD (DRI18212) study. People with…

A diagnosis of ulcerative colitis must have been confirmed according to the 2018 national consensus guidelines on the diagnosis and treatment of inflammatory bowel disease. A diagnosis of acute severe ulcerative colitis must be present, meaning 6 or more episodes of bloody stools per day plus at least one of the…

People who have been diagnosed with ulcerative colitis or Crohn's disease People whose calprotectin level (a marker of inflammation measured in stool) falls between 200 and 600

Adults (18 years of age or older) People who have a digestive ostomy (a surgical opening in the abdomen used to redirect waste), either permanent or temporary (lasting more than 6 months), who attend ostomy consultations Volunteers who have a permanent digestive ostomy and live in the Santiago or Barbanza healthcare…

People who are 18 years of age or older People who are scheduled to have a planned (non-emergency) colonoscopy People who are able to follow the requirements of the trial People who are able to understand and agree to participate by giving their informed consent People who have been diagnosed with inflammatory bowel…

Adults aged 18 or older who have been diagnosed with ulcerative colitis (a type of bowel disease affecting the large intestine) or Crohn's disease (another type of bowel disease). People who have received at least one injection under the skin of a medicine called infliximab, after first receiving it through a drip…

Adults aged 18 years or older. People who have been diagnosed with inflammatory bowel disease (IBD), which includes Crohn's disease or ulcerative colitis. People whose IBD is currently in remission, meaning their disease is not actively flaring, as confirmed by a doctor. People who are able to give their formal…

People who took part in a previous study called SPY123-201 and completed a specific part of it (called Part A), and whose doctor believes they are still benefiting from the treatment. People who completed another specific part of the previous study (called Part B). People who took part in Part B of the previous study…

Adults between 18 and 70 years of age. People who have been diagnosed with ulcerative colitis (a type of inflammatory bowel disease) for at least 6 months, based on recognised European guidelines. People whose ulcerative colitis is currently in clinical remission, meaning their symptom score is very low (partial Mayo…

People who are 21 years of age or older at the time of joining the trial People who have been diagnosed with ulcerative colitis (UC) or Crohn's disease (CD) People for whom a treating doctor determines that a biologic therapy is appropriate, because earlier standard treatments and/or other biologic treatments have not…

People who are 18 years of age or older People with ulcerative colitis (a type of inflammatory bowel disease) who are starting their first biologic treatment (a type of medication made from living cells) People who have had a confirmed diagnosis of ulcerative colitis for more than 3 months People whose ulcerative…

Adults aged between 18 and 50 years old. People who have a confirmed diagnosis of Crohn's disease, identified through standard clinical, imaging, camera, or tissue tests. People whose Crohn's disease is mildly to moderately active, shown by at least one of the following: a raised blood inflammation marker (CRP above…

People with Crohn's disease who are waiting to have surgery.

People who have recently been diagnosed with ulcerative colitis (a type of inflammatory bowel disease affecting the large intestine) for the first time. Children and teenagers between the ages of 6 and 18 years old. People whose ulcerative colitis was classed as moderate to severe at the time of diagnosis.

Children and teenagers aged 8 to 17 years old. People who have been diagnosed with ulcerative colitis (a type of inflammatory bowel condition) for more than 3 months, affecting any part of the colon except a very small area at the end (less than 5 cm). People whose ulcerative colitis was moderately active based on a…

Adults between 18 and 70 years of age. People of any gender (male or female). People who have been diagnosed with Crohn's disease affecting the small bowel, with one or more narrowings (strictures) in the bowel confirmed by CT scan, MRI, or endoscopy, that are causing symptoms of blockage. People with a CREOLE score…

You are between 18 and 65 years old (inclusive) at the time of screening You weigh between 50 and 110 kg (approximately 110–243 lbs) at screening Your Body Mass Index (BMI) — a measure of body weight relative to height — is between 18.0 and 30.0 at screening If you are a woman, you are either not pregnant and not…

People who have been clinically diagnosed with Inflammatory Bowel Disease (IBD), based on specific diagnosis guidelines used in China. People aged between 18 and 75 years old. People who understand and agree to follow the study requirements and sign a consent form. People who are identified as needing support or…

People who have been diagnosed with Crohn's disease according to a specific set of recognised diagnostic guidelines (Beijing Consensus, 2018). People whose condition meets the accepted medical criteria for treatment with infliximab (IFX). People aged 18 or older with a Crohn's Disease Activity Index (CDAI) score…

Children and teenagers between 6 and 17 years old (inclusive) Children weighing more than 25 kg at the time of joining the trial Children who have Crohn's disease and need a camera examination of the bowel (ileocolonoscopy) for diagnosis or check-up purposes Children with mild to severe Crohn's disease, as measured by…

People who have signed a consent form agreeing to take part in the study. People who are male or female and aged 18 or older. People who have been diagnosed with inflammatory bowel disease (IBD), including Crohn's disease, ulcerative colitis, or indeterminate colitis. People whose IBD is currently inactive or only…

Adults between 18 and 65 years old. People who have ulcerative colitis with active symptoms during a flare-up, but whose test results show low levels of inflammation in the gut (confirm with trial site for specific score thresholds).

People aged 18 or older. People who have been definitively diagnosed with left-sided ulcerative colitis (a form of bowel inflammation affecting the left side of the colon, up to about the middle of the large intestine). People whose disease has not responded to standard treatments and who have been identified as…

You have been diagnosed with Crohn's disease You have been diagnosed with acute anterior uveitis (a type of eye inflammation) You have been diagnosed with psoriatic arthritis that also affects the spine or back (axial involvement) You have been diagnosed with reactive arthritis (a type of joint inflammation triggered…

You are a boy or girl between 5 and 17 years old (not pregnant or breastfeeding) at the time of screening You have been diagnosed with ulcerative colitis (UC), confirmed through a combination of your medical history, a camera examination of your bowel, and tissue samples taken from your bowel Your ulcerative colitis…

Adults aged 18 to 69 years old may be considered for inclusion. All participants will need to sign a consent form agreeing to take part in the study. Because this is an observational study (meaning researchers observe rather than intervene), people who are pregnant or breastfeeding may also be considered for…

Adults aged 18 or older who have already been diagnosed with ulcerative colitis (a type of inflammatory bowel condition) and are currently experiencing active symptoms. Adults who have just recently been diagnosed with ulcerative colitis for the first time.

People diagnosed with Crohn's disease, ulcerative colitis, or inflammatory bowel disease (IBD) that has not been clearly classified as either type. People who have given voluntary written consent to participate (or whose legal representative has done so) before any screening takes place. People who are at least 18…

People who have been diagnosed with ulcerative colitis, whether male or female. People who are older than 18 years of age.

Adults between 18 and 65 years old who are right-handed and have active disease, measured by specific scoring tools used by doctors (a CDAI score of 150 or higher, or a Mayo score above 2).

People who are 18 years of age or older People who identify as Black/African American and/or Hispanic/Latino(a/x) People who have been diagnosed with Crohn's disease or ulcerative colitis People who are able to give informed consent in English People who score within a certain range on standardised questionnaires…

People who are 18 years of age or older. Both men and women are eligible. People who have been diagnosed with mild or moderate ulcerative colitis (UC), confirmed by a camera examination of the bowel (endoscopy). People who are currently being treated with a medicine called 5-aminosalicylic acid (also known as…

You are 18 years old or older You have been diagnosed with ulcerative colitis (UC) for at least 3 months Your UC is currently moderately to severely active, based on a standard scoring system Your doctor has recommended starting a targeted treatment for your UC, but you have not begun it yet If you are taking steroid…

People who are scheduled for planned (non-emergency) bowel removal surgery related to Crohn's disease. People who have been diagnosed with Crohn's disease before their surgery. People aged between 18 and 65 years old. People who are malnourished. People whose Crohn's disease is considered active, based on a standard…

People who have been diagnosed with inflammatory bowel disease (IBD) — either ulcerative colitis or Crohn's disease — and are currently being treated with a type of medication called TNF inhibitors (medicines that reduce inflammation by blocking a specific protein in the body). People who also have a condition…

You are between 6 and 17 years old at the time of joining the study. You have been diagnosed with moderate or severe ulcerative colitis (UC) for at least 1 month before your first study visit, confirmed by a specific scoring system. You have tried at least one standard treatment (such as steroids like prednisone, or…

People who have been diagnosed with ulcerative colitis (UC) for at least 12 weeks before joining the study. People who are 18 years of age or older. People of any gender or sex. People whose ulcerative colitis is currently active enough to warrant starting a type of medication called "small molecules," based on…

People who have been diagnosed with ulcerative colitis (a type of bowel disease), confirmed by camera examination of the bowel and tissue samples. People whose ulcerative colitis has been in remission (no active symptoms) for at least 3 months while taking two medications: Tofacitinib and mesalamine.

The person joining (or their legal representative) must have given written agreement to take part before any screening steps begin. People who have a previously confirmed diagnosis of Crohn's disease, based on clinical assessment, camera examination of the gut, tissue samples, and/or medical imaging. People who are 18…

People who have been diagnosed with ulcerative colitis (a type of inflammatory bowel disease affecting the large intestine). People whose ulcerative colitis has been assessed as mild to moderate in severity.

People diagnosed with Crohn's disease affecting the end of the small intestine (terminal ileum) and the colon. People who are over 18 years of age.

Adults aged 18 to 69 years old. People who are able to read and sign a consent form on their own, without assistance. People who are not currently pregnant or breastfeeding. For people with Crohn's disease (CD): those who have a confirmed diagnosis of CD that has been classified into one of three stages — mainly…

People who are willing to sign a consent form and are able to follow the study rules and procedures. Adults aged 18 to 75 years (inclusive) at the time of signing the consent form, of any gender. People who have been diagnosed with ulcerative colitis (UC) for at least 3 months, confirmed through standard clinical…

People who have been diagnosed with a type of Crohn's disease that causes tunnels or passages to form in the skin around the back passage (perianal fistulizing Crohn's disease). People who are receiving a medication called ustekinumab as part of their treatment.

Adults aged 18 to 65 years (inclusive) at the time of screening, either male or female. People who have been diagnosed with ulcerative colitis (a type of bowel disease) for at least 3 months before screening, confirmed through standard clinical, imaging, camera examination of the bowel, or tissue sample records — or…

People who have been clinically diagnosed with ulcerative colitis (a type of inflammatory bowel condition), for any length of time People between 18 and 65 years of age People who have signed a form agreeing to take part in the trial People whose colonoscopy or similar examination has shown signs of inflammation in…

People who have been diagnosed with Crohn's Disease. People aged 16 years or older. People who are scheduled to have surgery to remove part of the small intestine and/or large intestine (either for the first time or as a repeat procedure). People who are willing and able to give written consent to take part.

People who are able and willing to give their informed consent to take part. People who are able to take part in all parts of this clinical study. Men and women aged 18 to 80 years old at the time of their screening visit. People who have been diagnosed with moderate to severe ulcerative colitis, confirmed by clinical…

People who have been diagnosed with ulcerative colitis or Crohn's disease at least 3 months before joining the trial, based on standard recognised diagnostic criteria. People aged 18 or older. People who have been on a stable dose of vedolizumab (VDZ) or ustekinumab (UST) for at least 3 months before joining the…

You have agreed to take part and signed a consent form You are male or female and over 18 years old You have been diagnosed with Inflammatory Bowel Disease (IBD), which includes Crohn's disease, Ulcerative Colitis, or Indeterminate Colitis You are already scheduled for an outpatient colonoscopy for any reason

Adults aged 18 or older, male or female, who have been diagnosed with one of the following conditions: colitis-associated cancer (CAC), colorectal cancer (CRC), diverticulitis, ischaemic colitis (IC), or Crohn's disease (CD), and who previously had a tissue sample taken by endoscopy or had surgery as part of their…

The person joining (or their legal representative) must have given written agreement to take part before any screening tests are done. Adults aged between 18 and 70 years old, of any gender. People who have been diagnosed with ulcerative colitis, Crohn's disease, or inflammatory bowel disease that has not been clearly…

Adults aged 18 to 65 years (male or female). People with a confirmed diagnosis of ulcerative colitis (based on colonoscopy and tissue examination) that affects the left side of the colon, with mild to moderate active disease. People whose disease scores at least 4 on a standard activity scale (called the modified Mayo…

People who have been diagnosed with ulcerative colitis or Crohn's disease, confirmed through clinical assessment, endoscopy, and tissue examination. People who have been continuously taking biologic medicines (such as anti-TNF agents, integrin inhibitors, or JAK inhibitors) or immunosuppressant medicines (such as…

Adults aged 18 or older, either male or female People for whom a surgery to create a stoma (an opening in the abdomen to redirect waste) is planned, either as a scheduled procedure or in an emergency situation People enrolled in the French social security system

The person joining (or their legal representative) must have given written agreement to take part before any screening begins. People who are at least 18 years old at the time of signing the consent form. People who have been diagnosed with Crohn's disease, ulcerative colitis, or a related inflammatory bowel disease…

You have been diagnosed with Crohn's disease (CD) for at least 6 months Your Crohn's disease is currently considered mild to moderate in severity You are between 18 and 65 years old You have been on the same stable medication(s) for at least 3 months

People who are either not currently on any treatment, or who have been on a stable dose of certain medications for a set period — such as mesalamine for at least 6 weeks, low-dose steroids for at least 2 weeks, immunomodulatory drugs for at least 12 weeks, or biologics/small molecule drugs for at least 12 weeks (and…

Adults over 18 years old who have been diagnosed with ulcerative colitis (a type of inflammatory bowel disease) based on standard medical tests, including a physical assessment, a camera examination of the bowel, and a tissue sample analysis.

People of any gender aged 18 or older. People who have been diagnosed with active Crohn's disease (CD) affecting the small bowel, with or without involvement of the large bowel, before entering the study. People who are experiencing active Crohn's disease symptoms at the time the nutritional treatment begins. People…

Adults aged 18 and over (both male and female) who have been diagnosed with ulcerative colitis based on laboratory, clinical, and internal examination (endoscopy) results. The trial is looking to include 40 healthy volunteers (with no ulcerative colitis) and 50 people newly diagnosed with confirmed ulcerative colitis…

Adults aged 18 or older. People with UC that has mild-to-moderate activity, based on a specific scoring system used by doctors (called the Mayo score). People whose UC is being managed with a stable treatment — such as salicylates or immunosuppressants — that has been ongoing for more than 8 weeks. People who are able…

People who have been diagnosed with inflammatory bowel disease by a gastroenterologist (a specialist in digestive conditions).

People aged 18 or older People who have been diagnosed with a severe flare-up of ulcerative colitis, assessed using a specific set of medical criteria called the Truelove Witts criteria People who received at least one injection of the under-the-skin (subcutaneous) form of Infliximab, after first receiving two or…

People who have been diagnosed with Crohn's Disease within the last 12 months, confirmed through clinical, endoscopy, tissue, and/or imaging results, and whose disease is currently not active (based on a standard Crohn's disease activity score of 200 or below). People of any gender who are over 18 years of age. Women…

Adults aged 18 years or older. People who have a confirmed diagnosis of Inflammatory Bowel Disease (IBD) — a condition causing ongoing inflammation in the digestive tract. People who have had IBD for more than 3 months. People who have had a colonoscopy (a camera examination of the bowel) within the last 2 years…

Teenagers and adults of any age who have been diagnosed by a doctor with Crohn's disease, ulcerative colitis, or any other form of inflammatory bowel disease (such as indeterminate colitis or IBD unclassified).

You are 60 years of age or older at the time of joining the trial You have been diagnosed with moderate-to-severe Crohn's Disease or moderate-to-severe Ulcerative Colitis, confirmed by specific medical scoring tools (confirm with trial site) You are able to understand the study and give your own consent to participate

Adults aged between 18 and 75 years, of any gender. People who have been diagnosed with ulcerative colitis at least 3 months before the screening visit, with the diagnosis confirmed by endoscopy or radiology and tissue testing. People whose ulcerative colitis is currently moderate to severe and active, as measured by…

People who are covered by a social security system. People who speak French. People who are 18 years of age or older. People who have given their free, informed, and written agreement to participate before the trial begins. People who have been diagnosed with ulcerative colitis (a type of inflammatory bowel disease…

People who have extensive ulcerative colitis, indeterminate inflammatory bowel disease (IBD), or Crohn's disease affecting at least one-third of the colon, with a diagnosis history of at least 8 years People who have IBD or indeterminate IBD along with a liver condition called primary sclerosing cholangitis (PSC)…

You are scheduled to have a minimally invasive colorectal surgery (using keyhole or robotic techniques) You will not need an epidural (a type of pain relief injected into the spine) after surgery You will not be having a new stoma (a surgical opening on the abdomen for waste to leave the body) Your blood loss during…

Adults who have already been diagnosed with inflammatory bowel disease (either ulcerative colitis or Crohn's disease) and are currently being treated as an outpatient for a flare-up, meaning a noticeable worsening of symptoms such as stomach pain, nausea, vomiting, diarrhoea, joint pain, fever, bleeding, or unintended…

Adults aged 18 or older, of any gender People who have had a confirmed diagnosis of Crohn's disease for at least 3 months, based on medical history, lab tests, endoscopy, and imaging People whose colonoscopy shows one or more ulcers in the small intestine or colon, with a disease activity score (SES-CD) of at least 3…

Adults (male or female) aged 18 or older People who have been diagnosed with Crohn's disease, ulcerative colitis, or unspecified inflammatory bowel disease (IBD) for at least 1 month People who are currently being treated for IBD with either standard or more advanced medications People who have access to an email…

People who have been diagnosed with ulcerative colitis or Crohn's disease for more than 3 months, with the diagnosis confirmed according to European guidelines, and who are being seen in the gastroenterology department at Saint Antoine Hospital. People who are 18 years of age or older. People who are attending a…

People who are able to give free and informed consent. People aged 18 years or older. People who are covered by a social protection scheme or are an entitled person under such a scheme (excluding AME). People who have a consultation at the Gastroenterology and Nutrition Department of Saint-Antoine Hospital. People…

People who have been diagnosed with ulcerative colitis or Crohn's disease, confirmed by a specialist team, clinic records, or the opinion of the investigating doctor. People who are currently receiving regular infliximab or vedolizumab treatment given through a drip (intravenous infusion). People who are willing and…

Adults aged between 18 and 80 years old, of any gender. Willing and able to sign a consent form agreeing to take part in the trial. Diagnosed with a specific form of Crohn's disease that causes scarring and narrowing of the bowel (fibrostenosing Crohn's disease), confirmed by camera examination of the bowel…

Adults between the ages of 18 and 85. People who have been diagnosed with Inflammatory Bowel Disease (IBD) — either Ulcerative Colitis or Crohn's Disease — confirmed in their medical records. People who are receiving ongoing IBD care as outpatients at Victoria Hospital or St. Joseph's Hospital, with at least one…

You are 18 years old or older, of any gender You have been officially diagnosed with either ulcerative colitis (UC) or Crohn's disease (a type of inflammatory bowel disease) Your doctor has decided that you need to start a specific type of medication called an IL-23 inhibitor for the first time

People aged between 18 and 80 years old People who have been diagnosed with Crohn's disease (CD) affecting the small intestine (ileum) or both the small intestine and large intestine, of any type People who have been on a stable dose of any Crohn's disease treatment for at least 8 weeks (including biologics, small…

People who have been diagnosed with ulcerative colitis (UC), Crohn's disease (CD), or a related condition called PSC-IBD for at least 6 months. People who are 18 years of age or older. People whose medical treatment for their bowel condition has remained the same for the past 3 months. People whose daily habits —…

People who have been referred for hyperbaric oxygen therapy (a treatment involving breathing pure oxygen in a pressurised chamber) for a condition that is a newer or emerging use of this therapy.

Children and teenagers with inflammatory bowel disease (IBD) who are between 1 and 18 years old.

People aged 60 years or older at the time of screening. People who have been formally diagnosed with ulcerative colitis based on established medical guidelines (ECCO criteria). People whose ulcerative colitis has been in both clinical and endoscopic remission (meaning symptoms are controlled and the bowel lining looks…

People who have at least one medical or pharmacy insurance claim for an approved advanced medical treatment for ulcerative colitis (a type of inflammatory bowel disease), filed on or after the date that treatment was officially approved by the FDA. People who have at least two medical claims, recorded at least 30 days…

People who have an established diagnosis of Inflammatory Bowel Disease (IBD), either Ulcerative Colitis (UC) or Crohn's Disease (CD). People whose bowel disease is currently active, meaning it shows at least mild activity based on recognised scoring measures, or a stool test result showing a calprotectin level above…

People of any gender who have been diagnosed with Crohn's disease (confirmed using clinical, imaging, and tissue examination results in line with current guidelines), where the disease causes narrowing in the bowel (a specific pattern called B2 under a standard classification system), located in the right side of the…

People who are 18 years of age or older People who have already been diagnosed with Inflammatory Bowel Disease (IBD) that is considered mild to moderate in activity

People who are 18 years of age or older People who have been diagnosed with Inflammatory Bowel Disease (IBD) and are patients at the CHU of Guadeloupe hospital People who have had testing for a stomach bacteria called H. pylori (through stomach tissue samples and/or a blood test) at the time their IBD was diagnosed…

People who have been diagnosed with Crohn's disease or ulcerative colitis, confirmed by their medical records. People who have been experiencing fatigue for 6 months or longer. People who are 18 years of age or older. People whose fatigue score on the IBD Fatigue Assessment Scale is 11 out of 20 or higher. Women who…

Adults between 18 and 65 years old who have been admitted to hospital with a severe flare-up of ulcerative colitis (a condition causing inflammation of the large bowel)

People who choose to take part willingly and sign the consent form agreeing to join the study. People aged 18 to 70 years old, of any gender. People whose liver function blood tests are within an acceptable range (specific limits apply; confirm with trial site), except that a condition called Gilbert's syndrome is…

The patient must be a child or young person between 0 and 18 years old who is scheduled for a planned (non-emergency) same-day surgery or a procedure that requires anesthesia outside of an operating room The patient must need a drip or IV line placed into a vein A parent or legal guardian must be available and willing…

Children and teenagers between 6 and 18 years old who have been diagnosed with Crohn's disease within the last 36 months, with a disease activity score in the mild-to-severe range (as measured by a standard scoring tool for children with Crohn's disease) People with signs of active inflammation shown through blood or…

You are 18 years of age or older You have been formally diagnosed with both ulcerative colitis (a type of inflammatory bowel disease) and a liver condition called primary sclerosing cholangitis (PSC) Your ulcerative colitis is currently rated as moderate to severe, based on specific scores measured by your doctor and…

Adults aged 18 or older. People who have been diagnosed with Crohn's disease, confirmed through a camera examination of the gut (endoscopy) and tissue testing (histopathology), with the disease currently active based on a standard scoring measure. People whose doctor has determined they need to start a specific type…

People who are between 18 and 75 years old at the time of signing the consent form People who have been diagnosed with ulcerative colitis (UC) People who currently have active moderate to severe ulcerative colitis People whose ulcerative colitis extends beyond just the rectum into other parts of the colon People who…

The person must be able to give informed consent to participate. The person has a confirmed diagnosis of Crohn's disease. The person is planning to start one advanced Crohn's disease treatment from the following types: anti-TNF, anti-IL12/IL23, anti-IL23, anti-alpha 4 beta 7, or a JAK inhibitor. If the person is…

People who are 18 years of age or older People who have been diagnosed with ulcerative colitis (a type of inflammatory bowel disease) according to recognised European guidelines People whose ulcerative colitis is currently active and rated as moderate to severe, based on a specific scoring system used by doctors…

People diagnosed with Crohn's disease that is widespread, with a pattern of ongoing or recurring flare-ups, and who are currently experiencing either a severe flare (based on specific disease activity scores) or a moderate flare that has not responded to steroid treatment. People diagnosed with ulcerative colitis…

You have been formally diagnosed with ulcerative colitis (UC) You are between 18 and 65 years old (any gender) Your UC is currently mild to moderate in severity, based on a standard scoring tool used by doctors You are willing to attend 12 treatment sessions spread across three courses of a needle-embedding therapy…

Adults aged 18 years or older. People who have at least one long-term or immune-weakening health condition that national health guidelines identify as a reason to recommend vaccination. People who have given written consent to take part in the trial.

You have been diagnosed with ulcerative colitis (UC) for at least 6 months. Your symptoms are well controlled — meaning little to no stool frequency issues and no rectal bleeding, based on a standard scoring system doctors use. A recent camera examination of your colon (colonoscopy), done within the last 12 weeks…

People aged 18 to 75 years old, both men and women. People who have been diagnosed with Crohn's disease (CD) at least 1 month (30 days) before the study begins. People who have tried other treatments for Crohn's disease in the past but either no longer tolerate those treatments or the treatments have stopped working.

People aged between 16 and 75 years. People who have been diagnosed with Crohn's disease and have a narrowing (stricture) in the small bowel — either confirmed by imaging scans or found during a camera examination of the bowel (enteroscopy). People whose Crohn's disease has not responded well enough to standard…

Adults between 18 and 75 years of age People of Chinese ethnicity People who have been diagnosed with ulcerative colitis (a type of inflammatory bowel disease affecting the large intestine) with mild to moderate disease activity, as measured by a specific scoring tool called the SCCAI, with a score between 3 and 5…

Adults aged 18 or older. People who have been diagnosed with Crohn's disease and are having bowel (intestinal) removal surgery at CHRU Nancy hospital. People who have not objected to their personal data and biological samples being used for this research.

Adults between 18 and 75 years of age. People who have a confirmed diagnosis of Crohn's disease, supported by imaging, tissue sample, or camera examination of the gut, made at any point before the screening visit. People whose Crohn's disease is currently active, shown by a symptom score (called the CDAI) falling…

You have been diagnosed with moderate-to-severe inflammatory bowel disease (IBD) Your IBD has been hard to treat — meaning at least two different types of biologic or small molecule medications have not worked for you, OR you have had at least two bowel surgeries that did not resolve your condition Your bone marrow…

Adults between 18 and 75 years of age. People who have a confirmed diagnosis of Crohn's disease, shown through imaging, tissue samples, or a camera examination of the gut. People with active Crohn's disease at the time of screening, measured using a standard scoring system called the CDAI, with a score between 220 and…

The person has been diagnosed with Crohn's disease based on a specific 2019 set of guidelines used for children with inflammatory bowel disease. The person has a disease activity score of 30 or higher on a standard scale used to measure Crohn's disease severity in children (called the PCDAI). The person has never…

People who are 18 years of age or older. People who have a confirmed diagnosis of Crohn's disease. People whose Crohn's disease involves narrowing or blockages in the bowel (known as a stricturing form), confirmed through clinical assessment, a camera procedure, imaging, or surgery. People who are being cared for in a…

You are a man or woman aged between 18 and 75 years old You have been diagnosed with a type of primary sclerosing cholangitis (PSC) affecting the larger bile ducts, confirmed by a specific imaging scan or procedure of the bile ducts You have been diagnosed with inflammatory bowel disease (IBD), such as Crohn's disease…

Children and teenagers between the ages of 6 and 17 years old People who have been diagnosed with Crohn's disease or ulcerative colitis People whose condition is currently in remission or is considered mild to moderate People whose doctor has confirmed it is safe for them to take part in physical activity People who…

People who are willing to take part in the study voluntarily. People who have been diagnosed with Inflammatory Bowel Disease (either Crohn's Disease or Ulcerative Colitis) for at least 12 months. People who are being seen and monitored in an outpatient clinic setting. People who are 18 years of age or older. People…

People aged 18 or older People with moderate-to-severe ulcerative colitis, measured using a standard scoring system called the clinical Mayo score (a score above 6, with an endoscopic — camera examination — score of 2 or 3) People with moderate-to-severe Crohn's disease, measured using standard scoring tools (a…

People who are able to understand the trial and are willing to give their consent and follow the trial's procedures. People who were assigned male or female at birth, of any gender identity, aged 18 to 75 years old at the time of giving consent. People who are postmenopausal, have had a sterilisation procedure, are…

People who are able and willing to give informed consent to participate. People who are at least 18 years old. People who have been diagnosed with ulcerative colitis (UC), confirmed through clinical assessment and a camera examination of the bowel (endoscopy). People who have had ulcerative colitis for at least 3…

Adults aged 18 or older who have active ulcerative colitis, confirmed by a symptom score above a certain threshold (confirm with trial site)

People who are 18 years of age or older People who have been formally diagnosed with moderate to severe Crohn's disease People who have had a surgical procedure to remove part of the small intestine and/or large intestine

People aged 18 to 70 years old at the time of joining the trial. People who have been diagnosed with moderately to severely active ulcerative colitis (UC), based on specific disease activity scores (confirm with trial site). People who have had a confirmed UC diagnosis for at least 3 months before the screening visit.…

The person joining (or their legal guardian) must sign a written consent form approved by an ethics committee before any screening begins. Adults aged 18 to 69 years old who weigh at least 40 kg (about 88 pounds). People who have been diagnosed with inflammatory bowel disease (IBD) for at least 3 months before signing…

Adults aged 18 years or older People who are able to sign a form giving their agreement to take part in the study People who have a confirmed diagnosis of ulcerative colitis or Crohn's disease affecting the colon, or people without inflammatory bowel disease (IBD) who are having a routine check colonoscopy People who…

The child or teenager must be between 6 and 17 years old (any gender). They must have been diagnosed with moderate to severe active Crohn's disease in children, based on specific medical guidelines from 2019. Their doctor must have already decided, after carefully weighing the risks and benefits, that Adalimumab…

You have been diagnosed with ulcerative colitis (UC) for at least 3 months You are between 18 and 65 years old Your ulcerative colitis is considered moderate to severe, based on a specific scoring system used by doctors A camera examination of your bowel (colonoscopy) has shown a certain level of inflammation, based…

People who are willing and able to sign a consent form at the screening visit and attend all required study visits until the end of the trial People aged between 18 and 75 years at the time of screening People who have had a confirmed diagnosis of inflammatory bowel disease (IBD) for at least 1 year, based on a…

People who have been diagnosed with inflammatory bowel disease (a condition affecting the digestive system) within a specific time period set by the trial. People who have never been diagnosed with inflammatory bowel disease within a specific time period set by the trial.

People who are willing to follow all study procedures, take part in the VR therapy program, and be available for the full duration of the study. People aged 18 years or older. People who have a confirmed diagnosis of IBD (inflammatory bowel disease) and also experience anxiety, measured by a specific anxiety…

People who have a confirmed diagnosis of ulcerative colitis (UC), established through standard clinical and endoscopic testing. People with mild-to-moderate active UC, as measured by a specific symptom scoring tool (SCCAI score between 5 and 11), who also meet one of the following conditions: their UC has not…

Adults between 18 and 85 years of age. People who have a confirmed diagnosis of Crohn's disease, ulcerative colitis, or inflammatory bowel disease (IBD) linked to another existing condition, supported by medical records, imaging, scope findings, or tissue samples showing long-term gut inflammation; and/or people who…

People who have given written agreement to participate in the trial People aged between 18 and 75 years old People who have been diagnosed with Crohn's disease for at least 6 months, whose symptoms have not improved (or came back) after trying at least one advanced treatment such as adalimumab, infliximab, or similar…

You are between 18 and 80 years old You have a confirmed diagnosis of Crohn's disease You are able to give your consent to take part in the trial You are between 18 and 80 years old You have not had a major surgery to remove part of your large bowel You are able to give your consent to take part in the trial

People who are 18 years of age or older People who have been diagnosed with Ulcerative Colitis, confirmed through a combination of clinical assessment, camera examination of the bowel, and tissue sample analysis People whose Ulcerative Colitis is either currently active (with moderate to severe inflammation and…

People aged between 19 and 70 years. People who have been diagnosed with mild-to-moderate ulcerative colitis, based on a standard scoring tool called the partial Mayo score, with a score between 2 and 7. People who have signs of active inflammation at the time of joining, shown by either a blood marker called…

Children between the ages of 6 and 15 years old Able to swallow capsules Already scheduled to have a diagnostic camera examination of the digestive tract at Tampere University Has never previously been treated with oral vancomycin (a type of antibiotic) Does not currently have an active infection (such as a C.…

People who are 18 years of age or older People who have been diagnosed with Crohn's Disease or ulcerative colitis People who own a smartwatch and/or a smartphone People whose smartwatch is one of the following brands: Apple Watch, Samsung Watch, Fitbit, Garmin, or Polar (the trial will not provide devices to…

People with a suspected or confirmed narrowing of the intestine (supported by medical history, physical examination, and imaging results from the past 6 months). People who have been diagnosed with Crohn's Disease. People who have used non-steroidal anti-inflammatory drugs (such as ibuprofen or naproxen) on a…

People aged 18 to 80 years old at the time of giving consent. People who are willing to give written consent to take part in the trial voluntarily. People who have been diagnosed with ulcerative colitis (UC) for at least 3 months before the screening visit, confirmed by camera examination of the bowel and tissue…

People who have an established diagnosis of ulcerative colitis or Crohn's disease.

People who are willing and able to sign the consent form agreeing to take part in the study. People aged 18 to 70 years (inclusive), of any gender. People who have been formally diagnosed with Crohn's disease according to the 2023 Chinese Guidelines for the Diagnosis and Treatment of Crohn's Disease, and whose disease…

People aged 18 to 80 years old at the time of signing the consent form. People who are able to understand and sign a written consent form before any trial procedures begin. People who have had a confirmed diagnosis of ulcerative colitis (UC) for more than 3 months. People with currently active UC, based on specific…

A doctor has confirmed the person has a diagnosis of Crohn's disease or ulcerative colitis. The person has had ongoing pain (in the abdomen or elsewhere in the body) related to their IBD for at least 3 months. The person scores 60 or above on a standardised pain questionnaire called the NIH PROMIS Pain Interference…

People who have a confirmed diagnosis of Crohn's Disease recorded in their medical records. People aged between 16 and 75 years old. People with mild to moderately active Crohn's Disease, measured using a standard scoring tool called the Crohn's Disease Activity Index (CDAI), with a score between 150 and 250, AND with…

Men between the ages of 30 and 65 years old at the time of signing the consent form. People who agree to use an adequate form of contraception for up to 93 days after the last dose of the trial treatment. Men considered to be in good general health by the study doctor, based on a full medical history, physical…

Adults aged 18 to 75 years, of any gender. People who have been diagnosed with Crohn's disease (CD) for at least 12 weeks before the screening visit, confirmed by camera examination of the bowel (endoscopy) and tissue samples (biopsy). People with moderately to severely active Crohn's disease, shown by a specific…

Adults aged 18 or older who received hospital-level care after January 2018 and have a confirmed diagnosis of Crohn's disease (CD) or ulcerative colitis (UC), recorded using a standard medical coding system. People whose records show at least one hospital or clinic visit for Crohn's disease or ulcerative colitis, plus…

People who have been diagnosed with Crohn's disease (CD) affecting the small intestine (ileum) or both the small intestine and colon, confirmed by camera examination or imaging, with that diagnosis made at least 12 weeks before signing the consent form. People who have at least one narrowing (stricture) in the small…

Adults between 18 and 75 years of age, of any gender. People who are able to read and sign a consent form agreeing to take part in the study. People who have had a confirmed diagnosis of ulcerative colitis for at least 90 days before the screening visit. People whose ulcerative colitis is rated at a moderate level of…

People who are willing to sign and date a consent form that has been approved by an ethics review board, before any study-related checks begin. People who are aged 18 years or older and under 65 years old. People whose recent blood test results meet all of the following levels (confirm with trial site for exact…

People who are 18 years of age or older at the start of the trial, of any sex. People who have a confirmed diagnosis of active ulcerative colitis (a type of inflammatory bowel disease) and whose treating doctor believes they are likely to benefit from a medicine called etrasimod. "Active" disease is defined by…

People who have been diagnosed with ulcerative colitis (a type of inflammatory bowel disease) for at least 6 months, confirmed through clinical, endoscopic, lab, or imaging tests. People aged 18 years or older, of any gender. People who have been taking a JAK inhibitor medication (tofacitinib, upadacitinib, or…

People who have been diagnosed with Crohn's Disease (a condition causing inflammation in the digestive tract) for at least 12 weeks, affecting the large intestine, small intestine, or both, confirmed in the past through imaging, tissue samples, or a camera examination of the gut. People whose Crohn's Disease is…

Adults aged 18 or older who have never been diagnosed with, or currently suspected of having, inflammatory bowel disease (IBD) People who are willing to agree to having samples collected People who have been diagnosed with IBD — including ulcerative colitis, Crohn's disease, or IBD-unclassified — and are currently…

You have been diagnosed with Crohn's disease, ulcerative colitis, or a related inflammatory bowel disease (IBD), confirmed by medical tests, scans, or tissue samples You have symptoms that suggest an unclassified inflammatory bowel disease, with lab evidence of intestinal inflammation You have symptoms that could…

You (or your guardian) must be able to understand and agree to take part in the study You must be between 10 and 60 years old (inclusive) at the time of signing the consent form You have Crohn's disease that has come back severely after surgery, even with strong ongoing treatment You have widespread Crohn's disease…

You must be 18 years old or older You (or a family member on your behalf) must agree to take part and sign a consent form If you are in the patient group: you have been diagnosed with Crohn's disease or ulcerative colitis, confirmed through camera tests (endoscopy), imaging scans, and tissue samples If you are in the…

You have been diagnosed with axial spondyloarthritis (a type of inflammatory arthritis affecting the spine) or juvenile spondyloarthritis (the same condition diagnosed in young people). You have been diagnosed with Crohn's disease (a long-term condition causing inflammation in the digestive system). You have been…

People who have been diagnosed with Crohn's Disease (CD), meaning a doctor has confirmed at least 2 of the following: a history of symptoms such as abdominal pain, weight loss, tiredness, diarrhoea, or rectal bleeding; camera examination of the bowel showing specific patterns of inflammation or ulcers; imaging scans…

You have been diagnosed with Crohn's disease, and that diagnosis has stayed the same after at least three months of being monitored by a doctor. You are willing to undergo a procedure called Fecal Microbiota Transplantation (FMT), which involves transferring healthy gut bacteria from a donor into your digestive system.

People who have had ulcerative colitis (a type of inflammatory bowel disease) for a long time — specifically, at least 8 years if the whole colon is affected, or at least 10 years if only the left side of the colon is affected People who have signed a form agreeing to take part in the trial People who have had a…

People aged 18 to 65 years old at the time of enrolment. People who have been diagnosed with Crohn's disease (CD), ulcerative colitis (UC), or chronic granulomatous disease (CGD) colitis, confirmed by a camera examination of the bowel (endoscopy) or medical imaging, with active disease shown on a colonoscopy at the…

People who received injections of a treatment called ALLO-ASC-CD as part of an earlier Phase 1 clinical trial (NCT ALLO-ASC-CD-101). People who are able to provide written consent before the study begins and are able to follow the study requirements throughout.

You have been diagnosed with Crohn's disease using standard medical criteria Your Crohn's disease is currently active, based on symptoms measured by a scoring system (called CDAI) showing a score above 250 (if you have an ostomy bag, the number of times you empty it daily is used instead of stool count) A camera…

People who have Crohn's disease affecting the small intestine (ileum) or both the small intestine and part of the large intestine, and who need surgery for the first time to remove the affected section. People aged 18 years or older, both male and female. People with any type of Crohn's disease pattern — including the…

You have agreed to take part and signed a consent form before any study activities begin You have been diagnosed with Crohn's disease, confirmed through medical tests such as imaging, a camera examination of the gut, or tissue samples You are a man or woman aged 18 or older You are scheduled to have a specific bowel…

Children under 18 years old who have been newly diagnosed with, or are likely to have, inflammatory bowel disease (IBD) — a condition affecting the digestive system The diagnosis must be based on a full set of tests, including physical examination, blood tests, camera examination of the bowel, imaging scans, and…

People who have been diagnosed with inflammatory bowel disease (IBD), which includes conditions such as ulcerative colitis or Crohn's disease.

People who have mild to moderate Ulcerative Colitis, based on a specific scoring system called the partial Mayo Score (a score between 2 and 7 out of 9) People who are between 18 and 70 years old at the time they start the study

You have been diagnosed with Crohn's disease You are between 6 and 17 years old (inclusive) Your Crohn's disease affects specific parts of the bowel — either the small intestine only, or both the small intestine and large intestine (confirm with trial site regarding "L1 or L3 phenotypes") You have had surgery to…

You have active ulcerative colitis that is considered moderate to severe (based on a scoring system called the Mayo score, with a result above 6) You have previously used or are currently using a medication called 5-ASA (a common treatment for bowel inflammation) safely You are able to have an endoscopy (a camera…

People who are 18 years of age or older People who have a confirmed diagnosis of Crohn's disease (CD) or ulcerative colitis (UC), based on clinical, laboratory, imaging, endoscopy, or tissue analysis results People who weigh 45 kg (approximately 99 pounds) or more People who are registered members of the French Social…

You are 18 years old or older You have been diagnosed with Crohn's disease for more than 3 months Your Crohn's disease is currently active, meaning your symptom score is above a certain level AND at least one test (a blood inflammation marker, a stool test, an endoscopy, or an MRI scan) also shows signs of active…

You have been recently diagnosed with Crohn's disease, or your Crohn's disease has recently flared up, and you are being seen at one of the participating clinics Your Crohn's disease has been confirmed following established medical guidelines, including a full camera examination of your bowel and an MRI or CT scan of…

People who are 18 years of age or older People who have been diagnosed with Crohn's disease (a type of inflammatory bowel disease) for at least 3 months, based on medical tests, imaging, and/or tissue samples, and who have been confirmed not to have a related joint condition called spondyloarthritis People who have…

People who have been diagnosed with Crohn's Disease for at least 6 months, confirmed through accepted clinical, imaging, or laboratory methods People who have complex perianal fistulas (tunnels near the anal area) that have not responded to previous treatments, confirmed by examination under anaesthesia and MRI scan…

You have been officially diagnosed with Crohn's disease You have been officially diagnosed with ulcerative colitis You have been officially diagnosed with celiac disease You have been officially diagnosed with irritable bowel syndrome (IBS) You have been officially diagnosed with functional dyspepsia (ongoing stomach…

People aged between 18 and 75 years old at the time of joining People who have a confirmed diagnosis of ulcerative colitis (UC), established through standard tests such as a scope procedure, imaging, or tissue sample analysis People whose UC is currently active, based on a specific scoring system (called the Mayo…

Adults aged 18 to 74 years with moderately-to-severely active Ulcerative Colitis (UC) — a condition causing inflammation in the large intestine People whose UC has not responded well enough to, or who could not tolerate, certain medicines such as steroids, thiopurines (azathioprine or 6-mercaptopurine), methotrexate…

You are between 16 and 70 years old You have been diagnosed with mild or moderate active Crohn's disease, based on a specific disease activity score (confirm with trial site) You have tried at least one standard medication (such as mesalazine, steroids, immune-suppressing drugs, or anti-TNF treatments) but it did not…

You must be 18 years of age or older You must have Crohn's disease with an anal abscess or fistula (a condition causing pus or drainage near the anal area) and have a planned procedure to drain it You must have received written and spoken information about the study and not objected to taking part

You are between 13 and 28 years old You have been diagnosed with Crohn's disease for at least 6 months before joining, confirmed by scans or tissue samples Your Crohn's disease is currently active, shown by a disease activity score above 30, plus at least two of the following: raised inflammation levels in your blood…

People aged 18 or older who are seeking medical care at the Center for Inflammatory Bowel Diseases Clinic at UPMC.

You are between 12 and 80 years old (note: at Boston Children's Hospital, the maximum age is 30) You have been diagnosed with Crohn's disease based on standard medical tests including imaging, camera procedures, and tissue samples You have moderate-to-severe Crohn's disease, measured using a standard scoring system…

People who have been diagnosed with ulcerative colitis (UC), confirmed through medical history, a camera examination of the bowel, and tissue samples taken during that procedure. Children and teenagers aged 5 to 17 years old at the time of screening, who weigh more than 13.6 kg (about 30 pounds). People whose UC is…

People aged between 18 and 80 years old. People who have Crohn's disease with a newly developed fibrous (scar tissue) narrowing of the intestine, confirmed by both camera examination (colonoscopy) and imaging scans, where the narrowing can be reached by colonoscopy. People who have a known narrowing that was…

People who have already been diagnosed with inflammatory bowel disease (IBD), including Crohn's disease, ulcerative colitis, or indeterminate colitis People who are currently receiving treatment with either Infliximab or Vedolizumab every 4 to 8 weeks People between the ages of 5 and 25 years old at the time of…

You are an adult (man or woman) who has been diagnosed with Crohn's disease or ulcerative colitis and are starting treatment with ustekinumab or one of the comparison medications being studied. You have at least 1 year of recorded medical history in the Department of Defense electronic health records system before…

People aged 18 or older People who have had active ulcerative colitis (a type of inflammatory bowel disease) at some point in the past 12 months, confirmed through standard medical assessments People whose ulcerative colitis is currently in remission (symptoms are well controlled) based on a standard scoring system…

People who are willing and able to provide written consent to take part Men or women aged 18 or older People who have a confirmed diagnosis of ulcerative colitis (UC) People who are currently experiencing active symptoms, based on a specific disease activity score falling within a moderate range (partial Mayo Score of…

People who have been diagnosed with ulcerative colitis or Crohn's disease People who have either tried biologic treatments and they did not work, or who have never tried biologic treatments People whose condition means a doctor considers them suitable for a type of treatment called anti-TNF therapy People who have…

People who have been diagnosed with Crohn's Disease within the last 3 months, or healthy individuals who are matched as a comparison group for the study

People aged 18 years or older, of any gender People who are willing and able to sign a written consent form to take part in the registry and tissue sample collection People who have been diagnosed with, or are suspected to have, inflammatory bowel disease (a condition causing ongoing inflammation in the digestive…

You are 18 years old or older You are able to read and sign a consent form agreeing to take part You have Crohn's disease that causes narrowing or tunneling complications in the gut, and you need surgery to remove part of your small or large intestine (the ileum or ileocecal area)

Men between 18 and 49 years old People who have given written agreement to take part (or whose legal representative has done so) People with confirmed inflammation in the small intestine (ileum) and/or colon, whose disease is currently relatively stable and scores 8 or below on a standard disease activity measure…

People who have had ulcerative colitis for at least 6 months People who are 18 years of age or older People who are starting treatment with one of the following medications: infliximab, adalimumab, golimumab, vedolizumab, or tofacitinib People who are willing and able to provide written consent to participate

You have been diagnosed with melanoma Inflammatory bowel disease (Crohn's disease or ulcerative colitis, diagnosed by a gastroenterologist, with ulcerative colitis requiring at least 6 months of confirmed inflammation and current treatment with certain medications) Rheumatoid arthritis, diagnosed by a rheumatologist…