Osteoarthritis

Who might be able to join this trial: - You have a hip condition that means you need a total hip replacement surgery. - You are willing to give your consent to take part in the study. - You are able to stay involved for the full length of the study. - You are in generally stable health, and any heart, lung, blood, or o...

Who might be able to join this trial: - You must have previously taken part in a study where you received either the drug ICM-203 or a dummy treatment (placebo) that looked like ICM-203. Who may not be able to join: - There are no specific reasons listed that would prevent someone from joining this trial. Important:...

**Who might be able to join this trial:** - You are a suitable candidate for a total knee replacement surgery using a specific robotic surgical system (CORI) and a matching Smith+Nephew knee implant. - You need a cemented total knee replacement as your main treatment for one of the following: osteoarthritis or other n...

**Who might be able to join this trial:** - People who are female - People with a Body Mass Index (BMI) of 30 or higher (this means a higher body weight relative to height) - People whose knee shows no signs of arthritis on both X-ray and MRI scans - People who have no knee pain, or knee pain on fewer than 15 days per...

**Who might be able to join this trial:** - People with a body mass index (BMI) of 30 or higher (a measure of body weight relative to height that indicates obesity). - People who have tried and not succeeded in losing weight through lifestyle changes (such as diet and exercise) at least once before. - People who an or...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of signing the consent form - People who have been clinically diagnosed with osteoarthritis (OA) in the knee being studied, based on established medical criteria - People whose knee OA has been confirmed by X-ray (reviewed...

**Who might be able to join this trial:** - People who are willing and able to give written consent, follow study instructions, and attend all required visits - People aged between 20 and 75 years (male or female) - People who have had knee osteoarthritis (OA) symptoms for at least 6 months before the screening appoin...

**Who might be able to join this trial:** - People who were male or female at birth, aged 18 or older at the time of signing the consent form - People who have been clinically diagnosed with knee osteoarthritis and have confirmed changes visible on X-ray in the knee being studied (rated at a certain level of severity...

Who might be able to join this trial: - People aged 18 or older who have ongoing lower back pain, have sought or seriously thought about seeking care from a doctor or specialist for it in the past 6 weeks, and find it at least moderately interferes with work or daily activities (including housework) - OR people aged 45...

Who might be able to join this trial: - You are between 40 and 75 years old (male or female) - Your body weight falls within a certain range — specifically, your BMI (a measure of body weight relative to height) is below 40 - You have been diagnosed with knee osteoarthritis (wear-and-tear of the knee joint) in the main...

Who might be able to join this trial: - All patients who are seen at the UF&Shands Orthopaedics and Sports Medicine Institute and are willing to sign a consent form may be considered for participation. Who may not be able to join: - There are no stated exclusion criteria — all patients at this clinic who are intereste...

**Who might be able to join this trial:** - People who have painful arthritis at the base of the thumb (the joint where the thumb meets the wrist). - People who are able to understand and agree to take part in the study by giving their informed consent. **Who may not be able to join:** - People who are under 18 years...

Who might be able to join this trial: - You have been diagnosed with osteoarthritis (wear and tear) of the hip joint - You are experiencing pain in your hip joint Who may not be able to join: - An X-ray shows a clear fracture (broken bone) in your hip joint Important: Always verify eligibility with the trial site dir...

Who might be able to join this trial: - You have a tear in one or more of the ligaments in your knee - You have had surgery to repair or reconstruct the torn ligament(s), using any surgical method Who may not be able to join: - You do not wish to take part in the trial (participation must be your own choice) Importan...

**Who might be able to join this trial:** - People who have a non-inflammatory degenerative joint disease affecting the hip — such as osteoarthritis, bone tissue death (avascular necrosis), arthritis caused by injury, certain hip growth conditions, hip fractures, or a specific bone growth disorder — and who need a fir...

**Who might be able to join this trial:** - People who have been diagnosed with osteoarthritis, whether caused by natural wear and tear or a long-term injury. - People between 18 and 90 years of age. - People who are able to follow the treatment plan, attend lab tests, and take part in regular check-in interviews. - P...

**Who might be able to join this trial:** - People who have been diagnosed with osteoarthritis, whether from gradual wear and tear or a long-term injury. - People between 18 and 90 years of age. - People who are able to follow the treatment schedule, attend laboratory tests, and take part in regular check-in interview...

Who might be able to join this trial: - People who have osteoarthritis that causes pain. - People whose affected knee shows a specific level of bone activity (a measurement called SUV greater than 10) on a special type of bone scan using a substance called 18F-sodium fluoride. - People who are willing to take part volu...

**Who might be able to join this trial:** - You are 40 years of age or older - You can read, write, and speak English fluently - You are seeking medical care for pain at the base of your thumb - You have tenderness at the base of your thumb joint when examined by a doctor - A specific physical test on your thumb (invol...

**Who might be able to join this trial:** - People between the ages of 21 and 85, both male and female, who have never had surgery on their spine. **Who may not be able to join:** - People who have previously had surgery on the spine or the nervous system running through it - People who have or have had cancer, whethe...

**Who might be able to join this trial:** - People aged between 20 and 79 years old, both men and women - People who have been diagnosed with lumbar vertebral facet joint syndrome (a condition causing lower back pain related to small joints in the spine) - People who have had lower back pain for at least six months, r...

Who might be able to join this trial: - You must be older than 18 years old - You must speak Portuguese fluently or as your native language - You must have had low back pain (either constant or coming and going) for at least three months - Your back pain may or may not spread to your buttocks, and is made worse by bend...

**Who might be able to join this trial:** - People who are able to give informed consent to participate in the study - People who have had chronic pain lasting more than 3 months - People whose knee X-ray (taken standing, with knees straight) shows a Grade 2 or 3 level of knee joint changes, based on a standard medical...

**Who might be able to join this trial:** - Adults between 18 and 75 years of age (male or female) - People who have been diagnosed with osteoarthritis of the small joints in the lower spine (from the L1 to S1 region), as confirmed by a doctor involved in the trial - People who have had ongoing low back pain for at le...

Who might be able to join this trial: - People aged between 18 and 30 years old - People who have injured the ACL (a ligament in the knee) in one knee within the last 4 days - People who have swelling or blood in the injured knee joint Who may not be able to join: - People who have inflammatory arthritis, significant...

**Who might be able to join this trial:** - People who are beginning rehabilitation for their first-ever acute lateral ankle sprain (mild, moderate, or severe) - People whose ankle sprain happened within 72 hours before joining the study - People whose ankle sprain was diagnosed by a doctor, medic, athletic trainer, ph...

Who might be able to join this trial: - People who are 18 years of age or older - People who are able to attend exercise or program classes three times per week for six months, with at least a 66% attendance rate (meaning no more than about one-third of classes can be missed) - People who are able to also attend standa...

**Who might be able to join this trial:** - You are older than 55 years of age. - You are scheduled to have a specific type of shoulder replacement surgery called a primary reverse total shoulder replacement (for the first time). - You are able to fill out questionnaires on your own. - You are willing and able to come...

Who might be able to join this trial: - People who have knee osteoarthritis and are scheduled for a first-time full knee replacement surgery - People with a body mass index (a measure of body weight relative to height) below 32 - People who can complete a "Timed Up and Go" test (standing up from a chair, walking a shor...

**Who might be able to join this trial:** - You have signed an approved consent form agreeing to take part in the study. - You are a man or a woman who is not pregnant, and you are between 50 and 75 years old at the time the device is implanted. - You have been diagnosed with a non-inflammatory degenerative joint disea...

Who might be able to join this trial: - People aged 18 or older - People experiencing symptoms that suggest a torn hip labrum (the ring of cartilage around the hip socket), such as catching, clicking, or popping sensations in the hip, pain when sitting, or pain when moving the hip in certain ways - People whose symptom...

Who might be able to join this trial: - People who are older than 45 years of age - People whose main diagnosis is osteoarthritis (wear-and-tear arthritis) of the shoulder - People whose total shoulder replacement surgery was performed by Dr. Armstrong - People who received a local anesthetic (numbing medication inject...

Who might be able to join this trial: - People who have been referred to an exercise and education program because of knee osteoarthritis (a condition where the cartilage in the knee wears down) - People who are 18 years of age or older at the time of joining the trial - People who can read and understand Danish Who m...

Who might be able to join this trial: - You must be able to give written consent and be willing and able to follow all of the study's requirements. - You must be male or female and at least 19 years old when you sign the consent form. - You must have a confirmed diagnosis of osteoarthritis in a major joint, shown by an...

**Who might be able to join this trial:** - You are 18 years old or older - You need a total jaw joint (TMJ) replacement using an artificial implant - You are able to understand the study information and consent forms, are willing and able to follow the study requirements, and have signed a consent form approved by an...

Who might be able to join this trial: - People who are scheduled for a planned (non-emergency) first-time hip replacement surgery using a cemented cup with a specific size liner (32mm or 36mm), for any medical reason - People whose hip replacement surgery will be performed using a specific surgical technique called the...

**Who might be able to join this trial:** - People who are scheduled for a planned, first-time cemented total hip replacement surgery. - Men aged 70 or older, or women aged 65 or older. - People who are able and willing to follow study instructions and attend follow-up appointments. - People who understand what the stu...

Who might be able to join this trial: - People who have painful osteoarthritis in the joint at the base of the wrist where the two forearm bones meet (called the distal radioulnar joint) - People whose wrist joint in that area is considered stable (not prone to slipping out of place) Who may not be able to join: - Peo...

Who might be able to join this trial: - People who are generally healthy, with no known problems affecting the joint being studied in the trial. - People aged between 18 and 65 years old. - People who have given their agreement to participate in writing. - People who are able to understand and follow instructions throu...

**Who might be able to join this trial:** - People who are scheduled for a planned (non-urgent) first-time total hip or total knee replacement surgery - People who are aged between 55 and 95 years old - People whose blood test results show signs of malnutrition, meaning at least one of the following: a serum albumin le...

**Who might be able to join this trial:** - You have shoulder arthritis (of unknown cause) and have tried non-surgical treatments for at least 6 months without enough relief from pain or difficulty moving your shoulder - Your non-surgical treatment must have included pain or anti-inflammatory medications, physiotherapy...

Who might be able to join this trial: - People who have a specific type of wrist arthritis known as SLAC (Scapholunate Advanced Collapse) or SNAC (Scaphoid Nonunion Advanced Collapse) at stage II or III, meaning moderate to advanced joint damage in the wrist. - People aged between 18 and 75 years old. - People who have...

**Who might be able to join this trial:** *If you are a healthy volunteer (Control):* - You are 50 years of age or older. - You are willing to sign a consent form agreeing to have your walking movement recorded and analyzed. *If you have already had knee replacement surgery (Retrospective):* - You previously had a to...

**Who might be able to join this trial:** - You are between 40 and 65 years old and have been diagnosed with primary osteoarthritis (OA) in the inner part of your knee joint - Your knee osteoarthritis has been rated as moderate in severity (Grade II or III on a standard medical scale) - The inward bowing of your knee...

Who might be able to join this trial: - People who are receiving orthopaedic knee surgery or non-surgical knee treatment (such as advice, physiotherapy, or injections) at the UMC Utrecht. - People who are able to read and understand Dutch. - People who are willing and able to sign a broad consent form. Who may not be...

**Who might be able to join this trial:** - You are between 19 and 74 years old, and your body weight falls within a healthy to moderately overweight range (BMI under 40) - You are generally in good health, as assessed by the lead doctor based on your medical history - If you are a healthy volunteer, your blood pressu...

Who might be able to join this trial: - People aged 18 or older who have been informed about the study and agree in writing to take part - People who are scheduled to receive a reverse shoulder replacement on a shoulder joint that has not previously had an artificial implant Who may not be able to join: - People under...

**Who might be able to join this trial:** - People who are having a first-time shoulder replacement surgery on one shoulder (either a standard or reverse type of artificial shoulder joint) - People with a body mass index (a measure of body weight relative to height) between 18.5 and 35 - People who are able to give wri...

Who might be able to join this trial: - People who are having their ACL (a knee ligament) reconstructed for the first time - People between the ages of 25 and 50 - People who also have an injury to the meniscus (the cartilage cushion in the knee) Who may not be able to join: - People who are having a repeat or revisio...

**Who might be able to join this trial:** - People who have a stage II or III wrist condition known as scapholunate advanced collapse (SLAC) or scaphoid nonunion advanced collapse (SNAC), and whose doctor has determined they are suitable for the surgical procedures included in this trial **Who may not be able to join:...

Who might be able to join this trial: - People who are having surgery to remove a small wrist bone at the base of the thumb (called a trapeziectomy) to treat thumb arthritis - People who can read and communicate in English Who may not be able to join: - People who are currently pregnant - People who are currently taki...

Who might be able to join this trial: - People who are having a specific hip replacement device (the MobileLink acetabular cup system and a femoral stem, both made by Waldemar Link) implanted during their surgery - People who are 18 years of age or older - People who have read, understood, and signed the consent form a...

Who might be able to join this trial: - People whose knee X-rays show the most severe level of arthritis damage (grade IV on the Kellgren Lawrence scale) - People whose doctor or orthopaedic specialist has determined that a total knee replacement is needed - People who have ongoing knee pain that has not improved with...

**Who might be able to join this trial:** - You are a man or a woman (not pregnant) between 18 and 75 years old - You are willing to sign a consent form agreeing to take part in the study - Your doctor has recommended you for a first-time total knee replacement using one of two specific knee implant systems: the MicroP...

**Who might be able to join this trial:** - People who have given their written agreement to take part in the study - People who are receiving a specific type of knee replacement called a GEMINI SL Fixed Bearing PS knee prosthesis - People between 18 and 80 years of age **Who may not be able to join:** - People with a...

**Who might be able to join this trial:** - People aged 16 to 35 years - People who have had a single ACL reconstruction surgery (on one knee only, for the first time), using a graft taken from their own patellar tendon and bone **Who may not be able to join:** - People who have previously torn their ACL or had a prev...

**Who might be able to join this trial:** - Only one knee is affected (not both knees at the same time) - You have signs and symptoms of wear-and-tear damage to the cartilage in your knee - An X-ray or MRI scan shows signs of cartilage degeneration in your knee, ranging from mild to severe - You are able and willing to...

**Who might be able to join this trial:** - People between 25 and 75 years old - People who have already been diagnosed with osteoarthritis (joint wear and tear) in the shoulder joint (where the upper arm bone meets the shoulder socket) - People who can understand and communicate in English well enough to understand w...

**Who might be able to join this trial:** - People aged between 30 and 65 years old - People who have pain or other symptoms of osteoarthritis specifically in the kneecap area (called patellofemoral osteoarthritis), in one or both knees - People whose knee X-rays or MRI scans show a specific level of kneecap joint dam...

Who might be able to join this trial: - Adults aged 18 or older - People who have been diagnosed with primary shoulder joint arthritis (where the bones in the shoulder are rubbing together or nearly rubbing together), confirmed by X-ray and physical examination - People who have a baseline pain level greater than 4 out...

Who might be able to join this trial: - People aged 18 or older - People of any gender (male or female) - People who have had a hip or knee replacement surgery Who may not be able to join: - People under the age of 18 - People who have other health conditions that may make it difficult for them to return for follow-up...

**Who might be able to join this trial:** - You are 20 years of age or older. - Your shoulder's physical structure is suitable for receiving a shoulder replacement implant. - You need a shoulder replacement for one of these reasons: wear-and-tear arthritis or bone tissue death (avascular necrosis), rheumatoid arthriti...

**Who might be able to join this trial:** - People with knee cartilage degeneration affecting only one knee - People who have symptoms and physical signs of worn or damaged knee cartilage - People whose X-rays and MRI scans show signs of knee cartilage degeneration (graded on a standard scale from 1 to 4) - People who...

Who might be able to join this trial: - People who have been diagnosed with knee osteoarthritis at a moderate level (known as Kellgren-Lawrence Grade II or III) - People who have had knee pain for at least three months, with pain occurring on more than half of the days during that time - People whose pain scores at lea...

**Who might be able to join this trial:** - People aged 18 years or older - People who have been medically advised to have an anatomic primary total shoulder replacement because of osteoarthritis and/or arthritis caused by a past injury - People who are willing and able to follow the study's requirements throughout the...

**Who might be able to join this trial:** - You are 18 years old or older at the time of signing up for the study - You are willing and able to read and sign a consent form agreeing to take part - You are able and willing to follow all the steps and requirements of the study - Your doctor has decided that you are a sui...

Who might be able to join this trial: - You are aged 60 or older - You have been assessed as "pre-frail" or "frail" based on a standard frailty scoring system (scores 1–5 on this scale — confirm with trial site) - You are scheduled to have a planned hip or knee replacement surgery on one side of your body - Your estima...

Who might be able to join this trial: - People who have been diagnosed with severe knee osteoarthritis - People with a body mass index (BMI) between 45 and 60 Who may not be able to join: - People who have previously had a total knee replacement in the same knee - People who need both knees replaced at the same time -...

**Who might be able to join this trial:** - People who have moderate knee osteoarthritis, specifically rated as Kellgren-Lawrence grade 2 or 3, in the affected knee - People who have weakness in the quadriceps muscles (the large muscles at the front of the thigh), measured below a certain threshold - People who are ab...

**Who might be able to join this trial:** - People who have been diagnosed by a doctor with mild to moderate osteoarthritis (also called Degenerative Joint Disease) in the knee, shoulder, elbow, ankle, hip, or spine, rated as early-stage on a standard medical scale (grades 1–2) - People whose knee osteoarthritis meets...

Who might be able to join this trial: - You are 18 years old or older - You have painful tendon or joint problems in your shoulder, elbow, hand, or wrist that are causing symptoms - You have not had surgery to treat your condition - Your condition may include trigger finger, De Quervain's tenosynovitis (a painful wrist...

**Who might be able to join this trial:** - People who are 18 years or older and whose bones have finished growing - People who are able to understand the surgeon's explanations, follow instructions, and are willing to attend follow-up appointments and give consent to participate - People who are having a shoulder repl...

**Who might be able to join this trial:** - You need a first-time hip replacement on one side due to a non-inflammatory joint disease, such as osteoarthritis, bone tissue death (avascular necrosis), arthritis from a past injury, or certain hip conditions from childhood or injury. - You are between 50 and 75 years old a...

**Who might be able to join this trial:** - Adults aged 18 or older - People diagnosed with symptomatic finger joint osteoarthritis, based on the criteria set by the American College of Rheumatology - People who have had pain of at least 4 out of 10 in one specific finger knuckle joint (a middle finger joint, known as...

**Who might be able to join this trial:** - People aged 18 or older. - People who have had ongoing front-of-knee pain for more than 12 months that is moderate to severe (a pain score above 4 out of 10 on most or all days, either all the time or when moving). - People whose knee pain has not been adequately relieved —...

**Who might be able to join this trial:** - People who have been diagnosed with moderate to severe primary shoulder osteoarthritis (stage II or higher, based on a classification system called Samilson-Prieto), confirmed by both physical examination and imaging. - People aged between 20 and 90 years. - People with osteo...

Who might be able to join this trial: - People who have wrist arthritis causing symptoms, linked to a specific type of wrist damage known as SLAC or SNAC (conditions where the bones in the wrist gradually wear down due to an old injury or ligament problem) - People who are between 30 and 80 years of age Who may not be...

**Who might be able to join this trial:** - People who are willing and able to give their consent to take part in the study - People aged 45 years or older - People who have knee osteoarthritis graded 1 to 3 on an X-ray (using a standard medical grading scale) - People who have had knee pain for at least 3 months that...

Who might be able to join this trial: - People who need a joint replacement in a finger's middle knuckle (called the PIP joint) due to painful osteoarthritis (joint wear and tear) or a severe, unstable broken bone at that joint - People who are older than 18 years of age - People who can speak and write in Dutch - Peop...

Who might be able to join this trial: - Adults aged 18 or older - People who are scheduled to have a first-time total knee replacement (not a repeat procedure) - People whose surgery is planned to use spinal or epidural anaesthesia (anaesthetic injected into the spine area) - People who have given written consent to ta...

**Who might be able to join this trial:** - People who have been diagnosed with idiopathic shoulder osteoarthritis (wear-and-tear of the shoulder joint with no known cause) - People whose shoulder osteoarthritis has not improved after at least 6 months of non-surgical treatment, including pain medications, anti-inflamm...

**Who might be able to join this trial:** - People who are over 60 years old - People who have osteoarthritis in one knee only, confirmed by imaging showing moderate to severe damage in the knee joint (confirm with trial site for exact staging details) - People whose knee pain has averaged more than 40 out of 100 on a...

**Who might be able to join this trial:** - You are planning to receive treatment for knee pain caused by osteoarthritis — such as knee injections, nerve-blocking procedures, or knee replacement surgery — within 60 days of your screening visit - You are able to understand and fill out consent forms and questionnaires,...

**Who might be able to join this trial:** - People who have hip pain rated between 4 and 8 out of 10 on a pain scale, based on the past week - People who have imaging evidence of hip osteoarthritis, either on X-ray (early to moderate stage) or on MRI (showing early cartilage or joint rim changes, without recent injury...

**Who might be able to join this trial:** - People aged 18 to 95 years old, of any gender - People who currently live in Canada - People who are willing and able to give written consent to take part in the study - People who are able and willing to follow the study procedures and attend scheduled phone check-ins - Peo...

**Who might be able to join this trial:** - You are at least 30 years old - You are willing and able to follow the study schedule, attend visits, and understand instructions (spoken and written) - You are willing to sign a consent form to take part in the study - Your knee pain scores at least 4 out of 10 on a standard...

**Who might be able to join this trial:** - Adults aged 18 or older, of any gender - People who have been diagnosed with osteoarthritis, inflammatory arthritis, bone tissue death (osteonecrosis), or arthritis caused by a past injury, in the affected joint - People who are having a first-time total knee replacement, to...

**Who might be able to join this trial:** - You have been diagnosed with hip joint wear and tear (osteoarthritis) and your doctor has recommended a hip replacement surgery using a type that does not use bone cement - You are willing and able to give written consent to take part in the study **Who may not be able to jo...

**Who might be able to join this trial:** - People who have knee osteoarthritis with fluid build-up in the knee joint (known as an effusion), and who do not have an inflammatory disease **Who may not be able to join:** - People who are currently taking blood-thinning medications (anticoagulants) - People who have an i...

**Who might be able to join this trial:** - People between 30 and 80 years old (inclusive) - People whose knee X-ray shows a level of arthritis graded 2 to 4 on a standard scale called the Kellgren-Lawrence scale - People who have a specific type of bone injury called a bone marrow lesion (BML), visible on an MRI scan...

**Who might be able to join this trial:** - People who have been diagnosed with symptomatic osteoarthritis (a joint condition causing pain and stiffness) in the knee or hip - Veterans who receive care at Eastern Colorado Healthcare System Primary Care Clinics and have had at least one VA visit in the past year - People...

Who might be able to join this trial: - People who are 18 years of age or older - People who consider themselves a golfer (based on their own report) - People who are able to give their informed consent to take part in treatment - People who are scheduled for one of the following joint replacement or revision surgeries...

**Who might be able to join this trial:** - People of any gender - Adults (18 years and older) - People who have been assessed by a doctor as medically suitable for a partial hip replacement (hemiarthroplasty) using Corin hip devices, for conditions such as: hip joint wear and tear (osteoarthritis), bone tissue death d...

**Who might be able to join this trial:** **For the first part of the study (Diagnostic Arm):** - People who are Veterans and currently receive their healthcare through the VA system - People who have had ongoing pain in their shoulder, hip, or knee for at least one year - People whose painful joint shows mild to mode...

Who might be able to join this trial: - You are having a first-time total hip replacement surgery using a specific implant called the PROMIS stem Who may not be able to join: - No specific exclusion criteria have been listed for this trial (confirm with trial site) Important: Always verify eligibility with the trial...

**Who might be able to join this trial:** - People who have been diagnosed with osteoarthritis (wear-and-tear joint disease) in one or both hips or knees, confirmed by an X-ray showing a certain level of joint damage, where the condition has been causing pain for at least 3 months. - People who experience pain when wa...

Who might be able to join this trial: - People aged over 40 who have been diagnosed with knee osteoarthritis - People who are scheduled to have their first single-knee replacement surgery (on one knee only, for the first time) - People whose ultrasound results show moderate to severe inflammation and thickening of the...

**Who might be able to join this trial:** - You have been experiencing pain or symptoms in one knee for more than 6 months, diagnosed as knee osteoarthritis according to standard medical guidelines - Your knee osteoarthritis has been graded as mild to moderate (Grade 1 to 3) on a standard X-ray scoring system - Your kn...

Who might be able to join this trial: - People between 50 and 75 years old, of any sex - People with a body mass index (a measure of body weight relative to height) between 20.0 and 39.9 - People who have been diagnosed with primary osteoarthritis (joint damage caused by wear and tear, not another condition) - People w...

Who might be able to join this trial: - People between 45 and 75 years of age - People who have been diagnosed with knee osteoarthritis in one or both knees for at least the past 3 months, based on recognised classification standards - People who are physically able to take part in a movement and stretching program - P...

**Who might be able to join this trial:** - People between 20 and 60 years of age, male or female - People diagnosed with osteoarthritis affecting one compartment of the knee joint, at a moderate or lower level of severity (Kellgren-Lawrence grade 3 or below) - People whose knee alignment is off by more than 5 degrees,...

**Who might be able to join this trial:** - You are scheduled for a planned (non-emergency) first-time knee replacement surgery due to severe osteoarthritis - You are suitable for a specific type of knee replacement that preserves certain ligaments in the knee (called a cruciate retaining replacement, using a "Triathlo...

Who might be able to join this trial: - You have already finished all of your regular physical therapy sessions - You are between 16 and 35 years old - You had surgery to reconstruct your ACL (a ligament in the knee) between 6 and 60 months (up to 5 years) before joining the study - When you walk, your leg puts less fo...

**Who might be able to join this trial:** - People who are patients of an orthopedics service scheduled to have reverse shoulder replacement surgery - People classified as ASA physical status class I, II, or III — a standard medical rating of overall health (confirm with trial site) - People aged at least 18 years old...

**Who might be able to join this trial:** - You have been diagnosed with osteoarthritis (joint wear and tear) in one of the following areas: fingers or wrists, elbow, shoulder, knee, or ankle and foot joints - You have never before received low-dose radiation therapy on the affected joint - You are willing to attend al...

Who might be able to join this trial: - You have been diagnosed with knee arthritis (wear and tear of the knee joint) and have been referred for surgery. Who may not be able to join: - You have a cognitive disability or difficulties with thinking, memory, or understanding. - You have an inflammatory disease affecting...

Who might be able to join this trial: - People who are 18 years of age or older and are able to give their own consent to participate. - People who have been diagnosed with primary osteoarthritis (a common form of joint wear and tear, not caused by another condition). - People whose osteoarthritis has been graded as St...

Who might be able to join this trial: - People who are suspected to have symptomatic osteoarthritis (joint wear and tear) in the ankle, hindfoot, or midfoot area - People who give their written agreement to take part in the trial - People who are 18 years of age or older - People who have had an average pain level of 4...

**Who might be able to join this trial:** - You are 50 years of age or older (male or female) - You have been diagnosed with moderate knee osteoarthritis (a specific severity level called Kellgren-Lawrence grade 2 or 3), confirmed by an X-ray taken within the last 12 months - You have a pain level above 50 on a 100-poi...

**Who might be able to join this trial:** - People who have had ongoing knee pain for at least 6 months, with pain rated 4 or higher out of 10 at its worst - People diagnosed with moderate knee osteoarthritis (Grade II or III on a standard medical scale called the Kellgren Lawrence Classification) with a joint space of...

Who might be able to join this trial: - People who are over 65 years of age - People who have knee osteoarthritis where the knee is bowed inward (a condition sometimes called "varus alignment") - People whose medical records and information are complete - People who have agreed to take part in the study Who may not be...

Who might be able to join this trial: - People who are 18 years of age or older - People who have ongoing, symptomatic osteoarthritis in a finger's middle knuckle joint (called the PIP joint) - People whose X-rays show signs of osteoarthritis in that joint, rated at a moderate to severe level using a standard medical g...

**Who might be able to join this trial:** - People whose pain level falls between 40 and 95 on a standard pain rating scale (called a Visual Analog Scale) at the time of initial screening. - People who have experienced daily pain for at least 12 weeks, based on their own report or their medical records. - People who s...

**Who might be able to join this trial:** - Adults over 40 years of age - People who have pain at the base of the thumb that is triggered by pressure and movement - People whose thumb base pain has not improved with previous treatments such as over-the-counter pain relief (ibuprofen or acetaminophen), ice, splints or...

Who might be able to join this trial: - People who are 18 years of age or older - People for whom a hip arthroscopy (a keyhole procedure to look inside the hip joint) has been recommended by the study's lead doctor to treat a problem with the labrum (the cartilage ring around the hip joint) - People who are willing to...

Who might be able to join this trial: - People who have primary osteoarthritis (wear-and-tear arthritis) in one knee - People who are having a knee replacement surgery on one knee only - People whose surgery uses one of the following approaches: traditional surgery, surgical robot, computer navigation, or a personalise...

Who might be able to join this trial: - People who are scheduled to have a primary reverse shoulder replacement surgery due to osteoarthritis, a large rotator cuff tear, a failed rotator cuff repair, or shoulder instability that has led to arthritis - People whose shoulder socket bone has significantly shifted inward (...

**Who might be able to join this trial:** - People aged between 18 and 75 years, of any gender - People who have osteoarthritis causing symptoms in the middle joint of a finger (the proximal interphalangeal joint) - People who have been receiving medical treatment for functional symptoms for more than 3 months with no...

**Who might be able to join this trial:** - You are a man or woman between 18 and 75 years old. - You have been diagnosed with a painful condition affecting a specific joint in your wrist called the STT joint (where three small wrist bones meet). - You have been receiving medical treatment for your wrist symptoms for m...

**Who might be able to join this trial:** - People who are 18 years of age or older - People whose doctor has determined they are a suitable candidate for a total knee replacement based on a physical examination and medical history, including a diagnosis of severe knee pain and difficulty moving due to osteoarthritis...

**Who might be able to join this trial:** - Adults between 40 and 75 years old (men or women) - People who have pain or swelling in one knee due to osteoarthritis for at least 6 months - People whose knee osteoarthritis has been confirmed by X-ray - People who have already tried non-surgical treatments for at least 4 m...

**Who might be able to join this trial:** - People aged between 40 and 80 years old - People who have been diagnosed with knee osteoarthritis according to recognised clinical guidelines - People who have had knee pain for 3 months or longer, with pain rated at a moderate-to-high level on a standard osteoarthritis pain...

Who might be able to join this trial: - People who have had painful knee osteoarthritis symptoms for at least 6 months - Both men and women may be considered - People between the ages of 40 and 75 years old Who may not be able to join: - People younger than 40 or older than 75 years old - People with a history of bala...

**Who might be able to join this trial:** - You have been rated by an anesthesiologist as being in generally good to moderate health before surgery (this is called ASA classification 1–3; confirm with trial site if unsure which category applies to you) - Your body mass index (BMI) — a measure based on your height and w...

Who might be able to join this trial: - You had a shoulder replacement surgery using an FX Shoulder Solutions device, and your surgeon decided it was the right treatment for you, with the surgery taking place between January 1, 2018 and June 30, 2023. Who may not be able to join: - You did not have a shoulder replacem...

**Who might be able to join this trial:** - People who are older than 45 years of age - People who have painful thumb base joint arthritis (where the thumb meets the wrist) that has not improved after wearing a night splint for 3 months and at least 2 joint injections in a year - People who have been informed about the...

"Who might be able to join this trial: - People who are having an FX shoulder replacement device implanted, where the device is being used for the medical purposes it is approved and intended for. Who may not be able to join: - People who do not meet the inclusion criterion described above. Important: Always verify e...

**Who might be able to join this trial:** - People aged 50 or older - People whose thinking and memory are assessed as sufficiently intact to understand and agree to take part in the study (checked using a standard mental status screening test) - People who can read and write in English well enough to understand and c...

**Who might be able to join this trial:** - You are between 40 and 85 years old (male or female) - You have been diagnosed with osteoarthritis (a type of joint wear and tear) in the joint at the base of your thumb, confirmed by an X-ray or ultrasound - An ultrasound has shown inflammation in that thumb joint - You have...

Who might be able to join this trial: - You are 60 years of age or older and are scheduled to have a planned hip replacement surgery on one hip for arthritis - You are able to walk at least 10 meters (about 33 feet) on your own, with or without a walking aid such as a cane or walker, but without needing another person...

Who might be able to join this trial: - People who have been diagnosed with osteoarthritis through an X-ray, with a severity score of at least 2 out of 4 on a standard medical grading scale for osteoarthritis - People who are able to walk on their own without needing a walking aid such as a cane, walker, or crutches W...

**Who might be able to join this trial:** - Adults of any sex, aged over 35, who are not suitable candidates for total knee replacement surgery due to age (too young or too old), other health conditions, or technical reasons related to their anatomy or situation - People who score below 30 on the Oxford Knee Score (OKS...

**Who might be able to join this trial:** - People aged 25 to 45 with an ACL (knee ligament) injury who are planning to have ACL reconstruction surgery within 12 months of their injury - People aged 18 to 24 with an ACL injury who scored below 80 on a knee pain scale (called the KOOS Pain score, where 100 is the best p...

**Who might be able to join this trial:** **For people with knee osteoarthritis (target: 40 participants):** - People aged 45 or older - People who experience knee pain that is brought on or made worse by activity - People whose morning knee stiffness either does not occur or lasts no longer than 30 minutes - People w...

Who might be able to join this trial: - You are between 25 and 65 years old at the time of the procedure - Your Body Mass Index (BMI) is under 35 (a measure of body weight relative to height) - You have knee pain that gets worse with activity and is focused specifically on the inner side of the knee, not the whole knee...

Who might be able to join this trial: - People aged 40 to 70 years (inclusive) who are being considered for a primary cemented total knee replacement surgery. - People who are willing to participate and are able to attend the required study visits and follow-up appointments. - People who have signed the consent form th...

Who might be able to join this trial: - People who are currently on a waiting list for a partial or total knee replacement surgery - People who are able and willing to provide written consent to participate Who may not be able to join: - There are no listed exclusion criteria for this trial Important: Always verify e...

**Who might be able to join this trial:** - People who have already had, or have been scheduled to have, a revision knee replacement surgery using the specific implant components being studied (EVOLUTION® Revision Tibial System and EVOLUTION® STEMMED CS Femur with the EVOLUTION® MP CS Tibial Insert) - The decision to u...

**Who might be able to join this trial:** - People who are already registered in the Joint Academy database and have previously taken part in the Joint Academy treatment program for osteoarthritis (a joint condition causing pain and stiffness), and who agreed to have their data used for research. - People who have been...

**Who might be able to join this trial:** - People who are attending a follow-up consultation 1 year after having a total knee replacement - People who are adults (18 years or older) - People who are enrolled in a social security (health insurance) system - People who have been fully informed about the study and have s...

**Who might be able to join this trial:** - People aged 18 to 65 years old at the time of screening. - People who have been diagnosed with patellofemoral osteoarthritis (a type of knee joint wear affecting the kneecap area) rated as grade 1 to 3 on the Iwano Classification scale. - People who have cartilage damage rat...

**Who might be able to join this trial:** - People who are over 40 years old - People who are able to give informed consent (agree to participate after being fully informed) - People who have had knee pain caused by osteoarthritis for at least 6 months - People whose knee pain has not improved enough with treatments su...

Who might be able to join this trial: - People who are legally able to make their own decisions and give consent - People who have damage to both the cartilage and bone in a joint (osteochondral lesions) - People who have pain and swelling in a joint caused by inflammation - People who have inflammation around a tendon...

Who might be able to join this trial: - People who need their first total hip replacement due to severe hip pain or disability caused by osteoarthritis, rheumatoid arthritis, arthritis from an old injury, a hip joint that didn't form properly, bone death in the hip (AVN), or a recent hip fracture. - People who are able...

Who might be able to join this trial: - People who have been clinically diagnosed with osteoarthritis in one knee only (not both knees) - People who have been experiencing knee pain for more than three months - People whose knee stiffness in the morning lasts less than 30 minutes - People whose affected knee shows a cr...

**Who might be able to join this trial:** - You have been diagnosed with knee osteoarthritis, with knee pain that has lasted more than 3 months - You experience morning stiffness in your knee that lasts less than 30 minutes - You have a crackling or grinding sensation in your knee (sometimes called "crepitus") - You ha...

**Who might be able to join this trial:** - You are a man or woman between 40 and 75 years old (inclusive) with arthritis in one ankle joint, and your doctor has recommended you for a first-time total ankle replacement surgery. - You are willing and able to attend all required study appointments and follow-up visits. -...

**Who might be able to join this trial:** - People who have signed and dated a consent form to take part in the study (for children, both a signed assent from the child and a permission form from a parent or guardian are required) - People who had anterior cruciate ligament reconstruction (knee surgery to repair a tor...

**Who might be able to join this trial:** - People who currently live in British Columbia, Canada - People who are between 16 and 35 years old (inclusive) - People who are 9 to 36 months past their first ACL reconstruction surgery, where that surgery happened within 12 months of their first ACL tear - People who are n...

Who might be able to join this trial: - People over 50 years old (male or female) who have severe, end-stage knee arthritis and are waiting for a total knee replacement surgery - People who have already been scheduled for a total knee replacement at Prince of Wales Hospital - People who are able to take part in all stu...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been diagnosed with osteoarthritis in one hip, rated as grade II or III on a standard medical scale used to measure joint damage (confirm with trial site if unsure of your grading) - People who have had hip pain for mo...

Who might be able to join this trial: - People who live independently in the community in Sherbrooke (Quebec) or Hamilton or London (Ontario) - People aged 45 or older - People who have been diagnosed with knee osteoarthritis, OR who have knee pain that occurs with movement, with either no morning knee stiffness or mor...

Who might be able to join this trial: - People who are male or female and older than 18 years of age. - People who have been diagnosed with thumb base (CMC) joint arthritis at stage I, II, or III, confirmed by X-ray. - People whose thumb pain is rated 5 or higher on a standard 10-point pain scale. - People who are will...

**Who might be able to join this trial:** - People who have been diagnosed with osteoarthritis on the inner side of the knee joint, confirmed by X-ray showing bone spurs and narrowing of the joint space. - People who have had knee pain for more than 6 months. - People whose average knee pain over the past 6 months has...

Who might be able to join this trial: - People who have been diagnosed with osteoarthritis affecting the inner side of one knee, rated as moderate to severe (grade 3 or 4 on a standard medical scale) - People who have had at least 60 months (5 years) of follow-up care after their knee surgery - People whose medical rec...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with primary hip osteoarthritis (wear and tear of the hip joint) at any stage - People attending the orthopaedic department at a participating hospital, either in preparation for hip replacement surgery or for a consult...

Who might be able to join this trial: - You are a man or woman aged 41 or older who needs a total knee replacement surgery - Your knee condition is caused by natural wear and tear (osteoarthritis) or by bone tissue dying due to loss of blood supply (osteonecrosis) - You are generally in good health with no major health...

Who might be able to join this trial: - People who have painful knee osteoarthritis that has been assessed as needing a full knee replacement - People whose knee bends inward (a "bow-legged" alignment) by no more than 10 degrees - People whose knee ligaments, specifically the ligament at the back of the knee (posterior...

Who might be able to join this trial: - People aged between 40 and 85 years old who have been diagnosed with knee osteoarthritis lasting more than 3 months - People whose knee X-ray shows a Kellgren and Lawrence Score of 2 or higher (a measure of joint damage visible on imaging — confirm with trial site if unsure of yo...

Who might be able to join this trial: - You are a man or a woman who is not pregnant, between the ages of 40 and 90 years old - You need a full knee replacement for the first time (not a revision or repeat procedure) - Your surgeon has determined that a type of knee replacement that keeps a certain ligament in the knee...

Who might be able to join this trial: - People who are on a waiting list for their first knee replacement surgery on one knee - People whose main reason for needing knee surgery is osteoarthritis of the knee - People who live within 60 minutes of travel to the location where the trial is being run Who may not be able...

Who might be able to join this trial: - People who are scheduled to have a type of shoulder replacement surgery called a reverse total shoulder arthroplasty (a surgery where an artificial shoulder joint is placed in a reversed position compared to the natural joint) - People who are willing and able to give their infor...

Who might be able to join this trial: - Adults between 19 and 79 years of age - People who are proficient in English - People who are willing to sign a consent form agreeing to take part in the study - People who are scheduled to have a single knee replacement on one knee only (not both at the same time) - People whose...

**Who might be able to join this trial:** - People who are male or female, aged between 18 and 55 years old - People who have previously had a reconstruction of the ACL (a ligament in the knee) on one knee within the last 5 years, where that surgery did not succeed as expected - People who are already scheduled to have...

Who might be able to join this trial: - People aged 18 years or older - People with inflammatory or non-inflammatory bone and joint diseases that require either fluid to be drained from a joint or joint replacement surgery - People who have agreed to participate (non-opposition collected) - People who are affiliated wi...

**Who might be able to join this trial:** - People who are 18 years of age or older and have reached full bone maturity - People who are scheduled for their first (not repeat) planned shoulder replacement surgery — either a standard (anatomic) or reverse type - The shoulder replacement must be for one of these reasons...

Who might be able to join this trial: - People who are older than 65 years of age - People who are scheduled to have a cemented total hip replacement surgery Who may not be able to join: - People who have already been diagnosed with peripheral artery disease (a condition affecting blood flow in the arteries) in both a...

Who might be able to join this trial: - People between 50 and 85 years old - People who have osteoarthritis in one knee (not both) and are scheduled for their first total knee replacement surgery on that knee - People whose overall health before surgery falls within a certain accepted range, as assessed by their medica...

**Who might be able to join this trial:** - People who have been diagnosed with knee osteoarthritis, based on the official diagnostic criteria for arthritis - People who have no known allergies or medical reasons that would prevent them from taking the trial medications - People who are between 45 and 75 years old - Pe...

**Who might be able to join this trial:** - A doctor has already decided — separately from this study — that you need a total hip replacement using a specific implant called the DELTA Revision acetabular cup, as part of your normal medical care - You are 18 years old or older - You are willing and able to sign a writte...

Who might be able to join this trial: - People aged 18 years or older - People who have been diagnosed with hand osteoarthritis based on established medical criteria - People who have had an average finger pain level of 4 or more out of 10 (where 10 is the worst pain) across fingers 2 to 5, over the past 30 days - Peop...

Who might be able to join this trial: - Adults aged 25 years or older, of any gender - People who have been diagnosed with thumb base joint osteoarthritis (confirmed by imaging), are experiencing symptoms from it, and are already planned to have a surgical procedure called a trapeziectomy to treat it Who may not be ab...

**Who might be able to join this trial:** - People (male or female) who have lost part of their outer knee cartilage pad (lateral meniscus) and have pain on the outer side of the knee joint, OR who have lost part of their inner knee cartilage pad (medial meniscus) and have pain on the inner side of the knee joint - Pe...

Who might be able to join this trial: - People who are 18 years of age or older - People who are scheduled to have rotator cuff repair surgery - People who will be receiving standard anaesthesia during their surgery - People who are capable of having children must be using effective contraception for one month before,...

Who might be able to join this trial: - People between 40 and 65 years old. - Both men and women are eligible. - People who were physically active in sports before a knee problem stopped them from continuing — specifically, those who score a 3 or 4 on a standard physical activity scale called the "Saltin-Grimby Physica...

**Who might be able to join this trial:** - You are 50 years of age or older - A doctor has diagnosed you with knee osteoarthritis - You have a moderate-to-high level of knee pain, based on a specific pain questionnaire score (confirm with trial site) - You are able to give your informed consent to participate - If pla...

Who might be able to join this trial: - People who are 60 years of age or older - People who have been diagnosed with knee osteoarthritis by a rheumatologist - People who are fluent in English Who may not be able to join: - People who take blood-thinning medications, including warfarin, dabigatran, rivaroxaban, or api...

**Who might be able to join this trial:** **Patient group (people with early knee symptoms):** - People who meet specific diagnostic criteria for early-stage knee osteoarthritis, based on a combination of symptoms (such as pain when going up and down stairs or pain that gets worse with activity) and risk factors (conf...

**Who might be able to join this trial:** - Adults who are 18 years of age or older - People who have been assessed as suitable for a total knee replacement based on local medical guidelines and standard practice - People who are willing to take part in the study **Who may not be able to join:** - People whose knee al...

**Who might be able to join this trial:** - People who have been clinically diagnosed with hip osteoarthritis (a condition where the hip joint wears down over time) according to specific guidelines from a UK health authority called NICE - People whose hip osteoarthritis diagnosis has been confirmed by an X-ray showing...

**Who might be able to join this trial:** - People aged 18 years or older - People who have been diagnosed with thumb base joint arthritis (TMO), confirmed by an X-ray reviewed by a radiologist - People who are experiencing pain at the base of the thumb - People whose attending doctor has decided that a corticosteroid...

**Who might be able to join this trial:** - People who are willing to sign and date a consent form agreeing to take part in the study - People who are willing to follow all study procedures and are available for the full length of the study - People who can read and speak English - People who have recently had a low-e...

**Who might be able to join this trial:** - People who have been diagnosed with knee osteoarthritis (a condition where the cartilage in the knee breaks down over time) - People who experience moderate to severe knee pain (rated 4 out of 10 or higher) during physical activity, in one or both knees **Who may not be able...

**Who might be able to join this trial:** - People who are between 22 and 65 years old at the time of screening - People who have pain at the front of the knee caused by cartilage breakdown behind the kneecap, confirmed by MRI to be at a moderate-to-severe level (Modified Outerbridge score of 3 or higher) - People with...

**Who might be able to join this trial:** - People aged 50 or older - People who have been diagnosed with knee osteoarthritis - People who are scheduled for a planned, non-emergency knee replacement surgery on one knee - People whose overall health status falls within a certain acceptable range for surgery (confirm wi...

Who might be able to join this trial: - People who are between 18 and 45 years old - People with a body mass index (a measure of body weight relative to height) below 40 - People who have had an ACL (knee ligament) reconstruction surgery - People who have small meniscal (knee cartilage) lesions that are not causing sym...

Who might be able to join this trial: - People with knee osteoarthritis that has been rated as Grade 1, 2, or 3 on a standard medical scale (called the Kellgren-Lawrence scale) - People who have had knee osteoarthritis symptoms in one knee for at least 3 months before visiting the trial site - People whose osteoarthrit...

Who might be able to join this trial: - People from the Norrbotten region in northern Sweden who had a tibial plateau fracture (a break in the upper part of the shinbone where it meets the knee) between 2001 and 2015 Who may not be able to join: - People who have passed away without having had weight-bearing knee X-ra...

**Who might be able to join this trial:** - People who are having corrective knee bone surgery, and possibly related procedures such as meniscus repair or removal, ligament repair, cartilage treatment, or regenerative injections - People who are between 18 and 70 years old at the time of surgery - People who have arthr...

**Who might be able to join this trial:** - A person must give written consent before any assessments take place - The person must be able to communicate clearly with researchers and follow the study requirements throughout - The person must be between 50 and 70 years old (inclusive), of any gender - Men must weigh at...

**Who might be able to join this trial:** - People who have had ongoing knee joint pain for at least 3 months. - People whose body mass index (BMI) falls between 21.5 and 29.5 (a measure of body weight relative to height). - People who have knee osteoarthritis confirmed by X-ray, rated as mild to moderate severity (gra...

Who might be able to join this trial: - People over 18 years old who have had an artery-blocking procedure (called embolization) to treat long-term pain caused by osteoarthritis or another condition that causes pain in a specific area of the body. Who may not be able to join: - No specific exclusion criteria have been...

**Who might be able to join this trial:** - People who are willing and able to give written consent and follow all study procedures and schedules. - People aged 40 years or older (male or female). - Females who have a negative pregnancy test, are not breastfeeding, and do not plan to become pregnant from the screening...

**Who might be able to join this trial:** - People of any sex between 18 and 40 years old with knee osteoarthritis that is causing symptoms - Only one knee is affected (not both) - There are signs and symptoms of knee osteoarthritis present - Imaging (X-ray or MRI) shows signs of cartilage damage in the knee, graded be...

Who might be able to join this trial: - People who have been clinically diagnosed with chronic knee osteoarthritis - People between the ages of 40 and 90 years old - People who are about to start physical therapy for knee osteoarthritis (with a first appointment coming up within the next month, or who had their first p...

Who might be able to join this trial: - You have knee pain and/or have trouble with normal knee movement or function - Your knee arthritis has been assessed as mild or early-stage (graded 2 or lower on a standard medical scale called Kellgren-Lawrence) - A camera examination inside your knee (called arthroscopy) has sh...

**Who might be able to join this trial:** - People aged 50 or older - People with a body mass index (a measure of weight relative to height) of 40 or below - People who self-identify as Black, including African American - People who have had knee pain rated at least 4 out of 10 on average over the past week - People wh...

Who might be able to join this trial: - People who have been diagnosed with primary knee osteoarthritis according to standard medical guidelines set by the American College of Rheumatology - People whose knee X-rays show osteoarthritis rated at a score of 2 or higher on a standard scale (called the Kellgren and Lawrenc...

Who might be able to join this trial: - People aged between 65 and 80 years old at the time of surgery who have been diagnosed with primary hip osteoarthritis (hip joint wear and tear) - People who need a first-time total hip replacement surgery - People who are willing and able to attend scheduled follow-up appointmen...

**Who might be able to join this trial:** - People aged between 50 and 80 years - People experiencing hip osteoarthritis symptoms, including pain rated at least 6 out of 10 on a pain scale over the previous week - People with X-ray results showing moderate to severe hip osteoarthritis (classified as Grade 3 or 4 using...

Who might be able to join this trial: - People aged 40 years or older - People of any gender - People who have been diagnosed with stage II or III hip joint arthritis (coxarthrosis) or thumb base joint arthritis (rhizoarthrosis), confirmed by X-ray using standard medical classification systems - People experiencing pai...

**Who might be able to join this trial:** - Both men and women are welcome to participate. - You must be 50 years of age or older. - Your body weight relative to your height (BMI) must fall between 18.9 and 29.9 (generally considered a normal to slightly overweight range). - You must have been diagnosed with Grade II k...

**Who might be able to join this trial:** - People who identify as part of the Black American diaspora, including Black/African American or Afro-Caribbean communities - People between the ages of 50 and 92 years old - People who have had ongoing or recurring pain in their bones, joints, muscles, or related soft tissue...

Who might be able to join this trial: - You have been diagnosed with osteoarthritis and are scheduled to have a total knee replacement surgery with the specific surgeons involved in this study - You will be having regional anesthesia (numbing a specific area of the body) rather than being fully put to sleep during surg...

Who might be able to join this trial: - Adults between the ages of 45 and 80 years old - People who have been diagnosed with knee osteoarthritis - People whose knee osteoarthritis has not improved with standard, non-surgical treatments - People who are able to give their informed agreement to take part in the study - P...

Who might be able to join this trial: - Adults aged 18 years or older - People who have been diagnosed with knee osteoarthritis based on physical examination and imaging results (such as X-rays) - People whose treating doctor has determined them to be suitable for a procedure called geniculate artery embolization (a pr...

Who might be able to join this trial: - People who need a custom-made hip socket implant, as determined by CT scan and X-ray assessment - People who have had a pre-operative CT scan completed before surgery - Adults aged 18 years or older - People whose medical records are complete and fully available - People who are...

**Who might be able to join this trial:** - People between 35 and 55 years of age - People who have a degenerative tear in the inner cartilage pad (meniscus) of the knee, shown by pain on the inner side of the knee, tenderness along the inner knee joint, pain and limited movement when trying to do a full squat, and spe...

Who might be able to join this trial: - People aged 20 to 79 years old at the time of signing consent forms - People who have been diagnosed with knee osteoarthritis rated at a specific severity level (Kellgren-Lawrence Grade 2 to 4) based on a knee X-ray - People whose knee condition is suitable for a type of bone sur...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been rated as generally healthy or having only mild health conditions by your anesthesia team (called ASA grade I or II), can read and understand Chinese, and are able to communicate clearly with your doctors - You are planning to h...

**Who might be able to join this trial:** - You are between 40 and 60 years old - An X-ray has shown you have moderate knee osteoarthritis (specifically graded as "grade 2") - You have tenderness or soreness on the inner side of your knee (the area just below the knee joint) - Your pain level is 5 or higher on a scale...

**Who might be able to join this trial:** - You are between 40 and 65 years old - You are any gender - You have been diagnosed with knee osteoarthritis (a type of joint wear-and-tear) with a moderate severity rating (Kellgren-Lawrence score of 2 or 3) confirmed by an X-ray or scan - If both knees are affected, the mor...

**Who might be able to join this trial:** - People who speak English - People aged 50 years or older - People who have been diagnosed with knee osteoarthritis confirmed by X-ray at a grade 2 or higher, within the past 2 years - People who experience knee pain on at least 15 days per month - People whose worst daily pai...

**Who might be able to join this trial:** - You visited your GP about knee pain that was not caused by a recent injury - Your GP assessed your knee pain as being related to soft tissue issues or early wear-and-tear changes in the knee joint - You are between 35 and 69 years old (inclusive) **Who may not be able to joi...

**Who might be able to join this trial:** - Adults aged 18 to 70 years old at the time of screening. - People diagnosed with symptomatic patellofemoral osteoarthritis (a type of knee joint problem involving the kneecap area) graded 1–4 on the Iwano Classification scale (confirm with trial site). - People with moderate...

**Who might be able to join this trial:** - People who have been clinically diagnosed with osteoarthritis (OA) of the knee or hip - People aged between 45 and 80 years old - People who have X-ray findings showing moderate to advanced knee or hip OA (based on a standard scoring system called Kellgren & Lawrence, score o...

**Who might be able to join this trial:** - Adults under 70 years of age who were previously physically active and have knee osteoarthritis that significantly limits daily life - People whose knee osteoarthritis has not responded to standard treatments such as anti-inflammatory medications, injections, or pain relief m...

**Who might be able to join this trial:** - People who are able to give signed written consent to participate - Adults aged between 18 and 50 years old at the time of screening - People who have had surgery to reconstruct a torn ACL (anterior cruciate ligament) in one knee, within 6 months of the injury occurring - Peo...

**Who might be able to join this trial:** - People aged 18 or older, of any gender - People who have painful knee osteoarthritis in one or both knees, confirmed by an X-ray taken within the last year, showing a certain level of joint damage (confirm with trial site for exact scoring details) — or knee arthritis linked...

Who might be able to join this trial: - People who have been recommended to have a first-time total knee replacement surgery. - People who are covered by a social security (health insurance) scheme. - People who have been fully informed about the study and have signed a consent form before any study-related examination...

Who might be able to join this trial: - People who need one of the following specific surgeries: a bone-reshaping procedure on the wrist (radius), a complex hip replacement surgery, or a spinal fusion surgery in the mid-to-lower back area. - People who are able to read, understand, and sign a consent form agreeing to t...

**Who might be able to join this trial:** - People who are over 30 years of age - People who have been diagnosed with moderate knee osteoarthritis (Grade II or III on a standard medical scale called the KL scale) in one knee - People with a Body Mass Index (BMI) below 50 kg/m² - People who rate their knee pain as 4 or...

**Who might be able to join this trial:** - You have been diagnosed with knee osteoarthritis confirmed by symptoms, a physical examination, and X-rays showing a moderate-to-severe level of joint damage (stage III or higher on a standard medical scale) - You have severe knee pain that limits your daily activities, have...

**Who might be able to join this trial:** - People aged 40 years or older. - People diagnosed with hand osteoarthritis according to a specific set of medical guidelines (the 1990 American College of Rheumatology criteria). - People whose osteoarthritis affects at least two finger joints (the middle or end knuckle joint...

**Who might be able to join this trial:** - You are between 65 and 80 years old - You have been assessed with a Kellgren score of II or III, which is a measure of joint wear commonly used in knee arthritis (confirm with trial site) - You have not had any falls in the past 12 months **Who may not be able to join:** - Y...

Who might be able to join this trial: - People aged between 50 and 80 years old - People who have been diagnosed with knee osteoarthritis (a condition where the knee joint wears down over time), confirmed by X-ray showing mild to moderate changes, according to standard medical guidelines Who may not be able to join: -...

**Who might be able to join this trial:** - People diagnosed with knee osteoarthritis rated at a certain level of severity (stage 2 to 4 on a standard medical scale), confirmed by a knee X-ray taken within the past 3 years. - People whose knee osteoarthritis causes significant difficulty with physical activities, as m...

**Who might be able to join this trial:** - People aged 18 or older, of any gender - People whose main diagnosis is advanced, severely symptomatic knee osteoarthritis in one knee only, where the joint has reached end-stage deterioration - People whose knee function score (measured using a standard tool called the Knee...

Who might be able to join this trial: - People who have knee osteoarthritis that is causing symptoms and has reached an advanced (end-stage) level - People whose knee ligaments are still working properly - People who are older than 18 years of age Who may not be able to join: - People who have a neurological condition...

Who might be able to join this trial: - People who have primary osteoarthritis that causes significant, disabling pain - People who are older than 18 years at the time of surgery - People who are able to communicate with healthcare professionals and give informed consent to participate - People who are willing to atten...

**Who might be able to join this trial:** - You have severe hip pain or difficulty moving due to osteoarthritis, injury-related arthritis, a hip development condition, or loss of blood supply to the hip bone, and your doctor has recommended a total hip replacement. - You will be receiving a specific type of hip implant...

**Who might be able to join this trial:** - People aged between 18 and 90 years old - People who have been diagnosed with knee osteoarthritis (wear and tear of the knee joint) rated at a moderate or higher level of severity on a standard medical scale (Kellgren stage 2 or above), without joint instability when the kne...

Who might be able to join this trial: - People who are scheduled to have a total knee replacement surgery on one knee Who may not be able to join: - People who have an allergy to any of the drugs used in this study - People who have a history of alcohol or drug abuse - People who have a psychiatric illness Important:...

**Who might be able to join this trial:** - You are between 40 and 60 years old - You have been diagnosed with mild hip arthritis (early stage), and you may also have a torn hip labrum, a hip bone shape problem (femoroacetabular impingement), or mild hip socket shallowness (mild dysplasia) - After receiving a guided an...

Who might be able to join this trial: - People who have tried non-surgical treatments for osteoarthritis (a joint condition causing pain and stiffness) without enough improvement - People who are scheduled to have one of two specific hand surgeries: removal of a small wrist bone called the trapezium, or a joint replace...

**Who might be able to join this trial:** - People between 40 and 65 years of age (both men and women) - People who have been diagnosed with mild to moderate knee osteoarthritis (graded 1 or 2 on a standard scale) - People who have noticeable knee osteoarthritis symptoms in one or both knees, with findings confirmed by...

Who might be able to join this trial: - People between 50 and 65 years of age - People who have been diagnosed with Grade 3 osteoarthritis (a moderate-to-severe stage of joint wear and damage) - People who have given birth to 5 or more children - People who are still able to have children (fertile females) - People who...

**Who might be able to join this trial:** - People aged 18 to 90 years old who are due to have their first knee replacement surgery for knee arthritis - People who are mentally able to understand the study and agree to take part - People who are enrolled in the French social security system **Who may not be able to jo...

Who might be able to join this trial: - People who have been regularly experiencing pain, aching, or stiffness in or around the knee for at least 1 month - People who complete the screening questionnaire called the PhIT-OA questionnaire Who may not be able to join: - People who have already had a total knee replacemen...

**Who might be able to join this trial:** - People aged 50 years or older who have knee pain related to activity, and either no morning knee stiffness or morning knee stiffness that lasts 30 minutes or less - People with a BMI under 40 - People who have had knee pain on most days for 3 months or longer - People whose a...

**Who might be able to join this trial:** - People aged between 40 and 75 years old - People who have knee osteoarthritis with pain symptoms rated between 3 and 8 on a standard pain scale - People where only one knee is affected by symptoms - People whose knee cartilage damage has been confirmed by X-ray or MRI scan,...

**Who might be able to join this trial:** - People who have had a previous ACL (knee ligament) reconstruction surgery using tissue from their own body or a donor, and who now have a form of arthritis in that knee as a result - People who had their ACL reconstruction surgery at least one year ago - People between the a...

**Who might be able to join this trial:** - People who are willing and able to give their informed consent to take part - Men or women aged 40 years or older - People who have osteoarthritis (a type of joint wear and tear) in the inner part of the knee joint, confirmed by both knee pain and X-ray findings showing a sp...

**Who might be able to join this trial:** - You are 55 years of age or older (based on your national ID at the time of signing up for the trial) - You have been diagnosed with knee osteoarthritis (wear and tear of the knee joint) confirmed through your medical history, a physical exam, and X-rays or similar imaging - Y...

**Who might be able to join this trial:** - People aged between 18 and 80 years old - People with a body mass index (BMI) below 40 (a measure of body weight relative to height) - People who have knee osteoarthritis with symptoms and X-ray results showing a moderate level of joint damage (rated as grade 2 or 3 on a stan...

**Who might be able to join this trial:** - People who have been diagnosed with knee osteoarthritis according to specific Chinese Medical Association guidelines. - People who have had ongoing knee pain for more than six months, or whose knee osteoarthritis has come back or gotten worse after stopping common treatments...

Who might be able to join this trial: - People who are at least 18 years old and are having a specific type of shoulder replacement surgery for the first time (called a "reverse total shoulder arthroplasty") - The surgery must be taking place at one of three specific locations: Loyola University Medical Center (Maywood...

Who might be able to join this trial: - People who are having their first total hip or knee replacement surgery - People who are able to understand and agree to participate in the study (give informed consent) - People who speak English or Spanish Who may not be able to join: - People who have had previous lower back...

Who might be able to join this trial: - People who have been diagnosed with osteoarthritis of the jaw joint (the temporomandibular joint, or TMJ) on the side being treated. - People whose jaw joint MRI scan shows signs of inflammation. - People whose blood test results (checking general health, salt levels, and kidney...

**Who might be able to join this trial:** - People who have been diagnosed with knee osteoarthritis and have had knee complaints for at least 6 months **Who may not be able to join:** - People who have a rheumatological (joint or immune-related) disease other than osteoarthritis - People whose knee pain is caused by a...

**Who might be able to join this trial:** - People aged between 45 and 80 years old - People who meet at least three of the following six features of knee osteoarthritis (as assessed by a doctor): being over 50 years old, morning stiffness that lasts less than 30 minutes, a crackling or grinding sensation when the knee...

Who might be able to join this trial: - People aged between 35 and 60 years old - People with mild to moderate knee joint arthritis (tibiofemoral osteoarthritis), graded I, II, or III on the Kellgren-Lawrence scale - People who have pain at the front of the knee (patellofemoral osteoarthritis) - People where the inner...

**Who might be able to join this trial:** - You are 18 years of age or older - You have knee pain in one or both knees that has been diagnosed as knee osteoarthritis (if both knees are affected, only the more severely affected knee would be included) - Your knee osteoarthritis has been confirmed by a standing X-ray and...

Who might be able to join this trial: - People who are aged 65 or older. - People who have been diagnosed with hip, knee, or general osteoarthritis, recorded using a standard medical diagnosis code. - People who have confirmed through a standardised survey question that a doctor told them they have osteoarthritis or ar...

Who might be able to join this trial: - People with a BMI of 30 or higher who have knee osteoarthritis confirmed by an X-ray, and who are interested in receiving a steroid injection for their knee arthritis. Who may not be able to join: - People with a BMI below 30. - People with diabetes that is not well controlled,...

**Who might be able to join this trial:** - You are willing to sign and date a consent form agreeing to take part in the study - You are willing to follow all study procedures and are available for the full length of the study - You are male or female, between 21 and 80 years old - You have been diagnosed with hip oste...

Who might be able to join this trial: - People who have been diagnosed with hand osteoarthritis by their general practitioner - People aged 18 years or older - People who are experiencing reduced ability to carry out everyday activities (such as dressing, cooking, or personal care) Who may not be able to join: - Peopl...

**Who might be able to join this trial:** - People aged 18 to 70 years old, of any gender - People who have been diagnosed with knee osteoarthritis according to the American College of Rheumatology (ACR) diagnostic standards - People whose knee pain scores at least 4 out of 10 on a standard pain scale, and whose pain h...

Who might be able to join this trial: - People who have been diagnosed with osteoarthritis in the inner side of the knee by a doctor, or who meet a set of established medical guidelines for this type of knee osteoarthritis - People who pass a safety questionnaire (called the Get Active Questionnaire) confirming that st...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with osteoarthritis and are scheduled to have a knee replacement on one knee (not both at the same time) - Your other knee (the one not being replaced) has not had steroid or biologic injections in the past year - You...

**Who might be able to join this trial:** - People aged 14 to 64 years old (those aged 14 to 21 must have imaging showing their hip bones have finished growing) - People with a body mass index (BMI) under 35 - People who have already tried at least 6 weeks of non-surgical treatment, such as pain or anti-inflammatory m...

Who might be able to join this trial: - People who have been diagnosed with a musculoskeletal pain condition, specifically osteoarthritis, back pain, or fibromyalgia - People who are 18 years of age or older - People who are willing and able to give their informed consent to participate Who may not be able to join: -...

**Who might be able to join this trial:** - You have been diagnosed with knee osteoarthritis (worn knee joint) in one or both knees that causes symptoms such as pain or stiffness - You feel you are able to walk for 10 minutes without using a walking aid (such as a cane or walker) - You are able to go up and down stairs...

**Who might be able to join this trial:** - People who are able to read, understand, and sign a consent form agreeing to take part in the study - People who are willing and able to follow the study's instructions and attend all required visits - People who have been diagnosed with osteoarthritis (OA) of the knee, with...

**Who might be able to join this trial:** - People who have knee pain that gets worse with activity, located specifically on the inner side of the knee (not the whole knee) - People whose knee pain scores at least 40 out of 100 on a standard pain measurement scale called the WOMAC - People who have already tried non-su...

**Who might be able to join this trial:** - People who have given their written consent to take part after being fully informed about the trial. - Adults between 40 and 75 years of age at the time of screening. - People diagnosed with knee osteoarthritis according to recognised medical criteria, with symptoms lasting...

**Who might be able to join this trial:** - You are between 40 and 60 years old - You are any gender (male or female) - You have been experiencing knee pain for 3 months or longer - Your average knee pain has been at least 4 out of 10 in the past week - Your X-ray shows a moderate level of knee joint damage (graded as...

Who might be able to join this trial: - People who are having a hip or knee replacement surgery at the participating hospital - People who are having follow-up (revision) surgery after a previous hip or knee replacement Who may not be able to join: - People who have not given their consent in advance to take part in t...

**Who might be able to join this trial:** - People aged 18 to 80 years old (inclusive), of any gender, who agree to take part and sign a consent form - People who need total knee replacement surgery - People who are able to communicate clearly with the research team and are willing to follow the trial requirements **W...

**Who might be able to join this trial:** - You are between 40 and 80 years old - You have knee pain in one or both knees that has been diagnosed as osteoarthritis - Your knee X-rays (taken while standing) show a moderate to severe level of osteoarthritis (Grade 2–4 on a standard medical scale) - You have had knee pain...

**Who might be able to join this trial:** - People who are willing to take part and sign a written consent form agreeing to participate. - People who have previously been diagnosed with osteoarthritis of the knee or hip, based on recognised medical criteria. - People currently experiencing a flare-up of pain in the af...

Who might be able to join this trial: - The person has pain in one or both knees that is located in a specific area. - The person is considered a suitable candidate for a procedure involving access to an artery (a blood vessel that carries blood from the heart). Who may not be able to join: - The person has a known se...

**Who might be able to join this trial:** - People between 40 and 60 years of age - Both men and women are eligible - People who are able to walk for 6 minutes and complete a basic standing and walking test (called the Timed Up-and-Go test) - People who are able to get up from the floor - People who have been diagnosed...

Who might be able to join this trial: - People between 40 and 80 years of age - People who have been diagnosed with hip and/or knee osteoarthritis according to specific rheumatology guidelines set by the American College of Rheumatology - People experiencing a moderate to severe level of pain that interferes with daily...

**Who might be able to join this trial:** - People whose primary care provider is based at Mayo Clinic in Rochester, MN - People aged between 50 and 100 years old - People who experience at least moderate knee pain, as measured by a specific pain questionnaire called the ICOAP scale - People who have been diagnosed wit...

Who might be able to join this trial: - You are between 18 and 85 years old - You are scheduled to have a total knee replacement surgery for the first time - You are willing to sign a consent form agreeing to take part in the study - Your knee surgery is needed because of osteoarthritis (wear and tear of the knee joint...

**Who might be able to join this trial:** - You need to be scheduled for a first-time knee arthroscopy (a minor surgical procedure using a small camera) to treat a meniscal (cartilage cushion) injury or a small area of cartilage damage, specifically a cleaning-out or trimming procedure - Your knee shows no signs of art...

Who might be able to join this trial: - Adults over 18 years old who have knee osteoarthritis that has not improved with non-surgical treatments - People who are able to understand and agree to take part in the study by signing a consent form - People who are receiving a specific type of total knee replacement implant...

Who might be able to join this trial: - People aged 50 years or older. - People who have experienced pain in one or more areas of the body for 6 months or more. - People whose knee pain meets the recognised criteria for osteoarthritis, including having visible bone changes on an X-ray and/or knee pain on most days over...

Who might be able to join this trial: - People who receive their healthcare through the Department of Defense (DoD) and are registered as patients at David Grant Medical Center (DGMC) - Adults between 45 and 75 years old who have been diagnosed with knee osteoarthritis (joint wear and tear) in one or both knees, based...

Who might be able to join this trial: - People who are between 30 and 75 years old - People who have had ongoing knee pain for at least 6 months - People whose X-rays show moderate to severe osteoarthritis (Grade 3 or 4 on a standard medical scale) with significant narrowing of the space inside the knee joint - People...

**Who might be able to join this trial:** - You are between 30 and 65 years old. - Your knee quality-of-life score (measured by a questionnaire called KOOS) is 60 or below, meaning your knee significantly affects your daily life. - You are willing and able to follow all study requirements, including post-surgery rehab...

Who might be able to join this trial: - People who are between 45 and 75 years old (inclusive) - People who have been diagnosed with knee osteoarthritis based on standard medical criteria, which includes knee pain along with at least 3 of the following: being over 50 years old, morning stiffness lasting less than 30 mi...

**Who might be able to join this trial:** - You are 20 years of age or older. - Your shoulder anatomy is suitable to receive a shoulder replacement implant, as determined by your doctor. - You need a shoulder replacement due to one of the following: osteoarthritis, bone tissue death due to loss of blood supply (avascul...

**Who might be able to join this trial:** - People who have painful knee osteoarthritis and need a first-time total knee replacement surgery - People whose surgeon agrees that a total knee replacement is the most suitable treatment for their condition - People who have been assessed by a surgeon and anaesthetist and ar...

**Who might be able to join this trial:** - People aged between 21 and 79 years old (over 20 and under 80). - People who are alert, aware, and able to communicate clearly. - People who have knee osteoarthritis in one or both knees, with symptoms that have been present for more than 3 months. - People whose knee X-rays...

**Who might be able to join this trial:** - People who have long-term knee pain caused by moderate-to-severe knee osteoarthritis, confirmed by X-ray (specifically rated as Grade 3 or 4 on a standard medical scale called Kellgren-Lawrence) - People whose knee pain and limited movement have not improved enough after com...

**Who might be able to join this trial:** - You have been diagnosed with knee osteoarthritis (knee joint wear and tear) based on standard medical guidelines - You have had knee pain for more than 3 months - Your knee pain has not improved with standard treatments (such as physiotherapy or pain medication) for at least...

**Who might be able to join this trial:** - You are between 18 and 85 years old - A scan (MRI or CT) has confirmed you have arthritis in the small joints of your spine (called facet joints) - Special nerve block injections have confirmed that these spinal joints are the source of your back pain - Your back pain has la...

Who might be able to join this trial: - People who are 18 years of age or older - People who are having a total knee replacement surgery (either for the first time or as a repeat/revision procedure) using either a smart knee implant or a standard knee implant Who may not be able to join: - People who have a knee repla...

**Who might be able to join this trial:** - People aged between 45 and 65 years old - Both men and women are eligible - People who have had knee pain lasting at least 3 months - People whose knee pain during walking rates at least 2 out of 10 on a pain scale - People who have difficulty with walking and balance, as mea...

**Who might be able to join this trial:** - People aged between 35 and 85 years old. - People who have had an X-ray within the last month showing knee osteoarthritis rated as a specific level of severity (Kellgren Lawrence grade 2 or 3) (confirm with trial site). - People diagnosed with mild to moderate knee osteoarthr...

Who might be able to join this trial: - People who are older than 30 years of age - People who have one or both knees affected by the condition being studied - People who are currently experiencing symptoms related to their knee joint(s) Who may not be able to join: - Women of childbearing age who have a chronic infla...

Who might be able to join this trial: - People who have knee pain that meets a standard medical checklist called the ACR Criteria - People who have back pain that scores above 12 on a standard questionnaire called the ODI - People who are able to walk for at least 3 minutes without using any walking aids - People who a...

**Who might be able to join this trial:** - People who have been clinically diagnosed with knee osteoarthritis, meaning they have had knee pain for more than 3 months - People whose morning joint stiffness lasts less than 30 minutes - People whose knees make a cracking or grinding sound when moving (crepitus) - People...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been confirmed by MRI scan to have moderate to severe knee joint wear (grade III or IV) in one knee only - People whose knee pain is rated at least 3 out of 10 on a standard pain scale - People with a body mass index (...

Who might be able to join this trial: - People aged 50 years or older - People who are a patient of Dr. Howard Hirsch or Dr. Vinod Dasa and are scheduled for a total knee replacement surgery at Ochsner Kenner - People who plan to receive all of their post-surgery physical therapy as an outpatient at OTW Driftwood - Peo...

**Who might be able to join this trial:** - People who are between 18 and 65 years old - People who have been diagnosed with osteoarthritis affecting only one or both knees for more than 6 months **Who may not be able to join:** - People who have had major surgery on the affected knee, such as bone realignment, ligame...

**Who might be able to join this trial:** - You are 60 years old or older and have recently had a hip or knee joint replacement surgery **Who may not be able to join:** - You have a memory or thinking problem that would stop you from filling out questionnaires on your own - You have a history of losing consciousness,...

Who might be able to join this trial: - People who have been diagnosed with hip or knee osteoarthritis, but whose doctors have determined they do not currently need joint replacement surgery (and are not on a surgical waiting list) - People who are not currently receiving physiotherapy treatment - People who live outsi...

Who might be able to join this trial: - Adults aged 18 years or older - People having their first-ever total knee replacement surgery - People who are within 4 weeks after their knee replacement surgery - People who are medically stable enough to leave hospital and be cared for at home - People who have access to a sma...

Who might be able to join this trial: - You are an activity coach hired by the Active Aging Society and you speak English - You are an older adult aged 50 or over who speaks English and takes part in the CTM-RR program - You work in a healthcare setting and refer patients into this program (known as a referral partner)...

Who might be able to join this trial: - People aged 15 years or older. - People who have a specific type of knee cartilage tear (called a displaced longitudinal bucket-handle tear involving the posterior horn) confirmed by an MRI scan, along with difficulty fully straightening the knee. Who may not be able to join: -...

Who might be able to join this trial: - People who have had a total knee replacement surgery within the past 2 years and are currently admitted to the Orthopedic Rehabilitation Clinic at Ankara Etlik City Hospital, Physical Therapy Hospital. - People who are able to put their full body weight on the leg that was operat...

Who might be able to join this trial: - People who are having knee joint replacement surgery. - People of any nationality, whether Saudi or non-Saudi. - People who have a complete medical record available. Who may not be able to join: - People who have end-stage kidney failure. - People who have severe scarring of the...

**Who might be able to join this trial:** - People aged between 18 and 65 years old (any gender) - Bone growth is fully mature, as shown on imaging scans - There is damage or localised injury to the cartilage in a joint, caused by trauma or another reason - The injured area is on the lower weight-bearing surface of th...

Who might be able to join this trial: - People who have been diagnosed with osteoarthritis or avascular necrosis (bone tissue death due to lack of blood supply) of the hip joint, have already tried non-surgical treatments without enough improvement, and have been recommended for a total hip replacement surgery Who may...

**Who might be able to join this trial:** - You are at least 18 years old and your bones have finished growing - Your doctor believes you are physically and mentally able to follow the study's requirements, including attending all scheduled visits - You (or your legal representative) are willing and able to review and...

Who might be able to join this trial: - You have had a hip or knee replacement and have been admitted to hospital for intensive rehabilitation afterwards Who may not be able to join: - You are not able to understand Danish - You are not able to take part in physical tests - You are not able to understand and fill in q...

Who might be able to join this trial: - People who are willing and able to sign an approved consent form before taking part - People who are male or non-pregnant female, aged 21 years or older at the time of surgery - People who are willing and able to attend all required study visits and follow the study plan - People...

**Who might be able to join this trial:** - Adults between 18 and 75 years of age - People who have X-ray evidence of osteoarthritis in both knees, rated between 2 and 4 on a standard medical severity scale (the Kellgren-Lawrence scale) - People who have pain of 4 or higher (out of 10) in both knees, as measured on a...

**Who might be able to join this trial:** - People who are male, or female and not currently pregnant and not planning to become pregnant during the trial - People aged between 30 and 85 years old - People with a body mass index (BMI) of 45 or below - People who are already scheduled for a planned, non-emergency rever...

**Who might be able to join this trial:** This trial has several different groups. Depending on their situation, people may be considered for one of the following: **ACL Reconstruction Group:** - Adults aged under 70 who have injured their ACL within the past year and have a planned surgery to reconstruct it - Have s...

Who might be able to join this trial: - People who are over 40 years of age - People who have been diagnosed with moderate knee joint wear-and-tear (specifically graded 2–3 on a standard medical scale called the Kellgren-Lawrence score), and whose doctor has already recommended knee replacement surgery - People whose k...

**Who might be able to join this trial:** - Your Body Mass Index (BMI) is 27 or higher (a measure of body weight relative to height) - You have tried at least one diet to lose weight in the past, but it did not work - You have been diagnosed with osteoarthritis of the knee, AND at least one of the following applies to...

**Who might be able to join this trial:** - Men and women between 40 and 70 years old - People diagnosed with knee osteoarthritis based on established medical criteria, including knee pain plus at least 3 out of a specific set of 4 clinical signs (confirm with trial site for full details) - People who have had knee pai...

Who might be able to join this trial: - People who have been diagnosed with knee osteoarthritis, confirmed by both a physical examination and X-ray imaging. - People who have had an X-ray of the knee taken within the last 6 months. - People who are willing to take part in the study voluntarily. - People who have the me...

**Who might be able to join this trial:** - People who have osteoarthritis at the base of the thumb, confirmed by X-ray at a certain stage of severity (stages 1–3 on a medical scale used to classify this condition) - People who have physical signs of thumb base osteoarthritis, including pain when the joint is pressed a...

**Who might be able to join this trial:** - You are 65 years of age or older - Your general health has been assessed by a doctor and falls within a certain range of fitness for medical procedures (this is called ASA status I–III — confirm with trial site if unsure which category applies to you) - You are scheduled for...

**Who might be able to join this trial:** - You have hip and groin pain and have been diagnosed with hip osteoarthritis (wear and tear of the hip joint) confirmed by an X-ray. - You have had hip pain rated above 5 out of 10 on a pain scale for more than 6 weeks. - Your pain has not been adequately relieved by standard...

Who might be able to join this trial: - People who have been diagnosed with moderate knee osteoarthritis. - People whose knee has been graded as Kellgren-Lawrence grade 2 or 3 (a standard scale used to measure the severity of knee osteoarthritis — confirm with trial site if unsure what grade applies). - People whose Bo...

**Who might be able to join this trial:** - People aged 60 or older - People who have been diagnosed with knee osteoarthritis (a condition where the knee joint wears down over time), confirmed by a doctor's assessment and imaging, ranging from mild to severe - People who have had knee pain rated at least 3 out of 10 o...

Who might be able to join this trial: - People who are 18 years of age or older - People who are scheduled to have surgery at Klinikum rechts der Isar, Technical University of Munich (TUM) - People who have given written consent to take part in the study after receiving a full explanation of what the trial involves, in...

**Who might be able to join this trial:** - You are a patient at Mayo Clinic in Rochester, MN - You are 50 years old or older - You have been diagnosed with mild, moderate, or severe hand osteoarthritis, confirmed by an X-ray taken within the last 2 years - You experience hand pain of at least 40 out of 100 on a pain s...

Who might be able to join this trial: - People aged between 40 and 85 years old - People with a body mass index (a measure of body weight relative to height) of 35 or below - People who have been told by a doctor that they have osteoarthritis affecting the inner side of the knee - People who rate their knee pain while...

Who might be able to join this trial: - People who are male or female and aged 40 years or older - People whose body weight falls within a specific range based on their height (confirm with trial site for exact BMI limits) - People who have ongoing knee pain caused by osteoarthritis - People whose osteoarthritis has be...

Who might be able to join this trial: - Adults over 18 years old who are scheduled to have a planned (non-emergency) total hip replacement for osteoarthritis (joint wear and tear) - People with a Body Mass Index (BMI) below 35 - People who are able to walk more than 150 feet (about 45 metres) before the operation, even...

Who might be able to join this trial: - People between 40 and 60 years old - Both men and women are eligible - People whose hamstring muscles (the muscles at the back of the thigh) are tight, shown by specific movement tests where the hip cannot bend past 80 degrees or the knee cannot fully straighten (confirm with tri...

Who might be able to join this trial: - People between 18 and 75 years of age - People who are scheduled for a planned, first-time knee replacement surgery on one knee - People whose surgery is planned to use spinal anaesthesia (numbing the lower body rather than general anaesthesia) - People whose overall health statu...

**Who might be able to join this trial:** - People aged 19 years or older - People who have been diagnosed with osteoarthritis in one or both knees, based on specific medical criteria that include at least 3 of these 6 features: being aged 50 or older, morning stiffness lasting less than 30 minutes, a crackling or gra...

**Who might be able to join this trial:** - People aged 65 years or older - People who are scheduled for a planned (non-emergency) knee replacement surgery on one knee, under spinal or general anaesthesia - People whose overall health status falls within a range that anaesthetists classify as ASA I, II, or III (meanin...

**Who might be able to join this trial:** - Adults aged 65 years or older who are scheduled to have a planned (non-emergency) hip replacement surgery using spinal anaesthesia - People who are able to give written consent to participate - People who are able to understand and use a simple pain rating scale from 0 to 10...

**Who might be able to join this trial:** - People between 50 and 85 years of age - People who have been diagnosed with severe knee joint disease (wear and tear of the knee) based on recognised medical and imaging guidelines - People who are already on a waiting list for a single knee replacement surgery **Who may not...

**Who might be able to join this trial:** - People who are 65 years of age or older - People with a body weight that falls within a moderate, healthy range (a BMI between 18 and 30) - People whose overall physical health before surgery is rated as good to moderately managed (ASA classification I–III — confirm with tria...

**Who might be able to join this trial:** - People who have been diagnosed with knee osteoarthritis that causes symptoms, for at least 3 months. - People who have had knee pain for more than 3 months, with an average pain level of 3 or higher on a scale of 0 to 10. - People whose morning knee stiffness lasts less than...

**Who might be able to join this trial:** - You were admitted to the IRCCS Galeazzi Orthopedic Institute in 2018 for a total hip or knee replacement surgery, and then moved to an inpatient rehabilitation unit within the same facility after your surgery. - You are 18 years of age or older. - Your diagnosis was recorded...

**Who might be able to join this trial:** - People who have had knee pain for more than 6 months - People whose knee pain is rated more than 3 out of 10 in severity, caused by osteoarthritis, and has been present on more than half of days in the past month - People whose knee X-ray shows moderate to significant joint d...

Who might be able to join this trial: - People who are between 50 and 65 years old - People who have been diagnosed with primary knee osteoarthritis (wear-and-tear arthritis that originates in the knee itself, not caused by another condition) based on standard medical criteria - People whose knee osteoarthritis has bee...

**Who might be able to join this trial:** - People who are adults (18 years of age or older) - People who had a total knee replacement surgery performed between January 2013 and December 2024 - People whose knee replacement used a specific type of implant: an Anatomic, Amplitude, posteriorly stabilized, fixed polyethyl...