Chronic Kidney Disease

Who might be able to join this trial: - You are a man or woman aged 18 or older - You are on haemodialysis or peritoneal dialysis (kidney filtering treatments) and your condition is stable - Your phosphate levels are being managed and are stable - You are following a set diet to control your phosphorus intake - If you...

**Who might be able to join this trial:** - You are between 18 and 99 years old - You have been diagnosed with moderate to severe chronic kidney disease (CKD stage 3, 4, or 5, as measured by a specific kidney function test) - If you are **not** currently using ESAs (red blood cell-boosting injections), you have not us...

**Who might be able to join this trial:** - You are between 18 and 99 years old. - You are planning to start regular dialysis within the next 6 weeks, OR you have already been on dialysis for no more than 90 days and are not expected to stop during the study — this includes hemodialysis at least twice a week, or perit...

**Who might be able to join this trial:** - You have advanced kidney disease with a kidney function level (eGFR) of 25 or below - You are on dialysis and have been receiving it for at least 3 months - You have had a kidney transplant at least 6 months ago and your kidney function level (eGFR) is 45 or below - You are...

Who might be able to join this trial: - You are 45 years old or older, OR you are 18 years old or older and have diabetes - Your kidneys have permanently stopped working and you are receiving dialysis (either haemodialysis or peritoneal dialysis) and have been on dialysis for at least 3 months - You are currently takin...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who are receiving their very first kidney transplant, whether the kidney comes from a living or deceased donor - People who agree to use contraception during the study and for at least 90 days after the last dose of the study d...

**Who might be able to join this trial:** - People who are male or female, between 30 and 80 years of age at the time of signing consent - People who have been diagnosed with both type 2 diabetes and chronic kidney disease - People whose HbA1c blood sugar level measure is 9.5% or lower at the screening visit - People...

**Who might be able to join this trial:** - Children aged 6 months to under 18 years old at the time of signing the consent form. - Children who have been diagnosed with chronic kidney disease (CKD), a condition where the kidneys do not work as well as they should, meeting specific kidney function levels based on age...

**Who might be able to join this trial:** - You must be between 1 and 18 years old at the time of signing the consent form - You must have previously taken part in the FIONA clinical trial (study 19920) and must not have stopped the treatment early before the end of that trial - You must have a confirmed diagnosis of...

**Who might be able to join this trial:** - Adults aged 18 to 75 years (men or women). - For Part 1 only: People whose kidneys are working at a normal or near-normal level (no chronic kidney disease), based on a kidney function measurement called eGFR being 60 or above. - For Part 2 only: People with moderate-to-sever...

**Who might be able to join this trial:** - You have been diagnosed with chronic kidney disease (CKD) that is at risk of getting worse, confirmed by blood and urine tests done at least 3 months apart. - Your kidney function test results fall into one of two ranges: either your kidneys are working at a low-to-moderate l...

**Who might be able to join this trial:** - Women who are not able to become pregnant, or men. (In the US only, women who are able to become pregnant may also be considered if they have been using a highly effective, non-hormonal, low user-dependency form of contraception for at least 2 months before screening and agr...

**Who might be able to join this trial:** - A parent or legal guardian (and the child, where appropriate for their age and understanding) must agree to take part by signing a consent form before the trial begins. - Children and teenagers aged 2 to 17 years old at the time of the first screening visit. - Has chronic ki...

**Who might be able to join this trial:** - People aged 18 to 75 years old at the time of the initial screening visit - People who are able to understand what the study involves and are willing to sign a written consent form - People whose body weight falls within a healthy-to-moderately-overweight range (a body mass...

**Who might be able to join this trial:** - People who are able to give their informed consent to participate - People who agree to use effective contraception during the trial - People whose Body Mass Index (BMI) falls between 18.0 and 32.0 - People who are considered healthy based on a medical check-up and medical hi...

**Who might be able to join this trial:** - You are 18 years of age or older at the time of screening - You have been diagnosed with IgA nephropathy (a kidney disease), confirmed by a biopsy taken within the last 8 years - Your medical records show a significant level of protein in your urine within the last 6 months,...

Who might be able to join this trial: - People aged 18 or older, or children aged 10 to 17 years old - People who have a known, proven, or suspected kidney disease that involves the immune system, such as nephrotic syndrome, glomerulonephritis, membranous nephropathy, lupus nephritis, or kidney inflammation linked to o...

**Who might be able to join this trial:** - Children aged 1 to 16 years (for Cohorts 1 and 2), children aged 6 months to 16 years (for Cohort 3), or young people aged 16 to 22 years (for Cohort 4) - People with a measured level of kidney function (called GFR) that falls within a specific range depending on which cohor...

Who might be able to join this trial: - Men, women, and children who are having a kidney and/or pancreas biopsy performed at the University of Michigan. Who may not be able to join: - People who are not willing to give their consent to take part (for those having a biopsy in the future). Important: Always verify elig...

Who might be able to join this trial: - People of any age who have chronic kidney disease, which may be shown by an unusually high amount of protein in the urine or reduced kidney function found through blood tests - A small number of people who do not have chronic kidney disease Who may not be able to join: - People...

Who might be able to join this trial: - Adults over 18 years old who have been assessed as suitable candidates for a kidney transplant Who may not be able to join: - People who have taken a type of bone medication called bisphosphonates at any point in the 6 months before joining the study Important: Always verify el...

Who might be able to join this trial: - People aged 0 to 90 years old - People with advanced kidney disease (stage 5) who are on peritoneal dialysis (a type of dialysis done through the abdomen) - People with normal kidney function who are scheduled for planned abdominal surgery for a minor condition, such as a hernia...

Who might be able to join this trial: - People who have signed the written consent form for the trial - People with chronic kidney failure who have started dialysis treatment Who may not be able to join: - People who are pregnant - People with chronic kidney failure who have not yet started dialysis treatment Importa...

"Who might be able to join this trial: - People who have been diagnosed with chronic kidney disease at stage 4 or higher (this means the kidneys are working at a significantly reduced level) Who may not be able to join: - No specific exclusion criteria have been listed for this trial (confirm with trial site) Importa...

Who might be able to join this trial: - People who have been diagnosed with Type 1 or Type 2 diabetes, according to American Diabetes Association standards. - People who are willing to follow the study's requirements, including attending follow-up appointments at a clinical study site as outlined in the study plan. - P...

Who might be able to join this trial: - People who have Parkinson's disease (PD) Who may not be able to join: - No specific exclusion criteria have been listed in the available information (confirm with trial site) Important: Always verify eligibility with the trial site directly before applying.

Who might be able to join this trial: - People who are 18 years of age or older - People who have skin lesions (wounds or sores) that a treating doctor has identified as consistent with a condition called calciphylaxis - People who have been informed about the research nature of the study and have signed a written cons...

**Who might be able to join this trial:** - People who are fluent in English and can understand and agree to the study terms in writing - People who have end-stage kidney disease and are listed to receive their first kidney transplant (a single kidney, not a second transplant) - People who are willing to follow all stu...

**Who might be able to join this trial:** - People who have been diagnosed with chronic kidney disease classified as Stage 3 or 4, with kidney function test results (called GFR) falling between 15 and 59 mL/min/1.73 m² - People who are between 35 and 70 years of age (men and women) **Who may not be able to join:** - P...

**Who might be able to join this trial:** - Children aged 2 years up to (but not including) 18 years old at the time of consent - People with low iron levels in their blood, shown by either a haemoglobin level below 12.0 g/dL combined with low iron stores, or those considered at risk of developing low iron levels base...

**Who might be able to join this trial:** - Children aged from 28 days old up to (but not including) 18 years old. - Children who weigh at least 7 kg (approximately 15.4 lbs) at the time of screening. - Children who have been diagnosed with chronic kidney disease (CKD) and a condition called secondary hyperparathyroid...

Who might be able to join this trial: - Adults aged 18 years or older. - People who have been clinically diagnosed with chronic kidney disease, based on a set of medical guidelines called K/DOQI criteria. Who may not be able to join: - People who are currently experiencing a sudden or recent loss of kidney function (k...

**Who might be able to join this trial:** **Group 1 – People with reduced kidney function:** - Adults aged 18 or older - People whose kidneys are functioning at a very low level, based on a specific kidney test result (eGFR of 20 or below) (confirm with trial site) - People whose parathyroid hormone (a hormone that he...

**Who might be able to join this trial:** - You are between 45 and 79 years old - Your kidneys are working at a reduced level, based on a specific blood test result that your doctor can check (a score between 20 and 60 on a kidney function scale) - You are not currently on dialysis **Who may not be able to join:** - Y...

Who might be able to join this trial: - A parent or legal guardian must have given written consent, and the child must have given written agreement to participate, before any trial activities begin. - Children and teenagers aged 2 years old up to (but not including) 18 years old at the time of joining. - The child's ta...

Who might be able to join this trial: - Adults being treated at the unit for advanced chronic kidney disease, specifically those with kidney disease at stage 4 or 5, or stage 3 with rapid worsening, and without any medical reasons that would prevent participation Who may not be able to join: - People who are malnouris...

Who might be able to join this trial: - Children and young people between 1 and 21 years old (muscle strength testing is only done for those older than 3 years) - People whose kidneys are working at a reduced level, measured by a specific formula using height and a blood test result called creatinine - People whose mos...

Who might be able to join this trial: - People aged 18 or older - People who have been diagnosed with end-stage kidney failure (where the kidneys no longer work) and have been treated with a specific type of home dialysis called CAPD (fluid-based dialysis through the abdomen) for the past 3 months - People who have bee...

**Who might be able to join this trial:** - People who are physically able to take part in a home-based exercise program and complete all physical tests required by the study - People who can read and write in English well enough to fill out study questionnaires - People aged 19 or older, of any gender - People who are...

**Who might be able to join this trial:** - Adults aged 18 or older who have a confirmed diagnosis of chronic kidney disease (CKD) that is not being treated with dialysis, with kidney function or protein levels in the urine that meet specific medical thresholds (confirm with trial site) - People who live in remote area...

**Who might be able to join this trial:** - Adults between 18 and 70 years of age - People who are willing and able to sign a written consent form - People who are currently on a kidney transplant waiting list at one of the participating hospitals, with their transplant expected to happen between 3 and 24 months after...

**Who might be able to join this trial:** - People who self-identify as African American, Afro-Caribbean, or other Black individuals, at various stages of kidney disease or with no signs of kidney disease - Healthy Black adults aged 50 or older with no known history of kidney disease (recruited as controls) **Who may...

**Who might be able to join this trial:** - People who are currently receiving hemodialysis (kidney dialysis treatment) - People whose average blood pressure reading before dialysis is above 140 mmHg (the top number) over a 2-week period, OR whose average blood pressure reading after dialysis is above 130 mmHg over a 2...

**Who might be able to join this trial:** - People who received a heart transplant at least 3 months ago - People who are 18 years of age or older - People who do not have donor-specific antibodies (proteins that could attack the transplanted heart) at the time of joining the trial - People whose kidney function is sig...

Who might be able to join this trial: - People whose kidneys are filtering at a moderately reduced level (a kidney function score between 61 and 79) AND who also have a small but above-normal amount of protein in their urine, OR people whose kidneys are filtering at a more significantly reduced level (a kidney function...

Who might be able to join this trial: - People who are over 18 years old - People who have been diagnosed with chronic kidney disease (a long-term condition where the kidneys do not work as well as they should) - People who speak Chinese - Healthcare providers (such as doctors or nurses) who work in a kidney disease (N...

**Who might be able to join this trial:** - People aged 18 to 85 years old - People who are on long-term kidney dialysis (either hemodialysis or peritoneal dialysis) or who have severe chronic kidney disease managed without dialysis - People whose doctors have determined that treatment with a type of medication that s...

**Who might be able to join this trial:** - You are 18 years old or older and currently on dialysis (either newly started or already established on dialysis). - You are expected to need ongoing, long-term dialysis treatment. - You are willing and able to give your consent to take part in this study. **Who may not be a...

Who might be able to join this trial: - You are between 18 and 85 years old - Your doctor has planned for you to have an arteriovenous (AV) fistula created in your arm, and your anatomy is suitable for this procedure - You are able to communicate with the research team, can give written consent, and are willing and abl...

Who might be able to join this trial: - People aged 50 or older who are able to walk (with or without a walking aid) and have been diagnosed with moderate-to-severe chronic kidney disease (stages 3 or 4, not yet on dialysis), based on a specific kidney function measurement - People aged 50 or older who are able to walk...

Who might be able to join this trial: - People older than 20 years old who need to have a kidney ultrasound done in the emergency department at National Taiwan University Hospital. Who may not be able to join: - People who do not give their agreement to take part in the trial. - People who are unable to cooperate or f...

**Who might be able to join this trial:** - People aged 18 years or older. - People with advanced chronic kidney disease (stage 4 or 5, including those on dialysis), meaning the kidneys are working at 29% or less of normal function. - People whose bone density scan (DXA) shows significantly low bone density at the hip...

Who might be able to join this trial: - People who attend NHS Lothian inpatient or outpatient services and are considered to be at increased risk of cardiovascular disease (heart and blood vessel problems) - People who have chronic kidney disease (long-term reduced kidney function), as classified by an established medi...

Who might be able to join this trial: - People from birth up to age 5 are currently being enrolled (the trial notes that only participants under 6 years of age are being accepted at this time). - People who have been formally diagnosed with a condition called Primary Hyperoxaluria Type 1 (PH1), confirmed through geneti...

**Who might be able to join this trial:** - People between 1 and 60 years of age (male or female). - People who are willing and able to give signed agreement to take part, or who have a legally authorised representative who can do so on their behalf. Children aged 6–17 may also be asked to give their own agreement whe...

**Who might be able to join this trial:** - People with end-stage kidney disease (kidneys have stopped working) who need a new or replacement connection between an artery and vein (called an AV graft) in their arm to allow for dialysis treatment - People aged 18 to 90 years old - People whose arm anatomy is suitable f...

**Who might be able to join this trial:** - People who are over 19 years old - People who have moderate to advanced chronic kidney disease (specifically stages 3b, 4, or 5, including those on dialysis) - People who have been treated with a newer type of heart stent called a drug-eluting stent - People who have signed a...

Who might be able to join this trial: - Children and teenagers between 6 and 18 years old (inclusive) - People whose kidneys are working at a reduced level, measured by a specific kidney function test called GFR, falling between 15 and 59 ml/min per 1.73 m² using a formula designed for children - People whose blood pho...

**Who might be able to join this trial:** - People who have high levels of protein in their urine (above a certain threshold, measured by a urine test) OR have significantly reduced kidney function (stage 4 or 5 chronic kidney disease), AND - People who are showing signs of fluid build-up in their body — such as swell...

Who might be able to join this trial: - People who are 20 years of age or older at the time of screening. - People who have chronic kidney disease with kidney function and protein-in-urine levels within a specific range, and whose kidney function has been stable for at least 30 days before joining the trial. Who may n...

**Who might be able to join this trial:** - People who have moderate-to-severe chronic kidney disease, shown by kidney function test results below a certain level on at least two separate occasions - People who have a blood acid-base imbalance called metabolic acidosis, confirmed by blood test results on two separate...

Who might be able to join this trial: - You must be 18 years of age or older - If you are a healthy volunteer (no known kidney, heart, or liver problems), you should not have kidney disease, heart failure, liver scarring, or swelling caused by fluid buildup in the legs or body - If you have chronic kidney disease (CKD)...

Who might be able to join this trial: - You have been officially diagnosed with a primary kidney disease - You have regular check-ups (at least every 6 months) with a doctor at one of the participating clinics - Your kidneys are still working at a level above a certain threshold, measured by a blood test called eGFR be...

Who might be able to join this trial: - People aged 18 years or older, of any sex - People whose kidneys are working at a reduced but not critically low level, with a kidney function score (eGFR) between 15 and 45 ml/min/1.73m² - People with a blood potassium level between 4.5 and 5.5 mEq/L - People with a blood sugar...

Who might be able to join this trial: - People who received at least one dose of a medicine called vonsetamig as part of a previous clinical trial (NCT05092347, also called study R5459-RT-1944) - People who received a kidney transplant during that previous trial, after a compatibility matching process was completed - P...

**Who might be able to join this trial:** - Adults older than 18 years of age - People who have been receiving hemodialysis (a type of kidney treatment that filters the blood) for at least 3 months - People who receive hemodialysis three times per week - People who receive a blood-thinning medication called heparin dur...

Who might be able to join this trial: - You are 18 years old or older - You are scheduled to have surgery to remove one kidney due to kidney cancer, or to remove one kidney and its connecting tube (ureter) due to a type of cancer called upper tract urothelial carcinoma Who may not be able to join: - You have been diag...

Who might be able to join this trial: - People who have been diagnosed with chronic kidney disease (CKD), as defined by international kidney disease guidelines from 2012 - People who do not have CKD but do have one or more risk factors for developing it, such as high blood pressure, diabetes, high cholesterol, or high...

**Who might be able to join this trial:** - Adults aged 18 or older - People who are able to give their informed consent to participate - People who have been diagnosed with a type of irregular heartbeat called non-valvular atrial fibrillation (AF), whether it comes and goes, has lasted a long time, or is permanent - P...

**Who might be able to join this trial:** - Men between 18 and 85 years old - Men whose kidneys are working at a reduced level, with a specific kidney function score (eGFR) between 15 and 45 ml/min/1.73m² as measured by a standard formula called MDRD (confirm with trial site) - Men who have had two separate morning bl...

**Who might be able to join this trial:** This trial has four separate groups. People may be considered for one of the following groups: **Group 1 – People with chronic kidney disease on hemodialysis:** - Adults aged 18 or older who have chronic kidney disease (long-term kidney disease) and are currently receiving he...

Who might be able to join this trial: - People with kidney failure who needed a blood-cleaning treatment (a machine that filters the blood outside the body) and received all of their treatments using the specific devices being studied, between January 2019 and December 2019 — records must be available in the order the...

Who might be able to join this trial: - Your kidneys are not working well, specifically filtering at a low level (a blood test result called eGFR is below 30) — confirm with trial site if unsure - You are already scheduled to have a planned CT scan that uses an injected dye (contrast dye given through a vein) - You are...

Who might be able to join this trial: - People who have developed moderate to severe kidney injury (stages 2 or 3) as a result of heart surgery Who may not be able to join: - People who have long-term (chronic) kidney disease - People whose heart is not pumping well enough (with an ejection fraction below 45%, meaning...

Who might be able to join this trial: - People aged between 18 and 75 years old - People who have previously received a liver transplant - People who have developed new protein in their urine (measured on at least two separate occasions) and/or a decline in kidney function (measured on at least two separate occasions)...

**Who might be able to join this trial:** - You are 18 years old or older, but younger than 80 years old - Your kidneys are not working well (a blood test shows reduced kidney function below a certain level), OR you have been on regular dialysis for at least 3 months **Who may not be able to join:** - You have a muscl...

**Who might be able to join this trial:** - You must be over 18 years old - Your kidneys must have been working at a reduced level (less than 60% of normal function) for at least 3 months - You must have a significant blockage (70% or more) in at least one heart artery that is large enough to be treated (confirm with t...

**Who might be able to join this trial:** - People whose hemoglobin blood level is below 11 g/dL (a measure that indicates low red blood cell levels) - People whose iron storage level in the blood (ferritin) is below 100 ng/ml, or whose transferrin saturation (a measure of how much iron is being carried in the blood) i...

Who might be able to join this trial: - People aged 18 or older - People who have chronic kidney disease (CKD) with reduced kidney function, measured by a specific kidney test result falling within a certain range, or a moderately reduced kidney function with significant protein in the urine (confirm exact values with...

**Who might be able to join this trial:** - People aged 18 or older - People who have been receiving regular kidney dialysis (hemodialysis) for at least 3 months - People who are covered by a social security or health insurance plan - People who have read, understood, and signed a consent form agreeing to take part **...

Who might be able to join this trial: - People between 18 and 75 years of age - People who have been receiving hemodialysis three times per week for at least 6 months (applies only to those with end-stage kidney disease on ongoing hemodialysis) - People whose condition is medically stable and whose dialysis has been wo...

**Who might be able to join this trial:** - You are a Veteran aged 18 or older who has been diagnosed with end-stage kidney disease (kidney failure) and either will soon need to start regular dialysis, or have been on hemodialysis for no longer than 8 weeks at one of the six participating VA centers. - You meet specif...

**Who might be able to join this trial:** - People who have chronic kidney disease (CKD) at a moderate to severe stage (stages 3a to 5), with kidney function below a certain level, and who are not currently on dialysis - People who have a good nutritional status — meaning no signs of malnutrition based on blood tests...

Who might be able to join this trial: - People who have been diagnosed with IgA nephropathy (a kidney disease) confirmed by a biopsy (a small tissue sample taken from the kidney). - People who have a significant amount of protein leaking into their urine (at least 1.0g per day) even while taking the highest tolerable d...

**Who might be able to join this trial:** - Adults aged 18 or older, of any gender - People who have been diagnosed with anaemia caused by chronic kidney disease (CKD), with a haemoglobin level between 7.0 and 11.0 g/dL at the start of the trial - People who are able to understand the study information and agree to ta...

**Who might be able to join this trial:** **For the kidney transplant recipient (the patient):** - Adults aged 18 or older who have already received a kidney transplant from a living donor whose tissue type (HLA) closely matches theirs - The kidney transplant was received between 3 months and 5 years before the planne...

"Who might be able to join this trial: - People who are 18 years of age or older - People whose kidneys are working at a reduced level, specifically with a kidney filtration rate below 30 ml/min/1.73 m² (a measurement of how well the kidneys filter waste from the blood), which places them in a specific kidney care prog...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have moderate-to-moderately-severe kidney disease (known as CKD stage 3 or 4), where the kidneys are filtering at a reduced but not critically low level - People who have mild kidney disease (CKD stage 2) with high levels of a protein call...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have received a kidney transplant from a deceased or living donor, where the donor and recipient are not a full genetic (HLA) match, and where blood types are compatible - People whose kidney function (measured by a specific calculation c...

Who might be able to join this trial: - People with a Body Mass Index (BMI) between 18.5 and 34.9 (a measure of body weight relative to height that falls within a normal to overweight range) - People who are scheduled to donate or receive a kidney from a living donor Who may not be able to join: - People who have sign...

Who might be able to join this trial: - People who are willing and able to give their consent to take part before any study procedures begin. - People who are already on haemodialysis and need a new way to access their blood vessels for treatment, or people with end-stage kidney disease who are preparing to start dialy...

**Who might be able to join this trial:** - You must be willing and able to give written agreement to take part in the study - You must be at least 18 years old - You must have end-stage kidney failure and currently be receiving hemodialysis (a type of dialysis that cleans your blood using a machine) - Your body weight...

**Who might be able to join this trial:** - Adults aged 18 or older who have end-stage kidney disease and have chosen hemodialysis as their kidney treatment method - People who are able to understand and give consent to take part in a research study - People whose upper arm vein measures at least 2.0 mm wide *For one...

Who might be able to join this trial: - Adults between 18 and 90 years old. - People who self-identify as Black or African American, including those of African ancestry who identify as multiracial. Who may not be able to join: - People who have a cognitive impairment or are otherwise unable to give their own consent t...

**Who might be able to join this trial:** - People aged 18 or older - People who have signed a written consent form to take part in the study - People who are currently on ongoing dialysis treatment, OR whose kidney function test results (called eGFR) show a reading below 20 on at least two separate occasions at least...

Who might be able to join this trial: - People who are older than 18 years of age - People whose kidneys are working at a reduced but not severely low level (a specific kidney function test score between 25 and 60, which a doctor can measure) - People who have been on stable, unchanged doses of water pills (diuretics)...

Who might be able to join this trial: - People who are over 18 years of age - People whose patient or main carer can read and speak English - People whose patient or substitute decision maker is able to give informed consent to participate - People whose patient or main carer is mentally and physically able and willing...

Who might be able to join this trial: - Adults over 18 years old who are suspected to have sudden (acute) kidney injury and need a kidney biopsy in the nephrology (kidney) department - Adults over 18 years old who are suspected to have long-term (chronic) kidney disease and need a kidney biopsy in the nephrology (kidne...

**Who might be able to join this trial:** - You are 18 years old or older (if you are over 80, you must also be assessed as not severely frail, based on a standard frailty scoring tool) - You have moderate or advanced chronic kidney disease, based on a specific kidney function measurement (eGFR between 15 and 44.9, co...

Who might be able to join this trial: - People who are 18 years of age or older - People who are currently receiving hemodialysis treatment at one of the participating dialysis clinics - People who speak English or Spanish Who may not be able to join: - People who are not willing to report their symptoms using the SMa...

**Who might be able to join this trial:** - People aged between 18 and 75 years old - People who have been diagnosed with end-stage renal disease (kidney failure) - People whose kidneys' filtering membranes move waste products into the dialysis fluid at a faster-than-average rate, based on a standard test result (conf...

Who might be able to join this trial: - Adults who are 75 years of age or older - People with advanced chronic kidney disease, meaning their kidney function tests (called eGFR) have shown readings below 25 on at least two separate occasions more than 90 days apart in the past year, with at least one reading below 20 -...

**Who might be able to join this trial:** - A parent, legal guardian, or independent witness (depending on the child's age) has signed a consent form before any trial-related steps begin. - The patient has very high levels of antibodies that make transplant matching difficult, with a panel reactive antibody (PRA) leve...

**Who might be able to join this trial:** - Adults aged 18 or older who are on maintenance hemodialysis three times per week and still produce some urine - People who are willing and able to give informed consent to participate - Women who could become pregnant must have a negative pregnancy test at the screening stag...

**Who might be able to join this trial:** **For patients:** - Adults aged 18 or older - People who have recently started, or are expected to start within the next 12 weeks, regular in-centre haemodialysis (a type of kidney dialysis done at a clinic) due to kidney failure - People who have had no more than 36 haemodial...

Who might be able to join this trial: - People aged 18 years or older. - People who have chronic coronary syndrome (a long-term heart condition affecting blood supply) and are scheduled for planned, non-emergency heart bypass surgery (CABG) using a heart-lung machine, either on its own or combined with aortic valve rep...

Who might be able to join this trial: - You are over 20 years old. - You have been diagnosed with severe chronic kidney disease (stage 5) or end-stage kidney failure, with kidneys functioning at less than 15% of normal capacity, OR you are already receiving regular dialysis treatment (either haemodialysis or peritoneal...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time the graft is placed - People who have been diagnosed with end-stage kidney disease or serious kidney problems that require hemodialysis (a machine-based blood-cleaning treatment) - People who need a new way to access their...

**Who might be able to join this trial:** - You are 18 years old or older - You have been diagnosed with chronic kidney disease (CKD) at stage 3, 4, or 5, with or without a kidney transplant - If you are on dialysis (hemodialysis), you have been receiving it regularly for at least 3 months - Your doctor has determined...

Who might be able to join this trial: - Adults aged 18 or older who are attending outpatient services at Bagamoyo District Hospital, or the associated Fukayosi or Yombo dispensary Who may not be able to join: - People under 18 years of age - People who do not live within the Bagamoyo District Hospital catchment area -...

**Who might be able to join this trial:** - Adults between 18 and 70 years of age - People with a Body Mass Index (BMI) of 35 or higher (a measure of body weight relative to height) - People with serious kidney disease where the kidneys are working at less than 30% of normal function, and who are expected to reach comp...

**Who might be able to join this trial:** **For children (ages 5–17):** - Children between 5 and 17 years old - Children whose kidneys are working at a reduced but not severely low level, based on a specific kidney function calculation (confirm with trial site) - Girls who could become pregnant must have had a menstru...

Who might be able to join this trial: - You must have already received a treatment called REACT (a gelatin-hydrogel formula) in a previous clinical trial (one of these: RMCL-002, REGEN-003, or REGEN-004) for chronic kidney disease, and completed all required visits in that trial. Who may not be able to join: - You did...

**Who might be able to join this trial:** - People who have moderate-to-moderately-severe chronic kidney disease (CKD Stages 3 or 4), people who have received a kidney transplant with any level of kidney function, or people without kidney disease who are participating as comparison subjects - People who are not curren...

Who might be able to join this trial: - You are currently receiving hemodialysis (a kidney treatment that filters your blood using a machine) - You have been prescribed one of these heart/blood pressure medications through a VA pharmacy: metoprolol (succinate or tartrate), atenolol, labetalol, carvedilol, or bisoprolol...

**Who might be able to join this trial:** - Adults aged 18 or older, of any sex - People whose chronic kidney disease (CKD) diagnosis timing matches the study's requirements - People with CKD who are not currently on dialysis, with kidney function falling within a specific moderate range (Stage 2 to 3b, as measured by...

**Who might be able to join this trial:** - Adults aged 18 or older, of any sex - People whose chronic kidney disease (CKD) has been present for a similar duration to other participants (matched for comparison purposes) - People with CKD who are not on dialysis, and whose kidneys are functioning at a moderate level —...

Who might be able to join this trial: - People who have been diagnosed with Alport syndrome (a kidney disease) at the start of the trial screening process. - Teenagers aged 10 to under 18 who have high levels of protein in their urine (a urine test result of 300mg/g creatinine or above) and whose kidneys are still func...

**Who might be able to join this trial:** - People who have high blood pressure (hypertension) and are currently taking at least one medication to treat it **Who may not be able to join:** - People who have diabetes of any type, indicated by certain blood sugar or HbA1c test results above specific levels - People whos...

**Who might be able to join this trial:** - People who have been diagnosed with anemia related to chronic kidney disease (CKD) at stages 3, 4, or 5 — including those who are not on dialysis, as well as those receiving hemodialysis, peritoneal dialysis, or hemodiafiltration. - People not on dialysis whose kidneys are f...

**Who might be able to join this trial:** - Adults aged 18 or older - People who receive primary care at one of three Harris Health clinics: Smith Clinic, Harris Health Outpatient Center (on the LBJ campus), or Martin Luther King Jr. Health Center (MLK) - People who have had at least one visit at the clinic in the pas...

**Who might be able to join this trial:** - Adults between 18 and 80 years of age who have chronic kidney disease at stage 3, 4, or 5, meaning their kidneys are working at less than 60% of normal capacity based on a recent blood test done outside of hospital. **Who may not be able to join:** - People whose heart depen...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have had a nephrology (kidney specialist) visit for chronic kidney disease within the last 18 months - People whose most recent kidney function test shows significantly reduced kidney function, or whose calculated risk of k...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been referred to have a new arteriovenous fistula (AVF) — a surgically created connection between an artery and vein, often used for dialysis access — created for the first time - People who are willing and able to fol...

**Who might be able to join this trial:** - You must be an adult (over 18 years old) of any gender, race, or ethnicity - You must be able to understand the study information and give your written consent to participate - You must have received your first or second kidney transplant at least 3 months ago - If you have...

Who might be able to join this trial: - People who receive hemodialysis (kidney dialysis) three times per week on a standard schedule - People who have been on regular hemodialysis for at least 3 months - People aged 18 years or older - People who are willing and able to give their formal agreement to take part in the...

Who might be able to join this trial: - You are currently on dialysis - You are 18 years of age or older - You own a smartphone - You are willing to take part in an inpatient rehabilitation program during the study period - You are willing to sign a consent form agreeing to take part and allowing your data to be used...

**Who might be able to join this trial:** **For kidney transplant recipients:** - People with end-stage chronic kidney disease who are waiting to receive a kidney from a living donor - Adults (18 years or older) - People who have signed a consent form agreeing to take part - Women of childbearing age who are using an...

**Who might be able to join this trial:** - People aged 55 or older who have a primary care doctor at Brigham (or an appointment at one of 15 specific locations) and are being discharged from a Brigham and Women's Hospital general medicine unit - People being discharged to their own home, a home health care service, o...

Who might be able to join this trial: - People who are older than 18 years of age - People who have had a peritoneal dialysis (PD) catheter inserted through the skin between March 1st 2023 and March 1st 2026 (enrollment may be possible from 4 weeks before up to 12 weeks after the catheter insertion) Who may not be abl...

**Who might be able to join this trial:** - People who have had a daily headache every day since it started, lasting more than 3 months - People whose headache feels like a pressure sensation - People whose headache gets worse when lying with their head lower than their feet (such as in a tilted position) - People who...

**Who might be able to join this trial:** - The participant's kidney specialist and/or regular doctor agrees that the person may take part in the trial - People who are considered "pre-frail" based on a walking speed test (taking more than 6 seconds to walk 15 feet), OR who answer "yes" to at least one of the following...

**Who might be able to join this trial:** - Adults aged 18 or older who have end-stage kidney disease (kidneys that have stopped working) and have been assessed as pre-frail, frail, or very frail using a standard frailty measurement tool called Fried's Frailty Phenotype - People who are on, or in the process of being...

**Who might be able to join this trial:** - People who have a working dialysis access point in their arm (either a surgically created connection between an artery and vein, called a fistula, or a synthetic tube called a graft) that was created at least 30 days before the study procedure and is currently being used for...

Who might be able to join this trial: - You have chronic kidney disease and are currently receiving haemodialysis (a treatment that filters your blood using a machine) - You are over 18 years old - You have been on haemodialysis for at least 3 months - You have scored 14 or higher on a questionnaire called the HADS (Ho...

**Who might be able to join this trial:** - You identify as African American and are a military veteran - You are older than 18 years of age - Your kidney function test results fall within a specific moderate range, showing either moderately reduced kidney function with or without protein in the urine, or mildly reduce...

**Who might be able to join this trial:** - People who are on hemodialysis and have been diagnosed with overactive parathyroid glands caused by chronic kidney disease (a condition called secondary hyperparathyroidism), where their treating doctor has planned to give them a medication called Pacitol Injection based on i...

**Who might be able to join this trial:** **Patients:** - Adults aged 18 or older. - People with a confirmed diagnosis of stage 4 chronic kidney disease, based on specific kidney function test results recorded in their medical records within the past 90 days. - People who are able to speak and read English and complet...

**Who might be able to join this trial:** - You are a man or a woman (not pregnant or breastfeeding) between 18 and 84 years old at the time of signing the consent form. - You are able and willing to sign a written consent form before any study-specific steps are taken. - You are willing and able to attend all require...

Who might be able to join this trial: - Adults who have been diagnosed with chronic kidney disease (CKD) based on 2024 international kidney health guidelines, shown by either abnormal kidney function blood tests or unusual levels of protein in the urine - People who had a kidney MRI scan performed within 7 days of havi...

**Who might be able to join this trial:** - People who have significantly reduced kidney function (a specific kidney function score of 30 or below, measured on at least two separate occasions at least 2 months apart), do not currently need dialysis, and are not expected by their kidney doctor to need dialysis within t...

Who might be able to join this trial: - Adults aged 18 years or older. - People with end-stage kidney disease who have been receiving intermittent hemodialysis (kidney dialysis) for more than 3 months before the screening visit, with each dialysis session lasting at least 4 hours. - People whose dialysis sessions have...

**Who might be able to join this trial:** - You are 18 years of age or older - You are willing and able to understand what the study involves and have agreed to take part - You have been diagnosed with stage 4 or 5 chronic kidney disease (CKD) - You are already part of a specific kidney care pathway called the MRC path...

**Who might be able to join this trial:** - You are male or female, aged between 18 and 80 years old. - If you are a woman who could become pregnant, you agree to either avoid sex or use contraception throughout the study. - You are able to understand the study and give written consent to take part after being fully in...

**Who might be able to join this trial:** - People aged 18 or older who have a Greek social security number and are visiting a hospital, clinic, or private laboratory in Greece as part of their regular medical care - People who are willing and able to sign a written consent form agreeing to take part in the study **Wh...

Who might be able to join this trial: - People who have kidney failure and are currently on the waiting list for a kidney transplant - People who are 16 years of age or older - People who are able to give their own informed consent to take part in the study Who may not be able to join: - People who cannot have a CT sc...

Who might be able to join this trial: - You must be 18 years of age or older at the time you entered the study. - You must have been diagnosed with either end-stage kidney disease (very advanced kidney failure) or severe chronic kidney disease before entering the study — confirmed by a blood test that measures how well...

**Who might be able to join this trial:** - People aged between 18 and 75 years old, of any gender or ethnicity - People on dialysis or not yet on dialysis who have recently had a new wrist fistula (a surgically created connection between an artery and vein in the wrist) created but have not yet used it for dialysis t...

Who might be able to join this trial: - Adults aged 18 or older. - People with moderate-to-severe chronic kidney disease, specifically a kidney function level (eGFR) between 15 and 44 mL/min/1.73 m². - People who have protein in their urine above certain measured levels (confirm with trial site for exact values). - Peo...

**Who might be able to join this trial:** **For patients:** - Adults aged 18 or older who have been fully informed about the study and have not objected to taking part or to their data being used - People with end-stage kidney disease (kidney failure) who are receiving dialysis at one of the clinics taking part in the...

**Who might be able to join this trial:** - People who have chronic kidney disease at stages G1 through G4, with kidney function test results (eGFR) either at or above 60 (if protein levels in urine are also elevated) or between 15 and 60 - People who have been diagnosed with type 2 diabetes, shown through a blood sug...

**Who might be able to join this trial:** - Adults aged 18 or older who have been diagnosed with chronic kidney disease (CKD) and have a greater than 10% chance of needing dialysis within 2 years, based on a specific kidney risk calculation tool - People who are registered as patients at a kidney specialist (nephrolog...

**Who might be able to join this trial:** - People who have been continuously receiving medical care from the same healthcare providers (with both medical and pharmacy records) for at least 12 months before the start date. - People who have not been prescribed the medication finerenone at any point in the 12 months be...

**Who might be able to join this trial:** - People who have chronic kidney disease (CKD) at a moderate to severe stage (stages G3a to G4) and are being managed without dialysis - People aged between 18 and 65 years old - People who have been receiving dietary or nutritional monitoring for more than 6 months **Who may...

Who might be able to join this trial: - Children and teenagers under 18 years old - Both boys and girls are eligible - Patients and their parents or guardians who have been informed about the trial and have signed a consent form - Patients who are covered by social security (French public health insurance) - For the co...

Who might be able to join this trial: - You must be older than 18 years of age - You must have been diagnosed with Gastric Antral Vascular Ectasia (a condition affecting blood vessels in the stomach), confirmed by a camera examination of the stomach (endoscopy) - You must be willing to take part in the study - You must...

**Who might be able to join this trial:** - People aged 18 or older - People who have been receiving peritoneal dialysis (a type of kidney treatment that filters waste through the abdomen) for at least 3 months before joining - People whose peritoneal dialysis catheter (the tube used for the treatment) is working well...

Who might be able to join this trial: - People diagnosed with end-stage kidney disease (when the kidneys have nearly or completely stopped working) who are currently receiving dialysis treatment through a machine that filters the blood. - People with advanced kidney disease who are being monitored at a specialist clini...

**Who might be able to join this trial:** *For people with Fabry disease:* - You are 18 years of age or older - You are able to understand and agree to participate in the study (give informed consent) *For people in the control group (without Fabry disease):* - You are 18 years of age or older - You are able to under...

Who might be able to join this trial: - People with kidney failure (end-stage renal disease) who need a type of blood vessel access called an arteriovenous graft (AVG) placed in their arm to start or continue dialysis treatment - People who are at least 18 years old at the time of screening - People whose arm anatomy i...

Who might be able to join this trial: - People who either have significantly reduced kidney function (based on a blood test result from the past 6 months), or have received dialysis (any type) within the last 7 days - People who are scheduled to have non-heart surgery — whether planned in advance, urgent, or emergency...

Who might be able to join this trial: - People who are at least 18 years old and able to understand and consent to taking part in the trial - People who have been diagnosed with end-stage kidney disease (the most advanced stage of chronic kidney disease, where the kidneys are functioning at 15 ml/min or less) - People...

**Who might be able to join this trial:** - You are willing and able to give your consent to take part in the trial - You are male or female, aged 18 or older, and have chronic kidney disease (CKD) - You have been receiving regular in-center hemodialysis (kidney dialysis at a clinic) for more than 3 months - Your blood...

Who might be able to join this trial: - People who have been diagnosed with end-stage kidney disease and have been receiving hemodialysis (a machine-based blood-cleaning treatment) three times per week for at least one month. Who may not be able to join: - People who are currently acutely ill (suddenly or severely unw...

Who might be able to join this trial: - People who identify as African American - Adults between the ages of 18 and 70 - People whose kidneys are working at a reduced level, specifically with a kidney function score (called eGFR) below 45, due to a long-term kidney condition - People who are already enrolled in a progr...

Who might be able to join this trial: - Adults who have a blood urea (waste product) level higher than 120 - Adults who have a high potassium level in their blood (above 5.5), or a low bicarbonate level in their blood (below 15), or who need urgent dialysis because they have swallowed a toxic substance - Adults who nee...

Who might be able to join this trial: - People who have suspected or confirmed kidney problems and have been prescribed an MRI scan - People of any age or gender - People who are willing to take part in the trial and have signed a written consent form Who may not be able to join: - People who have a pacemaker made of...

Who might be able to join this trial: - People who are seriously unwell due to kidney disease and are currently on dialysis, have stage 4 chronic kidney disease (meaning the kidneys are working at 15–29% of normal function), have stage 5 chronic kidney disease (meaning the kidneys are working at less than 15% of normal...

Who might be able to join this trial: - People aged between 18 and 80 years old - People who have been diagnosed with coronary heart disease during a hospital stay through a procedure that looks at the heart's arteries (coronary angiography), including heart attacks with a specific pattern on a heart tracing (STEMI), o...

**Who might be able to join this trial:** - You have been diagnosed with atrial fibrillation or atrial flutter (any type — occasional, recurring, or continuous) - Your doctor has calculated a stroke risk score (called CHA2DS2-VASc) of 2 or more points (or 3 or more points if you are female) - You have advanced chronic...

**Who might be able to join this trial:** - You are 75 years old or older - Your kidneys are working at less than 30% of their normal function (advanced kidney disease) - You speak English - You have not yet made a decision about whether to have dialysis (a treatment that does the work of the kidneys) **Who may not be...

Who might be able to join this trial: - People aged between 18 and 90 years, of any gender, who are able to give their consent to participate before any study procedures begin. - People who are already on haemodialysis (a treatment that filters the blood using a machine) and need a new way to access their blood vessels...

Who might be able to join this trial: - You must be willing and able to sign a consent form agreeing to take part in the study. - You must be 18 years old or older. - You must have end-stage kidney disease and be receiving hemodialysis (a treatment that filters your blood using a machine). - You must be receiving treat...

**Who might be able to join this trial:** - People who have stage 3 or 4 chronic kidney disease (CKD), with kidney function test results falling within a specific range (confirm with trial site for exact values) **Who may not be able to join:** - People who have heart disease - People who have diabetes - People who ar...

Who might be able to join this trial: - People who have chronic kidney disease (CKD) and have been receiving hemodialysis (a treatment that filters the blood using a machine) for more than 6 months - People who have a type of surgically created blood vessel connection in their arm, called an arteriovenous fistula (AVF)...

Who might be able to join this trial: - The patient must be male and have a parent or relative involved - The patient must be between 6 and 17 years old - The patient must have been treated for a urinary condition called posterior urethral valves (PUV) during their first year of life, between 2006 and 2018 - The patien...

Who might be able to join this trial: - Adults who are being seen at a clinic for advanced chronic kidney disease - People whose kidneys are functioning at a very low level (a measure called eGFR at or below 12 mL/min/1.73m²) (confirm with trial site) - People who can communicate in English or French Who may not be ab...

Who might be able to join this trial: - People aged between 18 and 70 years old (inclusive) - People who have had Type 1 diabetes for at least one year, or people with Type 2 diabetes who manage their blood sugar using multiple daily insulin injections or an insulin pump - People whose HbA1c (a measure of average blood...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have given their written, voluntary agreement to take part after being fully informed about the study and having the chance to ask questions - People with advanced (stage 5) chronic kidney disease, with a kidney function measurement (eGFR...

Who might be able to join this trial: - People aged 18 or older, of any gender - People who have been informed about the study and do not object to taking part Who may not be able to join: - People who have a long-term, ongoing infection that is getting worse over time - People who have previously had an organ transpl...

"Who might be able to join this trial: - People who have kidney failure and are currently receiving hemodialysis or peritoneal dialysis (two types of kidney replacement treatment) Who may not be able to join: - People who have had a blood transfusion in the last 90 days - People who are currently taking any supplement...

Who might be able to join this trial: - You must be at least 18 years old at the time you are identified for the study - You must have signed a consent form agreeing to take part - Between 6 and 24 months must have passed since your qualifying health event or diagnosis - You may qualify if you have had a heart-related...

**Who might be able to join this trial:** - People who have chronic kidney disease (CKD) with kidney function at or above a certain level (an eGFR of 15 ml/min/1.73m² or higher) - People who are 18 years of age or older - People whose kidneys are leaking only a moderate amount of protein into their urine (no more than...

**Who might be able to join this trial:** - People who are scheduled to have a new surgical connection made between an artery and vein in the wrist or upper arm area (called an AV fistula) for kidney dialysis, and who agree to take part in the study. - Men and women who are not pregnant. - People between 18 and 80 year...

**Who might be able to join this trial:** - People aged 16 years or older, both male and female, may be included. - People who have been seen by the Kidney (Nephrology) team at the Royal Liverpool Hospital for a kidney-related condition may be included. - Adults who are considered vulnerable or unable to give consent m...

**Who might be able to join this trial:** - People aged 18 years or older - People who have been diagnosed with both Metabolic Syndrome (a combination of conditions including a large waist size, high blood fats, low "good" cholesterol, high blood sugar, and high blood pressure) and Chronic Kidney Disease (CKD) - People...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with Chronic Kidney Disease at stage 4 or 5 (the more advanced stages of kidney disease) - People who currently live in the United States or the United Kingdom Who may not be able to join: - People who are...

Who might be able to join this trial: - People who have been diagnosed with chronic kidney disease (CKD) - People whose kidneys are functioning at a reduced level (as measured by a specific kidney function test), or who are already on regular dialysis - People who are able to communicate, understand instructions, and f...

**Who might be able to join this trial:** - Adults between 18 and 65 years old who are planning to receive a single kidney transplant from a living donor. - The living kidney donor must also be between 18 and 65 years old. A close tissue match between donor and recipient is not required. - The donor and recipient must...

Who might be able to join this trial: - People who have high blood pressure that remains uncontrolled despite taking three different types of blood pressure medications, confirmed by a 24-hour blood pressure monitoring test showing readings above the thresholds set by current guidelines. - People who have end-stage kid...

**Who might be able to join this trial:** - People who have chronic kidney disease with a reduced kidney filtering rate (eGFR below 60 mL/min/1.73 m²) - People who have a new blockage in a coronary artery that is suitable for treatment with a specific type of metal heart stent, and where a special imaging technique cal...

Who might be able to join this trial: - People with advanced chronic kidney disease (stage 5) who are on dialysis and have low vitamin D levels (a blood test result showing 25(OH)D below 30 ng/mL) Who may not be able to join: - People who have been on dialysis for less than 3 months - People whose parathyroid gland ov...

Who might be able to join this trial: - You have sickle cell disease that has affected your kidneys (either confirmed by a doctor's assessment or a kidney biopsy), with a specific type of sickle cell disease called Hb SS and kidney function測 measured at 135 ml/min/1.73m² or above (confirm with trial site) - You have pr...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have diabetic kidney disease with reduced kidney function at a specific level (known as stage G3a, G3b, or G4 — confirm exact level with trial site) - People whose blood protein levels (albumin) are below a certain threshol...

Who might be able to join this trial: - People who have received a kidney transplant from a living donor - People who are currently on the standard three-drug anti-rejection medication regimen Who may not be able to join: - People who currently have an active infection - People who have received more than one organ as...

**Who might be able to join this trial:** - People whose blood potassium level was between 5.5 and 6.5 mEq/L at their first screening visit, and between 5.0 and 6.5 mEq/L at the follow-up visit when treatment is assigned. - People who have given their written agreement (or whose legal representative has done so) to ta...

Who might be able to join this trial: - People who have been diagnosed with chronic kidney disease, OR are currently receiving dialysis treatment, OR have had a kidney transplant - People who are over 18 years old - People who have given their consent to take part in the trial Who may not be able to join: - People who...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who speak English or Spanish - People who have been diagnosed with diabetes and have had a blood sugar control test (called an A1C) result of 8.0% or higher in the past two years, OR people who have been diagnosed with high blo...

Who might be able to join this trial: - People who are older than 55 years of age - People who have been diagnosed with stage 3 or 4 chronic kidney disease, or whose kidney function test (eGFR) shows a result below 45 mL/min/1.73m² Who may not be able to join: - People whose blood pressure is poorly controlled and con...

**Who might be able to join this trial:** - People aged between 18 and 80 years old, whose Care Partner is also at least 18 years old at the time of signing consent - People who have been diagnosed with end-stage kidney disease (kidney failure) and are being treated with regular dialysis, with their dialysis working we...

**Who might be able to join this trial:** - Adults (men and women) - People who have been diagnosed with Chronic Kidney Disease at a moderate stage, specifically with a kidney filtration rate between 30 and 90 mL/min/1.73m² (known as KDIGO stage G2 or G3) - People who have a moderate-to-high level of protein (albumin)...

**Who might be able to join this trial:** - Your kidneys are working at a low level (a kidney function score below 29 out of a possible 100+), as measured by a standard blood test - You do not have any known liver disease, whether long-term or recent - Your kidney specialist does not expect you to need dialysis or anot...

Who might be able to join this trial: - People aged between 18 and 70 years old - People who have been receiving kidney dialysis (either hemodialysis three times per week, or peritoneal dialysis) for at least 3 months, OR healthy people with no history of kidney problems - People for whom a seasonal flu vaccine would b...

Who might be able to join this trial: - You must be 18 years of age or older - You have been diagnosed with chronic kidney disease where your kidneys are working at a reduced level (specifically, an eGFR below 60 mL/min/1.73 m²) (confirm with trial site if unsure about your eGFR level) - You were found to have high pot...

Who might be able to join this trial: - People who are 60 years of age or older, OR people aged 45 to 59 years who have been diagnosed with diabetes (either Type 1 or Type 2), regardless of how their blood sugar is currently managed - People who have been regularly receiving some form of dialysis for at least the past...

Who might be able to join this trial: - People who are 50 years of age or older. - People who have been clearly diagnosed with degenerative (age-related wear and tear) heart valve disease, confirmed by ultrasound or medical history, with signs of calcium buildup in the valve — this includes cases ranging from no valve...

**Who might be able to join this trial:** - You have been diagnosed with advanced (stage 5) chronic kidney disease and have been receiving regular hemodialysis (kidney dialysis) for at least 3 months before the screening visit. - You experience moderate to severe itching, meaning your itching scores 4 or higher on a st...

Who might be able to join this trial: - People who have been diagnosed with chronic kidney disease (a long-term condition where the kidneys do not work as well as they should) - People who are between 18 and 65 years old - People who are willing to take part in the study on their own accord Who may not be able to join...

**Who might be able to join this trial:** - People who are able to understand the study and sign a written consent form - People aged 18 or older who have had at least one previous kidney transplant - People whose transplanted kidney has stopped working (for any reason), but lasted at least 3 months before failing - Pe...

Who might be able to join this trial: - You are between 18 and 85 years old (being older than 85 may still be considered in rare cases — confirm with trial site) - You have long-term kidney failure (your kidneys are no longer working well enough on their own) - You are currently on the waiting list for a kidney transpl...

Who might be able to join this trial: - People who have been diagnosed with chronic kidney disease - People who are in a stable condition (not experiencing acute illness or significant changes in health) - People who are between 6 and 18 years old - People who are willing to voluntarily take part in the research Who m...

**Who might be able to join this trial:** - People who identify as African American or Black - People who have had two kidney function test results (called eGFR) below 29, taken at least 90 days apart but within the past 2 years — OR — people whose kidney failure risk score shows a 10% or greater chance of kidney failu...

**Who might be able to join this trial:** - People who have end-stage kidney disease and are receiving hemodialysis (a treatment that filters the blood using a machine) - People who have been receiving hemodialysis for more than 3 months - People who are considered medically stable - People who are willing to take part...

**Who might be able to join this trial:** - People who are willing and able to give written consent before any study procedures begin. - People whose legally authorised representative has signed the consent form, if the person cannot sign themselves. - People who are currently on a waiting list for a kidney transplant....

Who might be able to join this trial: - You need to be scheduled to have a specific type of heart procedure called pulsed field ablation (PFA) for a heart-related condition - You must be willing and able to agree to take part in the study by signing a consent form Who may not be able to join: - You have a known allerg...

**Who might be able to join this trial:** - People who have been diagnosed with IgA nephropathy (a kidney condition), confirmed by a kidney biopsy - Adults aged 18 or older, of any gender - People who have already completed one full 9-month course of commercial TARPEYO® 16 mg (taken once daily), with that completion r...

**Who might be able to join this trial:** - People who are willing to sign a consent form and follow all study requirements - People who have been receiving hemodialysis (including hemodialysis, hemodiafiltration, or hemoadsorption) three times per week for at least 12 weeks, with no plans to change this during the st...

**Who might be able to join this trial:** - People who are able to communicate clearly with the research team, understand the study requirements, and are willing to sign a consent form before any study procedures begin. - People who are willing and able to attend scheduled visits and follow the treatment plan. - Peopl...

**Who might be able to join this trial:** - You are between 18 and 75 years old at the time of signing up - Your body weight is between 45 and 100 kg (approximately 99–220 lbs) - You have been diagnosed with chronic kidney disease (CKD) at a moderate-to-severe stage, but you are not currently on dialysis - You have be...

Who might be able to join this trial: - People who have moderate chronic kidney disease, meaning their kidneys are working at a reduced level (a lab measure called eGFR falls between 30 and 59 ml/min, which doctors classify as stage 3) Who may not be able to join: - People who have an active kidney inflammation condit...

**Who might be able to join this trial:** - People who have been diagnosed with chronic kidney disease at stage 3, 4, or 5 - People who are physically able to do exercise - People who live within 20 miles of the Wake Forest Reynolda Campus - People who speak and understand English fluently - People who do not plan to t...

**Who might be able to join this trial:** **Phase I (healthy volunteers):** - Adults between 18 and 55 years old at the time of signing the consent form. - People with a body weight between 45 kg and 110 kg, and a BMI between 18.0 and 30.0. - People who are generally healthy, with no significant ongoing illnesses or r...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been diagnosed with chronic kidney disease (stage 3–5), meaning their kidneys have been functioning at a reduced level for at least three months - People for whom a doctor has decided, as part of their normal care, tha...

Who might be able to join this trial: - People who are over 18 years of age - People whose kidneys are working at a reduced level (a kidney function score below 60 mL/min/1.73m²) - People with diabetes whose blood sugar control meets a specific threshold (a blood test called HbA1c showing 9% or below) - People who have...

**Who might be able to join this trial:** - People who identify as Black or African American - People between the ages of 35 and 80 years old - People who have been diagnosed with chronic kidney disease (CKD) at stage 1, 2, 3, or 4 - People who report spending 6 or more hours per day sitting or being inactive - People...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been receiving regular kidney dialysis (hemodialysis) for at least 6 months, using one of several specific types of dialysis filters or methods (confirm with trial site for which specific filter or method applies) - People...

**For Patients with Chronic Kidney Disease (CKD):** Who might be able to join this trial: - People aged 18 or older - People who have been diagnosed with chronic kidney disease (CKD) of any cause, with kidney function and protein-in-urine levels within specific ranges at screening (confirm with trial site) - People wh...

**Who might be able to join this trial:** *For doctors/clinicians:* - You are a kidney specialist (nephrologist) or a senior doctor in training who provides specialist care to older adults with serious kidney disease *For patients:* - You have been diagnosed with advanced chronic kidney disease (stage 4 or 5), meanin...

Who might be able to join this trial: - **Group A (Healthy donors):** Adults who donate blood through the Metropolitan Immunohematology and Transfusion Medicine Service — blood samples from this group are used anonymously, so no separate consent is needed from these donors. - **Group B (Kidney transplant patients):**...

Who might be able to join this trial: - People who have been diagnosed with chronic kidney disease (a long-term condition where the kidneys do not work as well as they should) and are attending Sohag University Hospital. - People who are older than 20 years of age. - People who have given their consent to take part in...

Who might be able to join this trial: - People who are in hospital for a kidney biopsy (where a small sample of kidney tissue is taken) on their own natural kidney, or for a kidney transplant - People who are over 18 years old - People who have been fully informed about the trial and have given their written agreement...

Who might be able to join this trial: - You carry a specific genetic variation called APOL1 high risk genotype (either G1/G1, G2/G2, or G1/G2) — this is determined by a genetic test - You have chronic kidney disease with a lasting higher-than-normal level of protein in your urine (confirm with trial site) Who may not...

**Who might be able to join this trial:** - Adults aged 18 or older who have been diagnosed with end-stage kidney failure and have been receiving dialysis at least once a week for the past two weeks. - Women who are able to become pregnant but are using a form of contraception, have decided not to have more children,...

**Who might be able to join this trial:** - People who have been diagnosed with a sudden, severe worsening of a long-term liver condition, where at least two major organs are failing at the same time (a condition graded as ACLF grade 2 or higher, confirmed using a specific medical scoring system) - People who are rece...

**Who might be able to join this trial:** - People with chronic kidney disease at stage G3, meaning their kidney filtration rate (a measure of how well the kidneys clean the blood) was between 30 and 59 units at their last clinic visit - Healthy people whose kidney filtration rate is within the normal expected range f...

**Who might be able to join this trial:** - You were born female - You are living with HIV and have been on a stable HIV treatment regimen for at least 180 days (about 6 months) - You are between 45 and 75 years old - You have at least one of the following: type 2 diabetes, reduced kidney filtering function (confirm wi...

Who might be able to join this trial: - People who work as registered nurses or Band 3 healthcare assistants (a support worker role) and carry out needling procedures in a haemodialysis (kidney dialysis) unit. - People who are employed at the kidney dialysis units run by East and North Hertfordshire NHS Trust (ENHT), i...

**Who might be able to join this trial:** - People aged 18 years or older - People who have chronic kidney disease and have been receiving haemodialysis (a machine-based kidney treatment) for at least 3 months - People whose blood test shows a homocysteine level above 15 µmol/L (homocysteine is a naturally occurring su...

**Who might be able to join this trial:** - People who are over 18 years old - People who have been on stable dialysis three times per week for at least three months due to permanent kidney failure - People whose blood potassium level (measured before dialysis, after the longest break between sessions) is between 4.0...

Who might be able to join this trial: - You are older than 18 months of age - You have been diagnosed with a moderate level of chronic kidney disease (specifically stages 2 to 3a), confirmed by a specific kidney function blood test done within the last 6 months - You are already scheduled to have a urological (urinary...

Who might be able to join this trial: - Adolescents (40 participants total) who have end-stage kidney disease (when the kidneys have stopped working properly) - People who are already receiving regular hemodialysis (a treatment that filters waste from the blood using a machine) Who may not be able to join: - People wh...

Who might be able to join this trial: - Dietitians who have worked with chronic kidney disease patients - Dietitians who are registered with the Saudi Commission for Health Specialties - Dietitians who have completed at least one year of work experience in their role - Dietitians who agree to take part in the study - D...

**Who might be able to join this trial:** - Adults aged 18 or older, of any gender - People who have been diagnosed with Chronic Kidney Disease (CKD) at Stage 3 or Stage 4, confirmed by a specific kidney function test called eGFR - People whose condition is currently stable, with no recent hospital stays for sudden kid...

**Who might be able to join this trial:** **Study A (for people with chronic kidney disease, or CKD):** - People whose urine shows a protein level (albumin-to-creatinine ratio) in a specific mid-range — not too low and not too high (confirm with trial site for exact values) - People whose kidneys are still functioning...

Who might be able to join this trial: - People who have been receiving hemodialysis and taking related medication for at least 6 weeks - People whose Kt/V score is greater than 1.2 (this is a measurement used to check how well hemodialysis is working — confirm with trial site) Who may not be able to join: - People who...

**Who might be able to join this trial:** - People who have been diagnosed with chronic kidney disease - People who have been receiving hemodialysis (a machine-based kidney treatment) for at least 6 months **Who may not be able to join:** - People who are currently pregnant - People who are currently breastfeeding - P...

Who might be able to join this trial: - Adults aged 18 or older who are receiving both a heart transplant and a kidney transplant at Cedars-Sinai Medical Center. Who may not be able to join: - People who receive both the heart and kidney transplants at the exact same time in a single surgery due to urgent medical need...

**Who might be able to join this trial:** - People who are willing to give informed consent to take part in the study and agree to be followed up for the rest of their life - People who have been diagnosed with end-stage renal disease (kidney failure requiring ongoing treatment) - People who have been on dialysis thro...

Who might be able to join this trial: - Adults who are considered frail and are being assessed as a possible kidney transplant recipient at Houston Methodist Hospital - People aged 55 years or older, of any gender - People who are willing and able to sign a dated consent form agreeing to take part in the study - People...

**Who might be able to join this trial:** - People who have been clinically diagnosed with chronic kidney disease (CKD) at any stage (stage 1 through 5), based on kidney function test results - People between 18 and 90 years of age, of any gender **Who may not be able to join:** - People in the control group (comparis...

Who might be able to join this trial: - Adults over 18 years of age. - People who are willing to sign a consent form agreeing to take part in the study. - People who have end-stage kidney disease and have been receiving regular hemodialysis (a machine-based kidney treatment) for more than 3 months. Who may not be able...

Who might be able to join this trial: - You have advanced kidney disease (stage 4 or 5), are on dialysis, or have had a kidney transplant - You are 18 years old or older - Your doctor has recommended that you receive a flu vaccine - You are able and willing to give your free and informed consent to participate Who may...

**Who might be able to join this trial:** - You are an adult with kidney failure who is treated with peritoneal dialysis (a type of home dialysis that uses fluid in the abdomen) and have been on a stable dialysis prescription using sugar-based dialysis fluid for at least 3 months. - Your kidneys have been tested and sh...

Who might be able to join this trial: - You are over 18 years old. - You are willing to sign a consent form agreeing to take part in the study. - You have end-stage kidney disease and have been receiving regular dialysis (a machine that cleans your blood) for more than 3 months. Who may not be able to join: - You are...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of signing the consent form. - People who have been diagnosed with chronic kidney disease, with kidney function test results showing an eGFR between 25 and 60 (a measure of how well the kidneys filter blood), and a urine pr...

**Who might be able to join this trial:** - People who have signed an informed consent form agreeing to take part - People aged 18 years or older - People who have been diagnosed with type 2 diabetes for at least 12 months - People who have been using insulin therapy for at least 6 months - People with chronic kidney...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with Chronic Kidney Disease (CKD) at a moderate to severe stage (stage 3–5), meaning the kidneys are not filtering blood as well as they should - People who are currently receiving kidney care at the NYU Nephrology outp...

Who might be able to join this trial: - Adults aged 18 or older who have been diagnosed with moderate to severe chronic kidney disease (stages 3–5), with kidney function measurements that have been stable for at least three months - People whose blood sugar and blood pressure levels are being managed and kept within a...

Who might be able to join this trial: - People who are older than 40 years of age - People with severely reduced kidney function, at a level doctors refer to as chronic kidney disease stage 4 or 5 (confirm with trial site) - People who have given their written agreement to take part in the trial Who may not be able to...

**Who might be able to join this trial:** - Adults aged 18 or older whose vital signs are stable, meaning body temperature between 36.0°C and 38.0°C, pulse between 50 and 120 beats per minute, breathing rate between 10 and 24 breaths per minute, and blood pressure of at least 90/60 mmHg. - People who are willing to tak...

**Who might be able to join this trial:** - You are willing to voluntarily sign a consent form to take part in the study. - You are aged 18 years or older but under 75 years old. - You have been diagnosed with moderate-to-moderately-severe chronic kidney disease (stages 3–4), meaning your kidneys are working at a reduc...

Who might be able to join this trial: - People who are able to understand written information and are willing to sign a written consent form to participate - People who are at least 18 years old at the time of signing the consent form - People who have been receiving hemodialysis (kidney dialysis) either three times pe...

Who might be able to join this trial: - Adults aged 18 or older. - People with advanced chronic kidney disease (a kidney function level below a certain threshold, measured by a blood test) who are not currently on dialysis. Who may not be able to join: - People diagnosed with a genetic kidney condition called autosoma...

**Who might be able to join this trial:** - Adults aged 19 years or older - People who have been diagnosed with end-stage kidney failure and are receiving dialysis more than three times per week - People who rate their back pain at 4 or higher out of 10 on a standard pain scale - People whose thinking and memory are cl...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with kidney failure at the most advanced stage (stage 5) - People who have been on regular dialysis for at least 3 months - People who are able to understand the trial procedures and follow the trial plan W...

Who might be able to join this trial: - People who have end-stage kidney disease (where the kidneys have stopped working properly) and who also have a serious blood infection (sepsis), with a specific protein linked to inflammation (interleukin-6) measured above a certain level in their blood Who may not be able to jo...

**Who might be able to join this trial:** - People aged 18 or older - People who are able to meet the study requirements, including attending follow-up appointments - People who have advanced chronic kidney disease and are already on hemodialysis (kidney dialysis), or who are expected to need hemodialysis within the n...

Who might be able to join this trial: - Children between 3 and 17 years of age - Children who are currently receiving ongoing dialysis treatment (hemodialysis, hemodiafiltration, or peritoneal dialysis) - Children whose treating doctor has decided to start them on a medication called cinacalcet, in line with 2019 Europ...

**Who might be able to join this trial:** - You have chronic kidney disease with kidney function measured at a specific level (eGFR between 15 and 60) — your doctor can confirm this from your blood test results - Your water tablet (diuretic) and blood pressure medication doses have been stable and unchanged for at lea...

Who might be able to join this trial: - Adults between 18 and 80 years of age - People who have been diagnosed with end-stage kidney failure and have been receiving regular dialysis treatment for more than 3 months - People who are willing and able to give their consent to participate and follow the study's procedures...

**Who might be able to join this trial:** - Adults aged 18 years or older - People who needed a breathing machine (mechanical ventilator) and/or heart/blood pressure support medications for more than 24 hours during their ICU stay - People whose doctor has decided they are ready to leave the ICU - People who have sign...

Who might be able to join this trial: - People who have been on regular hemodialysis (kidney dialysis) for at least 3 months - People with a body weight that falls within the normal to overweight range (BMI between 18.5 and 29.9 kg/m²) - People aged between 40 and 60 years old - People who attend hemodialysis sessions...

**Who might be able to join this trial:** - People who have provided signed consent to participate - People aged 18 years or older but under 65 years - People with chronic kidney failure who are scheduled to receive a kidney transplant - People with a body mass index (BMI) between 18 and 30 (a standard measure of body...

**Who might be able to join this trial:** - You are between 18 and 80 years old. - You have been diagnosed with chronic kidney disease, meaning your kidneys are not filtering blood at full capacity. - You have chronic heart failure with a weakened heart pump (your heart is pumping at 50% or less of its normal capacity...

**Cohort 1: Healthy Participants** Who might be able to join this trial: - Adults between 18 and 75 years old - People with normal kidney function - People without heart failure - People with a body mass index (BMI) between 25 and 30 (considered overweight but not obese) Who may not be able to join: - People with a l...

Who might be able to join this trial: - You have been diagnosed with IgA Nephropathy (a kidney condition), confirmed by a biopsy (a small tissue sample taken from your kidney) Who may not be able to join: - Your IgA Nephropathy is caused by another underlying condition (such as liver disease or another illness), rathe...

Who might be able to join this trial: - People who are 21 years of age or older - People who can speak and read English, or people who can speak and read Spanish and have a caregiver or family member who speaks English and can help them - People who are able to stand on both bare feet without assistance - People who ar...

Who might be able to join this trial: - People who are 18 years of age or older - People who are scheduled to have surgery to remove one entire kidney Who may not be able to join: - People who only have one kidney - People who have been diagnosed before surgery with advanced chronic kidney disease (specifically stages...

**Who might be able to join this trial:** - You are between 18 and 85 years old (any gender) - You have chronic kidney failure and have been receiving peritoneal dialysis regularly for at least 3 months, with no major changes to your treatment expected during the trial - You are able to understand the study, follow it...

**Who might be able to join this trial:** - People between 40 and 70 years old - Men, or women who have gone through menopause - People who have been diagnosed with Stage 3 chronic kidney disease, meaning their kidneys are working at a reduced level (confirmed by a specific kidney function test result between 30–59 ml/...

Who might be able to join this trial: - You are between 18 and 80 years old (any sex) - You have been diagnosed with chronic kidney disease (CKD) based on recognised medical guidelines - Your medical records and health information are complete and available - You are willing and able to give written permission to take...

**Who might be able to join this trial:** - Adults between 18 and 75 years of age at the time of signing the consent form - People with a documented diagnosis of end-stage kidney disease - People who have been receiving dialysis for at least the 90 days before signing the consent form - People on haemodialysis who rec...

Who might be able to join this trial: - People who are able to understand written information and are willing to sign a written consent form agreeing to take part - Adults aged 18 or older with a body mass index (a measure of body weight relative to height) between 18 and 35 - People who have been receiving regular dia...

Who might be able to join this trial: - Adults aged between 18 and 75 years, of any gender - People who weigh at least 45 kg and have a body mass index (BMI) of 18.5 or above - People who have been diagnosed with chronic kidney failure and have been on a stable dialysis routine (either peritoneal dialysis or hemodialys...

Who might be able to join this trial: - Adults aged 18 or older who have given their consent to participate - People who have been receiving regular hemodialysis (a kidney cleaning treatment) for at least 3 months in a row - People who attend 2 to 3 hemodialysis sessions per week Who may not be able to join: - People...

Who might be able to join this trial: - People who are 18 years of age or older. - People who have end-stage kidney disease and need a new blood vessel graft created for dialysis. - People whose upper arm is a suitable location for placing the graft. - People (or their legal guardian) who understand the study and are w...

Who might be able to join this trial: - People over 50 years old, or people over 18 years old who have at least one of the following health conditions: diabetes, high blood pressure, coronary heart disease, stroke, poor circulation in the legs or feet, irregular heartbeat (atrial fibrillation), or heart failure - Peopl...

**Who might be able to join this trial:** - People who have kidney failure requiring dialysis through a blood vessel access point, or who have chronic kidney disease and are expected to need dialysis within 6 months - People who have a specific vein in the arm (the cubital perforating vein) measuring between 2.0 and 5...

**Who might be able to join this trial:** - Adults over 18 years old who attend outpatient clinic visits at HTCM's peritoneal dialysis clinic - People who have been on peritoneal dialysis (a type of kidney treatment done at home through the abdomen) for at least 6 months - People whose blood protein (albumin) level is...

**Who might be able to join this trial:** - You are 50 years of age or older at the time of screening - You have advanced chronic kidney disease (stage 4 or 5) that is not being treated with dialysis, meaning your kidneys are working at less than 30% of normal capacity based on a blood test - Your parathyroid hormone (...

Who might be able to join this trial: - People aged 18 or older - People with advanced chronic kidney disease, meaning their kidneys are working at a low level — confirmed by at least two blood tests taken at least 90 days apart within the past 12 months, both showing kidney function at or below a certain threshold - P...

Who might be able to join this trial: - Adults aged 18 or older who have kidney disease at any stage of severity, including early signs of protein in the urine, more significant protein loss, chronic kidney disease at various stages (not yet requiring dialysis), or kidney disease after a kidney transplant where protein...

**Who might be able to join this trial:** - Women who have gone through menopause - People aged 50 years or older - People with moderate-to-severe chronic kidney disease (CKD stage 3 or 4), meaning kidney function is reduced but not at the point of needing dialysis, and kidney function has been stable for the past 3 m...

Who might be able to join this trial: - People who are willing and able to give written consent to participate in the trial - People who are between 18 and 80 years of age - People who have chronic kidney disease, defined by a specific measure of how well their kidneys are filtering blood (confirm with trial site for e...

Who might be able to join this trial: - People who are already participating in the OMAGOD pilot trial Who may not be able to join: - People who are not participating in the OMAGOD pilot trial Important: Always verify eligibility with the trial site directly before applying.

**Who might be able to join this trial:** - People aged 18 or older - People whose doctor has determined they need a new connection between an artery and vein (called an AVF) created at the wrist or lower forearm for dialysis access - People with end-stage kidney disease who are currently receiving regular hemodialysi...

**Who might be able to join this trial:** - People who are willing and able to give their informed consent to participate - People aged 18 years or older - People who fall into one of these three groups: those who have been on regular, stable haemodialysis (kidney-filtering treatment using a machine) for at least thre...

Who might be able to join this trial: - People aged 18 years or older - People who are currently living in the United States - People who are able to read and follow written instructions in English - People who have access to the internet and a device such as a computer, laptop, tablet, or smartphone - People who are w...

Who might be able to join this trial: - People who are waiting on a transplant list to receive a kidney - People aged 45 years or older, or people aged 18 to 44 years who have been on dialysis for 5 or more years Who may not be able to join: - People whose heart is pumping at less than 40% of its normal capacity (conf...

Who might be able to join this trial: - Adults aged 18 or older, of any gender - People who have been diagnosed with chronic kidney disease (CKD) - People whose kidneys are working at a reduced but not severely low level, based on a specific kidney function test result (eGFR between 25 and 60) - People whose urine sho...

**Who might be able to join this trial:** - People who have given their voluntary agreement to take part in the study and to be followed up for the rest of their life - People who have been diagnosed with end-stage renal disease (complete kidney failure) at the time of signing up - People who have been dependent on ki...

Who might be able to join this trial: - Adults of any gender aged 18 or older - People who have been diagnosed by a doctor with chronic kidney disease (CKD) that is linked to type 2 diabetes - People for whom a doctor has decided to prescribe finerenone (10 mg or 20 mg) in line with how it is approved for use in their...

Who might be able to join this trial: - People who are able to give written agreement to participate before any assessments are carried out. - For Part A (healthy volunteers): Men and women who are in good general health, confirmed through medical history, physical check-up, vital signs, heart tracing (ECG), and blood...

Who might be able to join this trial: - People who have been diagnosed with chronic kidney disease (a long-term condition where the kidneys do not work as well as they should), but not at the most advanced stage (end-stage kidney disease), based on medical records or certain lab results showing reduced kidney function...

Who might be able to join this trial: - Adults aged 18 years or older, of any sex - People who have been diagnosed with moderate-to-severe chronic kidney disease (stages 3 to 5) that is not being treated with dialysis, and who also have heart failure with a weakened heart pump (where the heart is pumping at less than 4...

**Who might be able to join this trial:** - People of Chinese background who are either healthy with normal kidney function, or who have been diagnosed with mild, moderate, or severe kidney impairment, based on a specific kidney function measurement (eGFR) taken by a doctor. - People aged 18 to 70 years old (inclusive...

**Who might be able to join this trial:** - Your urine protein levels must be at a certain elevated level, measured by a specific urine test called UPCR, showing a result of 1 or higher (confirm with trial site). - You must already be taking the highest dose of a certain type of blood pressure/kidney-protecting medicat...

**Who might be able to join this trial:** - People aged between 20 and 79 years. - People who have been on hemodialysis (a kidney filtering treatment) for more than 3 months. - People who do not currently take part in regular exercise outside of their dialysis sessions. - People who have not done any exercise during di...

Who might be able to join this trial: - People who have been diagnosed with type 2 diabetes and are currently receiving medication or making lifestyle changes to manage their blood sugar levels. - People whose HbA1c (a blood test that shows average blood sugar levels over the past few months) is between 6.5% and 10% at...

Who might be able to join this trial: - People who are on long-term peritoneal dialysis (a type of kidney treatment done at home using the abdomen) and have high blood pressure that is not well controlled (with readings above certain levels) Who may not be able to join: - People who are not expected to live longer tha...

**Who might be able to join this trial:** - People aged between 30 and 75 years old at the time of signing the consent form - People who have been diagnosed with Type 2 Diabetes for at least 1 year - People who have been diagnosed with Chronic Kidney Disease (a long-term condition where the kidneys do not work as well...

**Who might be able to join this trial:** - People aged 18 or older, of any gender, who have signed and dated a consent form before entering the trial - People with heart failure (regardless of how well the heart is pumping) and a certain level of kidney function, as measured by a blood test called eGFR, falling betwe...

**Who might be able to join this trial:** **For patients:** - People who are Singapore citizens or permanent residents, aged 21 or older - People who have been diagnosed with the most advanced stage of chronic kidney disease (stage 5) and are currently on dialysis - People who have been identified by National Kidney F...

Who might be able to join this trial: - You are willing to take part and have signed a consent form agreeing to join the study - You have been diagnosed with, or are suspected of having, chronic kidney disease based on current medical guidelines - You are already having a kidney biopsy done and a tissue sample is being...

Who might be able to join this trial: - Adults older than 18 years of age. - People who have been on regular dialysis (either hemodialysis or peritoneal dialysis) for at least 6 months. Who may not be able to join: - People living with significant cognitive or psychiatric conditions that would make it difficult to und...

**Who might be able to join this trial:** - People over 20 years old who are not pregnant at the time of screening - People who have diabetic kidney disease (a type of kidney damage caused by diabetes) with kidney function and certain blood marker levels that have been stable for at least 30 days - People whose kidney...

Who might be able to join this trial: - You must be 18 years old or older and currently being assessed to see if you are a suitable candidate for a kidney transplant. - You must currently be receiving dialysis treatment. - You must be willing and able to agree to take part in the trial. Who may not be able to join: -...

**Who might be able to join this trial:** - People who are generally in good health (those with stable, long-term medical or physical health conditions may still be considered, at the discretion of the trial doctor and study sponsor) - **For the severe kidney impairment group:** People whose kidneys are functioning at...

**Who might be able to join this trial:** - Adults between 18 and 65 years old who have end-stage kidney disease (kidneys no longer work), are on a transplant waiting list, and need a special treatment to make a safe kidney transplant possible. - For one group (Cohort 1): A living kidney donor has already been identif...

Who might be able to join this trial: - People between 18 and 70 years of age - People who have been diagnosed with chronic kidney disease (CKD) at any stage from 1 to 5 - People who are able to safely have an MRI scan, meaning they have no conditions or implanted devices that would make an MRI unsafe (such as a pacema...

Who might be able to join this trial: **If you have a cardiovascular (heart-related) condition:** - You have been diagnosed with at least one of the following: high blood pressure, type 2 diabetes, chronic kidney disease, or heart failure **If you are a healthy individual:** - Your body weight is in a healthy to slig...

**Who might be able to join this trial:** - Adults between the ages of 21 and 65 years old - People who have been diagnosed with end-stage renal disease (kidney failure at its most advanced stage) - People who have been receiving regular kidney dialysis (hemodialysis) for at least 3 months - People whose kidney special...

Who might be able to join this trial: - Adults (men or women) who are over 18 years of age - People who have been diagnosed with stage 4 or 5 chronic kidney disease (CKD), meaning their kidneys are working at a low level, as measured by a specific blood test result below 30 mL/min/m² - People who are not currently on d...

Who might be able to join this trial: - Adults who are on the waiting list for a single kidney transplant at Vanderbilt University Medical Center (VUMC) - Kidneys donated from deceased donors (either after brain death or after circulatory death), where the donor's legal decision-maker has agreed to donation and to the...

Who might be able to join this trial: - People aged 60 years or older - People who have unstable angina (a type of chest pain caused by reduced blood flow to the heart) and are scheduled to have a procedure called percutaneous coronary intervention (a procedure to open blocked or narrowed heart arteries) - People who h...

Who might be able to join this trial: - Adults aged 18 or older of any gender may be considered for this trial. - People who have diabetes with a blood sugar control measure (A1C) of 7.5 or higher may be eligible. - People who have had a stent placed in their heart may be eligible. - People who have had open-heart bypa...

Who might be able to join this trial: - People who are between 14 and 18 years old - People who currently live in Aguascalientes - People whose urine tests show a moderate amount of protein leaking into the urine (a specific measurement called ACR, falling between 30 and 300 mg/g) - People whose kidneys are filtering b...

Who might be able to join this trial: - People who have end-stage (terminal) kidney disease and are currently receiving hemodialysis (a machine that filters the blood) - People who have recently been admitted to hospital for a sudden or serious medical event Who may not be able to join: - People who have dementia or s...

Who might be able to join this trial: - People aged 18 to 79 years old at the time of signing the consent form, of any gender. - People whose kidneys are functioning at a reduced but not severely low level, and who also have a significant amount of protein in their urine — there are two combinations of kidney function...

**Who might be able to join this trial:** - People who weigh at least 55 kilograms and have a body mass index (BMI) between 19.0 and 40.0 - People who have no significant history of low blood sugar episodes that happened on their own or were caused by alcohol **For Group 1 only — additional criteria that may apply:**...

Who might be able to join this trial: - People who have chronic kidney disease caused by high blood pressure, across a range of severity levels, who do not have diabetes and do not smoke - People who have high blood pressure (diagnosed according to 2023 international guidelines) but do not yet have kidney damage, and w...

Who might be able to join this trial: - You must be willing and able to sign a consent form agreeing to take part in the trial - You have chronic kidney disease (CKD) at any stage (1 to 5) and are being treated without dialysis - You have been receiving regular kidney dialysis (hemodialysis) for at least 3 months - You...

Who might be able to join this trial: - Adults aged 18 years or older - People whose kidneys are functioning at a level of at least 10 ml/min/1.73 m² (a measure of kidney function that the trial site can confirm from blood test results) - People who have already had a kidney biopsy, a kidney donor biopsy, or a kidney r...

**Who might be able to join this trial:** - People who are currently enrolled in a chronic hemodialysis unit. - People who have been receiving hemodialysis treatment for more than 3 months. - People who are 40 years of age or older. - People whose hemoglobin (a measure of red blood cells) level is greater than 10 mg/dl...

Who might be able to join this trial: - People aged 18 years or older, of any gender. - People who are willing and able to sign a written consent form to take part in the study. - People with a confirmed diagnosis of chronic kidney disease (CKD), shown by either reduced kidney function lasting at least 3 months, or sig...