Phase 2 Chronic Kidney Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years old at the time of the initial screening visit
• People who are able to understand what the study involves and are willing to sign a written consent form
• People whose body weight falls within a healthy-to-moderately-overweight range (a body mass index between 18.5 and 40) at screening
• People who have been diagnosed with moderate chronic kidney disease (stages 2 to 3b) caused by kidney damage from Type 2 diabetes
• People whose urine protein-to-creatinine ratio falls within a specific range at screening, indicating a certain level of kidney protein leakage (confirm with trial site for exact values)
• People who are taking blood pressure and/or diabetes medications, where the doses of those medications have not changed for at least 90 days before screening
• People who are able to follow all study requirements, including staying overnight at the research site when required, in the investigator's opinion
• People born male who are either unable to father children, agree to use an approved form of contraception, or abstain from sexual activity that could result in pregnancy — and agree not to donate sperm or undergo IVF — for a set period after the last dose of study drug (confirm with trial site for exact timeframe)
• People born female who are unable to become pregnant, or who agree to use two highly effective forms of contraception, or abstain from sexual activity that could result in pregnancy — and agree not to donate eggs or undergo IVF — for a set period after the last dose of study drug (confirm with trial site for exact timeframe)
• For one specific group in the study only (Cohort 9): people who have been diagnosed with a mild-to-moderate form of diabetic eye disease (nonproliferative diabetic retinopathy)

Who may not be able to join:

• People with a known allergy to the study drug or any of its ingredients, a history of a severe allergic reaction to any medication, or a history of multiple food or drug allergies
• People who smoke more than 5 cigarettes per week at the time of screening (casual smokers of 5 or fewer per week may be considered, but would need to abstain from smoking during any overnight stays at the research site)
• People who test positive for recreational drugs (including cannabis) or alcohol at screening or the day before the study begins
• People with any other illness or medical history that could affect their safety, their ability to follow study requirements, or the ability of researchers to interpret the study results
• For one specific group only (Cohort 9): people who have a particular form of diabetic eye complication involving fluid in the centre of the eye (diabetic macular edema) that is being treated with anti-VEGF injections, or who have bleeding inside the eye (vitreous hemorrhage)

Important: Always verify eligibility with the trial site directly before applying.