Sleep Disorders

Who might be able to join this trial: - You are between 18 and 80 years old - You have been using a CPAP machine set to automatic (AutoSet) mode for at least 6 months - You are currently using a ResMed brand mask with your CPAP machine Who may not be able to join: - You are not able to sign a written consent form - Yo...

Who might be able to join this trial: - You must have been diagnosed with idiopathic Parkinson's disease (the most common form of Parkinson's, not caused by another condition) using a specific set of medical guidelines called the UK Parkinson's Disease Society Brain Bank Criteria. - You still have ongoing movement prob...

**Who might be able to join this trial:** - You are a man or woman aged 18 or older who has been diagnosed with long-term (chronic) atopic dermatitis (eczema) - Your eczema has not been well controlled with creams or ointments applied to the skin - Your eczema is considered to be of a certain level of severity, and it...

Who might be able to join this trial: **For people with Parkinson's Disease (PD):** - People aged 40 to 80 years old at the time of agreeing to participate - People who have been diagnosed with Parkinson's Disease (using specific UK brain bank guidelines) along with a sleep condition called REM sleep behavior disorder...

**Who might be able to join this trial:** - People who are willing to sign a written consent form agreeing to take part - People who can read and understand English - People who are 18 years of age or older - People who have been receiving treatment for obstructive sleep apnea (OSA) for at least 6 months - People who a...

**Who might be able to join this trial:** - You are older than 18 years of age - You are scheduled for a planned (non-emergency) surgery on the upper airway (such as the throat, nose, or mouth) - You have been diagnosed with obstructive sleep apnoea (a condition where breathing repeatedly stops and starts during sleep)...

Who might be able to join this trial: - People who have been diagnosed with an insomnia disorder, OR who score 10 or higher on a standard insomnia questionnaire (called the Insomnia Severity Index), AND who also score 10 or higher on a standard anxiety questionnaire (called the GAD-7). - People of any sex or gender. -...

**Who might be able to join this trial:** - You are willing to sign a written consent form to take part in the study - You can read and understand English - You are 18 years of age or older - You currently use a ResMed AirSense 10 or 11 machine - Your device is set to "AutoSet" (automatic pressure adjustment) mode - Yo...

Who might be able to join this trial: - People aged 55 years or older. - People who have been diagnosed with an insomnia disorder, meaning they have had trouble falling asleep, staying asleep, or waking too early at least 3 nights per week for at least 3 months, with at least one daytime problem caused by poor sleep, a...

Who might be able to join this trial: - People aged 55 years or older. - People who have been diagnosed with insomnia disorder, meaning they have trouble falling asleep, staying asleep, or wake up too early at least 3 nights per week, for at least 3 months, and this affects their daytime functioning — and who score 15...

Who might be able to join this trial: - People aged between 18 and 45 years old - People who are well-trained athletes who do sports or exercise that involves being on their feet and bearing weight through their legs (such as running) - People who currently do around 45 kilometres per week of this type of endurance tra...

**Who might be able to join this trial:** - People who have a confirmed diagnosis of moderate-to-severe obstructive sleep apnea (OSA) - People whose sleep study (done as part of the screening process) shows an AHI score of 15 or higher — this is a measure of how often breathing is interrupted during sleep - People wit...

**Who might be able to join this trial:** - People who were assigned male or female at birth - People who are 18 years of age or older at the time of signing the consent form - People who have previously been diagnosed with moderate-to-severe obstructive sleep apnea (a condition where breathing repeatedly stops during...

Who might be able to join this trial: - You must have already completed a previous clinical trial called SP889. Who may not be able to join: - You are currently experiencing a serious negative health reaction that is believed to be caused by the medication used in the previous trial (SP889). Important: Always verify...

Who might be able to join this trial: - Adults who have been diagnosed with obstructive sleep apnea (OSA) and are considering surgery as a treatment option Who may not be able to join: - People under 18 years of age - People who are pregnant - People who are not able to give their own consent to participate in English...

**Who might be able to join this trial:** - Girls who are in the middle to later stages of puberty (at least Tanner breast stage 3) and are no more than 2 years past their first period - Girls without signs of excess male hormones: those whose free testosterone level falls within the normal range for their stage of pu...

Who might be able to join this trial: - The person completing the telephone survey (either the participant or their legal guardian) must be at least 18 years old. - Parents or legal guardians may participate on behalf of children aged 0 to 17 years who meet the other criteria. - The person the survey is about must be b...

Who might be able to join this trial: - People who have been prescribed an oral appliance (a mouth device worn during sleep) by their doctor to treat obstructive sleep apnea. Who may not be able to join: - People who are under 18 years of age. - People who do not understand the English language. - People who are not w...

**Who might be able to join this trial:** - People who are between 21 and 70 years of age - People who have been diagnosed with moderate to severe obstructive sleep apnea, meaning their breathing stops or becomes very shallow 15 to 50 times per hour during sleep, as measured by an overnight sleep study - People who ar...

**Who might be able to join this trial:** - People who are already eligible for and participating in an ongoing study that has been approved by an Institutional Review Board (a committee that oversees research to protect participants) (confirm with trial site) **Who may not be able to join:** - Women who are pregnant...

"Who might be able to join this trial: - People of any age may be considered for this trial - People of any gender may be considered for this trial - People who have been diagnosed with obstructive sleep apnoea syndrome (a condition where breathing repeatedly stops during sleep), confirmed by a sleep test score of 5 or...

**Who might be able to join this trial:** - Adults between 18 and 50 years old who have been diagnosed with epilepsy, seizures, fainting, drowning, cardiac arrest, sudden death, or who have had an abnormal heart test (ECG) suggesting an irregular heartbeat - Blood relatives (aged 18 or older) of someone who has a histo...

Who might be able to join this trial: - People who have been diagnosed with central sleep apnea and have not responded to CPAP treatment (a common breathing device used during sleep) - People for whom a type of therapy called ASV (Adaptive Servo-Ventilation, a specialized breathing support device used during sleep) has...

**Who might be able to join this trial:** - People who are healthy men, or women who are not pregnant and not breastfeeding, between 18 and 39 years old (inclusive) - People who are able to show they understand the study rules by scoring at least 80% on a short multiple-choice quiz (one retest is allowed if the first a...

**Who might be able to join this trial:** - Adults aged 18 or older who have been referred to a sleep laboratory at a university hospital for a sleep study to investigate suspected obstructive sleep apnea (a condition where breathing repeatedly stops during sleep). **Who may not be able to join:** - People currently t...

**Who might be able to join this trial:** - People with a body mass index (BMI) of 40 or below - People who do not currently smoke or use tobacco products - People who have been diagnosed with high blood pressure, pre-high blood pressure, or high cholesterol and are receiving treatment for these conditions - People wh...

**Who might be able to join this trial:** - Adults aged 18 or older (both men and women) - People whose blood pressure is higher than normal during sleep (specifically, an average sleeping systolic blood pressure of 120 mmHg or more), measured at the time they are enrolled - People who follow a regular routine of being...

Who might be able to join this trial: - People who have served in the military as veterans Who may not be able to join: - People who have a history of bipolar disorder - People who have a history of macular degeneration (an eye condition affecting central vision) - People whose primary language is not English - People...

Who might be able to join this trial: - Adults aged 18 years or older - People whose sleep study results show a breathing disturbance score of 15 or more events per hour of sleep, with more than half of those events being non-obstructive in nature (this can be measured from either a diagnostic sleep study or one done w...

Who might be able to join this trial: - Adults who are pregnant and snore - People who have at least 8 teeth in both the upper and lower jaw - People whose throat and airway opening is rated as relatively unobstructed (Mallampati score I or II — confirm with trial site if unsure) - People whose tonsils are normal or on...

**Who might be able to join this trial:** - People with a body mass index (a measure of body weight relative to height) under 40. - People between 18 and 60 years old. - People recently diagnosed with sleep apnea that has not yet been treated, with a moderate or less severe level of breathing disruptions during sleep...

Who might be able to join this trial: - People who are willing and able to follow the study protocol throughout the trial - People who meet the requirements for having an fMRI brain scan (confirm with trial site) - People who are willing to avoid alcohol and recreational drugs for the entire duration of the study - Peo...

Who might be able to join this trial: - You are able to follow basic instructions and can sit comfortably while wearing some sensor leads attached to your body. - You are experiencing symptoms of stress, anxiety, or sleep problems, and you score at or above a certain level on at least one of the following self-reported...

**Who might be able to join this trial:** - Adults aged 18 years or older - Men or women - People who have signed a free and informed consent form - People who are part of a social protection scheme (such as health insurance or social security coverage) - People in one of the following groups: those with a primary slee...

**Who might be able to join this trial:** - People who experience more than 10 breathing interruptions per hour during non-REM (lighter stage) sleep while lying on their back, as measured by a sleep study. **Who may not be able to join:** - People who have a medical condition other than well-controlled high blood pres...

Who might be able to join this trial: - People who are 18 years of age or older, of any gender Who may not be able to join: - People who are not willing or able to use a CPAP machine (a breathing device worn during sleep) to treat obstructive sleep apnea - People who have other sleep disorders in addition to the condi...

**Who might be able to join this trial:** - Adults aged 18 and over, both men and women - People who have been referred to a sleep clinic because doctors suspect they may have obstructive sleep apnea (OSA) - People who have normal blood pressure and whose sleep study shows a breathing interruption score (AHI) of 30 or...

Who might be able to join this trial: - People between the ages of 56 and 85 years old - People who score 18 or above on a memory and thinking test called the Montreal Cognitive Assessment (MoCA) - People whose level of daily functioning is not significantly affected by memory problems, as measured by a standard rating...

**Who might be able to join this trial:** - People who have been experiencing ongoing, long-term excessive sleepiness, which has been identified by a sleep specialist and requires further objective testing at the Centre de Hypersomnias Rares - People who may or may not have already received a formal diagnosis of a chro...

Who might be able to join this trial: - Children who are older than one year of age. - Children who have been sent to a sleep clinic because doctors suspect they may have sleep apnoea. Who may not be able to join: - Children whose parents, legal guardians, or carers are not fluent in English, or who have special commu...

Who might be able to join this trial: - Adults aged 40 years or older - People who have a confirmed diagnosis of obstructive sleep apnoea (a condition where breathing repeatedly stops during sleep), with a test result showing 5 or more breathing interruptions per hour - People who have been referred for treatment with...

**Who might be able to join this trial:** - People who have been diagnosed with MGUS (a blood condition where abnormal proteins are found) or Multiple Myeloma (a type of blood cancer) - People who are already scheduled to have a bone marrow biopsy as part of their normal medical care **Who may not be able to join:** -...

**Who might be able to join this trial:** - People who are military Veterans (men or women) and have been diagnosed with central sleep apnea, meaning their sleep breathing test shows more than 15 breathing pauses per hour overall, with more than 5 of those per hour being the "central" type (where the brain fails to sen...

"Who might be able to join this trial: - You may be eligible if you are suspected of having sleep apnea because of symptoms such as snoring, stopping breathing during sleep (noticed by someone else), waking up feeling like you are choking, feeling overly sleepy during the day, not feeling rested after sleep, having tro...

"Who might be able to join this trial: - People who are at least 28 weeks pregnant - People who are receiving prenatal (pregnancy) care at Michigan Medicine - People who own either an Android or iPhone smartphone Who may not be able to join: - People who are less than 28 weeks pregnant - People who receive their prena...

Who might be able to join this trial: - People who are at least 18 years old and have not yet reached menopause - People who are scheduled to have a planned (non-emergency) breast cancer operation - People who have been assessed by a doctor as being in generally good to mild-risk health for anaesthesia (ASA classificat...

**Who might be able to join this trial:** - You have shown signs of memory or thinking problems, based on a score from one of three recognised memory tests (confirm with trial site for specific score ranges) - You have been diagnosed with mild memory problems or dementia possibly related to Alzheimer's disease, reduce...

**Who might be able to join this trial:** - People aged between 18 and 85 years old, of any sex - People who have been admitted to a stroke unit within 72 hours of their stroke symptoms starting - People whose first-ever stroke has been confirmed by a CT scan or MRI scan, regardless of where in the brain it occurred -...

**Who might be able to join this trial:** - People who are not very physically active, meaning they do less than 3 sessions per week of vigorous exercise lasting 20 minutes or more - People who are able to move around on their own without using a wheelchair **Who may not be able to join:** - People who have been diagn...

**Who might be able to join this trial:** - People who have been referred to the sleep-school program at Bjørgvin DPS psychiatric hospital - People who meet the recognised diagnostic criteria for insomnia alongside a moderate to severe psychiatric condition, confirmed through standard diagnostic tools used in Norway, i...

Who might be able to join this trial: - People whose symptoms and condition are consistent with a diagnosis of normal-pressure hydrocephalus (a condition where fluid builds up in the brain without increased pressure) Who may not be able to join: - People who have cerebrovascular disease (problems affecting the blood v...

Who might be able to join this trial: **For people with prostate cancer:** - Men aged 18 or older with prostate cancer that has been confirmed by a tissue sample (biopsy) showing a type called adenocarcinoma - People whose cancer is localised (contained in the prostate), locally advanced, or has spread to other parts...

Who might be able to join this trial: - Adults aged 18 or older - People with an Apnea-Hypopnea Index (AHI) score of 15 or more — this is a measure of how many times per hour breathing stops or becomes shallow during sleep (confirm with trial site) Who may not be able to join: - People with a Body Mass Index (BMI) of...

**Who might be able to join this trial:** - People who have been diagnosed with mild or moderate obstructive sleep apnea (a condition where breathing repeatedly stops during sleep), based on a specific sleep test score between 5 and 30 events per hour - People whose airway blockage during sleep occurs specifically in t...

Who might be able to join this trial: - You report having trouble sleeping, such as difficulty falling asleep, waking up during the night, or waking up too early. - You are between 13 and 17 years old. - You are able to understand, read, and write in English. - You have never used melatonin before. Who may not be able...

**Who might be able to join this trial:** - People who have a planned (non-emergency) aorto-bifemoral bypass operation scheduled, which is a surgery to reroute blood flow around a blocked section of the main abdominal artery down to the legs **Who may not be able to join:** - People who need emergency surgery rather t...

**Who might be able to join this trial:** **For caregivers:** - People aged 18 or older - People who care for someone with dementia and live with that person - People who are willing to be randomly assigned to a treatment group - People who can read and understand English - People who have been diagnosed with insomnia...

**Who might be able to join this trial:** - People who are willing and able to give written consent to participate. - People who have been clinically diagnosed with Delayed Sleep-Wake Phase Disorder (DSWPD), a condition where a person's sleep timing is significantly shifted later than normal. - People between the ages...

**Who might be able to join this trial:** - People whose current medications have been stable for at least 4 weeks, where those medications are ones known not to affect sleep patterns or the body's internal clock. **Who may not be able to join:** - People who are suspected to have dementia, or who score below 24 on a...

Who might be able to join this trial: - People who are suspected of having obstructive sleep apnea (a condition where breathing repeatedly stops and starts during sleep) - People aged 18 or older - People who can speak, read, and understand Chinese or English - People who are able to answer questions and follow instruc...

Who might be able to join this trial: - Adults who are suspected of having obstructive sleep apnoea (a condition where breathing repeatedly stops during sleep) and who have been recommended to have a sleep study (polysomnography) Who may not be able to join: - People under 18 years of age - People who are unable to re...

**Who might be able to join this trial:** - Girls aged 10 to 17 years who are in the middle or later stages of puberty, based on breast development stage and/or whether their periods have started. - Girls who have higher-than-normal levels of male hormones (such as testosterone) for their stage of puberty, or who have...

Who might be able to join this trial: - People aged 18 to 75 years, of any gender - People who have a confirmed HIV diagnosis - People whose CD4+ T cell count (a measure of immune system health) is at least 200 cells/mm³ - People who are either on a stable HIV medication regimen with no plans to change it, or not curre...

**Who might be able to join this trial:** - People who have signed a consent form agreeing to take part - Children and teenagers between 6 and 18 years old - Patients (and at least one of their legal guardians or parents) who have a good understanding of German - Patients who came to the Emergency Department at the Uni...

Who might be able to join this trial: - People who have been diagnosed with cancer that has not spread to other parts of the body (any cancer type) - People aged 18 years or older - People who can read and understand French or English without difficulty - People who have the basic mental ability to read, understand, an...

**Who might be able to join this trial:** - You are 60 years old or older - You have type 2 diabetes with blood sugar levels that are not well controlled (based on a specific blood test result, called HbA1c, falling between 7.1% and 10%) - You are of Chinese ethnicity - You have sleeping problems (insomnia), based on a...

Who might be able to join this trial: - People who are able to do light physical activity, such as a gentle walk - People who are able to wear a headband device while sleeping (called the DREEM 2 Headband) - People who are able to wear a Fitbit-style wristwatch - People who are able to complete a home finger-prick bloo...

**Who might be able to join this trial:** This trial has two stages, each looking for different types of volunteers. **Stage 1 – Healthy volunteers:** - You are between 20 and 80 years old - You currently live in São Paulo, Brazil - You do not have any physical or intellectual disability that would stop you from atte...

**Who might be able to join this trial:** - People who are men, or women who are not pregnant or breastfeeding, aged 18 to 50 years old, and who are free from certain health conditions, medications, or devices that would prevent participation. - People whose sleep trouble meets the criteria for primary insomnia, as sh...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who experience at least one insomnia symptom (such as trouble falling asleep, waking during the night, or waking too early) at least 3 times per week, for at least 3 months - People who have access to an internet-connected devi...

**Who might be able to join this trial:** - People aged 18 to 35 years old, both men and women (with equal numbers of each) - People with a Body Mass Index (BMI) between 20.0 and 24.9, which is considered a "normal" weight range - People who are either not regularly active or only moderately active on a habitual basis...

"Who might be able to join this trial: - Children who have been on a breathing machine (mechanical ventilator) through a tube placed in the mouth or nose for at least 48 hours by 7 a.m. on the third day in the Pediatric Intensive Care Unit (PICU) Who may not be able to join: - Children for whom life support is current...

**Who might be able to join this trial:** - Children and teenagers between the ages of 5 and 18 (for one part of the study involving xenon gas imaging), or between the ages of 3 and 18 (for other parts of the study) - Children who still have moderate or severe sleep apnea after having their tonsils and adenoids remove...

Who might be able to join this trial: - People who are older than 18 years of age and have been diagnosed with rotator cuff syndrome that is being treated without surgery. Who may not be able to join: - People who have had previous surgery on their shoulder. - People who are receiving a corticosteroid (steroid) inject...

Who might be able to join this trial: - Adults who have been admitted to hospital or visited an emergency room unexpectedly due to a sudden episode of breathing failure where too much carbon dioxide builds up in the blood (confirm with trial site) - People who do not currently use a breathing support machine (such as C...

"Who might be able to join this trial: - You must be an adult (18 years or older) - You must have been diagnosed with Restless Legs Syndrome - You must be a member of the Restless Legs Syndrome association - You must speak French - You must be able to understand what the study involves - You must be willing and able to...

**Who might be able to join this trial:** - You have been diagnosed with either mild memory problems (amnestic MCI), Alzheimer's disease dementia, or have been assessed as clinically normal - You are able to read and sign a consent form agreeing to take part - Your medications have not changed in the 4 days before the...

Who might be able to join this trial: - Chinese children between 6 and 11 years old who snore regularly (at least 3 nights per week) and have been diagnosed with obstructive sleep apnoea (a condition where breathing repeatedly stops during sleep) confirmed by an overnight sleep study, along with enlarged tonsils and ad...

**Who might be able to join this trial:** - People aged 18 to 85 years old - People who meet at least one of the following: they are a known carrier of a specific genetic mutation (in the PRNP gene); they have a biological parent and other family members who have had a prion disease diagnosis; or they are a family mem...

Who might be able to join this trial: - People who are at least 18 years old at the time the study begins - People who have insomnia that is not caused by another medical condition (sometimes called "non-organic insomnia") (confirm with trial site) - People who have trouble falling asleep and/or staying asleep, with th...

**Who might be able to join this trial:** - People aged 18 to 65 years old - People who have been diagnosed with opioid use disorder (a problematic pattern of opioid use) according to standard medical criteria, with signs of physical dependence on opioids - People whose urine test shows the presence of fentanyl or a si...

**Who might be able to join this trial:** - People who have been diagnosed with severe obstructive sleep apnea (a condition where breathing repeatedly stops during sleep), with a score of more than 30 breathing interruptions per hour, and who are not currently using a CPAP machine (a breathing device used during sleep...

Who might be able to join this trial: - You are between 18 and 60 years old - Your Body Mass Index (BMI) falls into one of these groups: over 30 (the main study group), between 20 and 25 (comparison group 1), or between 25 and 30 (comparison group 2) Who may not be able to join: - There are no listed reasons that woul...

Who might be able to join this trial: - People aged between 25 and 64 years old - People with a body mass index (a measure of body weight relative to height) between 18.5 and 42 - People with high blood pressure, where resting blood pressure readings average between 130/80 mmHg and 160/100 mmHg Who may not be able to...

Who might be able to join this trial: - People who have been diagnosed with COPD (a lung condition that makes it hard to breathe) or IPF (a condition where the lungs become scarred over time) Who may not be able to join: - People who have been admitted to hospital for a serious breathing problem in the last month befo...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who are currently living in the United States - People who are able to use the REFRESH app on their own personal smartphone **Who may not be able to join:** - People who are unable to give their own informed consent to partici...

**Who might be able to join this trial:** - People who provide at least 10 hours of caregiving per week (any type of caregiving counts) - People who are willing to give their informed consent to participate - People who are able to follow basic instructions - People who are able to sit comfortably for up to 90 minutes...

Who might be able to join this trial: - Children and teenagers between 6 and 18 years old - People who have been diagnosed with Inflammatory Bowel Disease (IBD), confirmed through a camera examination of the gut and/or tissue testing - People who are receiving care from the paediatric (children's) gastroenterology team...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with a sleep condition called Isolated REM Sleep Behavior Disorder (iRBD), based on specific international diagnostic guidelines Who may not be able to join: - People who are unable to give or take back the...

**Who might be able to join this trial:** - You have been diagnosed with Mild Cognitive Impairment (MCI), meaning you have memory concerns reported by yourself and/or shown through testing - Your memory impairment has been rated as mild on a standard assessment called the Clinical Dementia Rating scale (score of 0.5,...

**Who might be able to join this trial:** - People who have a blood cancer diagnosis and whose treatment has been stable (no changes to cancer-related medications in the past two weeks), whether on a steady medication plan or under observation - People who are not currently taking part in another clinical trial that in...

Who might be able to join this trial: - The child has been diagnosed with obstructive sleep apnea (a condition where breathing repeatedly stops during sleep), confirmed by an overnight sleep study done in an accredited sleep laboratory within the past 12 months. - A qualified ear, nose, and throat (ENT) specialist has...

**Who might be able to join this trial:** - Men and women (who are not pregnant or breastfeeding) between 18 and 39 years old - People who can show they understand the study by scoring at least 80% on a short multiple-choice quiz (one retest is allowed if the first attempt is unsuccessful) **Who may not be able to joi...

Who might be able to join this trial: - People who meet the criteria for bariatric (weight loss) surgery, meaning they have a BMI of 35 or above with health complications related to their weight, or a BMI of 40 or above, and have not lost enough weight through diet and physical activity changes alone - People who have...

Who might be able to join this trial: - People who are between 13 and 18 years old - People who are currently attending a traditional in-person high school (note: school closures during the COVID-19 pandemic are considered an exception to this requirement) - People who are in good physical and mental health - People (a...

Who might be able to join this trial: - People who were previously enrolled in the Pre-Vent Study under an approved research protocol, either by signing a consent form or under a protocol that allowed being contacted again for future research - People who were born before 29 weeks of pregnancy (very premature birth) -...

**Who might be able to join this trial:** - You were diagnosed with a brain tumor and received treatment at Texas Children's Hospital - Your treatment included surgery alone, or surgery combined with proton beam radiation therapy - Your brain tumor was not one of the following types: high-grade glioma, brain stem gliom...

Who might be able to join this trial: - Adults aged 18 or older who are willing and able to give their informed consent to participate - People who have been diagnosed with obstructive sleep apnea, with a breathing interruption score of 5 or more events per hour - People who are interested in surgical treatments for ob...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been in hospital for longer than 24 hours - People who have been in hospital for longer than 36 hours - People who have been in hospital for at least 72 hours, do not have a history of sleep problems, and do not have any c...

**Who might be able to join this trial:** - People aged between 39 and 69 years old - People who have had surgery for breast cancer that has not spread, and who may or may not be starting chemotherapy after surgery - People who have completed at least the end of primary school education - People who have a good level...

**Who might be able to join this trial:** - People who are eligible in the Defense Enrollment Eligibility Reporting System (DEERS) (confirm with trial site) - People who are currently serving in the military (Active Duty) or veterans who left the military within the past 10 years - People with significant post-traumati...

Who might be able to join this trial: - People (male or female) who have moderate or severe sleep apnea, meaning they stop breathing or have very shallow breathing more than 15 times per hour during sleep. - People who are already scheduled to have a procedure called DISE (a sleep evaluation where a camera is used to l...

**Who might be able to join this trial:** - People who are already taking part in the SunSAS study, or people who have had a sleep breathing test (polygraphy or polysomnography) that showed they are suitable for treatment with a CPAP machine or a mouth device (MAD) for obstructive sleep apnoea (OSA) - People who have h...

Who might be able to join this trial: - People aged between 15 and 24 years old (as defined by the World Health Organization) - People who are willing to provide written agreement to take part, and for those under 18, a parent or guardian must also give written agreement - People who have mild sleep difficulties — expe...

**Who might be able to join this trial:** **For the person living with dementia:** - A doctor has documented a diagnosis of Alzheimer's disease or a related dementia in their medical records - Living in the community (not in a care facility) - Aged 60 years or older - Experiencing more than one sleep problem more than...

Who might be able to join this trial: - You speak English as your primary language - You are a U.S. Military Veteran - You are experiencing depression, based on scoring above 10 on a standard depression questionnaire (called the PHQ) - You are experiencing insomnia (sleep problems), based on scoring above 10 on a stand...

Who might be able to join this trial: - You have large tonsils that a doctor has rated as a 3 or 4 on a standard size scale (called the Brodsky scale) - The child agrees and the parent or guardian gives their permission to take part in all check-ups before and after the study, including sleep tests - Both the child and...

Who might be able to join this trial: **For people with iRBD (a sleep behaviour disorder):** - People who have been diagnosed with isolated RBD (a sleep disorder where people act out their dreams), confirmed by a sleep study called a polysomnogram. - People who are able to walk 50 metres on their own without using a w...

**Who might be able to join this trial:** - Adults aged 18 or older who speak English - People who have had a spinal cord injury in the neck or mid-back region (between levels C2 and T12) within the last 30 days - People whose spinal cord injury may be complete or partial (a range of severity levels are included) - Peo...

**Who might be able to join this trial:** - People who have had poor sleep quality for at least 2 weeks, with a score of 5 or higher on a standard sleep quality questionnaire called the PSQI - People who are able to communicate in English - People who are mentally alert enough to answer questions clearly, as measured...

Who might be able to join this trial: - People who are over 18 years old - People who are admitted to a hospital internal medicine ward for at least 3 nights Who may not be able to join: - No specific exclusion criteria have been listed for this trial (confirm with trial site) Important: Always verify eligibility wit...

**Who might be able to join this trial:** - People who have been diagnosed with mild obstructive sleep apnea or with snoring that is not related to sleep apnea - People who are 18 years of age or older - People who are able to give their informed consent to receive treatment and take part in the study **Who may not be...

**Who might be able to join this trial:** - People who have been diagnosed with Tourette's disorder according to DSM-5 criteria (a standard diagnostic guide used by clinicians) - People who have also been diagnosed with Insomnia disorder according to DSM-5 criteria - People whose tic severity scores meet a minimum thr...

**Who might be able to join this trial:** - People who score above 5 on a standard sleep quality questionnaire called the Pittsburgh Sleep Quality Index, which suggests they are experiencing poor sleep **Who may not be able to join:** - People who score below 20 on a memory and thinking assessment called the VA-SLUMS...

**Who might be able to join this trial:** - People who have been diagnosed with head and neck cancer for the first time, where their treatment plan includes radiotherapy - People aged 18 or older - People who have given written agreement to take part - People who have not previously had radiotherapy - People with a li...

**Who might be able to join this trial:** - The child has been diagnosed with Down syndrome (Trisomy 21) - The child has been diagnosed with moderate to severe obstructive sleep apnea (OSA), confirmed by a sleep study showing a specific level of breathing disruptions during sleep (oAHI of 5 or higher) - The child is b...

**Who might be able to join this trial:** - You have been diagnosed with a neurodegenerative disease (a condition where nerve cells in the brain gradually break down, such as Alzheimer's or Parkinson's disease). - You experience insomnia, excessive sleepiness during the day, or confusion at night. - You frequently wak...

**Who might be able to join this trial:** - Adults who had a spinal cord injury or disease more than 6 months ago, with any level of injury severity (classified A through D on a standard spinal injury scale), and who show signs of a sleep breathing disorder - People without a spinal cord injury who have been diagnosed...

**Who might be able to join this trial:** *For the first part of the study (Aim 1):* - You are between 18 and 70 years old - You are able to read and agree to a consent form *For the second part of the study (Aim 2), all of the above, plus:* - You have moderate-to-severe sleep apnea, meaning your breathing stops or i...

**Who might be able to join this trial:** - You are 18 years old or older - You are seriously ill and admitted to the Medical Intensive Care Unit (MICU) and need a breathing machine, breathing support through a mask or high-flow oxygen through the nose, or medications to support your blood pressure - You were admitted...

**Who might be able to join this trial:** - People who are willing to sign and date a consent form agreeing to take part - People who are willing to follow all study procedures and are available for the full duration of the study - People who are male or female, aged 65 years or older - People who can speak and read En...

Who might be able to join this trial: - Children and teenagers between 3 and 17 years old who are having their tonsils removed (with or without their adenoids removed) at Loma Linda University Health Who may not be able to join: - Children who have a condition they were born with that affects their development, or who...

Who might be able to join this trial: - People who are in their first or second year of undergraduate study at UCLA - People between 18 and 22 years old - People who are currently living in the residential halls on the UCLA campus - People who score 8 or above on a standard sleep questionnaire called the Insomnia Sever...

**Who might be able to join this trial:** - You are a Veteran between 18 and 89 years old - You have been prescribed opioid medication by a doctor **Who may not be able to join:** - Your body mass index (a measure of body weight relative to height) is over 40 (confirm with trial site) - You have a heart condition that...

**Who might be able to join this trial:** - Adults living with chronic (long-term) pain - People who have shown good adherence to their treatment plans - People with severe, long-term difficulty sleeping (chronic insomnia) - People for whom non-medication sleep therapies (such as sleep hygiene or talking therapies) hav...

Who might be able to join this trial: - People aged between 55 and 85 years old - People who have been diagnosed with a stroke (confirmed by MRI or CT scan) more than one year ago - People who are able to walk at least 6 metres on their own without assistance - People who score between 18 and 27 on a standard memory an...

**Who might be able to join this trial:** - You have been diagnosed with mild Alzheimer's disease, with a memory test score between 21 and 30 out of 30 - You are either not taking Alzheimer's medications (such as donepezil or memantine), or you have been on a stable dose of these medications for at least 3 months - You...

**Who might be able to join this trial:** - You are currently serving or have previously served in the military or other uniformed services - You have been diagnosed with a traumatic brain injury (TBI) that meets the criteria set by the Veterans Affairs or Department of Defense - Your TBI happened more than 90 days ago...

Who might be able to join this trial: **For cancer patients:** - Adults aged 18 or older - Currently receiving cancer treatment or follow-up care at the MGH Cancer Center - Scores above 3 on a standard distress rating scale (the NCCN Distress Thermometer) - Reports that their distress or main concern is connected to t...

**Who might be able to join this trial:** - People who have been diagnosed with obstructive sleep apnea (OSA), where breathing repeatedly stops or is reduced during sleep, with a severity score of 10 or more events per hour — and where more than half of those events are caused by the airway being blocked (rather than...

Who might be able to join this trial: - People who have been diagnosed with Mucopolysaccharidosis type I Hurler-Scheie or Scheie syndrome. - People who are 10 years of age or older at the time of registering for the study. - People whose kidneys are functioning well enough, as shown by a kidney filtering rate above a c...

Who might be able to join this trial: - People who have had a moderate to severe traumatic brain injury at least one year ago - People who are currently experiencing insomnia (ongoing trouble sleeping) - People who have reliable access to the internet - People who are able to give informed consent to participate Who m...

**Who might be able to join this trial:** - People who are between 18 and 24 years old - People who drink alcohol at high-risk levels in the past month — for women, this means 4 or more drinks in a day or 8 or more drinks per week; for men, 5 or more drinks in a day or 15 or more drinks per week - People whose sleep o...

Who might be able to join this trial: - People who are in their first through fifth year after completing medical school (Post-Graduate Year 1–5) - People currently enrolled in a residency program in anesthesiology, general surgery, obstetrics and gynecology, general medicine, or pediatrics at the University of Virgini...

Who might be able to join this trial: - People who are 18 years of age or older - People who are currently pregnant and up to 34 weeks along (first, second, or third trimester) - People who are experiencing sleep difficulties, indicated by a score of 8 or higher on a standard sleep questionnaire called the Insomnia Sev...

**Who might be able to join this trial:** - People aged between 30 and 60 years old - People who have been diagnosed with an insomnia disorder and take more than 30 minutes to fall asleep at least 3 nights per week - People who are able to understand the goals and risks of the research and can provide written, signed,...

Who might be able to join this trial: - The child has been diagnosed with early-childhood insomnia based on DSM-5 criteria (a standard set of diagnostic guidelines) - The parents want the child to be able to fall asleep and stay asleep without much help, and prefer to sleep separately from the child - The family has tw...

**Who might be able to join this trial:** - People who agree to take part and sign a consent form - People who are at least 18 years old - People who score 3 or more points on a screening tool called the STOP-Bang questionnaire, which checks for signs of sleep apnoea - People who have completed an overnight sleep study...

Who might be able to join this trial: - People who have recently been diagnosed with obstructive sleep apnea (OSA), with a sleep test result showing 5 or more breathing interruptions per hour - People aged between 20 and 65 years old - People with a body mass index (a measure of body weight relative to height) between...

Who might be able to join this trial: - People who have been diagnosed with carpal tunnel syndrome (a condition causing pain, numbness, or tingling in the hand and wrist) using the diagnostic standards set by the American Academy of Neurology Who may not be able to join: - People who have nerve problems in the neck, s...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been diagnosed with insomnia based on standard medical diagnostic criteria (DSM-5) - People whose insomnia severity score is greater than 10 on a standard measurement scale - People who receive healthcare through a pu...

Who might be able to join this trial: - Adults between 18 and 40 years of age - People who are not currently using any drugs (including caffeine, nicotine, alcohol, and herbal medications) - People who have been confirmed by a doctor to be free of disease Who may not be able to join: - People who do not eat or cannot...

**Who might be able to join this trial:** - People who are female and aged 18 or older - People who have been diagnosed with a specific type of early-stage breast cancer (called Ductal Carcinoma In Situ or stage I–III invasive breast cancer), confirmed through a tissue sample test - People whose general physical funct...

Who might be able to join this trial: - People aged 12 to 18 who have been diagnosed with atopic eczema by a Consultant Dermatologist, or healthy individuals without eczema (as a comparison group). - People with atopic eczema whose condition requires treatment that works through the immune system, or those currently ma...

**Who might be able to join this trial:** - People who are the main nighttime caregiver (mother or father) of a healthy baby or toddler aged 6 to 24 months, born at full term, with no twin or multiple birth - Caregivers who are between 19 and 65 years old - Caregivers who are native Korean speakers, meaning they can l...

Who might be able to join this trial: - People aged 14 to 18 who are currently enrolled as a full-time student in grades 9 through 12 - People of any gender - People who are willing and have a schedule that allows them to go to bed earlier than they currently do - People who plan to sleep at home in their own bedroom f...

**Who might be able to join this trial:** - Adults between 21 and 75 years old - People who report smoking at least 5 cigarettes per day for the past year and want to quit at the time of screening - People whose breath test shows a carbon monoxide level above 8 ppm at the time of recruitment - People who are willing t...

Who might be able to join this trial: - People who work in healthcare and have likely insomnia, shown by a score of 16 or lower on a sleep assessment tool called the Sleep Condition Indicator (SCI) - People who consider themselves frontline healthcare workers involved in directly managing patients - People who have acc...

Who might be able to join this trial: - You are between 50 and 90 years old. - You are scheduled for a planned (non-emergency) surgery such as hip or knee replacement, hernia repair, kidney cancer surgery, urologic, gynecologic, or spine surgery, and you are expected to stay in the hospital for at least 24 hours afterw...

**Who might be able to join this trial:** - People who have been diagnosed with Idiopathic Hypersomnia (a condition causing excessive sleepiness) based on recognised medical guidelines - People aged between 18 and 65 years - People whose body mass index (a measure of body weight relative to height) falls between 18 an...

**Who might be able to join this trial:** - People aged 12 to 18 who have not yet finished high school - People who have sleep problems, based on a score of 8 or higher on a standard sleep difficulty questionnaire called the Insomnia Severity Index - People who have had more than 3 episodes of self-harm in their lifeti...

**Who might be able to join this trial:** - People between the ages of 21 and 55 (male or female) - People who have been diagnosed with Idiopathic Hypersomnia (a condition causing excessive daytime sleepiness without a clear cause) or Hypersomnia linked to a psychiatric disorder, based on standard diagnostic criteria -...

**Who might be able to join this trial:** - Children and teenagers between the ages of 5 and 17 years old - Children who have just been prescribed a non-invasive breathing support machine (a mask-based device that helps with breathing, often used during sleep) - Children who have already tried using the breathing devic...

Who might be able to join this trial: - People who have been referred for their first course of electroconvulsive therapy (ECT) for depression that has not responded to other treatments, including those with unipolar major depression or bipolar depression - People whose depression is considered treatment-resistant, mea...

Who might be able to join this trial: - People who are over 18 years of age - People who are pregnant and between 20 and 24 weeks along at the time of joining the trial Who may not be able to join: - People who have worked shifts past 11pm at any point in the month before joining the trial - People who have been diagn...

Who might be able to join this trial: - The parent or caregiver of a child who has been recently diagnosed with mild obstructive sleep apnea, meaning a sleep study showed an AHI score (a measure of breathing interruptions during sleep) between 1 and 5 - The parent or caregiver of a child who is between 3 and 12 years o...

**Who might be able to join this trial:** - People who have been formally diagnosed with obstructive sleep apnea (OSA). - People who have been using a CPAP or BiPAP breathing machine for at least 3 months, wearing it for more than 6 hours a night on at least 75% of nights, and whose sleep apnea is well controlled on th...

Who might be able to join this trial: - People who have high blood pressure, either not fully controlled (whether or not they are taking medication), or controlled but requiring two or more blood pressure medicines to keep it under control. - People considered at high risk for obstructive sleep apnea (a condition where...

Who might be able to join this trial: - People who report having difficulty sleeping - People who are not currently physically active or do not exercise regularly - People with a low household income - People who are physically able to do moderate-intensity exercise (such as brisk walking) Who may not be able to join:...

Who might be able to join this trial: - People who have been diagnosed with Prader-Willi Syndrome (PWS), confirmed through genetic testing - People who score 12 or above on the Epworth Sleepiness Scale (ESS), which is a standard questionnaire used to measure daytime sleepiness Who may not be able to join: - People who...

Who might be able to join this trial: - People who are willing to use a Mandibular Advancement Device (MAD), which is a type of mouthguard worn during sleep to help keep the airway open - People whose initial sleep test showed more than 15 breathing interruptions per hour during sleep - People who experience excessive...

**Who might be able to join this trial:** - Adults aged 21 years or older - People diagnosed with moderate to severe obstructive sleep apnea, meaning their breathing stops or becomes disrupted 15 or more times per hour during sleep - People whose sleep apnea is mostly obstructive, with fewer than 5 central or mixed bre...

**Who might be able to join this trial:** - People who are 40 years of age or older - People whose breathlessness is rated at grade 2 or higher on a standard 0–4 breathlessness scale, meaning at least some limitation to daily activities due to shortness of breath - People whose lung function tests show reduced airflow...

**Who might be able to join this trial:** - People who are enrolled in VA (Veterans Affairs) healthcare - People of any gender aged 18 or older - People who have been diagnosed with long-term (at least 6 months) non-cancer muscle or joint pain, recorded at two or more medical appointments, and who rate their pain at 3...

Who might be able to join this trial: - Adults who are living with chronic (long-term) pain - People who have a mood disorder alongside their chronic pain - People who also experience chronic insomnia (ongoing, persistent difficulty sleeping) - People who are already receiving regular ketamine injections as part of the...

Who might be able to join this trial: - People aged between 55 and 85 years old - People whose thinking and memory are considered normal, based on a cognitive screening test score of 29 or higher - People who have moderate to severe sleep apnea, confirmed by a sleep test taken within the past 12 months (or confirmed by...

**Who might be able to join this trial:** - You must be willing and able to give written consent to take part before joining the trial, following local rules and regulations. - You have been diagnosed with stage I, II, or III breast cancer (confirmed by a tissue sample/biopsy) and are currently receiving hormone-based...

Who might be able to join this trial: - People diagnosed with Parkinson's disease that meets recognised medical diagnostic standards (either a confirmed or probable diagnosis). - People of Chinese Han heritage (across three generations), aged between 50 and 80 years old, of any gender. - People whose Parkinson's diseas...

**Who might be able to join this trial:** - People between 22 and 70 years of age - People who are unable to use, refuse to use, or cannot tolerate CPAP or a mouth device (mandibular advancement device) for sleep apnea — or, if using one, are doing so for less than 4 hours a night on fewer than 5 days a week - People...

Who might be able to join this trial: - The baby was born weighing 2,500 grams (about 5.5 pounds) or more - The baby was born between 37 and 42 weeks of pregnancy (considered full-term) - The caregiver speaks English - The baby receives primary care at the paediatric clinic running this trial - The family comes from a...

Who might be able to join this trial: - People who have a confirmed diagnosis of Down Syndrome and whose doctor has decided they need to start non-invasive breathing support (such as a CPAP or BiPAP mask-based device). - People whose sleep study results show more than 2 breathing interruptions per hour, or more than 1...

**Who might be able to join this trial:** - You are 60 years of age or older when you sign up - You have sleep problems, based on a sleep questionnaire score of 16 or below, and/or you meet certain standard criteria for insomnia based on your symptoms - You have noticed problems with your memory or thinking in everyda...

Who might be able to join this trial: - People who report using Z-hypnotics (a type of sleeping pill, such as zopiclone or zolpidem) more than 4 days per week for more than 4 weeks Who may not be able to join: - People who have been diagnosed with dementia - People who have been diagnosed with psychosis - People who h...

Who might be able to join this trial: - Adult males between 18 and 65 years old, or pre-menopausal adult females between 18 and 50 years old — including those with a specific inherited form of diabetes called MODY2 - People whose weight has been stable (not changing by more than 5%) over the past 6 months - People with...

Who might be able to join this trial: - You are 18 years of age or older - You have been diagnosed with moderate-to-severe obstructive sleep apnea (OSA), which means you stop breathing frequently during sleep - You are able to attend the required study visits and sessions - You have reliable access to a phone Who may...

**Who might be able to join this trial:** - You are between 18 and 70 years old - You are willing to sign a consent form and follow all study requirements for the full duration of the trial - You own a smartphone (iPhone or Android) - You currently eat across a window of 12 hours or more per day, and are able to log yo...

Who might be able to join this trial: - People who are 70 years of age or older - People who are scheduled to have a major bone or joint surgery - People whose recovery in hospital after surgery is expected to last more than 24 hours Who may not be able to join: - People who have a cognitive (thinking or memory) condi...

Who might be able to join this trial: - People who have Down syndrome, meaning their cells carry an extra copy (all or part) of chromosome 21 Who may not be able to join: - People whose heart electrical activity test (ECG) shows abnormal results - People who have heart failure or cardiovascular (heart and blood vessel...

Who might be able to join this trial: - People aged 16 to 64 years old - People who have been diagnosed with a current or past mental or behavioural disorder that falls within specific recognised categories (confirm with trial site for the full list of qualifying diagnoses) - People diagnosed with autism spectrum disor...

**Who might be able to join this trial:** - People aged between 18 and 45 years old - People with a body mass index (a measure of body weight relative to height) between 25 and 35 - People who typically sleep 6.5 hours or less per night - People who typically have an eating window (the time from their first to last me...

Who might be able to join this trial: **For people living with dementia:** - People aged 60 or older - People who have been diagnosed with dementia by a doctor, or who report memory problems and score above a certain level on a standard memory assessment tool - People who score above 10 on a standard questionnaire tha...

Who might be able to join this trial: - People between the ages of 12 and 99 - People who are able to read, understand, and sign a consent form, or children under 18 whose parents can sign on their behalf, and who have been referred for an overnight sleep study at a clinical sleep laboratory - People who are suspected...

Who might be able to join this trial: - People who have been diagnosed with obstructive sleep apnea (OSA) - People aged 21 years or older - People who are currently wearing a Mandibular Advancement Device (a dental mouthpiece used to treat sleep apnea), adjusted to at least 50% of the maximum setting possible for that...

**Who might be able to join this trial:** - You are scheduled to have a type of lung surgery performed through small cuts in the chest (such as removal of part or all of a lung lobe) - Your overall health has been rated by a doctor as either fully healthy or having only mild health conditions that do not greatly limit...

Who might be able to join this trial: - People who have been assessed by their doctors as medically suitable for planned (non-emergency) heart bypass surgery (CABG) - People aged 21 years or older - People who speak English or Mandarin - People who are able to give their own consent to participate Who may not be able...

**Who might be able to join this trial:** - People between 20 and 65 years of age - People with an ASA physical status classification of Grade I, II, or III (a rating used by anaesthetists to describe overall health before surgery — confirm with trial site) - People who are scheduled for a planned, non-emergency surger...

Who might be able to join this trial: - Adults of Chinese background between 18 and 70 years old - People whose insomnia symptoms score 10 or higher on a standard insomnia rating scale called the Insomnia Severity Index Who may not be able to join: - People who have a psychotic disorder, such as bipolar disorder or sc...

Who might be able to join this trial: - People who have been diagnosed with mild to severe obstructive sleep apnea Who may not be able to join: - People who have chronic sinus inflammation with nasal polyps (growths inside the nose) - People who have enlarged adenoids (tissue at the back of the nasal passage) - People...

Who might be able to join this trial: - Adults aged 18 years or older - People who have been diagnosed with obstructive sleep apnea (a condition where breathing repeatedly stops during sleep) with a severity score of 5 or more on a standard sleep test, and whose condition requires CPAP treatment (a breathing machine us...

**Who might be able to join this trial:** - You have been diagnosed with Parkinson's disease according to standard medical guidelines, with symptoms at a moderate stage (not too mild and not too severe, known as Hoehn and Yahr stages 2–3). - You have been on a stable Parkinson's medication routine for at least one mont...

**Who might be able to join this trial:** - People who are over 18 years of age - People who are receiving care from a surgeon at MU Health Care - People who are having weight loss surgery through the Weight Management and Metabolic Center - People whose body mass index (a measure of body weight relative to height) fa...

**Who might be able to join this trial:** - You are between 50 and 80 years old - You have been diagnosed with mild cognitive impairment (early-stage memory or thinking difficulties) based on a specific set of medical guidelines known as Peterson's criteria - You have noticed problems with your memory or thinking yours...

Who might be able to join this trial: - You have had painful nerve damage (a condition affecting the nerves outside the brain and spinal cord) that has lasted for more than 3 months - Your pain has been moderate to severe, meaning you would rate it at least 4 out of 10 on a pain scale over the past week Who may not be...

Who might be able to join this trial: - Adults of Chinese background between 18 and 70 years of age. - People whose score on the Insomnia Severity Index is less than 10, meaning their sleep difficulties are mild or minimal (confirm with trial site). Who may not be able to join: - People who have a psychotic disorder s...

**Who might be able to join this trial:** - Chinese young people between 15 and 24 years old - People whose insomnia symptoms score 9 or above on a standard insomnia measurement scale (the Insomnia Severity Index) - People whose anxiety symptoms score 10 or above on a standard anxiety measurement scale (the General Anx...

Who might be able to join this trial: - People who have not experienced withdrawal symptoms in the past 2 weeks - People who are currently stabilised on buprenorphine, either having started it within the past 3 months or having had their dose adjusted within the past 3 months (for example, reducing the dose with a goal...

Who might be able to join this trial: **If you have sleep apnea (Cases):** - You are between 18 and 75 years old - You have been diagnosed with moderate to severe sleep apnea (meaning your breathing stops or becomes shallow at least 15 times per hour during sleep) - You are willing to use a PAP machine (a breathing de...

**Who might be able to join this trial:** - You are 60 years of age or older - You are scheduled to have heart surgery that involves a heart-lung bypass machine - You are expected to be admitted to the intensive care unit (ICU) after your surgery **Who may not be able to join:** - You have a known allergy or sensitivi...

Who might be able to join this trial: - People who have a primary diagnosis of a schizophrenia-related condition or a mood disorder that includes psychotic features, as confirmed by their treatment team or medical records. - People who have been assessed by a licensed psychologist or attending psychiatrist as being abl...

**For people with dementia:** Who might be able to join this trial: - People who have been diagnosed with dementia - People who are 50 years of age or older - People who have enough cognitive ability to answer survey questionnaires - People who are able to communicate in Mandarin or Taiwanese Who may not be able to j...

**Who might be able to join this trial:** - Adults aged 19 years or older. - People who have had surgery to remove part of the rectum (the lower part of the large bowel) due to rectal cancer, where the cancer was within 15cm of the opening of the back passage. - People who are at least 24 months (2 years) past their su...

Who might be able to join this trial: - People who are not currently meeting the recommended levels of physical activity - People between the ages of 21 and 75 years old - People with a body mass index (a measure of body weight relative to height) of 25.0 or above - People who typically sleep 6 hours or less per night...

Who might be able to join this trial: - People aged 50 years or older - People who identify as American Indian or Alaskan Native - People who have been diagnosed with obstructive sleep apnea (a condition where breathing repeatedly stops and starts during sleep) - People who have been prescribed PAP therapy (a breathing...

Who might be able to join this trial: - People of any gender - Children and teenagers between 3 and 18 years old - People who live in the city of São Paulo, Brazil - People who are scheduled to have a sleep study (called a polysomnography) at the Sleep Laboratory of the Children's Institute at Hospital das Clínicas, Un...

**Who might be able to join this trial:** **For young people:** - You are willing to take part and have permission from a parent or guardian - You are between 12 and 18 years old - You are currently a patient at Kids Plus Pediatrics - You are currently experiencing depression - You sleep less than 7 hours on school ni...

**Who might be able to join this trial:** **For people living with cognitive impairment:** - People who have been diagnosed with Alzheimer's Disease or a related form of dementia, or whose caregiver has reported that they likely have some level of memory or thinking problems - People who score between 12 and 24 on a s...

Who might be able to join this trial: - People aged between 18 and 65 years old - People who have given signed consent to take part in the study - People who are covered by a social security or health insurance scheme - People joining the insomnia group must have a known diagnosis of insomnia and be receiving treatment...

**Who might be able to join this trial:** - People who are aged between 18 and 40 years old at the time of signing the consent form - People who have been diagnosed with Idiopathic Hypersomnia (a condition causing excessive sleepiness) at a specialist sleep disorder centre, following recognised international diagnosti...

**Who might be able to join this trial:** - The child has been diagnosed with moderate to severe sleep apnea (a condition where breathing repeatedly stops during sleep), confirmed by a sleep study showing a certain level of breathing interruptions. - The child is between 2 and 17 years old. - The child has small tonsi...

**Who might be able to join this trial:** - People who are able to give informed consent to participate - People who are 25 years of age or older at the first study visit - People who have been diagnosed with any type of solid tumour and who are currently receiving, or have received in the past 18 months, treatment ai...

**Who might be able to join this trial:** *RBD Group:* - People who are patients at the Sleep Disorders Centre at Guy's and St Thomas' NHS Foundation Trust and have been diagnosed with REM Sleep Behaviour Disorder (a sleep condition where people act out their dreams). - People who are 50 years of age or older. *Contr...

**Who might be able to join this trial:** - You are between 18 and 80 years old - You were first diagnosed with stage 1 to 4 breast cancer within the last 10 years - You are currently experiencing both anxiety and sleep problems (insomnia), each rated above 3 out of 10 in terms of how much they affect you - If you take...

**Who might be able to join this trial:** - You can be male or female, of any race or ethnicity. - You must be 65 years of age or older and able to sign a consent form yourself. - You must show no signs of memory or thinking problems based on a standard assessment called the Clinical Dementia Rating (confirm with trial...

**Who might be able to join this trial:** - People who have been diagnosed with a stroke, confirmed by a CT scan or MRI. - People aged 65 years or older (both men and women). - People whose basic body functions, such as heart rate and blood pressure, are currently stable. **Who may not be able to join:** - People who...

Who might be able to join this trial: - You must be 18 years of age or older. - You have been diagnosed with breast cancer and are about to start treatment before surgery, or you have colon cancer and have had surgery to remove it and now need additional treatment — confirmed by a laboratory test. - Your kidneys are wo...

**Who might be able to join this trial:** - People aged 18 or older - People who can read and communicate effectively in English (at US sites), or in English or French (at the Canadian site) - People who meet the clinical criteria for chronic insomnia - People with a Body Mass Index (BMI) of 18.5 or higher **Who may n...

**Who might be able to join this trial:** - You must be an adult (18 years or older) - Your body weight relative to your height (BMI) must be less than 30 kg/m² - You have been diagnosed with mild to moderate sleep apnea (a condition where breathing repeatedly stops during sleep) - A special sleep test using a camera a...

**Who might be able to join this trial:** - People who have moderate-to-severe obstructive sleep apnea, meaning their sleep study showed 15 or more breathing interruptions per hour **Who may not be able to join:** - People who have a serious disease affecting a major organ (such as the heart, lungs, or kidneys) that w...

Who might be able to join this trial: - People who are at least 60 years old - People who are able to give informed consent (formally agree to take part in the study) - People who have tried a cannabis product at least once in the past with no negative effects - People who have not been using cannabis products regularl...

Who might be able to join this trial: - You are a student attending a high school or upper secondary school in Sweden. Who may not be able to join: - There are no specific exclusion criteria listed for this trial (confirm with trial site). Important: Always verify eligibility with the trial site directly before apply...

Who might be able to join this trial: - People who have been diagnosed with obstructive sleep apnea syndrome, confirmed by a test showing more than 5 breathing interruptions per hour during sleep - People who are right-handed Who may not be able to join: - People who have previously used breathing therapy machines (su...

Who might be able to join this trial: - People who have recently been diagnosed with moderate or severe sleep apnea, meaning their breathing stops or becomes shallow more than 15 times per hour during sleep. - People who are between 18 and 70 years old. - People who do not have a history of severe heart or brain/nervou...

Who might be able to join this trial: - People within the required age range (confirm age limits with trial site) who agree to take part and sign a consent form. Who may not be able to join: - People who have already been diagnosed with obstructive sleep apnea (a condition where breathing repeatedly stops and starts d...

Who might be able to join this trial: - People who are at least 18 years old at the time of receiving the device implant - People who have moderate to severe obstructive sleep apnoea, meaning their breathing interruptions during sleep fall within a specific measured range (between 15 and 65 events per hour) - People wh...

Who might be able to join this trial: - People aged between 18 and 45 years old - People who have been diagnosed with insomnia disorder according to a standard sleep disorder classification system (ICSD-3) - People whose insomnia severity score is above 10 on a standard questionnaire called the Insomnia Severity Index...

"Who might be able to join this trial: - Children aged 6 to 16 years old who have been diagnosed with CCHS (also known as Ondine Syndrome, a rare condition that affects automatic breathing) - Children with an IQ score above 70 - Children who speak French - Children whose both parents have signed a consent form agreeing...

**Who might be able to join this trial:** - Children who are between 6 and 12 years old (inclusive). - Children whose body weight is above average for their age and sex, based on World Health Organization reference standards. - Children who typically sleep 9 hours or less per night, based on a sleep diary filled in by...

Who might be able to join this trial: - People who have been examined at the University Hospital of Northern Norway (UNN) and have been given a diagnosis of long-term, non-cancer-related pain according to standard international diagnosis codes (ICD-10) - People who also have ongoing sleep problems (insomnia) alongside...

Who might be able to join this trial: - People aged between 12 and 18 years old. - People who have at least one parent with a history of depression or anxiety disorders, but who do not have a significant personal history of these types of conditions themselves. - People who score 10 out of 25 or higher on a standard sl...

**Who might be able to join this trial:** - People who have been diagnosed with ulcerative colitis based on specific Chinese medical guidelines (Beijing, 2018) - People who have complete medical records and are willing to sign a consent form **Who may not be able to join:** - People who have a history of mental illnes...

Who might be able to join this trial: - People who have been diagnosed with a moderate or severe depressive episode (without psychotic symptoms) at the time of joining the trial, based on standard international diagnostic guidelines. - People whose depression severity scores between 20 and 35 points on a standard clini...

Who might be able to join this trial: - Children who have been referred to an ear, nose, and throat (ENT) clinic because of symptoms related to breathing problems during sleep - Children who are between 18 months and 15 years old - Children (and/or their parents or guardians) who have a good understanding of the Swedis...

Who might be able to join this trial: - People who are currently experiencing a moderate or severe depressive episode without psychotic symptoms, as diagnosed using international medical guidelines (ICD-10) - People who have a diagnosis of recurring major depression or bipolar disorder (specific diagnostic codes: F33.1...

Who might be able to join this trial: - People who have a complaint of insomnia (trouble sleeping) - People aged between 18 and 75 years old - People who are able to independently fill out questionnaires or rating scales - People who agree to sign a consent form and commit to attending follow-up visits as part of the s...

**Who might be able to join this trial:** **For people with insomnia:** - Adults aged 18 to 64 years - People rated as generally healthy or with only mild health conditions (ASA physical status I–II) (confirm with trial site) - People with a body mass index (BMI) between 15 and 30 - People already scheduled to have a...

**Who might be able to join this trial:** - You are currently enrolled in a bachelor's degree program at one of the universities taking part in this study. - You are willing to give your consent to participate and have been fully informed about what the study involves. **Who may not be able to join:** - You are under...

Who might be able to join this trial: - People who are 18 years of age or older - People who have a good understanding of the Italian language - People who plan to continue with their pregnancy - People whose BMI (a measure of body weight relative to height) falls between 18 and 30, meaning they are neither underweight...

Who might be able to join this trial: - People who have been diagnosed with Obstructive Sleep Apnea (a condition where breathing repeatedly stops during sleep) confirmed by an overnight sleep study - People whose blood pressure does not drop as expected during sleep, as measured by a device worn to monitor blood pressu...

Who might be able to join this trial: - People who are between 18 and 65 years old, of any gender - People who are currently working as a nurse or nursing staff member (such as a Certified Nursing Assistant) in the United States - People who currently work night shifts or rotating shifts that include at least 2 nights...

Who might be able to join this trial: - The infant must be healthy, either male or female. - The infant must be 8 weeks old or younger. - The infant must have been diagnosed with infantile colic according to specific medical guidelines (called Rome IV criteria), meaning the baby cries or fusses for 3 or more hours per...

**Who might be able to join this trial:** - You have been diagnosed with a type of memory problem consistent with Alzheimer's disease (AD), confirmed by memory testing and either a spinal fluid test or a brain scan showing signs of AD. - You are between 55 and 80 years old. - You do not have significant problems with...

**Who might be able to join this trial:** - People who have signed an informed consent form agreeing to take part in the study - People who have been diagnosed with Parkinson's disease according to recognised medical diagnostic guidelines - People who have poor sleep quality, as shown by a score of more than 5 on a sta...

**Who might be able to join this trial:** *For babies identified as high-risk (detected shortly after birth):* - Babies born before 32 weeks of pregnancy - Babies born weighing less than 1,500 grams (about 3.3 pounds) - Babies diagnosed with a moderate to severe brain injury, such as bleeding in the brain, damage to b...

Who might be able to join this trial: - People who are 18 years of age or older - People for whom long-term CPAP therapy has been recommended to treat a sleep-related breathing condition - People who have not been able to tolerate CPAP and are using it for less than 3 hours per night on average, as assessed at a follow...

**Who might be able to join this trial:** - Your baby is 9 months old at the time of enrollment - Your baby was born at a normal weight (between 5.5 and 10 lbs) and after a typical length pregnancy (between 36 and 41 weeks) - You are able and willing to come back for follow-up visits at 3 and 6 months from enrollment (...

**Who might be able to join this trial:** - People who have given their voluntary written agreement to participate - Native Chinese speakers - Adults aged 18 to 60 years old, of any gender - People with a body mass index (a height-to-weight measurement) between 18 and 30 - People whose general health has been assessed...

Who might be able to join this trial: - People who are 60 years of age or older - People who are currently admitted to University of Washington Medical Center or Harborview Medical Center - People who have spent more than 24 hours in an intensive care unit (ICU) - People who have recovered from critical care and moved...

**Who might be able to join this trial:** - Adults aged 18 years or older, of any gender. - People who have worked a rotating night shift schedule for at least one year before the study begins, meaning at least 5 night shifts per month alternating with day and/or afternoon shifts. - People who do not plan to change th...

**Who might be able to join this trial:** - People who have a good enough understanding of English to give informed consent - People who are mentally able to give their own consent to participate - People aged between 55 and 85 years old, of any gender - People who have completed at least 8 years of education - People...

**Who might be able to join this trial:** - Men and post-menopausal women (the trial is looking for equal numbers of each, specifically 12 men and 12 post-menopausal women) - People with a body mass index (BMI) in either the normal range (18.5–24.9) or the overweight range (25–29.9) - People who self-report poor sleep...

**Who might be able to join this trial:** - People who are pregnant with one baby, between 14 and 31 weeks along at the time of screening - People who have been diagnosed with Insomnia Disorder according to standard psychiatric guidelines, lasting at least one month - People whose insomnia scores at least 11 on a stand...

Who might be able to join this trial: - Adults between 18 and 80 years old who are attending an anesthesia clinic for a dental procedure planned to be carried out under general anesthesia - People who have not previously been diagnosed with obstructive sleep apnea (a condition where breathing repeatedly stops and start...

**Who might be able to join this trial:** - People between 18 and 65 years old - People who have been diagnosed with relapsing-remitting or secondary progressive MS, confirmed by their neurologist - People with mild-to-moderate disability, scoring 6 or below on a scale called the Patient Determined Disability Steps (P...

Who might be able to join this trial: - People who have been diagnosed with RBD (a sleep condition where people act out their dreams) either on its own or linked to a brain/nerve disease - People aged 18 or older - People who can speak, read, and write in English - People who live in the United States - People who expe...

**Who might be able to join this trial:** - Your child is between 6 and 17 years old - Your child has been diagnosed with positional obstructive sleep apnea (a type of sleep apnea that is worse when sleeping on their back) based on an overnight sleep study, with specific test results meeting set thresholds (confirm wit...

Who might be able to join this trial: - Children aged 5 to 16 who have a blood cancer and are currently receiving treatment for it - Children whose parents have been told about the study and have agreed to take part - Children who are enrolled in the Social Security system Who may not be able to join: - Children who a...

**Who might be able to join this trial:** - People aged between 35 and 80 years old - People who have been diagnosed with dyslipidemia (a condition where blood fat levels such as cholesterol or triglycerides are abnormal), either through a previous diagnosis, current medication for it, or a recent blood test showing: t...

Who might be able to join this trial: - People aged 21 to 70 years old (inclusive) - People who have been diagnosed with migraine disease according to standard medical diagnostic guidelines (ICHD-3 criteria), or people who are generally healthy and do not have migraine (as a comparison group) Who may not be able to jo...

Who might be able to join this trial: **For people with serotonergic REM sleep behaviour disorder (5-HT RBD):** - People who have been diagnosed with REM sleep behaviour disorder (RBD), confirmed by a sleep study, and who have a history of acting out their dreams (or this was captured on video during the sleep study)....

Who might be able to join this trial: - Children and teenagers between 9 and 17 years old. - Patients who are scheduled to receive a stem cell transplant at Boston Children's Hospital. - Both the child and their main caregiver (such as a parent or guardian) speak English. Who may not be able to join: - Patients whose...

Who might be able to join this trial: - People who have been diagnosed with Delayed Sleep Wake Phase Disorder (a condition where a person's sleep schedule is shifted significantly later than normal). - People who currently live at an altitude equal to or higher than Denver, Colorado. - People whose Body Mass Index (BMI...

**Who might be able to join this trial:** - People diagnosed with moderate sleep apnea, meaning their breathing interruption score (called an AHI) is between 15 and 30 per hour - People with a Body Mass Index (BMI) under 35 - People who are covered by a social security or health insurance scheme - People who have agree...

Who might be able to join this trial: - People aged 20 or older who have been scheduled for an overnight sleep study (called a PSG) at Duke University Hospital - People who are able to understand the study information and sign a consent form before joining - People who are willing to participate, with the freedom to le...

**Who might be able to join this trial:** - Adults between 18 and 65 years old - People who have been diagnosed with moderate to moderately-severe sleep apnea, meaning their breathing stops or becomes shallow between 15 and 50 times per hour during a sleep study **Who may not be able to join:** - People who have been...

Who might be able to join this trial: - People who are generally healthy - People who do not have conditions affecting the heart, blood vessels, nervous system, lungs, liver, or kidneys - People who do not have any known skin allergies Who may not be able to join: - People who have been diagnosed with a heart, liver,...

**Who might be able to join this trial:** - Adults between 18 and 35 years old - People who are generally healthy, with no significant physical or mental health conditions (as decided by the study doctors) - Non-smokers - People who are not pregnant - People who normally sleep 7–9 hours per night and do not regularly t...

**Who might be able to join this trial:** **For all participants:** - People aged 18 to 75 years old, of any gender - People who are willing to follow all study procedures and be available for the full duration of the study - People who are able to understand and are willing to sign a written consent form **For parti...

**Who might be able to join this trial:** - People between 20 and 60 years old - People who have been working rotating shift schedules for at least 3 months and will continue doing so until the study ends - People who have sleep problems, such as sleeping less than 6 hours total or not being able to sleep effectively,...

**Who might be able to join this trial:** - Women who are in the late stage of the menopausal transition, as defined by a specific set of reproductive aging guidelines called STRAW+10 - People who score above 5 on a standard sleep quality questionnaire called the Pittsburgh Sleep Quality Index, which suggests poor sle...

Who might be able to join this trial: **For ongoing pregnancies:** - People who had been diagnosed with insomnia before becoming pregnant - People whose pregnancy is still ongoing and the outcome (such as miscarriage or live birth) is not yet known - People who took a sleep medication called QUVIVIQ at any point durin...

**Who might be able to join this trial:** - Women between 45 and 55 years old. - Women with a body mass index (a measure of body weight relative to height) between 25 and 30 kilograms per meter squared (confirm with trial site, as the upper limit appears unclear in the source). - Postmenopausal women who experience mod...

Who might be able to join this trial: - People who are taking part in a cardiac rehabilitation (heart recovery) program at one of the study centres, for any heart-related reason covered by Dutch medical guidelines - People aged 18 or older - People who are able to read and communicate in Dutch - People who are experien...

Who might be able to join this trial: - People whose body weight falls in the "overweight" range for their age and sex, meaning their BMI is at or above the 85th percentile but below the 95th percentile according to standard growth charts (for people aged 21–23, the equivalent values for a 20-year-old are used) - Peopl...

**Who might be able to join this trial:** - People attending a sleep clinic appointment to receive results from a sleep study for suspected obstructive sleep apnea (OSA) - People aged 18 years or older - People who have signed the informed consent form **Who may not be able to join:** - People who are unable to comple...

Who might be able to join this trial: - People who have signed and dated a consent form agreeing to take part - People who are unable to tolerate or have chosen not to use a CPAP or similar breathing pressure machine for sleep apnea - People who do not have very large tonsils (rated 3 or 4 out of 4 on a standard sizing...

Who might be able to join this trial: - People who are 18 years of age or older - People who have no medical reasons preventing them from having an MRI scan (for example, having certain types of metal implants in the body) Who may not be able to join: - People who are pregnant or who are planning to become pregnant du...

Who might be able to join this trial: - Adults aged 18 or older who are scheduled for a planned (non-emergency) heart surgery. Who may not be able to join: - People who are not willing to give their consent to take part in the trial. - People who are already taking sleep medications before their surgery. - People who...

**Who might be able to join this trial:** - People aged between 35 and 50 years old - People who have been diagnosed with COPD (a lung condition that makes it hard to breathe) at a moderate stage (classified as Stage 2 or Stage 3 according to a standard medical grading system called the GOLD criteria) - Both men and wo...

Who might be able to join this trial: - Adults aged 18 or older, of any gender - People who have been recently diagnosed or re-diagnosed with acute myeloid leukemia, acute lymphoblastic leukemia, Non-Hodgkin's lymphoma, multiple myeloma, or myelodysplastic syndrome - People who are staying in hospital for at least 7 da...

Who might be able to join this trial: - People who are pregnant and between 20 and 40 years old - People who are in their second or third trimester of pregnancy - People who have an uncomplicated pregnancy - People experiencing pregnancy-related lower back pain that scores more than 3 out of 10 on a standard pain scale...

**Who might be able to join this trial:** - Adolescents aged 13 to 18 who are in middle school or high school and have been diagnosed with, or have experienced symptoms of, chronic insomnia disorder — either currently or within the past year — based on a self-reported screening checklist. - Adolescents who live in one...

**Who might be able to join this trial:** - Pregnant women carrying a single baby who have a connection to the military - Between 18 and 45 years of age - Able to communicate during the screening process - Has access to a computer, smartphone, or tablet with an internet connection - Willing to use whichever bassinet is...

Who might be able to join this trial: - People aged between 18 and 65 years old - People who have been working night shifts for at least the past year - People who typically sleep between 5 and 9 hours within any 24-hour period - People with a Body Mass Index (BMI) between 20.0 and 35.0, whose weight has stayed within...

Who might be able to join this trial: - People aged 65 years or older - People who have been diagnosed with high blood pressure - People who can speak and read Danish - People who are able to give informed consent to participate - People who do not have other health conditions that would prevent them from taking part i...

**Who might be able to join this trial:** - Adults between 18 and 80 years of age - People who have been diagnosed with Obstructive Sleep Apnea Hypopnea Syndrome (a condition where breathing repeatedly stops or becomes shallow during sleep), with a specific severity score of 5 or more events per hour - People who are r...

Who might be able to join this trial: - People who have been diagnosed with severe sleep-disordered breathing (a condition where breathing is seriously disrupted during sleep) - People who are expected to be able to handle the procedures involved in the study - People who either do not have heart failure, or whose hear...

**Who might be able to join this trial:** - You have been diagnosed with major depressive disorder (a serious form of depression) without hallucinations or delusions, and your first episode of depression began before age 60 - Your current depression has not improved enough (less than 50% better, but at least some impr...

Who might be able to join this trial: - People who have been diagnosed with obstructive sleep apnea (a condition where breathing stops and starts during sleep) and have had a specific implanted device called the Inspire system fitted to help treat it - People in Group 1: Those who have already had an overnight sleep st...

Who might be able to join this trial: - You must be 18 years old or older. - You must have been diagnosed with moderate to severe obstructive sleep apnea (a condition where breathing repeatedly stops during sleep), confirmed by a sleep study. - You must be able to understand and complete a questionnaire as part of the...

**Who might be able to join this trial:** - Adults aged 18 to 80 years old - People who have already been diagnosed with obstructive sleep apnea (OSA), or who score at moderate-to-high risk on a standard sleep apnea screening questionnaire called the STOP-Bang Questionnaire - People who are already scheduled to have k...

**Who might be able to join this trial:** - People who have coronary artery disease (a condition where the blood vessels supplying the heart are narrowed or blocked), with or without other health conditions such as smoking, diabetes, high blood pressure, high cholesterol, kidney problems, being overweight, anxiety, de...

Who might be able to join this trial: - People who have been diagnosed with Shift Work Disorder (a sleep condition caused by working non-traditional hours) according to recognised international diagnostic standards. - People who are willing and able to provide written consent before any study procedures begin. - People...

**Who might be able to join this trial:** - You have been diagnosed with moderate or severe obstructive sleep apnea (a sleep condition where breathing repeatedly stops and starts during sleep) - You currently use a CPAP machine (a device that helps you breathe during sleep) with a nasal mask - Your CPAP data from the l...

Who might be able to join this trial: - People who have been diagnosed with moderate or severe obstructive sleep apnea (a condition where breathing repeatedly stops during sleep) - People who are currently using a CPAP machine with a nasal mask to treat their sleep apnea - People whose CPAP data from the last 7 days sh...

Who might be able to join this trial: - People who have a full set of teeth, up to and including the second molars at the back of the mouth - People who have had a sleep study done (either a full overnight study in a clinic or a home-based breathing monitor test) - People who have been diagnosed with obstructive sleep...

Who might be able to join this trial: - Children aged 3 years old up to (but not including) 18 years old - Children scheduled for a planned tonsil removal, with or without adenoid removal - A parent or legal guardian has signed a consent form on the child's behalf - Children aged 12 and older must also sign a written c...

**Who might be able to join this trial:** - People aged 18 or older, of any gender, with no upper age limit - People who have already been recommended to have an overnight sleep study (called a polysomnography) as part of their normal medical care, for any reason - People who typically sleep at least 6 hours per night,...

Who might be able to join this trial: - You must be a permanent resident of the household (meaning you live there full-time as your main home). Who may not be able to join: - Your roof has damage, cannot be safely accessed, or is unstable in a way that would prevent a cool roof coating from being applied. - You are un...

**Who might be able to join this trial:** - A doctor has diagnosed the person with knee osteoarthritis (this can be self-reported) - The person experiences ongoing knee pain that is at least moderate in intensity - The person has ongoing sleep problems consistent with insomnia, based on a specific sleep questionnaire...

**Who might be able to join this trial:** - You are 65 years old or older - You have been taking sleep medications (such as benzodiazepines or similar sleeping pills) at least 3 times a week on average over the past 3 months, based on what you or a family member/carer reports - You are taking these sleep medications sp...

**Who might be able to join this trial:** - People who have been diagnosed with obstructive sleep apnea (OSA), whether or not they are currently being treated for it, and who are scheduled for planned (non-emergency) surgery at the AUMC operating theatres with an expected hospital stay of at least 3 nights - People who...

Who might be able to join this trial: - Adults with a Body Mass Index (BMI) of 35 or higher who report that they snore - People who have a bed partner able to answer questions about their snoring - People who have already had a sleep study showing either no sleep apnea, or only mild sleep apnea (meaning the sleep study...

**Who might be able to join this trial:** **For people who snore or have sleep apnea (OSA):** - People aged 50 years or older. - People who snore and/or have sleep apnea (OSA) in a way that affects their own sleep quality or their sleep partner's sleep quality. - People who are currently using a snoring or sleep apnea...

Who might be able to join this trial: - Children aged 5 to 17 years, with or without Down Syndrome, may be considered for this trial. - Children who have been diagnosed with obstructive sleep apnea (a condition where breathing is repeatedly blocked during sleep) with a severity score between 5 and 40 breathing disrupti...

Who might be able to join this trial: - People who are female and between 18 and 45 years old - People with a body mass index (BMI) between 30 and 40, which is a measure of body weight relative to height - People whose excess weight is not caused by another medical condition (confirm with trial site) Who may not be ab...

Who might be able to join this trial: - People of any gender are eligible - People who speak German or Italian - People who have been diagnosed with a spine condition - People aged 14 years or older - People who consider themselves to be cognitively intact (thinking and memory functioning normally, based on their own a...

Who might be able to join this trial: - People who have been diagnosed with a type of irregular heartbeat called atrial fibrillation (AF), either the kind that comes and goes or the kind that persists over time - People who own a compatible smartphone - People aged 18 years or older Who may not be able to join: - Peop...

Who might be able to join this trial: - People who are living in a shelter at the time they are recruited for the trial - People who are over 18 years old Who may not be able to join: - People who have an allergy to medical tape (this applies to the diagnosis part of the study) - People who need major dental work or w...

Who might be able to join this trial: - High school students between the ages of 14 and 19 years old - People who have been diagnosed with Type 1 diabetes for at least one year - People who use an insulin pump or a similar automated device to manage their insulin - People who typically sleep 7 hours or less per night o...

Who might be able to join this trial: - People who are between 19 and 35 years old - People who have given birth by caesarean section (a surgical birth) - People who are having their first baby - People who are breastfeeding Who may not be able to join: - People who do not wish to take part in the research Important:...

Who might be able to join this trial: - People who have been diagnosed with a sleep condition called isolated REM Sleep Behaviour Disorder (iRBD) by a specialist in movement disorders, confirmed using recognised international sleep disorder guidelines - People who are able and willing to give written consent to take pa...

Who might be able to join this trial: - People who have been diagnosed with a neurocognitive disorder (such as dementia) caused by Alzheimer's disease, Parkinson's disease, Lewy body dementia, or mixed dementia, as defined by recognised psychiatric guidelines (DSM-5). - People whose score on a standard memory and think...

**Who might be able to join this trial:** - People who have a partial tear of a specific shoulder tendon (the supraspinatus), where the tear is smaller than 1 cm and affects less than half the tendon's thickness, confirmed by an ultrasound scan - People whose shoulder pain has been disrupting their sleep for at least...

**Who might be able to join this trial:** - Your child shows signs of obstructive sleep apnea, such as snoring or breathing pauses during sleep noticed by others, confirmed by a score of 0.33 or higher on a standard children's sleep questionnaire - Your child is already scheduled to have their adenoids, tonsils, or bot...

Who might be able to join this trial: - Adults aged 18 years or older - People who score above 8 on the Insomnia Severity Index, a questionnaire that measures how serious someone's sleep problems are - People who are considered physically inactive based on a standard activity questionnaire called the IPAQ Who may not...

**Who might be able to join this trial:** - You must be a generally healthy person - You must be a surgery resident doctor who works 24-hour shift rotations - Both males and females are welcome to participate - You must be 18 years old or older - People of any racial or ethnic background are welcome to join **Who may...

**Who might be able to join this trial:** - Men and women of any racial or ethnic background, between the ages of 25 and 45 (inclusive) - People who have been diagnosed with insomnia through a specific structured interview called the DUKE - People who are fluent in English and able to read and write in English - People...

Who might be able to join this trial: - People who have been diagnosed with insomnia disorder based on standard diagnostic guidelines (DSM-5) - People whose sleep quality score on the PSQI questionnaire is above 5, indicating poor sleep - People who are 18 years of age or older and have completed at least a junior high...

Who might be able to join this trial: - You have been diagnosed with insomnia disorder according to standard medical guidelines (DSM-5). - Your sleep quality score is above 5 on a standard questionnaire called the Pittsburgh Sleep Quality Index (PSQI), indicating poor sleep. - You are 18 years old or older and have com...

Who might be able to join this trial: - Adults who have been diagnosed with obstructive sleep apnea (OSA), a condition where breathing repeatedly stops and starts during sleep, ranging from mild to severe - People with sleep apnea who are about to start getting used to a CPAP machine (a breathing device worn during sle...

Who might be able to join this trial: - People who are over 18 years of age - People who have no communication difficulties - People who communicate in Turkish - People who do not have a diagnosed mental illness - People who are willing to take part in the study - People who are able to understand and complete forms an...

Who might be able to join this trial: - People who have been referred to the Sleep Clinic at St. Olavs Hospital for an assessment of a sleep or wakefulness problem. - People who are 18 years of age or older. - People who are willing and able to sign a written consent form to participate. - People who have been diagnose...

**Who might be able to join this trial:** - People aged 50 or older, of any sex - People who have been diagnosed with COPD (a chronic lung condition) according to recognised 2022 medical guidelines, whose condition is currently stable (no flare-ups in the last 4 weeks), and who have been recommended for breathing reha...

Who might be able to join this trial: - People with no known heart, blood vessel, or metabolic conditions (such as diabetes), and no sleep disorders - People who have not smoked in the past 3 months - People who are cleared for physical activity based on a standard health readiness questionnaire called the PAR-Q+ - Peo...

**Who might be able to join this trial:** - People who have been diagnosed with mild to moderate sleep apnoea (a condition where breathing repeatedly stops and starts during sleep) that does not meet the guidelines for treatment with a CPAP machine or a special dental device (called a mandibular advancement device) - P...

"Who might be able to join this trial: - People who work as a radiographer (a healthcare professional trained to perform medical imaging examinations) Who may not be able to join: - No specific exclusion criteria have been listed for this trial (confirm with trial site) Important: Always verify eligibility with the t...

Who might be able to join this trial: - People aged 55 or older. - People who are able to manage their own daily activities independently and who score 26 or higher on a standard memory and thinking test. - Women who have been through menopause (this applies because hormonal changes can affect sleep and the body's inte...

Who might be able to join this trial: - You are between 18 and 85 years old - You have been diagnosed with swelling (lymphedema) in one arm following breast cancer surgery - A doctor has confirmed your lymphedema is at stage 2 - You are willing to voluntarily agree to take part in the study Who may not be able to join...

Who might be able to join this trial: - People who have normal cognitive function, as measured by a telephone-based memory and thinking test (score of 29 or higher). - People who have been diagnosed with moderate to severe obstructive sleep apnea (a condition where breathing repeatedly stops during sleep). - People who...

Who might be able to join this trial: - You are willing and able to sign a consent form agreeing to take part in the study. - You have been officially diagnosed with Delayed Sleep-Wake Phase Disorder (DSWPD), a condition where you naturally fall asleep and wake up much later than normal. - You carry a specific gene var...

Who might be able to join this trial: - Children born to first-time mothers who were at 20 weeks of pregnancy between November 1st, 2024 and October 31st, 2025. Who may not be able to join: - Families who are not able to receive digital mail or communications (such as emails or electronic messages). Important: Always...

Who might be able to join this trial: - People aged 18 to 65 years old - People who have been assessed as having Alcohol Use Disorder (AUD), meeting at least 2 criteria as defined by a standard diagnostic tool called DSM-5 - People who have sleep problems, scoring 5 or higher on a standard sleep quality questionnaire c...

Who might be able to join this trial: - People who are not classified as obese - People who have been diagnosed with obstructive sleep apnea in a mild or moderate form Who may not be able to join: - People who have heart (cardiac) conditions - People who have metabolic diseases (such as diabetes or thyroid disorders)...

**Who might be able to join this trial:** - Adults aged 18 or older who speak English and whose sleep apnea treatment with a hypoglossal nerve stimulator (HGNS) — a device implanted to treat sleep apnea — has been working well, meaning it has reduced their breathing interruptions during sleep by at least 50% to below...

**Who might be able to join this trial:** - You are scheduled to have heart surgery (bypass surgery with or without valve work, or valve surgery alone) that requires opening the breastbone and using a heart-lung bypass machine, and your surgery is planned at least 10 days from now. - You are 60 years of age or older. -...

**Who might be able to join this trial:** - People who have a narrow upper jaw (a palate or upper jaw that is considered too narrow, often requiring expansion treatment) **Who may not be able to join:** - People who have one or more missing teeth that never developed (a condition where some adult teeth are congenitall...

**Who might be able to join this trial:** - You have given your free and informed agreement to take part and signed a consent form - You are covered by a health insurance plan - You are able to understand, read, and write in French - *(For people with depression)* You have been diagnosed with depression based on stand...

**Who might be able to join this trial:** - You are between 18 and 29 years old - You currently live in Washington State - You have a valid email address - You have at least moderate sleep problems, such as trouble falling asleep, staying asleep, or waking up too early (based on a standard sleep questionnaire score) -...

Who might be able to join this trial: - People aged 70 years or older - People of any sex - People of any race or ethnicity - People who have been admitted to one of the specific hospital units taking part in this study Who may not be able to join: - People who are going through withdrawal from alcohol or other substa...

**Who might be able to join this trial:** - People who are either currently admitted to hospital or attending as an outpatient - People aged 18 to 65 years old - People who have been formally diagnosed with both depression and non-organic insomnia (sleep problems not caused by a physical condition) according to the DSM...

**Who might be able to join this trial:** - You are between 18 and 25 years old - You are in good physical and mental health - *(Cannabis-using group only)* You have been using cannabis frequently (6 or more days per month) or daily for the past 3 months - *(Cannabis-using group only)* You are willing to stop using ca...

Who might be able to join this trial: - People who are 18 years of age or older - People who are living in Saskatchewan for the full duration of the treatment period - People who report having trouble sleeping, such as difficulty falling asleep, staying asleep, or waking up too early, and whose sleep problems cause dis...

Who might be able to join this trial: - People who have been diagnosed with heart failure based on international medical guidelines - People who are 18 years of age or older - People who are able to have a conversation over the phone - People who are willing to take part in the study Who may not be able to join: - Peo...