Narcolepsy Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with narcolepsy type 1, narcolepsy type 2, or idiopathic hypersomnia (a condition causing excessive sleepiness), confirmed by sleep testing that meets recognised diagnostic standards.
• If you have narcolepsy type 1, you must have tested positive for a specific gene marker called HLA DQB1*06:02.
• You have a body mass index (BMI) of 18.5 or above (a measure of weight relative to height).
• You are 18 years old or over.
• You are willing to make changes to your diet, which may include eating animal products such as meat and dairy.
• You are willing to regularly check your ketone levels using a finger-prick blood test and urine test strips.
• Your current everyday diet includes a moderate or high amount of carbohydrates — more than 130g of carbohydrates per day.
• You are willing to give consent to participate and to follow the study's requirements throughout.
• You have access to a computer, laptop, tablet, or smartphone with a reliable internet connection.
• You can read and understand English well enough to read an information sheet on your own, or you have someone who can support you during consultations if needed.

Who may not be able to join:

• Your BMI is below 18.5, or you have a history of an eating disorder with a score above 3 on a specific eating disorder questionnaire (EDE-Q).
• You have lost more than 5% of your total body weight in the last 3 months.
• You have previously had weight-loss (bariatric) surgery, or you are currently taking prescribed weight-loss medication.
• You have been diagnosed with an unstable psychiatric (mental health) condition, not including anxiety or depression.
• You have a cognitive (thinking or memory) impairment that would make it difficult to understand the study or give informed consent.
• You have a physical impairment that would prevent you from meeting the study's requirements.
• You are not able to read or understand English, and cannot read the participant information sheet.
• You do not have reliable internet access or a suitable device to take part in online video consultations and complete questionnaires.
• You are currently breastfeeding, pregnant, or could become pregnant and are not willing to avoid pregnancy during the study.
• Your current everyday diet is already low in carbohydrates or ketogenic — meaning you eat fewer than 130g of carbohydrates per day.
• Your current diet excludes all animal products (for example, if you follow a vegan diet).
• Your blood test results suggest another possible cause for your excessive sleepiness, as judged by the study doctor (confirm with trial site).
• You have changed your medication or dosage within the last 4 weeks.
• You have an inherited metabolic disorder, a history of dangerously low blood sugar (hypoglycaemia), or a condition called insulinoma.
• You have Type 1 or Type 2 diabetes and require insulin injections.
• You have uncontrolled medical conditions or significant health problems that the study doctor believes could put you at risk from the dietary changes involved in this study (confirm with trial site).
• You currently have a cancer diagnosis, not including certain skin cancers or non-harmful (benign) cancers.
• You are currently enrolled in another clinical trial involving a drug or medical intervention, or you have received an experimental drug within the last 12 weeks.

Important: Always verify eligibility with the trial site directly before applying.