NCT06819891

Who might be able to join this trial:

• You have been officially diagnosed with Crohn's disease (CD)
• Your Crohn's disease is considered moderately to severely active
• You weigh at least 40 kilograms (about 88 pounds)
• Previous treatments for Crohn's disease (either standard or newer therapies) have not worked well enough, stopped working, or caused you problems you could not tolerate
• If you are male or female and able to have children, you must agree to follow the trial's specific birth control requirements

Who may not be able to join:

• You have been diagnosed with a different type of bowel inflammation, such as ulcerative colitis, indeterminate colitis, ischemic colitis, infectious colitis, radiation colitis, or microscopic colitis
• You have had 3 or more bowel removal surgeries where more than 2 sections of your bowel were removed
• You have been diagnosed with short bowel syndrome (a condition where too much of the small intestine is missing or not working)
• You currently have an ileostomy, colostomy, or ileoanal pouch (surgical openings or pouches created to redirect waste from the bowel)
• You have a narrowing in your bowel causing symptoms, a very severe bowel inflammation (fulminant colitis), or a life-threatening bowel complication called toxic megacolon
• You currently have an abscess (a pocket of infection) in your abdomen or around your back passage (perianal area)
• You have certain types of abnormal tunnels or connections (fistulas) between the bowel and other organs or skin, including some types around the back passage with more than 3 openings
• You have been diagnosed with, or are suspected to have, a liver condition called primary sclerosing cholangitis
• You are currently pregnant, breastfeeding, or planning to become pregnant during the trial
• You have, or have had in the past, cancer of the digestive tract, or certain types of abnormal cell changes in the colon
• You have a history of cancer outside the digestive tract — with the exception of certain treated skin cancers or treated cervical cancer that has not spread
• During the screening process, you show signs of certain infections, including C. difficile (a gut infection), CMV, HIV, Hepatitis B, or Hepatitis C
• You have active tuberculosis (TB), or latent (inactive) TB that has not been fully and successfully treated
• You have previously received or are currently taking specific medications that are not allowed in this trial, including any treatment that targets a protein called TL1A (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.