Phase 2 Crohn's Disease and Colitis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who have been diagnosed with ulcerative colitis (a type of inflammatory bowel disease affecting the large intestine) for at least 3 months before the study start date, confirmed by a camera examination of the bowel and tissue samples taken either before or during the screening period
- People whose ulcerative colitis is active and affects a section of the bowel starting at least 15 centimetres from the back passage, as confirmed by a camera examination during screening (a small proportion of participants — up to around 15% — may have disease limited only to the rectum)
- People whose disease is rated as moderately to severely active, based on specific scoring tools that measure symptoms such as rectal bleeding and the appearance of the bowel lining during the camera examination
Who may not be able to join:
- People who have been diagnosed with Crohn's disease or a type of inflammatory bowel disease that doctors have not been able to clearly classify
- People who have, or are suspected to have, severe life-threatening inflammation of the colon, a dangerously enlarged colon, a hole in the bowel wall, or other conditions that are likely to require surgery during the early treatment phase
- People who have already tried four or more different classes of advanced treatments for their condition (whether approved or investigational) without success
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: SKYLINE-UC Study Director, Spyre Therapeutics
Phone: 1-650-402-4238
Australian sites
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
6 site(s) in Australia. Confirm current status and contact details directly with the trial site.
Primary endpoints
Part A: Change in Robarts Histopathology Index (RHI); Part B: Percentage of participants with clinical remission
Can't join this trial?
Data last synced from ClinicalTrials.gov: 6 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.