NCT02122380

Who might be able to join this trial:

• You are a woman between 18 and 40 years old
• Your body mass index (BMI) is 30 or higher (considered obese range)
• You have been diagnosed with polycystic ovary syndrome (PCOS) by meeting at least two of these three conditions: irregular or absent periods; signs of higher-than-normal male hormones (such as excess hair growth or elevated testosterone levels, without using hormone therapy or Metformin); or a history of polycystic ovaries confirmed by an ultrasound

Who may not be able to join:

• You are a current smoker
• You have Type 1 or Type 2 diabetes, shown by a high fasting blood sugar level at your screening visit or by taking diabetes medication
• You have high blood pressure that is untreated and above certain levels, or you take blood pressure medication
• You have a history of low blood sugar episodes
• You are pregnant or breastfeeding
• You have had your uterus and both ovaries surgically removed
• You are currently using hormonal birth control (pill or patch), unless you have stopped at least 8 weeks before the study starts
• You are currently taking insulin-sensitizing medications such as Metformin, unless you have stopped at least 8 weeks before the study starts
• You have anemia (low red blood cell levels) found at your screening visit
• You have a history of heart disease, heart failure, or stroke
• You have high blood pressure in your lungs (pulmonary hypertension)
• You have abnormal thyroid, prolactin, or certain hormone levels found at your screening visit
• Your kidneys are not functioning well enough (confirm with trial site)
• Your liver is not functioning well enough, shown by certain blood test results
• You have taken part in another clinical drug trial within the past month
• You are allergic to any medications used in this study
• You regularly work night shifts or have an unusual sleep schedule that disrupts your body clock
• You or a close family member (parent, sibling, or child) has a history of pancreatic cancer
• You have a personal history of pancreatitis (inflamed pancreas) or known problems with your pancreas
• You have a blood clotting disorder
• You regularly take anti-inflammatory painkillers such as ibuprofen, naproxen, or aspirin
• You have a mental health condition that would prevent you from fully understanding or participating in the study
• You are unable or unlikely to follow the study requirements or attend all follow-up visits
• You have any other ongoing condition requiring regular medication that could affect your safety or the study results (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.