NCT02354586

Who might be able to join this trial:

• You must be willing to have your tumor tested for a specific genetic marker (HRD) and have a blood test to check for a gene change called BRCA mutation.
• If you could become pregnant, you must have a negative pregnancy blood test within 72 hours before starting treatment.
• You must have been diagnosed (confirmed by lab testing) with high-grade (Grade 2 or 3) serous ovarian cancer, fallopian tube cancer, or primary peritoneal cancer that has come back, and you must have previously been treated with chemotherapy — including a platinum-based treatment that worked for at least 6 months.
• You must have completed exactly 3 or 4 previous chemotherapy treatment courses.
• You must have finished your last chemotherapy treatment more than 4 weeks before starting this trial.
• You must have cancer that can be measured on scans, according to a standard medical measurement system (confirm with trial site).
• You must have a stored tumor tissue sample available, or be willing to have a fresh tissue sample (biopsy) taken before the trial starts.
• You must agree to give blood samples at the start and end of the trial for genetic analysis.

Who may not be able to join:

• You may not be eligible if you had severe, long-lasting (more than 4 weeks) blood-related side effects or severe ongoing fatigue (Grade 3 or higher) during your last cancer treatment.
• You may not be eligible if you received radiation therapy to the pelvis area within the last year.
• You may not be eligible if you have brain or spinal cord metastases (cancer that has spread to the brain or surrounding tissue) that are causing symptoms and are not under control.
• You may not be eligible if you have a serious, uncontrolled medical condition, a major non-cancer illness, or an active infection that is not being controlled.
• You may not be eligible if you have had a blood transfusion (platelets or red blood cells) within 4 weeks before starting the trial.
• You may not be eligible if you have a history of, or have currently been diagnosed with, certain blood or bone marrow disorders called MDS (myelodysplastic syndrome) or AML (acute myeloid leukemia).

Important: Always verify eligibility with the trial site directly before applying.