NCT02839265

Who might be able to join this trial:

• You have been diagnosed with advanced non-small cell lung cancer (stage 3 or 4), confirmed by a biopsy or tissue sample, that cannot be cured
• You are 18 years old or older
• You have already received at least one standard chemotherapy treatment or targeted drug therapy before joining the trial
• A recent scan (within the last 21 days) shows your cancer is measurable and includes at least one lung tumor larger than 1 cm that can be treated with a specific type of focused radiation (SBRT), plus at least one other measurable tumor outside that radiation area
• You have had a physical examination within the last 30 days before registering for the trial
• You are generally well enough to carry out daily activities, with only mild limitations at most (confirm with trial site)
• You are willing and able to sign a consent form agreeing to take part

Who may not be able to join:

• You received chemotherapy, biological therapy, immunotherapy, radiation therapy (other than for pain relief), or had major surgery less than 21 days ago
• You have brain tumors that have not yet been treated, or if you have a history of brain tumors, your brain cancer has been getting worse recently or you received brain-directed treatment within the past 60 days
• You have been taking high-dose steroid tablets regularly within the last 21 days (steroid nasal sprays or inhalers are allowed)
• You still have significant side effects (grade 2 or higher) from a previous cancer treatment that have not resolved
• You have had an organ transplant from another person, or you have an autoimmune disease (a condition where your immune system attacks your own body)
• You currently have another active cancer (apart from lung cancer) that requires systemic treatment — though certain early-stage or fully resolved past cancers may still be allowed (confirm with trial site)
• You have serious uncontrolled health conditions such as severe heart failure, unstable chest pain, uncontrolled irregular heartbeat, or a mental health or personal situation that might make it difficult to follow the trial requirements
• Your recent blood test results (within 10 days of starting treatment) show that your blood cell counts or kidney function fall below the levels required for the trial (confirm with trial site)
• You are a woman of childbearing age with a positive pregnancy test

Important: Always verify eligibility with the trial site directly before applying.