NCT02979821

Who might be able to join this trial:

• You have been diagnosed with stage IV lung adenocarcinoma (an advanced form of lung cancer)
• Your tumor has a specific genetic change called a HER2 mutation, confirmed by genetic testing — and you have been confirmed negative for certain other mutations (EGFR, ALK, and ROS1), with tumor DNA still detectable
• You have already received at least one round of chemotherapy in the past (not including EGFR-targeted therapy)
• You are reasonably active and able to care for yourself, with only limited restriction of physical activity (confirm with trial site what this means for your situation)
• You have at least one tumor that can be measured on a scan
• Your blood counts and organ function (kidneys, liver, bone marrow) meet minimum health levels, as shown by recent blood tests

Who may not be able to join:

• Doctors estimate you have less than 3 months to live
• You have cancer that has spread to the brain or spinal cord that has not been treated with surgery or radiation — though people whose brain metastases are stable after treatment or are not causing symptoms may still be eligible (confirm with trial site)
• You have a serious or unstable health condition affecting your lungs, heart, liver, or kidneys, as judged by your doctor
• You have previously been treated with EGFR-targeted therapy (a specific type of targeted cancer drug)

Important: Always verify eligibility with the trial site directly before applying.