NCT03150810

Who might be able to join this trial:

• You are 18 years of age or older and have an advanced or spreading (metastatic) solid tumour cancer
• You are relatively active and able to carry out daily activities with little or no limitation (confirm with trial site for exact fitness level required)
• Your cancer can be detected and measured or evaluated through scans or tests, except for prostate cancer patients who may not need measurable disease
• You are willing to provide a stored sample of tumour tissue
• For certain specific groups joining the expansion phase: you have ovarian cancer with a specific genetic mutation (HRD+ or BRCA) and have had at least one platinum-based chemotherapy treatment, without your cancer returning within 6 months of that treatment
• For certain specific groups: you have triple-negative breast cancer with a specific genetic mutation (HRD+ or BRCA) and have had up to 3 prior treatments for advanced disease
• For certain specific groups: you have prostate cancer with a specific genetic mutation (HRD+ or BRCA), with either no prior chemotherapy or up to two prior taxane-based chemotherapy treatments, and your prostate cancer has been documented as getting worse
• For certain specific groups: you have small cell lung cancer or gastric (stomach) cancer and have had no more than 2 prior treatments
• For certain specific groups: you have another type of solid tumour with a specific genetic mutation (HRD+) (confirm with trial site)

Who may not be able to join:

• You have previously been treated with a type of drug called a PARP inhibitor
• Your cancer has stopped responding to platinum-based chemotherapy (applies to the expansion phase of the trial)

Important: Always verify eligibility with the trial site directly before applying.