NCT03366480

Who might be able to join this trial:

• You are 18 years of age or older
• You are willing and able to give your written agreement to take part in the trial
• You have been diagnosed with advanced, returning, or spread endometrial (womb) cancer of any type except carcinosarcoma or leiomyosarcoma; OR you have a confirmed diagnosis of squamous non-small cell lung cancer at an advanced or late stage (excluding certain mixed or rare types)
• You have tumour tissue available for testing — either a stored sample from the last 6 months or a new biopsy
• In the doctor's opinion, you are expected to live for at least 12 weeks
• You have at least one measurable tumour that can be tracked to see if the treatment is working
• Your general health and ability to carry out daily activities is rated at a good level (ECOG score of 0 or 1)
• You agree to use two reliable forms of contraception during the trial and for 6 months after the last dose of the study drug (applies to both men and women who could father or become pregnant)
• Your blood counts, liver function, and kidney function all meet the required levels as shown in blood tests (confirm specific values with trial site)
• Any side effects from previous cancer treatments have largely cleared up

Who may not be able to join:

• You have previously been treated with a drug that targets a specific cell signalling pathway called PI3K/Akt/mTOR (confirm with trial site)
• You received chemotherapy as a preventative or supportive treatment within the last 6 months
• You have brain tumours that are causing symptoms; those with treated, symptom-free brain tumours may still be considered if stable on medication for at least 1 month and without significant nerve damage
• You have stomach or gut problems that prevent you from swallowing tablets or absorbing medication properly
• You are currently pregnant or breastfeeding (a pregnancy test will be required within 7 days before starting treatment)
• You have had a heart attack within the last 12 months, or have significant heart failure, unstable chest pain, or a heart rhythm problem requiring medication
• You have high blood pressure that is not currently being controlled (those whose blood pressure is managed with medication may still be eligible)
• You have an active, uncontrolled hepatitis B, hepatitis C, or HIV infection
• You have another medical or mental health condition that, in the doctor's opinion, could interfere with treatment or put you at risk

Important: Always verify eligibility with the trial site directly before applying.