NCT03370744
Who may be able to join
Who might be able to join this trial:
Normal Cognition (NC) group:
- You are older than 60, right-handed, and of Han Chinese nationality
- You have no concerns or worries about your own memory or thinking ability
- Your results on standard memory and thinking tests are within the normal range for your age, sex, and education level
- Your physical examination shows no health problems
- Your medical and family history, and any additional health tests, show no conditions that could affect memory or thinking
- You are able to attend brain MRI scans once a year for five years in a row
Subjective Cognitive Decline (SCD) group:
- You feel that your memory or thinking has gradually gotten worse compared to before, and this is not linked to a specific event (such as an illness or injury)
- You do not meet the criteria for mild cognitive impairment (MCI) (confirm with trial site)
SCD-plus group:
- You feel that your memory or thinking has gradually gotten worse compared to before, and this is not linked to a specific event
- You have worries or concerns about your memory complaint
- You do not meet the criteria for mild cognitive impairment (MCI) (confirm with trial site)
Mild Cognitive Impairment (MCI) group:
- You have a clinical assessment score (called CDR) of 0.5, meaning very mild impairment, but you do not have dementia
- Your test scores show noticeable difficulty in at least one area of thinking, such as memory, language, or speed of thinking
- Your test scores show some level of difficulty across all three thinking areas tested
- Your score on a daily activities questionnaire (called FAQ) is 9 or higher (confirm with trial site)
Alzheimer's Disease (AD) group:
- You have been diagnosed with Alzheimer's disease according to recognised international guidelines, with a CDR score of 1 (confirm with trial site)
Who may not be able to join:
- You have claustrophobia (fear of enclosed spaces), have metal implants or devices in your body (such as metal dentures or pacemakers), or have any other reason you cannot have an MRI scan
- You are left-handed or use both hands equally
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Trial details
Where this trial is recruiting
Primary endpoints
The altered volume pattern in SCD/SCD-plus with progression.; The altered DTI pattern in SCD/SCD-plus with progression.; The altered functional MRI pattern in SCD/SCD-plus with progression.; The altered FDG-PET pattern in SCD/SCD-plus with progression.; The altered AV45-PET pattern in SCD/SCD-plus with progression.; Genotype of SCD/SCD-plus with progression.; AD7c-NTP level of SCD/SCD-plus with progression.; Gut microbiota of SCD/SCD-plus with progression.
Can't join this trial?
Data last synced from ClinicalTrials.gov: 30 June 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.