NCT03717935

Who might be able to join this trial:

• You are female
• You are between 12 and 21 years old
• You exercise less than 2 hours per week of moderate activity (such as jogging or swimming)
• Your BMI is at or above the 90th percentile for your age and gender (meaning you are in the heavier range compared to others your age)
• You have been diagnosed with Polycystic Ovary Syndrome (PCOS) with irregular periods more than 24 months after your first period started, and higher-than-normal testosterone levels
• You have been found to have fatty liver disease, confirmed by a special scan called a FibroScan, with a specific score above 225 (this will be checked at your first visit)

Who may not be able to join:

• You are currently taking certain medications, including metformin, steroid tablets (taken within the last 10 days), certain antipsychotic medications, immune-suppressing drugs, HIV medications, or hormonal contraception including patches or vaginal rings
• You are currently pregnant or breastfeeding (and becoming pregnant during the study would also mean you would need to leave the study)
• You have been seriously ill and needed to be in hospital within the last 60 days
• You have diabetes, based on a specific blood test result (HbA1c above 6.4%)
• Your BMI is below the 90th percentile for your age and sex, or you weigh more than 325 lbs or less than 84 lbs
• You have anaemia (low levels of a protein in your blood called haemoglobin, below 11 mg/dL)
• You have a diagnosed major psychiatric or developmental condition that affects your ability to give informed consent
• You have any metal implants in your body that are not safe to use with an MRI scanner
• You are currently taking blood pressure medications
• You have a known liver disease other than fatty liver disease, or certain liver enzyme levels in your blood are too high (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.