NCT04851834

Who might be able to join this trial:

• You are 18 years of age or older
• You are willing and able to give your consent to participate in the trial
• You have been diagnosed with an advanced or spreading solid tumour cancer (confirmed by tissue or cell testing), and your cancer has not responded to standard treatments, you cannot tolerate standard treatments, or you have chosen not to have standard treatment
• Alternatively, you have ovarian or bladder cancer (or another solid tumour) where the trial doctor believes re-treatment with certain chemotherapy drugs (cisplatin or carboplatin) may help you
• Alternatively, you have a type of brain tumour called high-grade glioma (such as glioblastoma) and are newly diagnosed and undergoing, or are planned to undergo, a standard 42-day course of combined chemotherapy and radiation treatment
• You are generally in good physical health and able to carry out light daily activities (confirm with trial site)
• You are able to swallow tablets or capsules and are willing to keep a daily record of taking the study drug
• Your heart is functioning well enough, including a normal heart rhythm and adequate pumping strength based on a heart scan done within the past 60 days
• Your liver is functioning well enough, based on blood test results at the time of screening
• Your blood counts (white blood cells, red blood cells, and platelets) are at acceptable levels at screening
• Your kidneys are functioning well enough, based on a calculated measure of kidney filtration rate
• Your blood clotting ability is within a normal range at screening
• If you are a woman who could become pregnant, you must agree to use effective contraception from signing consent until at least 45 days after your last dose of the study drug, and must not donate eggs during this time
• If you are a man, you must agree to use effective contraception from signing consent until at least 90 days after your last dose of the study drug, and must not donate sperm during this time
• If you are a woman who cannot become pregnant (due to surgery or being post-menopausal), you meet the criteria for this category (confirm with trial site)
• Your doctor estimates you have a life expectancy of at least 3 months
• You are able and willing to attend all required visits, follow the treatment plan, and complete all tests and study procedures

Who may not be able to join:

• You have taken another experimental drug or a certain type of chemotherapy (hypomethylating agent) within the past 5 half-lives of that drug (confirm with trial site for timing)
• You have brain tumour spread (metastases) that are currently causing symptoms
• You have had a heart attack within the past 6 months, have significant heart failure, unstable chest pain, or an unstable irregular heartbeat
• You are unable to swallow tablets or capsules
• You have a stomach or bowel condition that could affect how your body absorbs the study drug, in the opinion of the trial doctor
• You have had a bowel blockage, a hole in the gut, or an abdominal abscess within the past 6 months
• You are taking, or have recently taken (within 7 days), certain herbal or prescription medicines or foods — such as grapefruit or Seville oranges — known to strongly affect the way the body breaks down the study drug, unless approved by your treating doctor
• You have had a significant active infection within 2 weeks before starting the study drug
• You have tested positive for HIV, active hepatitis B, or hepatitis C
• You have been diagnosed with another cancer within the past 2 years (with some exceptions, such as certain skin cancers or cancers that were fully treated and have shown no signs of returning — confirm with trial site)
• You have had major surgery within 28 days before starting the study drug, or minor surgery within 7 days (some exceptions may apply — confirm with trial site)
• You have received cancer treatment (such as chemotherapy, targeted therapy, antibody therapy, or radiation) within 28 days before starting the study (or within a shorter timeframe depending on the specific drug — confirm with trial site)
• You still have significant side effects (above a mild level) from a previous cancer treatment that have not resolved, with some limited exceptions (confirm with trial site)
• You are pregnant or breastfeeding, or plan to breastfeed during the study or within 15 days after your last dose
• You had a positive pregnancy test at