NCT04935762

Who might be able to join this trial:

• You are between 30 and 80 years old (inclusive) at the time you give your consent to take part.
• You have been diagnosed with Parkinson's Disease using a specific standard set of diagnostic guidelines (confirm with trial site).
• You have been experiencing "freezing of gait" — sudden episodes where your feet feel stuck and you cannot move them even though you intend to walk — for at least 3 months, including at least one of these patterns: difficulty starting to walk, freezing when turning or going through doorways, unexpected freezing while already walking, or freezing when doing something else at the same time.
• You freeze at least once a week, with episodes lasting at least 2 seconds.
• You are willing to attend some visits having stopped certain Parkinson's medications beforehand for a set period of time, as instructed by the study team.
• If you are a man who has not had a vasectomy or a medical reason for infertility, you must agree to use a condom during the study when having sex with a woman who could become pregnant; if your partner is pregnant or breastfeeding, you must agree to use a condom or avoid intercourse until after your follow-up visit.
• If you are a woman who could become pregnant and have a male partner, you must have a negative pregnancy test and agree to use reliable contraception, be in a relationship with a confirmed sterile partner, or abstain from intercourse for the duration of the study and for 30 days after the last dose.
• If you are a woman who cannot become pregnant (e.g., post-menopausal), you may still be eligible if this is documented.
• Your body weight is at least 50 kg and your Body Mass Index (BMI — a measure of weight relative to height) is between 18 and 35 at the time of screening.
• Any other health conditions you have (for example, high blood pressure or high cholesterol) have been stable and managed for at least 3 months before the screening visit.
• You are willing and able to follow the study rules and procedures, including filling in questionnaires and wearing sensor devices; if you cannot give consent yourself, a legally authorised representative may do so on your behalf.

Who may not be able to join:

• You have high blood pressure that is not well controlled even with lifestyle changes or medication.
• You show signs of other brain or movement disorders similar to but different from Parkinson's Disease (confirm with trial site).
• You have a current or recent history (within the past 2 years) of epilepsy, a brain lesion, a head injury involving loss of consciousness, or a diagnosed serious mental health condition such as schizophrenia or bipolar disorder, or you have unstable psychiatric symptoms.
• You have a significant medical condition or abnormal test result that the study team believes makes it unsafe for you to take an experimental drug (confirm with trial site).
• You have a history of cancer, with the exception of certain fully treated and cured skin cancers.
• You have any significant illness identified through your medical history, a physical examination, a heart tracing (ECG), or blood/lab tests at the screening visit.
• Your heart tracing (ECG) shows abnormal results, including a specific measurement called QTcF that is too high (over 450 ms for men or 470 ms for women), a heart rate below 50 beats per minute, or significant abnormalities in how electrical signals travel through your heart.
• Your kidneys are not working well enough, based on a specific calculation of kidney function (confirm with trial site).
• You are currently taking any prescription medicines, over-the-counter medicines, or herbal supplements that are not allowed by the study.
• You have taken part in another drug trial within the past 90 days (or longer, depending on the drug), or you are currently enrolled in another treatment study.
• You have had a known or suspected problem with alcohol or substance misuse in the past 12 months.
• You have had thoughts of suicide with intent or a plan within the 3 months before the screening visit.
• You currently have an active COVID-19 infection.
• You have a reason you cannot wear the study's body sensor patches, such as having an implanted pacemaker or defibrillator, another active implanted device, or a known allergy to the sensors.
• You have a known allergy to adhesives or hydrogel (