NCT05364021

Who might be able to join this trial:

• You are male, or female and not currently pregnant or breastfeeding, and are between 12 and 65 years old
• You have been diagnosed with Dravet syndrome, Lennox-Gastaut syndrome, or another similar condition involving both developmental challenges and epilepsy
• You have a minimum number of seizures within every 4-week period while already taking between 1 and 4 seizure medications
• All of your current seizure medications and epilepsy treatments have been the same for at least 4 weeks before the study starts, and are expected to stay the same throughout the study
• You (or your parent or caregiver) are able and willing to attend study appointments, keep a daily diary, and take the study medication as directed

Who may not be able to join:

• You have a current or past history of heart or blood vessel problems, such as heart valve disease, heart attack, stroke, high pressure in the lung arteries, or abnormal blood pressure
• You have glaucoma (a condition affecting eye pressure), kidney problems, liver disease, or any other health condition that could affect your ability to take part or could put you at risk
• You currently have, or recently have had, moderate or severe depression, an eating disorder such as anorexia or bulimia, or you are considered at risk of suicidal thoughts or behaviour
• You are currently taking certain medications, including appetite suppressants, a type of antidepressant called MAOIs, or specific drugs that affect serotonin levels — including fenfluramine, atomoxetine, vortioxetine, or other weight loss medications
• You test positive for drugs on a screening test, unless the only substance detected is THC (cannabis) and you have been prescribed cannabidiol (a cannabis-based medicine)

Important: Always verify eligibility with the trial site directly before applying.