NCT05382286

Who might be able to join this trial:

• You have triple-negative breast cancer (a specific type of breast cancer) that has spread or cannot be removed by surgery, and you have not yet received any systemic (whole-body) treatment for this advanced stage of the disease.
• If you previously had early-stage breast cancer (Stage I to III) and were treated, at least 6 months must have passed since that treatment ended before your cancer came back.
• If your cancer was found to have already spread at the time of your first diagnosis (called "de novo" metastatic), you may still be eligible.
• Your tumor must test positive for a protein called PD-L1, which will be checked using a recent or stored tissue sample.
• Your cancer must be measurable on a CT scan or MRI.
• You must be in relatively good general health, able to carry out daily activities with little to no limitation (confirmed by a standard health scale used in cancer trials).
• Your heart, liver, kidneys, and other organs must be functioning well enough as shown by blood tests.
• If you are able to have children and are sexually active with a partner of the opposite sex, you must agree to use specific birth control methods as required by the trial.
• If you have HIV, you must be on HIV medication and your HIV must be well controlled.

Who may not be able to join:

• You are pregnant (confirmed by a blood test) or currently breastfeeding.
• You have previously received a type of cancer treatment that targets certain immune system receptors (confirm with trial site).
• You have received systemic cancer treatment (other than hormone therapy) in the past 6 months, or radiation therapy in the past 2 weeks.
• You are currently taking part in another clinical trial involving an experimental treatment or device within the past 4 weeks (being in an observation-only study is acceptable).
• You have previously been treated with a specific class of chemotherapy drugs called topoisomerase 1 inhibitors, or certain targeted drug treatments that contain this type of drug.
• You currently have another active cancer (in addition to your breast cancer).
• You currently have a serious active infection that requires antibiotic treatment.
• You have HIV and also have a history of two specific conditions: Kaposi sarcoma or Multicentric Castleman Disease.
• You currently have an active hepatitis B or hepatitis C infection.
• You have an active autoimmune disease (where the immune system attacks the body) that has needed medical treatment in the past 2 years.

Important: Always verify eligibility with the trial site directly before applying.