NCT05815862

Who might be able to join this trial:

• You have been diagnosed with advanced lung cancer or ovarian cancer, confirmed by a lab test of tissue or cell samples
• You are between 18 and 75 years old at the time of signing the consent form
• You are generally able to carry out light activity and care for yourself (your doctor will assess this using a standard scale)
• You have at least one tumour that can be measured on a scan
• Your major organs (such as liver, kidneys, and heart) are working normally
• If you are a woman who could become pregnant, you have a negative pregnancy test within 7 days before joining, you are not breastfeeding, and you agree to use contraception during the study and for 6 months after it ends
• If you are a man, you agree to use contraception during the study and for 6 months after it ends
• You are willing to take part voluntarily and sign a consent form, and are able to follow the study requirements

Who may not be able to join:

• You have had or currently have another type of cancer within the last 3 years
• You are unable to take oral (swallowed) medication for any reason
• You still have side effects from a previous cancer treatment that have not fully resolved (beyond minor hair loss)
• You had major surgery or a serious injury within 4 weeks before starting the study
• You have unhealed wounds, broken bones, active stomach or small intestine ulcers, persistent blood in your stool, ulcerative colitis, or other conditions that could cause serious gut bleeding or tearing
• You have had a stroke, mini-stroke, blood clot in a deep vein, or a blood clot in the lungs within the 6 months before starting the study
• You have a history of substance abuse involving mind-altering drugs and are unable to stop, or you have a mental health disorder
• You have any severe or uncontrolled illness (confirm with trial site)
• You received chemotherapy, radiotherapy, or other cancer treatments within 4 weeks before starting the study
• You received certain traditional Chinese medicines with anti-cancer properties within 2 weeks before starting the study
• You have previously been treated with specific anti-cancer drugs that target blood vessel growth, including Cabozantinib, Anlotinib, Endostar, or Bevacizumab
• Scans show that the tumour has grown into major blood vessels, or the study doctor thinks there is a high risk of serious bleeding from blood vessels
• You have a history of lung scarring, severe lung damage, severe radiation-related lung injury, drug-related lung disease, or scans show active severe lung inflammation
• You have fluid build-up around the lungs, in the abdomen, or around the heart that is uncontrolled and needs repeated draining
• You have cancer that has spread to the brain with active symptoms, or symptoms that have only been controlled for less than 2 weeks
• You have taken part in another clinical trial using an experimental cancer drug within the 4 weeks before starting this study
• You have a type of lung cancer (central squamous cell carcinoma) that carries a high risk of coughing up blood
• Your doctor believes you have another condition that could put your safety at risk or prevent you from completing the study

Important: Always verify eligibility with the trial site directly before applying.