NCT05880849

Who might be able to join this trial:

• You have signed a consent form before any study assessments begin.
• You are male or female, aged between 55 and 80 years old.
• You are able to understand what the study involves and have had the chance to ask questions.
• You have tested positive for at least one copy of a gene variant called ApoE4.
• You have scored 24 or higher on a standard memory and thinking test called the MMSE (a result from the past 3 months may be accepted).
• In the doctor's opinion, you are in generally good health based on your medical history, physical exam, blood tests, and heart tests.
• Your blood test shows a normal level of a substance called homocysteine (between 5 and 15 mcmol/L).
• You have completed a diet interview with a dietician as part of the study process.
• If you are female, you must be post-menopausal or not able to become pregnant.

Who may not be able to join:

• You have a current medical or neurological condition (such as a brain injury, Parkinson's disease, or multiple sclerosis) that could affect memory or thinking tests.
• You are unable or unwilling to take part in memory and thinking assessments.
• You have a serious, advanced, or unstable illness (such as significant heart disease or severe kidney or liver problems) that could affect your safety or the study results.
• You have been diagnosed with any form of cancer in the past 5 years, whether treated or not.
• You are unable or unwilling to have a lumbar puncture (a procedure where a small sample of fluid is taken from your lower back).
• Your diet includes a high amount of choline (more than 450mg per day), as assessed by the dietician.
• The doctor believes, for any other reason, that joining the trial could put you at unnecessary risk or affect the study results (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.