NCT06653153

Who might be able to join this trial:

• You have had a specific blood or fluid test (measuring a protein called phosphorylated tau) that suggests the presence of Alzheimer's-related changes in the brain.
• You have a reliable person (such as a family member or close friend) who knows you well and can report on your daily activities and thinking abilities, plus a backup person who can do the same.
• You are able to see, hear, and read well enough to complete memory and thinking tests at the start of the study.
• Your score on a standard memory and thinking test (called the MMSE) shows no or very minimal cognitive problems.
• Your score on a daily functioning questionnaire (called the FAQ) shows no or very minimal difficulty with everyday tasks.
• If you are already taking medication for Alzheimer's symptoms, your dose has been the same for at least 30 days before joining the study.

Who may not be able to join:

• You have been diagnosed with dementia or another significant brain or neurological condition that affects thinking and memory.
• You have a serious or unstable health condition that the study doctor believes could affect the study results.
• You have a history of cancer that the study doctor considers at high risk of coming back.
• You have a history of significant or severe allergic reactions to multiple medications or drugs.
• You have an abnormal lab test result or other health finding that the study doctor believes could be harmful to you or affect the study.
• You have any reason you cannot safely have an MRI scan (for example, certain metal implants).
• Your MRI scan, reviewed by a central specialist, does not meet the study's required standards.
• You have ever previously received a passive anti-amyloid immunotherapy treatment (a specific type of Alzheimer's antibody treatment) (confirm with trial site).
• You have previously received an active Alzheimer's vaccine (Aβ immunization) in another study.

Important: Always verify eligibility with the trial site directly before applying.