NCT06789224

Who might be able to join this trial:

• Your doctor (the investigator) has determined that you are a suitable candidate for a procedure where your own blood is collected and cleaned during surgery for possible reuse.
• You have been diagnosed with one of the following cancers: prostate, gallbladder, bladder, endometrial (uterine lining), stomach, ovarian, pancreatic, colon or rectal, non-small cell lung cancer, peritoneal carcinomatosis (cancer spread to the lining of the abdomen), kidney, or liver cancer.
• If you have one of the first group of cancers listed (not kidney or liver), and a tissue sample from your tumor is available or can be tested within 5 days of signing consent, a specific protein marker on your tumor cells (called EpCAM) should test positive.
• If you have kidney or liver cancer, a tissue sample from your tumor must already be available and must have tested positive for the EpCAM protein marker before your surgery.
• You are scheduled to have surgery to remove your tumor.
• Your doctor expects that at least 400 mL (roughly a small cupful) of blood can be collected during your tumor surgery.
• You have been rated as generally healthy enough for surgery, with an anesthesia risk score of 3 or below on a standard medical scale (confirm with trial site).

Who may not be able to join:

• You have received certain additional cancer treatments (such as chemotherapy delivered directly into the abdomen during surgery, known as HIPEC) before the blood collection part of the procedure is finished.
• You have a low level of a certain type of white blood cell called lymphocytes (confirm with trial site for specific levels).
• You have a type of cancer that is not on the list above, particularly cancers that are unlikely to have the EpCAM protein marker.
• You develop a serious bloodstream infection (sepsis) during surgery.
• You have severe liver scarring (cirrhosis) rated at the highest level of severity on a standard medical scale (Child-Pugh score C).
• Your blood platelet count (cells that help your blood clot) is below a certain low level (confirm with trial site for specific numbers).
• You have a known allergy or medical reason to avoid a drug called Catumaxomab, or any of the other materials used in the blood collection and cleaning procedure.
• You currently have an active COVID-19 infection confirmed by a positive PCR test before surgery.

Important: Always verify eligibility with the trial site directly before applying.