NCT07295847

Who might be able to join this trial:

• You are able to understand and sign a consent form agreeing to take part
• Your overall physical health and body function are considered adequate at the start of the study
• You are willing and able to stop taking certain medications for a set period of time before the study begins
• A doctor has reviewed your health and considers you a suitable candidate for the study
• You are willing to use a reliable form of birth control (or meet other acceptable criteria) during the study

Who may not be able to join:

• Your Body Mass Index (BMI — a measure of body weight relative to height) is below 18 or above 35 at the start of the study
• You have previously received a type of treatment called CAR T-cell therapy
• You are unable or unwilling to stay within roughly 2 hours' travel of the study clinic for the first 28 days after receiving the study treatment
• You have ever had a bone marrow or organ transplant, or are currently on a waiting list for one
• You have taken part in another clinical trial or received an experimental drug too recently before screening
• You have certain heart conditions that a doctor determines could make it unsafe for you to participate (confirm with trial site)
• You need extra oxygen while resting (not including oxygen used at night for sleep apnoea) or require a breathing machine
• You have high blood pressure that is not well controlled (above 160/100 mmHg) or are experiencing symptoms caused by high blood pressure
• You have a disease affecting your brain or nervous system that a doctor believes could put you at risk
• You have another active autoimmune or inflammatory condition, although some may be considered after discussion with the medical team
• You have had significant bleeding or an active bleeding problem in the 90 days before the study screening
• You have a history of cancer or are currently being treated for a previous cancer, although some types may be considered as exceptions
• You have a known inherited condition that affects how your immune system works
• You have an active infection (viral, bacterial, or fungal) or have needed antibiotic/antiviral/antifungal treatment in the 4 weeks before screening
• You have tested positive for HIV
• You have an active hepatitis infection
• You have active syphilis or have tested positive for the bacteria that causes syphilis
• You have received a live vaccine (a vaccine made with a weakened live virus or bacteria) within 4 weeks before certain study procedures
• Your vaccinations are not up to date according to the guidelines recommended for people with weakened immune systems in your area
• You have a known serious allergy or dangerous reaction to the study drug (AZD0120) or any of its ingredients, including a substance called dimethyl sulfoxide
• You have a known allergy or serious reaction to two medicines called fludarabine or cyclophosphamide, which are used as part of the treatment process
• You have recently had major surgery or have surgery planned during the time you would be in the study
• You are currently pregnant, breastfeeding, or planning to become pregnant during the study or within 1 year of receiving the study treatment
• You are planning to father a child during the study or within 1 year of receiving the study treatment
• There is any other reason — in the doctor's opinion — why taking part would not be in your best interest or could affect your ability to safely receive or tolerate the treatment

Important: Always verify eligibility with the trial site directly before applying.