Kyprolis (Carfilzomib)

carfilzomib 30 mg injection, 1 vial · INJECTION · PBS code 13637R

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What it costs

AU$602.75 PBS-determined price per pack

Most patients pay only the standard PBS co-payment, not the full price above — up to AU$25.00 per script (general) or AU$7.70 (concession/Safety Net) in 2026. The figure above is what the PBS pays the pharmacy; the Australian Government subsidises the rest. Always confirm the current amount with your pharmacist.

• First listed on the PBS: 2023-10-01.
• Repeats: 17.
• PBS program: IN.

Eligibility criteria for subsidised access

The following is the government's own wording from the PBS Schedule, shown unchanged.

Listing of Pharmaceutical Benefits (NHL) - Schedule 4 part 1

Relapsed and/or refractory multiple myeloma

Initial treatment for Cycles 1 to 3

The condition must be confirmed by a histological diagnosis; AND

The treatment must be in combination with lenalidomide and dexamethasone; AND

Patient must have progressive disease after at least one prior therapy; AND

Patient must not have previously received this drug for this condition.

Progressive disease is defined as at least 1 of the following:

(a) at least a 25% increase and an absolute increase of at least 5 g per L in serum M protein (monoclonal protein); or

(b) at least a 25% increase in 24-hour urinary light chain M protein excretion, and an absolute increase of at least 200 mg per 24 hours; or

(c) in oligo-secretory and non-secretory myeloma patients only, at least a 50% increase in the difference between involved free light chain and uninvolved free light chain; or

(d) at least a 25% relative increase and at least a 10% absolute increase in plasma cells in a bone marrow aspirate or on biopsy; or

(e) an increase in the size or number of lytic bone lesions (not including compression fractures); or

(f) at least a 25% increase in the size of an existing or the development of a new soft tissue plasmacytoma (determined by clinical examination or diagnostic imaging); or

(g) development of hypercalcaemia (corrected serum calcium greater than 2.65 mmol per L not attributable to any other cause).

Oligo-secretory and non-secretory patients are defined as having active disease with less than 10 g per L serum M protein.

Provide details of the histological diagnosis of multiple myeloma, prior treatments including name(s) of drug(s) and date of the most recent treatment cycle; the basis of the diagnosis of progressive disease or failure to respond; and which disease activity parameters will be used to assess response once only through the Authority application for lenalidomide.

Listing of Pharmaceutical Benefits (NHL) - Schedule 4 part 1

Relapsed and/or refractory multiple myeloma

Continuing treatment for Cycles 3 to 12

Patient must have previously received PBS-subsidised treatment with this drug for this condition; AND

The treatment must be in combination with lenalidomide and dexamethasone; AND

Patient must not have progressive disease while receiving treatment with this drug for this condition.