Type 2 Diabetes Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Men or women between 18 and 65 years old at the time of screening
• People with fasting blood sugar below 100 mg/dl and a two-hour blood sugar reading below 140 mg/dl (these are measured through specific blood tests — confirm with trial site)
• People with a body mass index (BMI) between 24 and 40
• People whose weight has stayed roughly the same (within about 4 pounds) over the past 3 months
• People with no signs of serious disease affecting major organs, based on physical examination, medical history, and blood/lab tests
• Women who could become pregnant must have a negative pregnancy test at screening and at treatment visits, and must use an approved form of contraception throughout the study until 7–14 days after the last dose. Accepted methods include the pill, injectable progesterone, a hormonal or copper IUD, a subdermal implant, a diaphragm with spermicide, spermicidal foam/gel/film/cream/suppository, or a male partner who has had a vasectomy for more than 6 months
• People who have signed and dated a consent form showing they have been told about all aspects of the study
• People who are willing and able to attend scheduled visits and follow all study procedures

Who may not be able to join:

• People with a recent history (within the past 3 months) of unstable or serious conditions affecting the blood, hormones, lungs, digestive system, heart, liver, mental health, immune system, or nervous system
• People who have a parent, sibling, or child with diabetes
• People with a BMI below 24 or above 40
• People whose weight has changed by more than about 4 pounds in the past 3 months
• People who take part in very intense, heavy exercise programs
• People who follow a schedule where they eat at night and sleep during the day (rather than a typical daytime eating and night-time sleeping pattern)
• People taking medications known to affect blood sugar levels or brain function (with the exception of metformin and/or pioglitazone — confirm with trial site)
• People with signs of serious disease in major organs, based on physical exam, medical history, or lab results
• Women who are pregnant or who are unwilling to use birth control during the study
• People who have donated about a pint (500 mL) of blood within 8 weeks before screening
• People with a serious medical, psychiatric, or laboratory condition that the investigator believes would make participation risky or affect the study results
• People with blood detected in their urine
• People with a history of heart failure
• People with a family history of pancreatic, bladder, or breast cancer
• People with a history of pancreatitis (inflammation of the pancreas)
• People with reduced kidney function, measured by an eGFR below 60 ml/min/1.73m² (a kidney filtering rate measured by a blood test — confirm with trial site)
• People with elevated creatinine levels in the blood — above 1.5 mg/dl for men or above 1.4 mg/dl for women (a measure of kidney function)
• People with a history of a significant drop in blood pressure when standing up (orthostatic hypotension)
• People with liver enzyme levels (ALT or AST) more than three times the upper limit of normal on blood tests
• People with a known allergy or sensitivity to pioglitazone, dapagliflozin, or saxagliptin

Important: Always verify eligibility with the trial site directly before applying.