Epilepsy Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who are at least 18 years old
- People who have temporal lobe epilepsy that has not been controlled by at least two different anti-seizure medications, as confirmed by a specialist neurologist at Brigham and Women's Hospital
- People who have at least 1 to 2 seizures per month on average, and who either know when their own seizures happen or have a reliable caregiver who does, and can keep a record of seizure frequency
- People who have the mental ability to read and understand a consent form and can describe any symptoms they experience during or after treatments
Who may not be able to join:
- People with a cognitive or psychiatric condition that prevents them from giving informed consent or cooperating with testing
- People with dementia, another progressive brain disease, delirium, or active psychosis
- People who have metal fragments or magnetic materials in their head
- People with severe heart disease, raised pressure in the skull, or who use a TENS (nerve stimulation) device
- People whose epilepsy is of the "primary generalised" type, or whose seizures are not actually epileptic in origin
- People who have had a prolonged, uncontrolled seizure episode (status epilepticus) in the 3 months before joining the study
- Women who are pregnant, or who are able to become pregnant and are not willing to use reliable contraception during the treatment period
- People who are unable to have a brain MRI scan for any reason, such as having metal implants in the body or being unable to lie still
- People who currently have a brain tumour or an abnormal blood vessel in the brain
- People with serious, uncontrolled medical conditions such as diabetes, high blood pressure, lung disease, heart failure, or coronary artery disease, or any other condition that could pose a health risk during participation
- People who have holes or gaps in the skull in the area where treatment would be given, due to injury or previous surgery
- People with implanted devices such as pacemakers, medication pumps, or other electronic implants (note: people with a Vagal Nerve Stimulator may still be considered, as the device would be turned off before each treatment session and turned back on afterwards — confirm with trial site)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Ellen J Bubrick, MD, Brigham and Women's Hospital
Phone: 617-732-7432
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Patient tolerability of moderate term, repeated exposure toPulsed Low-Intensity Focused Ultrasound (PLIFUS) (Adverse Events assessment); Efficacy of PLIFUS in reducing seizure frequency; Effect of PLIFUS on patient EEG (evaluate number of attenuated epileptiform discharges)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.