Primary Biliary Cholangitis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 2 and 25 years old at the time of screening.
• You have been diagnosed with large duct PSC (a liver/bile duct condition), confirmed by a special imaging scan of the bile ducts showing certain abnormal patterns.
• You have been diagnosed with small duct PSC, confirmed by a liver tissue sample (biopsy) showing specific signs of the disease.
• You are willing and able to follow all study procedures and remain available for the full length of the study.
• You (and/or your parent or guardian) are able to give informed consent to participate.
• For the imaging part of the study only: you are between 8 and 25 years old, have no reason you cannot have an MRI scan, and have no skin condition that could be made worse by a type of MRI-related procedure (confirm with trial site).

Who may not be able to join:

• You have previously had a liver transplant.
• You have previously had a bone marrow transplant.
• You have a condition that seriously weakens your immune system (such as certain rare immune disorders or HIV/AIDS) that could cause a different type of bile duct disease.
• You have a history of certain rare diseases affecting immune cells, such as Langerhans cell histiocytosis or hemophagocytic lymphohistiocytosis (confirm with trial site).
• You have had bile duct damage caused by a lack of blood flow (ischemic cholangitis).
• You have a history of blood clots in the portal vein affecting the bile ducts, a liver vein-blocking condition, or bile duct damage from abdominal radiation.
• You have a history of repeated serious bile duct infections (recurrent pyogenic cholangitis).
• You have had bile duct surgery for gallstones before the scan or biopsy used to determine your eligibility.
• You have had bile duct surgery for a cyst in the bile duct (choledochal cyst).
• You have a history of liver cancer (hepatocellular carcinoma or hepatoblastoma).
• You have had a bile duct injury during surgery.
• You were born with a CMV (cytomegalovirus) liver infection.
• You have Sickle Cell Disease.
• You have cystic fibrosis, biliary atresia, Caroli disease, congenital hepatic fibrosis, or a specific inherited bile duct disorder called MDR3 disease.
• You have liver damage caused by heart problems (cardiac hepatopathy).
• You have certain metabolic (body chemistry) disorders, including Wilson's disease, glycogen storage disorder, or Alpha-1 Antitrypsin deficiency.
• You have been diagnosed with systemic lupus erythematosus (SLE), an autoimmune disease.
• You are currently pregnant at the time of enrollment.

Important: Always verify eligibility with the trial site directly before applying.