Phase 2 Stomach Cancer Trial, Recruiting (NCT04278222)

Phase 2 Stomach Cancer Trial, Recruiting NCT04278222 Sponsor: Shanghai Changzheng Hospital Condition: Stomach Cancer

Printed from Voxsanity (voxsanity.com.au) — NCT04278222 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.

Back to Stomach Cancer

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

You have been diagnosed with stomach (gastric) cancer that has spread to other parts of the body (stage IV), confirmed by a tissue sample test
You have not had any previous systemic (whole-body) cancer treatment, OR your cancer came back or spread more than 12 months after completing chemotherapy given after surgery
You have at least one tumour that can be measured on a scan
You may have had radiotherapy up to 3 weeks before joining, but the area treated with radiotherapy cannot be used to measure how well the treatment is working
Your general health and ability to carry out daily activities meets a specific level set by doctors (confirm with trial site)
Your blood counts, liver function, and kidney function results are within acceptable ranges (confirm with trial site for specific numbers)
You are willing and able to give written consent to take part
Your doctor estimates you are likely to live for more than 3 months

Who may not be able to join:

Your cancer tests positive for a protein called HER2 in a specific way (confirm with trial site)
Your cancer has a particular genetic feature called dMMR or MSI-H (confirm with trial site)
You have had a heart attack, unstable chest pain, or have serious heart failure
You have previously been treated with a drug called anlotinib or any immunotherapy (immune checkpoint inhibitor) drugs
You have known or suspected cancer spread to the brain, an autoimmune disease, or have had an organ transplant
You have had a serious wound or surgery within 4 weeks before joining the trial
You are currently taking high-dose steroid tablets (more than 10mg of prednisone) or other medicines that suppress the immune system
You have had another type of cancer in the past 5 years, unless it was a certain type of easily treated skin cancer or a very early-stage cervical condition that was fully cured
You are pregnant or breastfeeding
You are not legally able to make your own decisions or sign consent forms
You have another serious illness that your doctor believes would make it unsafe for you to take part

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.

Last synced 27 July 2026

Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.

Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

GP referral letter

Print a one-page summary to share with your doctor.

Voxsanity

Clinical trials and treatments, explained plainly · voxsanity.com.au

Date:

To: My Doctor

Re: Clinical trial enquiry

I am writing to enquire about the following clinical trial which may be relevant to my care:

Trial: NCT04278222

Sponsor: Shanghai Changzheng Hospital

Phase: Phase 2

Status: Recruiting

Condition: Stomach Cancer

More information: https://clinicaltrials.gov/study/NCT04278222

Eligibility summary (AI generated)

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

You have been diagnosed with stomach (gastric) cancer that has spread to other parts of the body (stage IV), confirmed by a tissue sample test
You have not had any previous systemic (whole-body) cancer treatment, OR your cancer came back or spread more than 12 months after completing chemotherapy given after surgery
You have at least one tumour that can be measured on a scan
You may have had radiotherapy up to 3 weeks before joining, but the area treated with radiotherapy cannot be used to measure how well the treatment is working
Your general health and ability to carry out daily activities meets a specific level set by doctors (confirm with trial site)
Your blood counts, liver function, and kidney function results are within acceptable ranges (confirm with trial site for specific numbers)
You are willing and able to give written consent to take part
Your doctor estimates you are likely to live for more than 3 months

Who may not be able to join:

Your cancer tests positive for a protein called HER2 in a specific way (confirm with trial site)
Your cancer has a particular genetic feature called dMMR or MSI-H (confirm with trial site)
You have had a heart attack, unstable chest pain, or have serious heart failure
You have previously been treated with a drug called anlotinib or any immunotherapy (immune checkpoint inhibitor) drugs
You have known or suspected cancer spread to the brain, an autoimmune disease, or have had an organ transplant
You have had a serious wound or surgery within 4 weeks before joining the trial
You are currently taking high-dose steroid tablets (more than 10mg of prednisone) or other medicines that suppress the immune system
You have had another type of cancer in the past 5 years, unless it was a certain type of easily treated skin cancer or a very early-stage cervical condition that was fully cured
You are pregnant or breastfeeding
You are not legally able to make your own decisions or sign consent forms
You have another serious illness that your doctor believes would make it unsafe for you to take part

Important: Always verify eligibility with the trial site directly before applying.

Access in Australia: A treatment being studied in a clinical trial is generally not yet listed on the PBS. Where a medicine is not approved or not available through a trial, the TGA Special Access Scheme may allow a doctor to access unapproved therapeutic goods for individual patients. See voxsanity.com.au/sas-navigator/ for a plain English explainer.

This information was sourced from ClinicalTrials.gov via Voxsanity (data last synced 27 July 2026). It is not medical advice. Please verify the trial's current status directly with the trial site before acting.

Trial details

Status

Recruiting

Phase

Phase 2

Sponsor

Shanghai Changzheng Hospital

Registry

ClinicalTrials.gov

Start date

10 February 2020

Est. completion

31 October 2024

Where this trial is recruiting

🇨🇳 China

Primary endpoints

objective response rate

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov