Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with stomach cancer (specifically a type called adenocarcinoma) that has been confirmed by a tissue sample, and doctors believe it can be surgically removed.
• Your cancer is at a stage where it has grown into or through the stomach wall (but has not spread to distant parts of the body), based on scans.
• You have not had any chemotherapy, targeted therapy, or surgery to remove any part of your tumor before joining this trial.
• You are between 18 and 75 years old.
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 7 days before the trial starts, and you must agree to use highly effective contraception throughout the study.
• If you are a man, you must agree to use a condom during treatment and not to father a child during the study, and your partner (if she could become pregnant) must also use effective contraception.
• You are reasonably well and able to carry out daily activities (confirm with trial site for exact fitness level required).
• Scans (CT or MRI) have confirmed that the cancer has not spread to distant areas of the body, and has not grown into surrounding organs.
• A keyhole surgical procedure (laparoscopy) has confirmed the cancer has not spread to the lining of the abdomen before chemotherapy begins.
• Your blood counts, liver function, and kidney function are within acceptable levels (confirm with trial site for exact values).
• You are willing and able to give written consent and follow the study plan, including planned surgery.

Who may not be able to join:

• You have not received any pre-surgery (neoadjuvant) chemotherapy, or you received a different chemotherapy regimen other than FLOT before joining.
• You have a known allergy or sensitivity to any of the chemotherapy drugs used in FLOT (5-FU, leucovorin, oxaliplatin, or docetaxel).
• You have any other known medical reason why you cannot take the FLOT chemotherapy drugs.
• You have significant active heart disease, a serious heart muscle condition, or severe heart failure (confirm with trial site for exact definition).
• You have a significant heart valve problem.
• Your cancer has grown into major blood vessels or nearby organs, or has spread to certain lymph nodes in the abdomen that are considered distant spread.
• You have another serious illness or an active infection.
• You have significant nerve damage in your hands or feet (confirm with trial site for exact definition).
• You have had major surgery within 28 days before joining the trial (a staging laparoscopy is an exception).
• You have significant liver scarring (cirrhosis) at a certain level of severity, or any cirrhosis combined with a history of brain complications from liver disease or fluid build-up in the abdomen.
• You are currently taking part in, or have taken part in, another interventional clinical trial within 30 days before joining or during this study.
• You are pregnant, breastfeeding, or planning to become pregnant.
• You are receiving any other cancer treatment, including radiotherapy, at the same time.

Important: Always verify eligibility with the trial site directly before applying.