Phase 2 Haemophilia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are male and at least 18 years old
• You have been diagnosed with severe or moderately severe hemophilia A, confirmed by your medical history
• You have received treatment (either regular preventive or as-needed) for hemophilia A on at least 150 separate days
• If you use as-needed (not regular) treatment, you have had at least 12 bleeding episodes in the past 12 months
• Your body mass index (a measure of body weight relative to height) is 30 or below
• You are willing to use two forms of contraception until at least 3 consecutive sperm samples test negative after receiving the study treatment

Who may not be able to join:

• You have pre-existing immunity to a specific virus used to deliver the treatment (called AAV8), detected by blood tests
• You currently have, or have a history of, high levels of antibodies that block the clotting factor used to treat hemophilia A (called inhibitors)
• You have moderate-to-severe liver scarring, detected by a liver scan
• You have a history of long-term kidney disease
• You currently have an active infection or a condition that affects your immune system
• You have had heart surgery and need blood-thinning medication
• You have any heart-related or genetic risk factors that increase your chances of developing blood clots (confirm with trial site)
• You currently have an active infection with Hepatitis B, Hepatitis C, HIV-1/2, or syphilis
• You have previously received any gene therapy or similar treatment
• You are currently taking antiviral medication for Hepatitis B or C

Important: Always verify eligibility with the trial site directly before applying.