Phase 1 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been confirmed by tissue or cell testing to have advanced solid tumours, where standard cancer treatments have either stopped working or are no longer available.
• People aged between 18 and 70 years old (male or female).
• People who are expected to live for at least 3 months.
• People whose general physical functioning falls within a certain range on a standard health scale (ECOG score of 0–2, meaning able to carry out at least some daily activities — confirm with trial site).
• People who have at least one tumour that can be measured or assessed using standard imaging methods.
• People who have not received radiotherapy, chemotherapy, immunotherapy, other anti-tumour treatments, or surgery (other than diagnostic biopsy) within the 4 weeks before joining, and who do not have surgery planned during the study period.
• People whose blood counts (red cells, white cells, and platelets) are within acceptable levels, without having needed a blood transfusion or blood-boosting medications in the 14 days before screening.
• People whose heart, liver, and kidney function test results fall within acceptable ranges as defined by the trial.
• People whose blood clotting test results are within normal limits.
• People (and their partners) who are willing to use reliable contraception during the study and for 3 months after the last dose. Women who could become pregnant must have a negative pregnancy blood test within 14 days before joining and must not be breastfeeding.
• People who are willing to sign an informed consent form, showing they understand what the trial involves, including possible side effects.
• People who are willing to follow the study rules and attend follow-up visits.

Who may not be able to join:

• People who still have side effects from previous cancer treatment that have not reduced to a mild level (with some exceptions, such as hair loss).
• People who have a known or suspected allergy to paclitaxel or any of its ingredients, or who have a history of serious allergic reactions (mild seasonal allergies without symptoms are excluded).
• People who have a tendency to bleed, or who are currently taking blood-thinning or clot-dissolving medications.
• People whose cancer has previously been treated with paclitaxel and was found by doctors to be resistant to it.
• People who have active cancer that has spread to the brain or central nervous system — although people with previously treated and stable brain metastases may still be considered.
• People who have had a stroke or a temporary stroke-like episode (TIA) in the 6 months before screening.
• People who currently have an active infection requiring antibiotic or antiviral treatment.
• People who have had another type of cancer in the past 5 years (with the exception of certain fully treated skin and cervical cancers).
• People who have other serious illnesses that the doctors believe could put them at risk or prevent them from completing the trial (such as bowel obstruction, lung scarring, or gastrointestinal bleeding).
• People with a known history of neurological or psychiatric conditions, including epilepsy or dementia.
• People who have taken certain medications that affect how the body processes drugs (specific CYP2C8 and/or CYP3A4 interacting medicines) within 30 days before starting the trial drug — confirm the specific medications with the trial site.
• People who have received a blood transfusion or blood products such as albumin within 2 weeks before the trial.
• People who have moderate to severe nerve damage in their hands or feet (peripheral neuropathy above grade II).
• People who have had a heart attack in the past 6 months, serious or unstable chest pain, certain heart bypass procedures, severe heart failure, uncontrolled high blood pressure, significant heart rhythm problems, or concerning heart test (ECG) results.
• People who have HIV, active hepatitis B, or active hepatitis C infection (based on specific blood test results — confirm with trial site).
• People who have consumed more than 14 standard alcoholic drinks per week in the 2 weeks before screening, or who have a history of drug abuse.
• People who have taken part in another clinical trial within the past month.
• People who are pregnant or breastfeeding.
• People who the trial doctors consider unsuitable for any other reason.

Important: Always verify eligibility with the trial site directly before applying.