Type 2 Diabetes Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 years or older
• People who have been diagnosed with Type 2 diabetes, based on American Diabetes Association criteria
• People whose kidneys are functioning at a sufficient level, shown by a kidney function test result (eGFR) above 30 mL/min/1.73 m², measured within the last six months
• People who have high levels of a protein called albumin in their urine, confirmed on more than one test (above 700 mg/g on a spot urine test, or above 700 mg on a 24-hour urine collection)
• People who are able to provide written informed consent to participate

Who may not be able to join:

• People who have had signs of sudden (acute) kidney failure in the six months before, or at the time of, the kidney biopsy procedure
• People whose blood count (haemoglobin) is too low, indicating anaemia that could raise the risk of complications from a kidney biopsy
• People whose blood clotting test result (INR) is above 1.4 at the time of the biopsy
• People with a low platelet count (below 100 x 10⁹/L), which affects the blood's ability to clot
• People with uncontrolled high blood pressure (top number above 160 mmHg and/or bottom number above 100 mmHg)
• People who have only one functioning kidney
• People who have a blockage in their urinary tract or fluid build-up around the kidneys at the time of the biopsy
• People with multiple cysts on both kidneys
• People who have an active infection in or around the kidneys, or a skin infection over the area where the biopsy would be performed
• People who are unwilling to receive a blood transfusion if needed
• People who are unable to lie flat in bed for six hours following the biopsy
• People who have any other medical reason that the local clinical guidelines consider a reason not to perform a kidney biopsy (confirm with trial site)
• People who are unable to understand written or spoken information about the trial
• People who have previously received a kidney transplant
• People who have previously had a medically performed kidney biopsy
• Women who are pregnant or planning to become pregnant before the kidney biopsy is carried out
• People currently being treated with a blood-thinning medication called Marcoumar (phenprocoumon)
• People who are considered to have a high risk of blood clots and who would need to stop their blood-thinning medication around the time of the biopsy, including those with a mechanical heart valve; certain heart rhythm conditions with additional risk factors or a recent stroke; recent or recurrent blood clots in the veins; or who have had certain recent heart procedures or stent placements (confirm specific timeframes and procedures with trial site)
• People who are unable to stop taking anti-inflammatory pain medicines (such as ibuprofen or similar NSAIDs) for seven days before the biopsy

Note: Some of the reasons listed above may change over time. If someone does not meet the criteria now due to a reversible condition, the trial site may be able to reassess eligibility at a later date.

Important: Always verify eligibility with the trial site directly before applying.