Early Phase 1 Type 2 Diabetes Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People of any gender are eligible to participate.
• People with a body mass index (BMI) between 18.5 and 40, whose weight has been stable for the past 6 months.
• People aged 18 to 64 years old.
• People who have blood sugar levels in the pre-diabetes range, based on at least one of several standard tests — or people who have been consistently taking Metformin for at least 1 year to prevent pre-diabetes from becoming diabetes (confirm with trial site for exact test values).
• People who currently do less than 150 minutes of moderate or vigorous physical activity per week and sit for more than 6 hours per day, based on a standard self-reported questionnaire.
• People who take fewer than 6,500 steps per day on average, as measured by a pedometer over 5 days (including at least one weekend day).
• People who pass the medical, physical, blood, and urine screening checks required by the trial.
• People who drink fewer than 3 cups of caffeinated beverages per day.
• People willing to avoid any additional structured exercise beyond what the study prescribes.
• People willing to follow a controlled diet for 3 days before and during clinic visits at the research centre.
• People willing to avoid over-the-counter and prescription medications (except oral contraceptives) for 3 days before inpatient clinic visits.
• People willing to wear a Fitbit® activity monitor and upload their daily activity data throughout the entire study.
• People willing to follow the physical activity programme and be randomly assigned to one of two study groups.
• People willing to complete all study procedures.

Who may not be able to join:

• Women who are pregnant, breastfeeding, or post-menopausal.
• People whom the study doctor considers unsafe to participate.
• People with a history of a systemic, psychiatric, or neurological disease, or a history of drug or alcohol abuse.
• People with a history of heart disease, diabetes, uncontrolled high blood pressure, untreated thyroid problems, kidney or liver disease, abnormal cholesterol levels, or any other condition that affects weight or fat metabolism.
• People who test positive for HIV or hepatitis B or C.
• People who have taken medications affecting weight, triglycerides, energy intake or expenditure, or sleep in the past 3 months.
• People whose blood test results are found to be significantly abnormal by the study doctor.
• People who currently smoke or who smoked within the 3 months before screening.
• People who have donated more than 400 mL of blood within 90 days of the screening visit.
• People who have worked night shifts within 1 month before the study or who would do so during the study.
• People who do not complete the required trial screening days used to assess their willingness and ability to participate in the study activities.

Important: Always verify eligibility with the trial site directly before applying.