Epilepsy Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For healthy volunteers:

• You have no history of mental health conditions or other major health problems

For patients (Cohort I – first seizure group):

• You are between 16 and 55 years old
• You have had a first seizure that strongly suggests epilepsy, but you do not yet fully meet the official diagnosis criteria for epilepsy

For patients (Cohort II – diagnosed epilepsy group):

• You are between 16 and 55 years old
• You have been officially diagnosed with epilepsy according to recognised international criteria

For patients (Cohort III – epilepsy with brain scan findings group):

• You are between 18 and 55 years old
• You have been officially diagnosed with epilepsy according to recognised international criteria
• Your MRI brain scan shows a specific area that appears to be linked to your seizures, matching your seizure pattern and/or brainwave test results

Who may not be able to join:

Healthy volunteers:

• You have a current or past neurological condition, serious physical illness, or take medications that could affect test results
• You are not fluent in Danish, or you have significant vision or hearing difficulties
• You have a current or past learning disability
• You are pregnant or breastfeeding (if female)
• You have been exposed to more than 10 millisieverts (a unit measuring radiation) in research studies in the past year, or you are regularly exposed to radiation through your work
• You have a reason you cannot have an MRI scan, such as a pacemaker or metal implants
• You have had a serious head injury
• You have a current or past problem with alcohol or drug misuse
• You have used any drugs (other than tobacco or alcohol) in the last 30 days
• You have used cannabis more than 50 times in your lifetime
• You have used any individual other substance more than 10 times in your lifetime
• You are currently taking any medication that affects mood, thinking, or mental health

Patients (all groups, Cohorts I–III):

• Your life expectancy is less than 10 years
• You have a known genetic syndrome, significant intellectual disability, or a condition that has caused major changes to your brain structure, such as a brain tumour, major stroke, or serious brain injury
• You weigh less than 40 kg (approximately 88 lbs)
• Your kidneys are not working well enough (confirm with trial site for specific kidney function levels)
• Your liver function is moderately reduced
• You have a heart rhythm or electrical condition, such as Brugada syndrome or long QT syndrome
• You take certain medications that could interfere with the study drugs or the study itself — including some seizure medicines, certain antidepressants, or other specific drugs (confirm with trial site for the full list)
• You have a reason you cannot have an MRI scan, such as a pacemaker or magnetic implants
• You are unable to complete an MRI scan or, if in Cohort III, a PET scan — for example, due to claustrophobia or severe back pain
• You have been exposed to more than 10 millisieverts of radiation in research studies in the past year, or are regularly exposed to radiation through work (Cohort III only)
• You are pregnant or breastfeeding
• You are not fluent in Danish, or you have significant vision or hearing difficulties, or a severe intellectual disability
• You have a current or past problem with alcohol or drug misuse

Important: Always verify eligibility with the trial site directly before applying.