Phase 3 Stomach Cancer Trial, Recruiting NCT05477576 Sponsor: RayzeBio, Inc. Condition: Stomach Cancer
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Phase 3 Stomach Cancer Trial, Recruiting

NCT05477576
Recruiting Phase 3

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You have been diagnosed with a slow-growing (Grade 1 or 2) neuroendocrine tumour originating in the gut or pancreas that cannot be removed by surgery and has spread, and you are reasonably well enough to carry out daily activities (confirm with trial site)
  • Your tumour has been growing after receiving 2 to 4 rounds of a specific type of radiation treatment called lutetium-177 (Lu-177), your disease was controlled for at least 6 months after that treatment, and scans show your tumour is visible and responds to a special type of imaging called SSTR-PET
  • Your kidneys are working well enough, based on a blood test measuring kidney filtration rate
  • Your blood counts are at acceptable levels — including red blood cells, white blood cells, and platelets
  • Your liver protein (bilirubin) levels are not too high, based on a blood test
  • Your blood protein (albumin) level is adequate, or your blood clotting is within a normal range

Who may not be able to join:

  • You have previously had a type of radiation treatment delivered directly to the liver (radioembolization)
  • You have significant heart problems, such as moderate-to-severe heart failure, reduced heart pumping ability, or an abnormal heart rhythm reading on an ECG
  • You have high blood pressure that remains uncontrolled even while taking at least 3 blood pressure medications, one of which is a water tablet (diuretic)
  • You have poorly controlled diabetes, shown by a blood sugar level test (HbA1c) of 8% or higher
  • You have previously had a type of targeted radiation therapy other than Lu-177 (confirm with trial site)
  • You need to take high-dose steroid tablets or injections, or you cannot stop taking them during the trial (steroid inhalers or creams are generally acceptable)
  • You have a history of severe liver scarring (cirrhosis) or have had a liver transplant

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 15 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Ye Yuan, MD, RayzeBio Sr. Medical Director

Phone: +1 619 657 0057

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Sponsor
RayzeBio, Inc.
Registry
ClinicalTrials.gov
Start date
24 March 2022
Est. completion
1 December 2026

Where this trial is recruiting

🇧🇪 Belgium 🇧🇷 Brazil 🇨🇦 Canada 🇫🇷 France 🇳🇱 Netherlands 🇰🇷 South Korea 🇪🇸 Spain 🇺🇸 United States

Primary endpoints

Phase 1b: RP3D; Phase 3: PFS as determined by BICR

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 15 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov