Phase 3 Irritable Bowel Syndrome Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with Irritable Bowel Syndrome with Constipation (IBS-C) and are currently experiencing symptoms.
• Your abdominal pain reaches a significant level of severity during a lead-in monitoring period before the trial begins (the exact level is defined by the study protocol — confirm with trial site).
• You have had symptoms on at least one day per week for the last 3 months, and your symptoms first started at least 6 months before your diagnosis.
• Your abdominal pain is not being adequately controlled at the time you are assessed for the trial.

Who may not be able to join:

• You have another active condition that could also cause abdominal pain, such as inflammatory bowel disease, diabetes, or an unstable thyroid condition.
• You are pregnant, planning to become pregnant, or currently breastfeeding. (A pregnancy test will be done at the first visit, and a positive result would mean you cannot join.)
• You have any other condition that, in the doctor's judgment, might make it difficult for you to follow the study requirements or complete it (confirm with trial site).
• You have had abdominal surgery in the past, other than having your gallbladder or appendix removed.
• You are currently taking certain medications, including prucalopride, domperidone, alosetron, tegaserod, warfarin, certain antipsychotic medications, anti-diarrhoea medications, or you use opioid or antispasmodic medications more than 2 days per week. Regular use of anti-inflammatory painkillers (such as ibuprofen or naproxen) would also exclude you.
• You are currently taking antidepressants or other medications that affect serotonin levels in the body, including SSRIs (such as escitalopram), SNRIs, or tricyclic antidepressants.
• You are unable to avoid a specific list of medications during the trial, including certain antidepressants (tricyclics and MAO inhibitors), migraine medications (triptans), fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, and St. John's Wort. Note that MAO inhibitors must not be used within 14 days of starting or stopping the study medication.
• You have a known allergy or sensitivity to the medications escitalopram or citalopram, or any of their ingredients.
• You have a known allergy to the adhesive patches used for heart monitoring (ECG electrodes).
• You have been diagnosed with angle-closure glaucoma, bipolar disorder, a history of seizures, a previous suicide attempt, or known suicidal thoughts.
• You have a known heart condition involving a prolonged QTc interval, or you regularly take a medication known to prolong QTc (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.