Stomach Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years, of any gender
• People who are willing to take part and who have signed (or whose legal guardian has signed) a consent form
• People who have been diagnosed with stomach cancer or pancreatic cancer that cannot be surgically removed, has come back at a late stage, or has spread to other parts of the body — confirmed by laboratory tissue testing and classified as Stage III or IV
• People who have at least one tumour that can be clearly measured and tracked using standard imaging criteria (known as RECIST 1.1)
• People whose tumour tissue shows a moderate to high level of a protein called Claudin 18.2, confirmed by a specific laboratory staining test
• People who have already received both first-line and second-line standard treatments for their cancer
• People who are not considered suitable for, or who have chosen not to undergo, further aggressive treatments such as chemotherapy, radiotherapy, surgery, or certain immune-blocking therapies
• People who have not received any antibody-based drug treatments in the two weeks before starting the cell therapy
• People with a general health and activity level rated between 0 and 2 on a standard medical scale (ECOG score), meaning they are able to carry out at least some daily activities
• People for whom a blood collection procedure from a vein would not pose a health risk
• People whose doctors estimate they have a life expectancy of more than 3 months

Who may not be able to join:

• People who have previously had an allergic reaction to any ingredient used in cell-based treatments
• People whose blood test results show very low levels of white blood cells, a type of infection-fighting cell (granulocytes), another type of immune cell (lymphocytes), or platelets
• People whose liver function tests show bilirubin, ALT, or AST levels above certain thresholds, or whose kidney function test (creatinine) is above a certain level (confirm specific values with trial site)
• People with moderate to severe heart failure (Grade III or IV on a standard heart function scale), or whose heart pumping function measured by an ultrasound scan is below 50%
• People with abnormal lung function where the level of oxygen in their blood, measured while breathing normal indoor air, is below 92%
• People who have had a heart attack, heart procedure (such as angioplasty or stenting), unstable chest pain, or another serious heart condition in the 12 months before joining the trial
• People with severe high blood pressure that has not been brought under control with medication
• People who have previously experienced serious brain injury, loss of consciousness, epilepsy, significant reduced blood flow to the brain, or bleeding in the brain
• People with autoimmune diseases, conditions that weaken the immune system, or who need medication to suppress their immune system
• People who have an active infection that is not currently under control
• People who have previously received any CAR-T cell therapy or other treatments involving genetically modified T cells
• People who have received a live vaccine within the 4 weeks before joining the trial
• People who test positive for HIV, hepatitis B (HBV), hepatitis C (HCV), or syphilis, or who are carriers of hepatitis B
• People with a history of alcohol misuse, drug misuse, or a mental health condition
• People who have taken part in another clinical trial within the 3 months before joining this one
• Women who are pregnant or breastfeeding, who plan to become pregnant during the trial, or who are able to become pregnant but are unable to use reliable contraception throughout the trial
• People whom the trial investigators determine to be unsuitable for any other reason (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.