Phase 4 Type 2 Diabetes Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 40 and 80 years old at the time of signing the consent form
• People who have had Type 2 diabetes for at least 5 years, with blood sugar levels (HbA1c) between 7.0% and 10.5%
• People with a Body Mass Index (BMI) of 25 or higher (considered overweight or obese)
• People who have two specific fatty buildups in their heart arteries, detected by a special heart scan (CT scan of the coronary arteries), where each buildup causes more than 20% narrowing of the artery
• People who have been on a stable diabetes medication regimen for more than 4 weeks before the start of the trial
• People taking hormonal contraceptive pills must switch to a non-pill contraceptive method, or add a barrier method (such as condoms), for 4 weeks after starting the trial medication and for 4 weeks after each dose increase

Who may not be able to join:

• People who have had a major heart or cardiovascular event in the last 60 days
• People who have Type 1 diabetes
• People who are currently using a medication class known as GLP-1 receptor agonists (such as medications like semaglutide or liraglutide)
• People who have had a serious low blood sugar episode, or who cannot feel the warning signs of low blood sugar, within the last 6 months
• People who are currently receiving or planning treatment for diabetic eye disease (retinopathy) or fluid buildup in the eye (macular edema)
• People who have previously had, or are currently planning, a procedure to open or bypass blocked arteries in the heart, neck, or legs (such as a stent or bypass surgery)
• People with a history of pancreas inflammation (pancreatitis)
• People with a history of a dangerous diabetes-related condition involving very high blood sugar with acid buildup (ketoacidosis) or an extremely high blood sugar emergency (hyperosmolar state or coma)
• People who have a known problem with their stomach emptying too slowly, or who have had or are planning surgery on the stomach outlet or any form of weight-loss (bariatric) stomach surgery
• People who currently have cancer, have had cancer in the past that is considered significant, or have been in remission from a significant cancer for less than 5 years
• People who have a personal or family history of a specific type of thyroid cancer (medullary thyroid carcinoma) or a related inherited condition (Multiple Endocrine Neoplasia type 2)
• People who have had a blood transfusion or significant blood loss within the past 90 days, or who have a known blood condition that could affect the accuracy of HbA1c blood sugar tests
• People who have had or are planning heart bypass surgery
• People for whom the heart CT scan (CCTA) is not safe or suitable — for example, due to a serious allergy to the contrast dye used — or whose scan did not meet the required quality standards after two attempts
• People with severely uncontrolled high blood pressure (above 180/100 mmHg) at the screening visit, even while on blood pressure medication
• People with advanced heart failure (classified as NYHA Class III or IV) at the screening visit
• People with significantly reduced kidney function (eGFR below 40 ml/min/1.73m²) as measured at the screening visit
• People who have been hospitalised for a major heart event, including heart failure, in the past 2 months

Important: Always verify eligibility with the trial site directly before applying.