Phase 2 Hepatitis B Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing and able to sign a consent form and follow all study requirements throughout the trial
• You are willing to use effective birth control from the time you join until 30 days after your last dose of the study drug (applies to men and women who could become pregnant)
• You are between 18 and 70 years old; if male, you weigh at least 45 kg (about 99 lbs); if female, you weigh at least 40 kg (about 88 lbs); and your body mass index (BMI) falls between 18 and 32
• You have chronic hepatitis B (CHB), whether or not you have previously taken antiviral medications for it

Who may not be able to join:

• You have a known allergy, or the research team suspects you may be allergic, to any ingredient in the study drug
• You have taken certain medications that affect how the body processes drugs (called CYP3A4 inhibitors, inducers, or substrates) in the 28 days before joining (confirm with trial site)
• You have used immune-suppressing or immune-modifying drugs, or certain cancer-fighting drugs, in the 6 months before joining, or received a live vaccine in the month before joining
• You had a significant infection requiring IV antibiotics in the 2 weeks before joining, or you currently have an infection that needs treatment
• You have a significant liver disease caused by something other than hepatitis B, as determined by the research team
• You have advanced liver disease (such as fluid in the abdomen, brain problems from liver failure, bleeding from enlarged veins in the food pipe, or significant scarring of the liver)
• You have liver cancer, certain elevated liver-related blood markers, signs of possible cancer in the liver on a scan, or any other cancer diagnosed within the past 5 years (with some exceptions — confirm with trial site)
• You have a history of bone fractures related to weak bones (pathological fractures) or osteoporosis
• You have stomach or digestive problems that could affect how your body absorbs oral medications, such as severe ulcers, significant nausea, vomiting, or diarrhea
• You have serious ongoing disease affecting your heart, lungs, kidneys, blood, immune system, mental health, nerves, or other major body systems
• You had a major injury or major surgery in the 3 months before joining, or you are planning surgery during the study
• You donated or lost 400 mL (about 2 cups) or more of blood in the 3 months before joining, received a blood transfusion in the 3 months before joining, or donated/lost 200 mL or more in the month before joining
• Certain blood test or lab results fall outside acceptable ranges, including low platelet or white blood cell counts, high bilirubin, low albumin, reduced kidney function, or abnormal clotting results (confirm specific values with trial site)
• You test positive for hepatitis C, HIV, or syphilis
• You have regularly consumed more than about 20 grams of alcohol per day (roughly 1.5 standard drinks) over the past 3 years
• You have had a problem with drug dependence or drug misuse in the past year
• You have taken part in another clinical trial and received an experimental drug or used an experimental medical device within the past 3 months
• You are currently breastfeeding or have a positive pregnancy test at screening
• The research team believes there are other reasons that make participation unsuitable for you

Important: Always verify eligibility with the trial site directly before applying.