Irritable Bowel Syndrome Trial, Recruiting NCT05972291 Sponsor: VA Office of Research and Development Condition: Irritable Bowel Syndrome
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Irritable Bowel Syndrome Trial, Recruiting

NCT05972291
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are a Veteran between 18 and 65 years old who has been diagnosed with Gulf War Illness (GWI) and have ongoing stomach problems such as abdominal pain, diarrhea, or bloating
  • Your stomach symptoms began during your deployment in the Persian Gulf (confirm with trial site if unsure)
  • A specific gut test (called a lactulose/mannitol test) shows that your intestines are more "leaky" than normal
  • You are willing and able to participate in and follow the requirements of the study

Who may not be able to join:

  • You are currently taking part in another research study, or you are not able to give your formal consent to participate
  • You are pregnant (based on a urine test) or currently breastfeeding
  • You have a history of inflammatory bowel disease (such as Crohn's or ulcerative colitis), lactose intolerance, or celiac disease
  • A breath test has shown you have too much bacteria in your small intestine
  • A blood test has shown a positive result for a marker linked to celiac disease (confirm with trial site)
  • You have used anti-inflammatory pain medications (like ibuprofen or naproxen) in the 2 weeks before or during the study
  • You have a known allergy to glutamine or whey protein
  • You have had abdominal surgery (other than removal of your gallbladder, uterus, or appendix more than 6 months ago)
  • Your blood test results for kidney function (BUN and/or creatinine) are outside the normal range
  • Results from part of the gut test (mannitol recovery) fall outside the normal range (confirm with trial site)
  • You have a history of kidney disease
  • You have an allergy to monosodium glutamate (MSG)
  • You are currently taking anti-seizure medications

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 23 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: QiQi Zhou, MD PhD, Memphis VA Medical Center, Memphis, TN

Phone: (901) 523-8990

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
16 October 2023
Est. completion
30 July 2026

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

To determine if oral glutamine supplementation will improve the Symptom Severity Scale in Veterans with GWI and chronic GI Symptoms.; To determine if oral glutamine supplementation will restore intestinal permeability in Veterans with GWI.

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov