Phase 1 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have been diagnosed with an advanced solid tumor (confirmed by a tissue or lab test) that is one of the following cancer types: colorectal cancer, esophageal cancer, stomach cancer, pancreatic cancer, non-small cell lung cancer, breast cancer, or bile duct cancer
• Your cancer has gotten worse or you could not tolerate standard treatments, and surgery or local treatments are no longer suitable options — the number of prior treatments required before joining varies by cancer type (confirm with trial site for your specific cancer)
• A test on your tumor tissue taken within the last 3 months shows a protein called CEA at a high level (IHC score 3+), or your blood CEA level is at least twice the upper limit of normal if no tissue sample is available
• You have at least one measurable tumor that can be tracked during the trial
• Your general physical health is rated as good to moderately functional on a standard scale used by doctors (ECOG score 0–1 for most cancer types; 0–2 for pancreatic cancer) (confirm with trial site)
• Your doctors expect you to live for at least 12 more weeks
• You do not have serious mental health conditions
• Your blood counts, heart function, kidney function, liver function, and blood oxygen levels meet certain minimum health standards (confirm with trial site for specific values)
• You are able to have blood drawn or collected through a vein without other complications
• You agree to use effective contraception for 1 year after receiving the cell treatment, and agree not to donate eggs or sperm during that time
• You (or your legal guardian) are willing to sign a consent form agreeing to take part in the trial

Who may not be able to join:

• You have previously received CAR-T therapy or any other type of gene-modified cell therapy
• You have brain tumors or brain spread with symptoms, or brain lesions in critical areas (cases without symptoms in non-critical areas may be reviewed individually — confirm with trial site)
• You received an experimental drug or unapproved treatment within the 4 weeks before screening
• You received a live vaccine within the 4 weeks before screening
• You had a radioactive seed implant (iodine-125) within the 8 weeks before screening
• You took high-dose steroid tablets or injections (equivalent to more than 10mg/day of prednisone) within 2 weeks before the blood collection procedure, not including inhaled steroids
• You received certain immune checkpoint or chemotherapy drugs within 2–4 weeks before the blood collection procedure (confirm with trial site for specific timeframes)
• You have an active infection requiring treatment within 1 week before screening
• You have a bowel blockage, active bleeding in the gut, a history of major gastrointestinal bleeding in the past 3 months, severe stomach ulcers, or severe bowel inflammation
• You have a history of serious breathing or lung disease
• You have large fluid build-ups around the lungs, abdomen, or heart that cannot be controlled with treatment
• You have significant heart problems, including severe heart failure, a heart attack or heart bypass surgery within the past 6 months, serious heart rhythm problems, or a history of severe heart muscle disease
• You have an active autoimmune disease (such as Crohn's disease, rheumatoid arthritis, or lupus) that requires treatment with immune-suppressing medications
• You test positive for active hepatitis B, hepatitis C, HIV, syphilis, or cytomegalovirus (CMV) (confirm with trial site for exact testing requirements)
• You currently have a blood clot in a vein (such as a pulmonary embolism) and need blood-thinning medication
• You have had another type of cancer within the past 3 years (exceptions may apply for certain early-stage skin or cervical cancers — confirm with trial site)
• You are pregnant, currently breastfeeding, or plan to have a child within 1 year of receiving the cell treatment
• Your doctor determines there are other reasons you should not participate in the study

Important: Always verify eligibility with the trial site directly before applying.