Type 2 Diabetes Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults between 40 and 70 years old (men and women)
• People with a body mass index (BMI) in either the lean range (18.0–25.0) or the obese range (30.0–38.0)
• People with a fasting insulin level below 9.0 mU/l (for the lean or insulin-sensitive obese group) or above 9.0 mU/l (for the insulin-resistant obese group)
• People with a fasting blood sugar level below 6.1 mmol/l
• People with a normal body temperature below 37.5°C at the time of screening
• People in the insulin-resistant obese group who have a parent, sibling, or child with confirmed type 2 diabetes
• People whose weight has been stable (within 5 kg) for at least 3 months before screening
• People who are fluent in Swedish and able to follow instructions
• People who have given their consent to take part

Who may not be able to join:

• People in the lean or insulin-sensitive obese group who have a parent, sibling, or child with type 2 diabetes
• People who drink more than 10 units of alcohol per week, or who had a known high alcohol intake at any point in the past 10 years
• People who smoke cigarettes daily, or who use smokeless tobacco daily in a way that would make it difficult to go without nicotine during a visit to the research centre
• People who exercise at a very high level on a regular basis (corresponding to the highest activity level on the Saltin-Gimby scale) (confirm with trial site)
• People following a special weight-loss diet such as Atkins or 5:2 (vegetarian diets are accepted if followed for more than one year)
• People with impaired fasting glucose, meaning a fasting blood sugar between 6.1 and 6.9 mmol/l
• People who have been diagnosed with type 2 diabetes
• People with a history of or ongoing heart disease, such as angina or a previous heart attack, currently treated with blood-thinning medications
• People with heart failure or a heart rhythm problem that requires medication
• People who have had a stroke or mini-stroke and are being treated with blood-thinning medications
• People with reduced blood flow to the legs causing pain when walking (peripheral arterial disease)
• People with blood pressure above 170/105 mmHg at screening, or who are taking more than one type of medication to treat high blood pressure
• People with high blood fats — specifically, triglycerides above 5.0 mmol/l or cholesterol above 7.5 mmol/l
• People with a blood disorder such as untreated anaemia, or a condition that causes abnormal bleeding
• People with reduced kidney function (eGFR below 60 ml/min/1.73 m²)
• People with an underactive thyroid (TSH above 4.0 mIE/l) who also have symptoms
• People with liver disease such as hepatitis B, cirrhosis, or significantly raised liver enzyme levels
• People with a long-term inflammatory condition such as rheumatoid arthritis, ulcerative colitis, or Crohn's disease (coeliac disease, indigestion, or irritable bowel syndrome are not excluded)
• People with chronic bronchitis or chronic obstructive pulmonary disease (COPD) with active symptoms
• People with a history of pancreatitis or another pancreatic condition requiring treatment
• People who experience migraines triggered by stress
• People with a back or spinal condition that makes it uncomfortable to lie flat during the study
• People with a drug addiction that would interfere with the study procedures
• People with a psychiatric condition that would interfere with the study procedures
• People taking medication that could affect fat tissue metabolism, if that medication cannot be stopped 10 days before the study visits
• People currently taking beta-blocker medications
• People who have used antibiotics within the past three months
• People who have had a cancer diagnosis within the past 5 years
• People whose physical examination or blood test results suggest that participation would not be appropriate
• People who are pregnant or planning to become pregnant during the study
• People who do shift work more than once per week in a way that may disrupt their body clock
• People who the principal investigator believes should not participate for any other reason

Important: Always verify eligibility with the trial site directly before applying.