Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People whose physical fitness is rated as good (a performance score of 0–1 on a standard medical scale), and this rating has been stable for at least 7 days
• People who have been confirmed through a tissue biopsy to have stomach cancer or cancer of the junction between the stomach and oesophagus that has spread to other parts of the body or cannot be surgically removed
• People who have received one prior chemotherapy treatment for this cancer and the cancer has since grown, OR people who completed adjuvant (post-surgery) chemotherapy but whose cancer returned or grew within 6 months of finishing that treatment
• People whose first treatment included a PD-1 immunotherapy drug, and whose cancer did not progress for more than 9 months during that first treatment
• People who have at least one tumour that can be measured on a scan, according to standard medical guidelines (RECIST 1.1)
• People whose blood, liver, and kidney function results meet the specific levels required by the trial (confirm details with trial site)
• People whose blood clotting results are within the normal range required by the trial
• Women of childbearing age for whom a pregnancy test taken within 14 days before joining comes back negative, and who agree to use contraception during the trial and for 8 weeks after the last dose
• Men who are surgically sterilised or who agree to use contraception during the trial and for 8 weeks after the last dose
• People with a life expectancy of at least 3 months
• People who have voluntarily agreed to take part and have signed a consent form
• People expected to be able to attend all required follow-up visits and comply with the trial schedule

Who may not be able to join:

• People who have previously been treated with a type of drug called a VEGFR inhibitor
• People who have previously received paclitaxel chemotherapy — unless it was given before or after surgery and finished more than 6 months before the cancer progressed
• People who have received a live vaccine within 4 weeks before joining, or who may need one during the trial
• People who have an active autoimmune disease, or who have had one within the 4 weeks before joining
• People who have previously had a bone marrow transplant or an organ transplant from another person
• People with high blood pressure that cannot be controlled with medication (specifically, readings at or above 150/90 mmHg)
• People who have a condition that affects how they absorb medication, or who are unable to swallow and take tablets by mouth
• People with active stomach or bowel conditions such as ulcers, ulcerative colitis, active bleeding from a tumour, or other conditions that may increase the risk of bleeding or a hole forming in the digestive tract
• People who have had significant bleeding (more than 30 mL), vomiting blood, or blood in the stool within the past 3 months, or a blood clot, stroke, or mini-stroke within the past 12 months
• People who have had a serious heart-related condition within the past 6 months, including heart attack, severe chest pain, or bypass surgery; or who have moderate-to-severe heart failure, certain irregular heartbeats requiring medication, or a heart pumping function below 50%
• People with an active or uncontrolled serious infection
• People known to have HIV, active hepatitis B (with virus levels above a certain threshold), or hepatitis C with detectable virus levels
• People with any other significant medical condition, abnormal test results, or health concern that, in the treating doctor's judgement, would make participation unsafe or affect the trial results
• People whom the trial investigators consider unsuitable for any other reason

Important: Always verify eligibility with the trial site directly before applying.