Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You are in generally good physical condition and able to carry out daily activities with little or no limitation (confirm with trial site regarding specific fitness scoring)
• You have been diagnosed through a tissue biopsy with stomach cancer or cancer at the junction of the stomach and food pipe (gastroesophageal junction) that has spread or cannot be surgically removed
• You have already received one round of chemotherapy for this cancer and it stopped working, OR you completed adjuvant (post-surgery) chemotherapy but your cancer came back or got worse within 6 months of finishing it
• You have not previously been treated with immunotherapy drugs known as PD-1 or PD-L1 inhibitors
• You have at least one measurable tumour that can be tracked during the trial (confirm with trial site)
• Your blood, liver, and kidney function meet certain minimum health levels based on recent lab tests (confirm with trial site for specific values)
• Your blood clotting function is within a normal range and you have no active bleeding
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 14 days before joining and agree to use reliable contraception during the trial and for 8 weeks after the last dose
• If you are a man, you must either have had a sterilisation procedure or agree to use reliable contraception during the trial and for 8 weeks after the last dose
• Your doctor expects you to live for at least 3 more months
• You are willing to participate, have signed a consent form, and are able to attend all required follow-up visits

Who may not be able to join:

• You have previously been treated with a type of drug called a VEGFR inhibitor
• You have previously received the chemotherapy drug paclitaxel, unless you had it as part of pre- or post-surgery treatment and it ended more than 6 months before your cancer got worse
• You have received a live vaccine within 4 weeks before joining, or may need one during the study
• You have an active autoimmune disease, or have had one within the past 4 weeks
• You have previously had a bone marrow transplant or an organ transplant from another person
• You have high blood pressure that cannot be controlled with medication (generally a reading of 150/90 mmHg or higher)
• You have a condition that affects how you absorb medicines, or you are unable to swallow pills
• You have active stomach or intestinal problems such as ulcers, inflammatory bowel disease, or tumours that are actively bleeding, or other conditions that could lead to bleeding or a hole forming in the gut
• You have had significant bleeding episodes in the last 3 months, or a stroke or similar blood clot event in the last 12 months
• You have had a serious heart condition in the last 6 months, such as a heart attack, severe chest pain, or heart bypass surgery; or you have significant heart failure, certain irregular heart rhythms, or reduced heart pumping function
• You have a serious active infection that is not under control
• You are known to have HIV, active hepatitis B, or active hepatitis C infection
• You have any other significant medical condition, abnormal test results, or health issue that the research doctor believes makes participation unsafe or unsuitable
• The trial doctors consider you unsuitable for inclusion for any other reason

Important: Always verify eligibility with the trial site directly before applying.