Irritable Bowel Syndrome Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 75 years old
• You have been diagnosed with diarrhea-predominant irritable bowel syndrome (IBS-D), confirmed using a standard set of medical criteria called Rome IV
• Your IBS symptoms are moderate to severe, based on a specific symptom score (Francis score above 175 out of 500)
• Any treatments you currently take for IBS have stayed the same for more than 1 month
• You are covered by a social security/health insurance system
• You have read, understood, and signed the study consent form
• If you are a woman who could become pregnant, you have been using a reliable form of contraception (such as the pill, an IUD, or tubal ligation) for at least 1 month, and have a negative pregnancy test
• If you are a woman who has gone through menopause, this has been confirmed (no periods for at least 12 months without a medical reason, or confirmed by a blood test)

Who may not be able to join:

• You have taken probiotics, anti-inflammatory medicines, steroids, or antibiotics (by mouth or injection) in the past month or plan to during the study
• You have a known active autoimmune condition such as type 1 diabetes, lupus, multiple sclerosis, thyroid disease, ankylosing spondylitis, rheumatoid arthritis, or psoriasis
• You have a known allergy to glutamine
• You cannot take glutamine, protein powder, lactulose, or mannitol for any medical reason (including an intolerance to sugar-free chewing gum)
• You have used certain laxatives, lactulose, or protein/glutamine supplements in the 4 weeks before the study starts
• You have significant kidney problems, liver problems, or a known heart condition
• You have a history of certain digestive diseases such as coeliac disease, inflammatory bowel disease (e.g. Crohn's or colitis), or abdominal surgery other than appendix or gallbladder removal
• You have or are suspected of having a blocked or nearly blocked bowel
• You have or are suspected of having a hole (perforation) in your digestive tract
• You have abdominal pain whose cause has not been identified
• You regularly drink more than 14 units of alcohol per week
• You are pregnant, have recently given birth, or are breastfeeding, or you do not use contraception (for women who could become pregnant)
• You are under a legal order restricting your freedom, or are under legal guardianship or protective supervision
• You are currently taking part in another clinical trial, or have done so within the past 2 weeks
• You have a medical, psychological, or sensory condition that would prevent you from fully understanding what the study involves or from giving informed consent

Important: Always verify eligibility with the trial site directly before applying.