Phase 2 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have been diagnosed with an advanced solid tumour cancer (one that has spread, cannot be removed by surgery, or has come back) that is not a brain tumour that started in the brain or spinal cord
• Your cancer has gotten worse during or after your most recent cancer treatment, or you were unable to tolerate that treatment
• Your cancer can be measured on scans, following standard measurement guidelines
• You are generally well enough to carry out light activity and care for yourself (your doctor will assess this)
• You have previously received standard approved treatments that were available to you, unless those treatments were not suitable or you chose not to have them
• You have not taken part in another experimental drug trial within the past 3 weeks (or 5 half-lives of that drug, whichever is shorter, with a minimum of 2 weeks) before starting this trial
• Your doctor expects you to live for at least 3 more months
• Patients with a known BRCA2 gene mutation that stops the gene from working normally may be given extra consideration for joining

Who may not be able to join:

• You are taking steroid tablets (such as prednisone) at a dose higher than 10 mg per day on an ongoing basis (low-dose steroids for a medical condition, or inhaled, skin, or eye steroids are generally allowed)
• You have had full-dose radiotherapy within the last 6 weeks, or lower-dose (palliative) radiotherapy within the last 2 weeks
• You have brain tumour spread (metastases) that are causing symptoms or getting worse — stable, previously treated brain metastases may be allowed if they have not changed for at least 4 weeks
• You have a digestive system condition that could affect how your body absorbs the study drug, or you have had a bowel blockage in the last 6 months, or fluid drained from your abdomen within the last 8 weeks
• You have spreading cancer in the membranes around the brain or spinal cord (leptomeningeal disease) that is active and worsening (confirm with trial site)
• You have certain heart rhythm abnormalities detected on an ECG, a personal or family history of a specific inherited heart condition (long QT syndrome), are taking medications known to affect heart rhythm, or have other heart rhythm risk factors (confirm with trial site)
• You have had a heart attack or unstable chest pain within the last 6 months, or have significant heart problems such as uncontrolled high blood pressure or heart failure
• You have an active or long-term serious infection, including tuberculosis, hepatitis B, hepatitis C, or HIV-related illness — some well-controlled infections with undetectable virus levels may still be allowed (confirm with trial site)
• You have uncontrolled kidney disease, pancreas disease, or liver disease (some liver conditions may still be allowed — confirm with trial site)
• You have had another cancer in the last 2 years that needed treatment, unless it was an early-stage cancer treated with the aim of curing it (such as certain skin cancers or early bladder cancer) and you no longer need ongoing chemotherapy
• You are currently taking certain medications including proton pump inhibitors (such as omeprazole), or certain drugs that strongly affect how the liver breaks down medications (confirm with trial site)
• You are currently taking warfarin (Coumadin) or similar blood-thinning medications of the same type

Important: Always verify eligibility with the trial site directly before applying.