Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have fully understood the study and have voluntarily signed a consent form
• People aged 18 or older
• People who have been diagnosed through laboratory testing with advanced stomach cancer or cancer at the junction of the stomach and oesophagus, and who have already had at least one course of treatment for it
• People who have previously received immune therapy drugs (including PD-1 drugs), either before surgery, after surgery, or as a main treatment — and for people whose cancer spread or came back within 6 months of finishing that treatment, that earlier treatment counts as their first-line treatment
• People whose general physical fitness is rated 0 or 1 on a standard medical scale, and whose fitness level has not declined in the 7 days before joining
• People with a Body Mass Index (BMI) of 18 or higher
• People whose doctors expect them to live for at least 3 months
• People whose blood, liver, kidney, and heart results fall within the ranges required by the trial (confirm with trial site for exact values)
• Women who are able to become pregnant and are using effective contraception
• People who are willing to attend follow-up appointments and cooperate with the study requirements

Who may not be able to join:

• People who are unlikely or unwilling to follow the study plan and procedures
• People who have previously been treated with a type of drug that targets a protein called VEGFR
• People who have previously been treated with paclitaxel (a chemotherapy drug), unless that treatment was given before or after surgery and ended more than 6 months before the cancer got worse
• People whose cancer tests positive for a marker called HER-2
• People who have received a live vaccine within 4 weeks before joining, or who may need one during the study
• People who have had another cancer in the past 5 years, except for certain skin cancers or cervical pre-cancers that were fully treated with surgery
• People who have an active autoimmune disease, or who had one within the 4 weeks before joining
• People who have previously had a bone marrow transplant or an organ transplant from another person
• People who are known to be allergic to the study drug or any of its ingredients
• People with electrolyte (blood chemical) abnormalities that the doctor considers medically significant
• People with high blood pressure that cannot be controlled with medication, defined as a top reading of 150 mmHg or higher and/or a bottom reading of 90 mmHg or higher
• People who have a condition affecting how their body absorbs medication, or who are unable to swallow tablets or capsules
• People with active stomach or gut conditions such as stomach ulcers, ulcerative colitis, active tumour bleeding, or other conditions the doctor believes could cause gut bleeding or a tear in the gut
• People with a significant history of bleeding — including more than 30 mL of bleeding in the past 3 months, coughing up blood in the past 4 weeks, or a stroke or mini-stroke in the past 12 months
• People with significant heart disease, including a heart attack, severe chest pain, or heart bypass surgery in the past 6 months; certain types of heart failure; irregular heart rhythms requiring medication; or a low heart pumping function
• People with a serious active infection that is not under control
• People known to have HIV; people with active hepatitis B (confirmed with specific blood test results); or people with active hepatitis C (confirmed with specific blood test results)
• People who still have side effects from previous cancer treatment that are above a mild level (except for hair loss, low lymphocyte counts, or certain mild nerve side effects from a specific chemotherapy)
• People who are pregnant or breastfeeding
• People who have received a blood transfusion, blood products, or certain blood-boosting medicines (such as albumin or G-CSF) within 28 days before joining
• People with any other medical condition, abnormal test result, or physical finding that the doctor believes would make the study drug unsafe or make it hard to interpret the study results
• People whose urine tests show a high level of protein (2+ or more on a standard test, confirmed by a 24-hour urine collection showing more than 1.0g of protein)
• People who the trial doctors consider unsuitable for the study for any other reason

Important: Always verify eligibility with the trial site directly before applying.