Phase 2 Stomach Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing and able to give your consent to take part before any study procedures begin
• You fall into one of three groups: (A) you have advanced or spreading stomach, gastroesophageal junction, or esophageal cancer of a specific type (HER2-negative, PDL1 CPS ≥5%) that cannot be removed by surgery or treated with radiotherapy, and you are about to start a specific combination of chemotherapy and immunotherapy; OR (B) you have advanced or spreading liver cancer (with a specific liver function rating called "Child's A") that cannot be removed by surgery or treated with radiotherapy, and you are about to start a specific immunotherapy combination; OR (C) you have advanced or spreading lung cancer of a specific type (adenocarcinoma, PDL1 TPS ≥50%, without certain gene changes) that cannot be removed by surgery or treated with radiotherapy, and you are about to start a specific immunotherapy drug alone
• Your cancer can be measured on a scan, with at least one tumour that has never been treated with radiotherapy and is large enough to be measured accurately
• You are reasonably active and able to carry out daily activities (your doctor will assess this using a standard scale rated 0–2)
• Your blood counts, liver, and kidney are working well enough, based on blood tests done within the last 28 days (your doctor will check specific values)
• Your doctors expect you to live for at least 12 weeks
• If you are a woman who could become pregnant, you must be using reliable contraception, not be breastfeeding, and have a negative pregnancy test before starting treatment
• If you are a woman who cannot become pregnant, this must be confirmed by one of the following: being over 50 and having had no periods for at least 12 months after stopping any hormone treatment; being under 50, having had no periods for 12 months after stopping hormone treatment, and having hormone levels in the post-menopausal range; or having had a surgical procedure such as removal of the uterus or ovaries (but not tubal ligation alone) (confirm with trial site)
• If you are a male patient, you must be willing to use barrier contraception (such as condoms)
• You are willing to follow the study plan, attend scheduled appointments, and complete all required visits and tests

Who may not be able to join:

• You have previously been treated with immune checkpoint inhibitors or certain experimental antibody therapies
• You have or have had a second type of cancer, unless it was a fully treated non-melanoma skin cancer, fully treated cervical cancer caught early, or another cancer that was completely cured with no signs of return for 5 or more years
• You have spinal cord compression or cancer that has spread to the brain that is currently causing symptoms or requires steroid medication (stable, symptom-free brain metastases that do not need steroids may be acceptable — confirm with trial site)
• You have had a major operation within 4 weeks before starting the study, or you have not yet fully recovered from a recent major operation
• You have serious uncontrolled health conditions such as very high blood pressure, active uncontrolled bleeding problems, or active infections including hepatitis B, hepatitis C, or HIV
• You have an autoimmune disease (a condition where your immune system attacks your own body)
• You are pregnant, breastfeeding, or have a positive pregnancy test before joining, or you and your partner are not using effective contraception
• Your doctor does not feel it is appropriate for you to take part in the trial
• You have previously had a bone marrow transplant using donor cells from another person

Important: Always verify eligibility with the trial site directly before applying.